DE69620473D1 - Strahlungsschützende phospholipiden - Google Patents

Strahlungsschützende phospholipiden

Info

Publication number
DE69620473D1
DE69620473D1 DE69620473T DE69620473T DE69620473D1 DE 69620473 D1 DE69620473 D1 DE 69620473D1 DE 69620473 T DE69620473 T DE 69620473T DE 69620473 T DE69620473 T DE 69620473T DE 69620473 D1 DE69620473 D1 DE 69620473D1
Authority
DE
Germany
Prior art keywords
phospholipids
derivatized
disclosed
ether
radiation protective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69620473T
Other languages
English (en)
Other versions
DE69620473T2 (de
Inventor
Oren Tirosh
Ron Kohen
Joshua Katzhendler
Yechezkel Barenholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Publication of DE69620473D1 publication Critical patent/DE69620473D1/de
Application granted granted Critical
Publication of DE69620473T2 publication Critical patent/DE69620473T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/335—Polymers modified by chemical after-treatment with organic compounds containing phosphorus
    • C08G65/3353—Polymers modified by chemical after-treatment with organic compounds containing phosphorus containing oxygen in addition to phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Birds (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
  • Radiation-Therapy Devices (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE69620473T 1995-12-11 1996-12-10 Strahlungsschützende phospholipiden Expired - Lifetime DE69620473T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/570,440 US5817856A (en) 1995-12-11 1995-12-11 Radiation-protective phospholipid and method
PCT/IL1996/000175 WO1997021429A1 (en) 1995-12-11 1996-12-10 Radiation-protective phospholipid

Publications (2)

Publication Number Publication Date
DE69620473D1 true DE69620473D1 (de) 2002-05-08
DE69620473T2 DE69620473T2 (de) 2002-11-14

Family

ID=24279658

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69620473T Expired - Lifetime DE69620473T2 (de) 1995-12-11 1996-12-10 Strahlungsschützende phospholipiden

Country Status (8)

Country Link
US (2) US5817856A (de)
EP (1) EP0900075B1 (de)
AT (1) ATE215360T1 (de)
AU (1) AU705529B2 (de)
DE (1) DE69620473T2 (de)
ES (1) ES2175152T3 (de)
IL (1) IL124732A0 (de)
WO (1) WO1997021429A1 (de)

