DE69616546T2 - Vorrichtung zur reinigung und modifizierung von peptiden - Google Patents
Vorrichtung zur reinigung und modifizierung von peptidenInfo
- Publication number
- DE69616546T2 DE69616546T2 DE69616546T DE69616546T DE69616546T2 DE 69616546 T2 DE69616546 T2 DE 69616546T2 DE 69616546 T DE69616546 T DE 69616546T DE 69616546 T DE69616546 T DE 69616546T DE 69616546 T2 DE69616546 T2 DE 69616546T2
- Authority
- DE
- Germany
- Prior art keywords
- purifying
- modifying peptides
- peptides
- modifying
- conjugating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00279—Features relating to reactor vessels
- B01J2219/00281—Individual reactor vessels
- B01J2219/00283—Reactor vessels with top opening
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00351—Means for dispensing and evacuation of reagents
- B01J2219/00353—Pumps
- B01J2219/00355—Pumps peristaltic
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00277—Apparatus
- B01J2219/00479—Means for mixing reactants or products in the reaction vessels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
- B01J2219/00718—Type of compounds synthesised
- B01J2219/0072—Organic compounds
- B01J2219/00725—Peptides
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
- C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/484,740 US6359114B1 (en) | 1995-06-07 | 1995-06-07 | System for method for the modification and purification of proteins |
PCT/US1996/009525 WO1996040733A1 (en) | 1995-06-07 | 1996-06-07 | A system and method for the modification and purification of peptides |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69616546D1 DE69616546D1 (de) | 2001-12-06 |
DE69616546T2 true DE69616546T2 (de) | 2002-05-02 |
Family
ID=23925411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69616546T Expired - Lifetime DE69616546T2 (de) | 1995-06-07 | 1996-06-07 | Vorrichtung zur reinigung und modifizierung von peptiden |
Country Status (10)
Country | Link |
---|---|
US (2) | US6359114B1 (de) |
EP (1) | EP0832097B1 (de) |
JP (1) | JP3752695B2 (de) |
AT (1) | ATE207931T1 (de) |
AU (1) | AU698179B2 (de) |
DE (1) | DE69616546T2 (de) |
DK (1) | DK0832097T3 (de) |
ES (1) | ES2163025T3 (de) |
PT (1) | PT832097E (de) |
WO (1) | WO1996040733A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6359114B1 (en) | 1995-06-07 | 2002-03-19 | Aphton Corp. | System for method for the modification and purification of proteins |
DE69740173D1 (de) * | 1996-02-08 | 2011-05-26 | Cancer Advances Inc | Immunologische methoden zur behandlung von gastrointestinalem krebs |
AU4145897A (en) * | 1997-02-14 | 1998-09-08 | Warner-Jenkinson Company, Inc. | Method and apparatus for purifying water-insoluble compounds |
GB2348155B (en) * | 1997-02-14 | 2000-11-01 | Warner Jenkinson Co Inc | Apparatus for purifying water-insoluble compounds |
WO1998037200A2 (en) | 1997-02-21 | 1998-08-27 | Genentech, Inc. | Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies |
NZ511550A (en) * | 1997-05-12 | 2005-03-24 | Aphton Corp | CCK-B/gastrin receptor inhibitors for the treatment of tumors |
US20040001842A1 (en) * | 1997-05-12 | 2004-01-01 | Dov Michaeli | Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors |
NL1006071C1 (nl) * | 1997-05-16 | 1998-11-17 | Chemferm Vof | Werkwijze voor het verwijderen van hoogmoleculaire verbindingen uit een processtroom. |
US20030068326A1 (en) * | 1998-05-15 | 2003-04-10 | Aphton Corporation | Method for the treatment of gastroesophageal reflux disease |
PT1077721E (pt) * | 1998-05-15 | 2007-06-21 | Receptor Biologix Inc | Prevenção e tratamento da hipergastrinemia. |
GB9909630D0 (en) * | 1999-04-28 | 1999-06-23 | Zeneca Ltd | Reactor |
US6602414B2 (en) * | 2000-03-30 | 2003-08-05 | Formulations Pro | Molecule separation device and method combining multiple filtration media |
JP2005508838A (ja) * | 2001-03-23 | 2005-04-07 | アフトン コーポレーション | 膵癌の組合せ治療 |
US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
