DE69619117D1 - Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten - Google Patents

Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten

Info

Publication number
DE69619117D1
DE69619117D1 DE69619117T DE69619117T DE69619117D1 DE 69619117 D1 DE69619117 D1 DE 69619117D1 DE 69619117 T DE69619117 T DE 69619117T DE 69619117 T DE69619117 T DE 69619117T DE 69619117 D1 DE69619117 D1 DE 69619117D1
Authority
DE
Germany
Prior art keywords
pct
substants
antineoplastic
phenol substituted
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69619117T
Other languages
English (en)
Other versions
DE69619117T2 (de
Inventor
Eric Niesor
Craig Leigh Bentzen
Mong Nguyen
Jean-Luc Thuillard
Trung Phan
Jean Flach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Symphar SA
Original Assignee
Symphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Symphar SA filed Critical Symphar SA
Application granted granted Critical
Publication of DE69619117D1 publication Critical patent/DE69619117D1/de
Publication of DE69619117T2 publication Critical patent/DE69619117T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
DE69619117T 1995-07-28 1996-07-26 Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten Expired - Fee Related DE69619117T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH02213/95A CH690163A5 (fr) 1995-07-28 1995-07-28 Dérivés gem-diphosphonates substitués utiles en tant qu'agents anti-cancers.
PCT/EP1996/003301 WO1997004785A1 (en) 1995-07-28 1996-07-26 Use of phenol substituted diphosphonates as antineoplastic agents

Publications (2)

Publication Number Publication Date
DE69619117D1 true DE69619117D1 (de) 2002-03-21
DE69619117T2 DE69619117T2 (de) 2002-09-19

Family

ID=4228513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69619117T Expired - Fee Related DE69619117T2 (de) 1995-07-28 1996-07-26 Verwendung von phenol substituierten diphosphonaten als antineoplastische substanten

Country Status (15)

Country Link
US (1) US6127350A (de)
EP (1) EP0845991B1 (de)
JP (1) JPH11511127A (de)
CN (1) CN1091601C (de)
AT (1) ATE212847T1 (de)
AU (1) AU723094B2 (de)
CA (1) CA2228212A1 (de)
CH (1) CH690163A5 (de)
DE (1) DE69619117T2 (de)
DK (1) DK0845991T3 (de)
ES (1) ES2172675T3 (de)
HK (1) HK1015686A1 (de)
PT (1) PT845991E (de)
WO (1) WO1997004785A1 (de)
ZA (1) ZA966364B (de)

