ES2175152T3 - Fosfolipidos protectores de las radiaciones. - Google Patents

Fosfolipidos protectores de las radiaciones.

Info

Publication number
ES2175152T3
ES2175152T3 ES96940103T ES96940103T ES2175152T3 ES 2175152 T3 ES2175152 T3 ES 2175152T3 ES 96940103 T ES96940103 T ES 96940103T ES 96940103 T ES96940103 T ES 96940103T ES 2175152 T3 ES2175152 T3 ES 2175152T3
Authority
ES
Spain
Prior art keywords
phospholipids
derivatized
disclosed
ether
radiation protective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96940103T
Other languages
English (en)
Inventor
Oren Tirosh
Ron Kohen
Joshua Katzhendler
Yechezkel Barenholz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
Yissum Research Development Co of Hebrew University of Jerusalem
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yissum Research Development Co of Hebrew University of Jerusalem filed Critical Yissum Research Development Co of Hebrew University of Jerusalem
Application granted granted Critical
Publication of ES2175152T3 publication Critical patent/ES2175152T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/335—Polymers modified by chemical after-treatment with organic compounds containing phosphorus
    • C08G65/3353—Polymers modified by chemical after-treatment with organic compounds containing phosphorus containing oxygen in addition to phosphorus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14—Liposomes; Vesicles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Biophysics (AREA)
  • Birds (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
  • Radiation-Therapy Devices (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)

Abstract

SE EXPONEN NUEVOS FOSFOLIPIDOS VINCULADOS AL ETER, OBTENIDOS COMO DERIVACION CON POLIETILENGLICOL EN EL GRUPO DE LA CABEZA POLAR. LAS DOBLES CAPAS DE LIPIDOS QUE CONTIENEN ESTOS FOSFOLIPIDOS MUESTRAN UNA ELEVADA ESTABILIDAD OSCILATIVA. SE EXPONE IGUALMENTE EL USO DE LIPIDOS VINCULADOS AL ETER Y DERIVADOS DEL PEG EN COMPOSICIONES COSMETICAS HIDRATANTES Y PARA PROTECCION CONTRA LAS RADIACIONES.
ES96940103T 1995-12-11 1996-12-10 Fosfolipidos protectores de las radiaciones. Expired - Lifetime ES2175152T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/570,440 US5817856A (en) 1995-12-11 1995-12-11 Radiation-protective phospholipid and method

Publications (1)

Publication Number Publication Date
ES2175152T3 true ES2175152T3 (es) 2002-11-16

Family

ID=24279658

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96940103T Expired - Lifetime ES2175152T3 (es) 1995-12-11 1996-12-10 Fosfolipidos protectores de las radiaciones.

Country Status (8)

Country Link
US (2) US5817856A (es)
EP (1) EP0900075B1 (es)
AT (1) ATE215360T1 (es)
AU (1) AU705529B2 (es)
DE (1) DE69620473T2 (es)
ES (1) ES2175152T3 (es)
IL (1) IL124732A0 (es)
WO (1) WO1997021429A1 (es)