KR20040049830A (ko) * | 2001-07-09 | 2004-06-12 | 애프톤 코포레이션 | 간, 폐 및 식도의 암 및 전암 상태의 치료 및 예방 |
US20050169979A1 (en) * | 2002-07-03 | 2005-08-04 | Dov Michaeli | Liposomal vaccine |
AU2003267984A1 (en) * | 2002-07-03 | 2004-01-23 | Receptor Biologix, Inc. | Liposomal vaccine |
US20040247661A1 (en) * | 2002-07-03 | 2004-12-09 | Dov Michaeli | Liposomal vaccine |
US7235376B2 (en) * | 2003-03-28 | 2007-06-26 | Receptor Biologix, Inc. | Gastrin hormone immunoassays |
JP5576592B2 (ja) * | 2004-03-29 | 2014-08-20 | キャンサー アドヴァンシズ インコーポレイテッド | ガストリンホルモンに対するモノクローナル抗体 |
EP1794586B1 (de) | 2004-09-22 | 2013-01-30 | Cancer Advances, Inc., | Monoklonale antikörper gegen progastrin |
EP2552496A4 (de) * | 2010-03-26 | 2013-12-04 | Ge Healthcare Bio Sciences | Sterilisierungsverfahren |
EP2682168A1 (de) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Reinigung biologischer Moleküle |
WO2014137903A2 (en) | 2013-03-08 | 2014-09-12 | Genzyme Corporation | Integrated continuous manufacturing of therapeutic protein drug substances |
TWI709570B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析法及製法 |
TWI709569B (zh) | 2014-01-17 | 2020-11-11 | 美商健臻公司 | 無菌層析樹脂及其用於製造方法的用途 |
EP3015542A1 (de) * | 2015-05-07 | 2016-05-04 | Bayer Technology Services GmbH | Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes |
JP7469225B2 (ja) | 2017-06-15 | 2024-04-16 | キャンサー アドヴァンシーズ インク. | 腫瘍及び癌に対する体液性及び細胞性免疫を誘発するための組成物及び方法 |
KR20210049155A (ko) | 2018-08-31 | 2021-05-04 | 젠자임 코포레이션 | 멸균 크로마토그래피 수지 및 제조 공정에서 이의 용도 |
EP3939691B1 (de) * | 2020-07-13 | 2023-11-22 | Sartorius Stedim Biotech GmbH | Vorrichtungsanordnung zur herstellung von biokonjugaten |
WO2023034490A2 (en) * | 2021-09-02 | 2023-03-09 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | A hierarchically organized system for contemporaneous fractionation of multiple fractions |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4762913A (en) | 1973-05-07 | 1988-08-09 | The Ohio State University | Antigenic modification of polypeptides |
US5006334A (en) | 1973-05-07 | 1991-04-09 | The Ohio State University | Antigenic modification of polypeptides |
SE434914B (sv) * | 1975-07-07 | 1984-08-27 | Jonsson U R S | Forfarande for att ur en suspension av bakterier och ett vetskeformigt medium genom filtrering avskilja mediet under samtidig anrikning av bakterierna |
US4042682A (en) | 1976-04-07 | 1977-08-16 | Hoffmann-La Roche Inc. | Endogenous morphine-like compound |
US4385113A (en) * | 1978-03-20 | 1983-05-24 | Nasa | Rapid, quantitative determination of bacteria in water |
US4443540A (en) * | 1980-05-09 | 1984-04-17 | University Of Illinois Foundation | Protein hydrolysis |
IL64501A (en) | 1980-12-22 | 1985-07-31 | Astra Laekemedel Ab | 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use |
US4608336A (en) | 1981-08-27 | 1986-08-26 | Miles Laboratories, Inc. | #3B theophylline immunoassay employing 9-theophylline reagents |
DE3144705C2 (de) * | 1981-11-11 | 1983-12-08 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat |
US4420425A (en) * | 1982-08-02 | 1983-12-13 | The Texas A&M University System | Method for processing protein from nonbinding oilseed by ultrafiltration and solubilization |
US4414113A (en) * | 1982-09-29 | 1983-11-08 | Ecodyne Corporation | Liquid purification using reverse osmosis hollow fibers |
US4609662A (en) | 1982-10-14 | 1986-09-02 | Burroughs Wellcome Co. | Method for using purine derivatives |
US4621140A (en) | 1984-02-23 | 1986-11-04 | Syntex (U.S.A.) Inc. | Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives |
US4605500A (en) * | 1984-04-24 | 1986-08-12 | Mitsubishi Rayon Co., Ltd. | Hollow-fiber filter module |
US5024762A (en) * | 1985-03-05 | 1991-06-18 | Memtec Limited | Concentration of solids in a suspension |
US4701304A (en) * | 1985-04-19 | 1987-10-20 | Applied Protein Technologies, Inc. | Apparatus for automated synthesis of peptides |
US4803170A (en) | 1985-05-09 | 1989-02-07 | Ultra Diagnostics Corporation | Competitive immunoassay method, device and test kit |
US5106734A (en) | 1986-04-30 | 1992-04-21 | Novo Nordisk A/S | Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin |
IE64511B1 (en) | 1988-03-11 | 1995-08-09 | Takeda Chemical Industries Ltd | Automated synthesizing apparatus |
US5262053A (en) * | 1988-07-15 | 1993-11-16 | Filtrox-Werk Ag | Filtration process, use of stabilizers installation for a filtration process, and procedure for operating said installation |
US5683916A (en) * | 1988-10-31 | 1997-11-04 | Hemasure Inc. | Membrane affinity apparatus and purification methods related thereto |
US5023077A (en) * | 1989-01-24 | 1991-06-11 | Aphton Corporation | Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease |
US4986918A (en) * | 1989-11-08 | 1991-01-22 | Romicon Inc. | Membrane separation system and method of operation |
FR2666245B1 (fr) * | 1990-08-31 | 1992-10-23 | Lyonnaise Eaux | Procede de commande des modes de fonctionnement d'un appareil automatique de filtration d'eau sur membranes tubulaires. |
IL95561A0 (en) | 1990-09-02 | 1991-06-30 | Weizmann Kiryat Membrane Prod | Method for the purification and concentration of biologically active materials |
US5256294A (en) | 1990-09-17 | 1993-10-26 | Genentech, Inc. | Tangential flow filtration process and apparatus |
US5132015A (en) * | 1990-10-04 | 1992-07-21 | Rohm And Haas Company | Flow control for ultra filtration systems |
US5171767A (en) * | 1991-05-06 | 1992-12-15 | Rohm And Haas Company | Utrafiltration process for the recovery of polymeric latices from whitewater |
US5227071A (en) * | 1992-01-17 | 1993-07-13 | Madison Chemical Company, Inc. | Method and apparatus for processing oily wastewater |
US5188733A (en) | 1992-02-26 | 1993-02-23 | Trustees Of Boston University | Apparatus and process for effecting sequential peptide syntheses |
GB9210980D0 (en) * | 1992-05-22 | 1992-07-08 | Dow Danmark | Cassette membrane system and method of use for low pressure separations |
US5380495A (en) * | 1993-08-27 | 1995-01-10 | Chang; Heng-Wei | Solid phase peptide synthesizer |
US5525235A (en) * | 1994-05-17 | 1996-06-11 | Energy Biosystems Corporation | Method for separating a petroleum containing emulsion |
US6359114B1 (en) | 1995-06-07 | 2002-03-19 | Aphton Corp. | System for method for the modification and purification of proteins |
US6027853A (en) * | 1998-01-16 | 2000-02-22 | Olin Microelectronic Chemicals, Inc. | Process for preparing a radiation-sensitive composition |
-
1995
- 1995-06-07 US US08/484,740 patent/US6359114B1/en not_active Expired - Lifetime
-
1996
- 1996-06-07 AT AT96918342T patent/ATE207931T1/de not_active IP Right Cessation
- 1996-06-07 PT PT96918342T patent/PT832097E/pt unknown
- 1996-06-07 DK DK96918342T patent/DK0832097T3/da active
- 1996-06-07 AU AU61029/96A patent/AU698179B2/en not_active Expired
- 1996-06-07 WO PCT/US1996/009525 patent/WO1996040733A1/en active IP Right Grant
- 1996-06-07 EP EP96918342A patent/EP0832097B1/de not_active Expired - Lifetime
- 1996-06-07 DE DE69616546T patent/DE69616546T2/de not_active Expired - Lifetime
- 1996-06-07 JP JP50182897A patent/JP3752695B2/ja not_active Expired - Lifetime
- 1996-06-07 ES ES96918342T patent/ES2163025T3/es not_active Expired - Lifetime
-
2002
- 2002-03-15 US US10/098,690 patent/US20020095028A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JPH11507348A (ja) | 1999-06-29 |
DK0832097T3 (da) | 2001-11-19 |
WO1996040733A1 (en) | 1996-12-19 |
DE69616546D1 (de) | 2001-12-06 |
AU6102996A (en) | 1996-12-30 |
ATE207931T1 (de) | 2001-11-15 |
PT832097E (pt) | 2002-04-29 |
US20020095028A1 (en) | 2002-07-18 |
AU698179B2 (en) | 1998-10-29 |
EP0832097B1 (de) | 2001-10-31 |
JP3752695B2 (ja) | 2006-03-08 |
ES2163025T3 (es) | 2002-01-16 |
US6359114B1 (en) | 2002-03-19 |
EP0832097A1 (de) | 1998-04-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: RECEPTOR BIOLOGIX, INC. (N.D.GES.D. STAATES DE, US |