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JP4220382B2 (ja) 2001-07-16 2009-02-04 ユニヴェルシテ・パリ・１３ 新しいビスホスホナート誘導体、その製造法及び使用
FR2827289B1 (fr) * 2001-07-16 2004-07-23 Univ Paris 13 Nouveau derive d'acide diphosphonique, son application en therapeutique et procede de preparation
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ES2382814T3 (es) 2005-05-17 2012-06-13 Merck Sharp & Dohme Ltd. Ácido cis-4-[(4-clorofenil)sulfonil]-4-(2,5-difluorofenil)ciclohexanopropanoico para el tratamiento del cáncer
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BRPI0806245B1 (pt) 2007-01-10 2022-01-25 Msd Italia S.R.L. Compostos de fórmula i e seus usos
BRPI0808523A2 (pt) 2007-03-01 2014-08-19 Novartis Vaccines & Diagnostic Inibidores de pim cinase e métodos de seu uso
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EP2170076B1 (de) 2007-06-27 2016-05-18 Merck Sharp & Dohme Corp. 4-carboxybenzylamino-derivate als histondeacetylase-hemmer
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
WO2010144909A1 (en) 2009-06-12 2010-12-16 Novartis Ag Fused heterocyclic compounds and their uses
WO2011046771A1 (en) 2009-10-14 2011-04-21 Schering Corporation SUBSTITUTED PIPERIDINES THAT INCREASE p53 ACTIVITY AND THE USES THEREOF
CA2784807C (en) 2009-12-29 2021-12-14 Dana-Farber Cancer Institute, Inc. Type ii raf kinase inhibitors
CN103080093A (zh) 2010-03-16 2013-05-01 达纳－法伯癌症研究所公司 吲唑化合物及其应用
WO2011163330A1 (en) 2010-06-24 2011-12-29 Merck Sharp & Dohme Corp. Novel heterocyclic compounds as erk inhibitors
CA2805265A1 (en) 2010-08-02 2012-02-09 Merck Sharp & Dohme Corp. Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
WO2012024170A2 (en) 2010-08-17 2012-02-23 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en) 2010-08-23 2014-11-11 Merck Sharp & Dohme Corp. Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
US8946216B2 (en) 2010-09-01 2015-02-03 Merck Sharp & Dohme Corp. Indazole derivatives useful as ERK inhibitors
EP2615916B1 (de) 2010-09-16 2017-01-04 Merck Sharp & Dohme Corp. Kondensierte pyrazolderivate als neue erk-hemmer
WO2012058210A1 (en) 2010-10-29 2012-05-03 Merck Sharp & Dohme Corp. RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
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US20150299696A1 (en) 2012-05-02 2015-10-22 Sirna Therapeutics, Inc. SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
US10112927B2 (en) 2012-10-18 2018-10-30 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2014063054A1 (en) 2012-10-19 2014-04-24 Dana-Farber Cancer Institute, Inc. Bone marrow on x chromosome kinase (bmx) inhibitors and uses thereof
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MX363243B (es) 2012-11-28 2019-03-14 Merck Sharp & Dohme Composiciones para tratar cáncer y usos de dichas composiciones.
RU2690663C2 (ru) 2012-12-20 2019-06-05 Мерк Шарп И Доум Корп. Замещенные имидазопиридины в качестве ингибиторов hdm2
US9540377B2 (en) 2013-01-30 2017-01-10 Merck Sharp & Dohme Corp. 2,6,7,8 substituted purines as HDM2 inhibitors
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
JP6491202B2 (ja) 2013-10-18 2019-03-27 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の多環阻害剤
ES2676734T3 (es) 2013-10-18 2018-07-24 Syros Pharmaceuticals, Inc. Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas
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EP4019515A1 (de) 2015-09-09 2022-06-29 Dana-Farber Cancer Institute, Inc. Hemmer von cyclinabhängigen kinasen
CN106986789B (zh) 2016-01-20 2019-07-16 中国人民解放军军事医学科学院生物医学分析中心 对苯二酚类化合物及其制备方法与在抗肿瘤或免疫调节中的应用
JOP20190055A1 (ar) 2016-09-26 2019-03-24 Merck Sharp & Dohme أجسام مضادة ضد cd27
AU2018252546A1 (en) 2017-04-13 2019-10-10 Sairopa B.V. Anti-SIRPα antibodies
US10947234B2 (en) 2017-11-08 2021-03-16 Merck Sharp & Dohme Corp. PRMT5 inhibitors
WO2019148412A1 (en) 2018-02-01 2019-08-08 Merck Sharp & Dohme Corp. Anti-pd-1/lag3 bispecific antibodies
WO2020033284A1 (en) 2018-08-07 2020-02-13 Merck Sharp & Dohme Corp. Prmt5 inhibitors
EP3833668A4 (de) 2018-08-07 2022-05-11 Merck Sharp & Dohme Corp. Prmt5-inhibitoren

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH675422A5 (de) * 1988-03-31 1990-09-28 Symphar Sa
JPH0377894A (ja) * 1989-08-18 1991-04-03 Toray Ind Inc メチレンジホスホン酸化合物

Also Published As

Publication number Publication date
ZA966364B (en) 1997-02-11
PT845991E (pt) 2002-07-31
ATE212847T1 (de) 2002-02-15
CN1192148A (zh) 1998-09-02
WO1997004785A1 (en) 1997-02-13
EP0845991B1 (de) 2002-02-06
HK1015686A1 (en) 1999-10-22
JPH11511127A (ja) 1999-09-28
AU6787496A (en) 1997-02-26
US6127350A (en) 2000-10-03
DK0845991T3 (da) 2002-05-27
DE69619117T2 (de) 2002-09-19
CN1091601C (zh) 2002-10-02
AU723094B2 (en) 2000-08-17
CH690163A5 (fr) 2000-05-31
EP0845991A2 (de) 1998-06-10
CA2228212A1 (en) 1997-02-13
ES2172675T3 (es) 2002-10-01

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee