DE69616546D1 - Vorrichtung zur reinigung und modifizierung von peptiden - Google Patents

Vorrichtung zur reinigung und modifizierung von peptiden

Info

Publication number
DE69616546D1
DE69616546D1 DE69616546T DE69616546T DE69616546D1 DE 69616546 D1 DE69616546 D1 DE 69616546D1 DE 69616546 T DE69616546 T DE 69616546T DE 69616546 T DE69616546 T DE 69616546T DE 69616546 D1 DE69616546 D1 DE 69616546D1
Authority
DE
Germany
Prior art keywords
purifying
modifying peptides
peptides
modifying
conjugating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69616546T
Other languages
English (en)
Other versions
DE69616546T2 (de
Inventor
Stephen Grimes
L Karr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Receptor Biologix Inc
Original Assignee
Aphton Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aphton Corp filed Critical Aphton Corp
Application granted granted Critical
Publication of DE69616546D1 publication Critical patent/DE69616546D1/de
Publication of DE69616546T2 publication Critical patent/DE69616546T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00281—Individual reactor vessels
    • B01J2219/00283—Reactor vessels with top opening
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B01J2219/00355—Pumps peristaltic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00479—Means for mixing reactants or products in the reaction vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00725—Peptides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B60/00—Apparatus specially adapted for use in combinatorial chemistry or with libraries
    • C40B60/14—Apparatus specially adapted for use in combinatorial chemistry or with libraries for creating libraries
DE69616546T 1995-06-07 1996-06-07 Vorrichtung zur reinigung und modifizierung von peptiden Expired - Lifetime DE69616546T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/484,740 US6359114B1 (en) 1995-06-07 1995-06-07 System for method for the modification and purification of proteins
PCT/US1996/009525 WO1996040733A1 (en) 1995-06-07 1996-06-07 A system and method for the modification and purification of peptides

Publications (2)

Publication Number Publication Date
DE69616546D1 true DE69616546D1 (de) 2001-12-06
DE69616546T2 DE69616546T2 (de) 2002-05-02

Family

ID=23925411

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69616546T Expired - Lifetime DE69616546T2 (de) 1995-06-07 1996-06-07 Vorrichtung zur reinigung und modifizierung von peptiden

Country Status (10)