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US5817856A (en) * 1995-12-11 1998-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method
US6306433B1 (en) * 1997-08-12 2001-10-23 Pharmacia Ab Method of preparing pharmaceutical compositions
US20040247662A1 (en) * 1998-06-25 2004-12-09 Dow Steven W. Systemic immune activation method using nucleic acid-lipid complexes
US20030022854A1 (en) * 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
AU2001226338A1 (en) * 2000-01-11 2001-07-24 Clinical Results, Inc. Dermatological suspensions (micro-matrix)
WO2001058910A2 (en) * 2000-02-10 2001-08-16 Liplasome Pharma A/S Lipid-based drug delivery systems
US20050129722A1 (en) * 2002-03-13 2005-06-16 Collagenex Pharmaceuticals, Inc. Water-based delivery systems
CA2476859C (en) * 2002-03-13 2011-09-20 Collagenex Pharmaceuticals, Inc. Water-based delivery systems
ITMI20021033A1 (it) * 2002-05-15 2003-11-17 Acraf Composizione oftalmica acquosa comprendente un lipide mesomorfico liotropico
WO2004002453A1 (en) 2002-06-28 2004-01-08 Protiva Biotherapeutics Ltd. Method and apparatus for producing liposomes
US7939170B2 (en) * 2002-08-15 2011-05-10 The Rockefeller University Water soluble metal and semiconductor nanoparticle complexes
US20080214437A1 (en) * 2002-09-06 2008-09-04 Mohapatra Shyam S Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases
US7655772B2 (en) 2002-09-06 2010-02-02 University Of South Florida Materials and methods for treatment of allergic diseases
US20040166083A1 (en) * 2003-02-26 2004-08-26 The Andrew Jergens Company Personal care water-in-oil emulsion products
US20060198882A1 (en) * 2003-03-21 2006-09-07 Yechezkel Barenholz Stable liposomes or micelles comprising a sphinolipid and a peg-lipopolymer
CA2523413A1 (en) 2003-04-25 2004-11-11 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
EP1648519B1 (de) * 2003-07-16 2014-10-08 Protiva Biotherapeutics Inc. Lipid verkapselte interferierende rns
NZ592917A (en) * 2003-09-15 2012-12-21 Protiva Biotherapeutics Inc Stable polyethyleneglycol (PEG) dialkyloxypropyl (DAA) lipid conjugates
WO2005094420A2 (en) * 2004-02-17 2005-10-13 University Of South Florida Materials and methods for treatment of inflammatory and cell proliferation disorders
US20050181035A1 (en) * 2004-02-17 2005-08-18 Dow Steven W. Systemic immune activation method using non CpG nucleic acids
WO2005121348A1 (en) * 2004-06-07 2005-12-22 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering rna
US20060116270A1 (en) * 2004-07-16 2006-06-01 Mehdi Hatamian Centrifuge system
EP1793805A1 (de) * 2004-09-09 2007-06-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomale formulierungen mit einem amphipatischen schwachbasen-artigen tempamin zur behandlung von neurodegenerativen erkrankungen
CN101048138B (zh) * 2004-09-09 2010-12-08 耶路撒冷希伯来大学伊萨姆研发公司 脂质体糖皮质激素用于治疗炎性状态的用途
WO2006051549A2 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combination therapy associating preferably a ceramide with a cytotoxic drug
US7361752B2 (en) * 2004-12-14 2008-04-22 Alnylam Pharmaceuticals, Inc. RNAi modulation of MLL-AF4 and uses thereof
WO2006086992A2 (en) * 2005-02-18 2006-08-24 Liplasome Pharma A/S Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands
CN101365424A (zh) * 2005-12-08 2009-02-11 耶路撒冷希伯来大学伊森姆研究发展公司 通过超声辐射改变脂质体组成的方法
US20070218116A1 (en) * 2006-03-14 2007-09-20 Schwendener Reto A Compositions and methods for the treatment of tumors and tumor metastases
WO2007127428A2 (en) * 2006-04-28 2007-11-08 University Of Florida Research Foundation, Inc. Double-stranded/self-complementary vectors with a truncated cba promoter and methods of gene delivery
CA2656990A1 (en) * 2006-04-28 2007-11-08 University Of South Florida Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
CA2600220C (en) * 2006-09-07 2014-12-09 Canadian Blood Services Surface cross-linked lipidic particles, methods of production and uses therefor
PL2279254T3 (pl) 2008-04-15 2017-11-30 Protiva Biotherapeutics Inc. Nowe preparaty lipidowe do dostarczania kwasów nukleinowych
US20120100206A1 (en) 2009-06-11 2012-04-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
IL292615B2 (en) 2009-07-01 2023-11-01 Protiva Biotherapeutics Inc Nucleic acid-lipid particles, preparations containing them and their uses
WO2011000106A1 (en) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Improved cationic lipids and methods for the delivery of therapeutic agents
EP2531175A2 (de) 2010-02-01 2012-12-12 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Liposomen mit amphipathischen wirkstoffen und herstellungsverfahren dafür
WO2012000104A1 (en) 2010-06-30 2012-01-05 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
AU2011342896A1 (en) 2010-12-13 2013-07-04 Quiapeg Pharmaceuticals Ab Functionalized polymers
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
LT2731591T (lt) 2011-07-13 2020-12-28 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Liposomos, kuriose kartu inkapsuliuotas bisfosfonatas ir amfipatinis agentas
CA2876315C (en) 2012-06-12 2021-05-25 Marek Kwiatkowski Conjugates of biologically active molecules to functionalized polymers
EP3247333B1 (de) 2015-01-20 2021-07-21 Tetraderm Group LLC Vielseitiger topischer arzneimittelabgabeträgerstoff multifaktorieller gewebefeuchthaltemittel, das mukosale und hautbarrierewiederherstellung bereitstellt
CA2985330A1 (en) 2015-03-17 2016-09-22 Lipomedix Pharmaceuticals Ltd. Methods for the treatment of bladder cancer
CN105439827A (zh) * 2016-01-12 2016-03-30 江苏省计量科学研究院 一种1,2-O-双十六烷基-rac-甘油的合成方法
WO2018163131A1 (en) 2017-03-10 2018-09-13 Quiapeg Pharmaceuticals Ab Releasable conjugates
CA3112473A1 (en) 2018-09-12 2020-03-19 Quiapeg Pharmaceuticals Ab Releasable glp-1 conjugates
FR3089814B1 (fr) * 2018-12-18 2021-04-02 Oreal Procede de traitement des fibres keratiniques comprenant l’application d’un agent de couplage et d’un phospholipide, composition et utilisation
MX2023006056A (es) 2020-11-25 2023-06-06 Akagera Medicines Inc Nanoparticulas lipidicas para suministro de acidos nucleicos y metodos de uso de las mismas.
CN114796055B (zh) * 2022-05-19 2023-08-15 广东艾粒生物科技有限责任公司 富含脂质体纳米粒的美白敷料及其制备方法

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US5817856A (en) * 1995-12-11 1998-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method

Also Published As

Publication number Publication date
EP0900075A1 (de) 1999-03-10
IL124732A0 (en) 1999-01-26
US6165501A (en) 2000-12-26
US5817856A (en) 1998-10-06
AU7707596A (en) 1997-07-03
ES2175152T3 (es) 2002-11-16
WO1997021429A1 (en) 1997-06-19
DE69620473T2 (de) 2002-11-14
AU705529B2 (en) 1999-05-27
EP0900075B1 (de) 2002-04-03
ATE215360T1 (de) 2002-04-15

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