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US5817856A (en) * 1995-12-11 1998-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method
US6306433B1 (en) * 1997-08-12 2001-10-23 Pharmacia Ab Method of preparing pharmaceutical compositions
US20040247662A1 (en) * 1998-06-25 2004-12-09 Dow Steven W. Systemic immune activation method using nucleic acid-lipid complexes
US20030022854A1 (en) 1998-06-25 2003-01-30 Dow Steven W. Vaccines using nucleic acid-lipid complexes
US20030017183A1 (en) * 2000-01-11 2003-01-23 Pollock David E. Dermatological suspensions(micro-matrix)
ES2230268T3 (es) * 2000-02-10 2005-05-01 Liplasome Pharma A/S Sistema de liberacion de farmacos basados en lipidos.
US20050129722A1 (en) * 2002-03-13 2005-06-16 Collagenex Pharmaceuticals, Inc. Water-based delivery systems
NZ534377A (en) * 2002-03-13 2008-04-30 Collagenex Pharm Inc Water-based topical delivery system consisting of cholesterol, fatty acids water and a phospholipid/ceramide portion.
ITMI20021033A1 (it) * 2002-05-15 2003-11-17 Acraf Composizione oftalmica acquosa comprendente un lipide mesomorfico liotropico
DE60334618D1 (de) 2002-06-28 2010-12-02 Protiva Biotherapeutics Inc Verfahren und vorrichtung zur herstellung von liposomen
US7939170B2 (en) * 2002-08-15 2011-05-10 The Rockefeller University Water soluble metal and semiconductor nanoparticle complexes
US7655772B2 (en) 2002-09-06 2010-02-02 University Of South Florida Materials and methods for treatment of allergic diseases
US20080214437A1 (en) * 2002-09-06 2008-09-04 Mohapatra Shyam S Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases
US20040166083A1 (en) * 2003-02-26 2004-08-26 The Andrew Jergens Company Personal care water-in-oil emulsion products
EP1610763A2 (en) * 2003-03-31 2006-01-04 Yissum Research Development Company Of The Hebrew University Of Jerusalem Stable liposomes or micelles comprising a sphingolipid and a peg-lipopolymer
CA2523413A1 (en) 2003-04-25 2004-11-11 The Penn State Research Foundation Method and system for systemic delivery of growth arresting, lipid-derived bioactive compounds
ES2559828T3 (es) * 2003-07-16 2016-02-16 Protiva Biotherapeutics Inc. ARN de interferencia encapsulado en lípidos
NZ581166A (en) * 2003-09-15 2011-06-30 Protiva Biotherapeutics Inc Polyethyleneglycol-modified lipid compounds and uses thereof
CA2559853A1 (en) * 2004-02-17 2005-10-13 University Of South Florida Materials and methods for treatment of inflammatory and cell proliferation disorders
US20050181035A1 (en) * 2004-02-17 2005-08-18 Dow Steven W. Systemic immune activation method using non CpG nucleic acids
AU2005252273B2 (en) * 2004-06-07 2011-04-28 Arbutus Biopharma Corporation Lipid encapsulated interfering RNA
US20060116270A1 (en) * 2004-07-16 2006-06-01 Mehdi Hatamian Centrifuge system
US7744920B2 (en) * 2004-09-09 2010-06-29 Hadasit Medical Research Services & Development Limited Use of liposomal glucocorticoids for treating inflammatory states
US20080063702A1 (en) * 2004-09-09 2008-03-13 Yechezkel Barenholz Liposomal Formulations Comprising an Amphipathic Weak Base Like Tempamine for Treatment of Neurodegenerative Conditions
AU2005303389A1 (en) * 2004-11-15 2006-05-18 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combination therapy associating preferably a ceramide with a cytotoxic drug
WO2006066158A2 (en) * 2004-12-14 2006-06-22 Alnylam Pharmaceuticals, Inc. Rnai modulation of mll-af4 and uses thereof
WO2006086992A2 (en) * 2005-02-18 2006-08-24 Liplasome Pharma A/S Drug delivery systems containing phqspholipase a2 degradable lipid prodrug derivatives and the therapeutic uses thereof as. e.g. wound healing agents and peroxisome proliferator activated receptor ligands
EP1962796A2 (en) * 2005-12-08 2008-09-03 Yissum Research Development Company Of The Hebrew University Of Jerusalem Methods for affecting liposome composition by ultrasound irradiation
US20070218116A1 (en) * 2006-03-14 2007-09-20 Schwendener Reto A Compositions and methods for the treatment of tumors and tumor metastases
WO2007127487A2 (en) * 2006-04-28 2007-11-08 University Of South Florida Materials and methods for reducing inflammation by inhibition of the atrial natriuretic peptide receptor
WO2007127428A2 (en) * 2006-04-28 2007-11-08 University Of Florida Research Foundation, Inc. Double-stranded/self-complementary vectors with a truncated cba promoter and methods of gene delivery
CA2600220C (en) * 2006-09-07 2014-12-09 Canadian Blood Services Surface cross-linked lipidic particles, methods of production and uses therefor
WO2009127060A1 (en) 2008-04-15 2009-10-22 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
EP2440250A1 (en) 2009-06-11 2012-04-18 Yissum Research Development Company of the Hebrew University of Jerusalem, Ltd. Targeted liposomes comprising n-containing bisphosphonates and uses thereof
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
IL292615B2 (en) 2009-07-01 2023-11-01 Protiva Biotherapeutics Inc Nucleic acid-lipid particles, preparations containing them and their uses
US20130052259A1 (en) 2010-02-01 2013-02-28 Yechezkel Barenholz Liposomes comprising amphipathic drugs and method for their preparation
US9006417B2 (en) 2010-06-30 2015-04-14 Protiva Biotherapeutics, Inc. Non-liposomal systems for nucleic acid delivery
EP2651448B1 (en) 2010-12-13 2018-11-28 QuiaPEG Pharmaceuticals AB Water-soluble, non-peptidic, non-nucleotidic phosphoramidate functionalized polymers
US10184942B2 (en) 2011-03-17 2019-01-22 University Of South Florida Natriuretic peptide receptor as a biomarker for diagnosis and prognosis of cancer
ES2819059T3 (es) 2011-07-13 2021-04-14 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Liposomas que encapsulan conjuntamente un bifosfonato y un agente anfipático
CA2876315C (en) 2012-06-12 2021-05-25 Marek Kwiatkowski Conjugates of biologically active molecules to functionalized polymers
EP3247333B1 (en) 2015-01-20 2021-07-21 Tetraderm Group LLC Versatile topical drug delivery vehicle and multifactorial tissue moisturizer that provides mucosal and skin barrier restoration
WO2016149516A1 (en) 2015-03-17 2016-09-22 Lipomedix Pharmaceuticals Ltd. Methods for the treatment of bladder cancer
CN105439827A (zh) * 2016-01-12 2016-03-30 江苏省计量科学研究院 一种1,2-O-双十六烷基-rac-甘油的合成方法
EP4011396A1 (en) 2017-03-10 2022-06-15 QuiaPEG Pharmaceuticals AB Releasable conjugates
JP2021535920A (ja) 2018-09-12 2021-12-23 キアペグ ファーマシューティカルズ アクチエボラグ 放出可能なｇｌｐ−１コンジュゲート
FR3089814B1 (fr) * 2018-12-18 2021-04-02 Oreal Procede de traitement des fibres keratiniques comprenant l’application d’un agent de couplage et d’un phospholipide, composition et utilisation
AU2021385572A1 (en) 2020-11-25 2023-06-22 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids, and related methods of use
CN114796055B (zh) * 2022-05-19 2023-08-15 广东艾粒生物科技有限责任公司 富含脂质体纳米粒的美白敷料及其制备方法

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US5817856A (en) * 1995-12-11 1998-10-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Radiation-protective phospholipid and method

Also Published As

Publication number Publication date
ATE215360T1 (de) 2002-04-15
EP0900075B1 (en) 2002-04-03
AU7707596A (en) 1997-07-03
DE69620473D1 (de) 2002-05-08
US6165501A (en) 2000-12-26
AU705529B2 (en) 1999-05-27
DE69620473T2 (de) 2002-11-14
IL124732A0 (en) 1999-01-26
EP0900075A1 (en) 1999-03-10
WO1997021429A1 (en) 1997-06-19
US5817856A (en) 1998-10-06

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