Country Link
US (2) US6359114B1 (de)
EP (1) EP0832097B1 (de)
JP (1) JP3752695B2 (de)
AT (1) ATE207931T1 (de)
AU (1) AU698179B2 (de)
DE (1) DE69616546T2 (de)
DK (1) DK0832097T3 (de)
ES (1) ES2163025T3 (de)
PT (1) PT832097E (de)
WO (1) WO1996040733A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6359114B1 (en) 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
ES2361474T3 (es) * 1996-02-08 2011-06-17 Cancer Advances, Inc. Procedimientos inmunológicos para el tratamiento del cáncer gastrointestinal.
GB2348155B (en) * 1997-02-14 2000-11-01 Warner Jenkinson Co Inc Apparatus for purifying water-insoluble compounds
GB2337214B (en) * 1997-02-14 2000-09-20 Warner Jenkinson Co Inc Method for purifying water-insoluble compounds
IL131406A0 (en) 1997-02-21 2001-01-28 Genentech Inc Antibody fragment-polymer conjugates and humanized anti-il-8 monoclonal antibodies
EP0981369B1 (de) * 1997-05-12 2004-11-17 Aphton Corporation Immunogene zusammensetzungen gegen den cck-b-gastrin-rezeptor und verfahren zur behandlung von tumoren
US20040001842A1 (en) * 1997-05-12 2004-01-01 Dov Michaeli Immunogenic compositions to the CCK-B/gastrin receptor and methods for the treatment of tumors
NL1006071C1 (nl) * 1997-05-16 1998-11-17 Chemferm Vof Werkwijze voor het verwijderen van hoogmoleculaire verbindingen uit een processtroom.
US20030068326A1 (en) * 1998-05-15 2003-04-10 Aphton Corporation Method for the treatment of gastroesophageal reflux disease
DK1077721T3 (da) * 1998-05-15 2007-09-03 Receptor Biologix Inc Forebyggelse og behandling af hypergastrinæmi
GB9909630D0 (en) * 1999-04-28 1999-06-23 Zeneca Ltd Reactor
US6602414B2 (en) * 2000-03-30 2003-08-05 Formulations Pro Molecule separation device and method combining multiple filtration media
WO2002076499A2 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
KR20040049830A (ko) * 2001-07-09 2004-06-12 애프톤 코포레이션 간, 폐 및 식도의 암 및 전암 상태의 치료 및 예방
US20050169979A1 (en) * 2002-07-03 2005-08-04 Dov Michaeli Liposomal vaccine
US20040247661A1 (en) * 2002-07-03 2004-12-09 Dov Michaeli Liposomal vaccine
US20040208920A1 (en) * 2002-07-03 2004-10-21 Dov Michaeli Liposomal vaccine
US20060020119A1 (en) * 2004-03-29 2006-01-26 Stephen Grimes Monoclonal antibodies to gastrin hormone
CN1781023A (zh) 2003-03-28 2006-05-31 埃弗顿有限公司 胃泌素激素免疫测定
WO2006032980A1 (en) * 2004-09-22 2006-03-30 Receptor Biologix, Inc. Monoclonal antibolies to progastrin
EP2552496A4 (de) * 2010-03-26 2013-12-04 Ge Healthcare Bio Sciences Sterilisierungsverfahren
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
MX2015012114A (es) 2013-03-08 2016-01-12 Genzyme Corp Fabricacion continua integrada de principios activos proteinicos terapeuticos.
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
EP3015542A1 (de) * 2015-05-07 2016-05-04 Bayer Technology Services GmbH Modulare anlage und verfahren zur kontinuierlichen, keimreduzierten produktion und/oder aufbereitung eines produktes
US11583576B2 (en) 2017-06-15 2023-02-21 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
WO2020046602A1 (en) 2018-08-31 2020-03-05 Genzyme Corporation Sterile chromatography resin and use thereof in manufacturing processes
EP3939691B1 (de) * 2020-07-13 2023-11-22 Sartorius Stedim Biotech GmbH Vorrichtungsanordnung zur herstellung von biokonjugaten
WO2023034490A2 (en) * 2021-09-02 2023-03-09 University Of Pittsburgh - Of The Commonwealth System Of Higher Education A hierarchically organized system for contemporaneous fractionation of multiple fractions

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006334A (en) 1973-05-07 1991-04-09 The Ohio State University Antigenic modification of polypeptides
US4762913A (en) 1973-05-07 1988-08-09 The Ohio State University Antigenic modification of polypeptides
SE434914B (sv) * 1975-07-07 1984-08-27 Jonsson U R S Forfarande for att ur en suspension av bakterier och ett vetskeformigt medium genom filtrering avskilja mediet under samtidig anrikning av bakterierna
US4042682A (en) 1976-04-07 1977-08-16 Hoffmann-La Roche Inc. Endogenous morphine-like compound
US4385113A (en) * 1978-03-20 1983-05-24 Nasa Rapid, quantitative determination of bacteria in water
US4443540A (en) * 1980-05-09 1984-04-17 University Of Illinois Foundation Protein hydrolysis
IL64501A (en) 1980-12-22 1985-07-31 Astra Laekemedel Ab 9-substituted 4-hydroxybutyl guanine derivatives,their preparation and antiviral use
US4608336A (en) 1981-08-27 1986-08-26 Miles Laboratories, Inc. #3B theophylline immunoassay employing 9-theophylline reagents
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4420425A (en) * 1982-08-02 1983-12-13 The Texas A&M University System Method for processing protein from nonbinding oilseed by ultrafiltration and solubilization
US4414113A (en) * 1982-09-29 1983-11-08 Ecodyne Corporation Liquid purification using reverse osmosis hollow fibers
US4609662A (en) 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4621140A (en) 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4605500A (en) * 1984-04-24 1986-08-12 Mitsubishi Rayon Co., Ltd. Hollow-fiber filter module
US5024762A (en) * 1985-03-05 1991-06-18 Memtec Limited Concentration of solids in a suspension
US4701304A (en) * 1985-04-19 1987-10-20 Applied Protein Technologies, Inc. Apparatus for automated synthesis of peptides
US4803170A (en) 1985-05-09 1989-02-07 Ultra Diagnostics Corporation Competitive immunoassay method, device and test kit
US5106734A (en) 1986-04-30 1992-04-21 Novo Nordisk A/S Process of using light absorption to control enzymatic depolymerization of heparin to produce low molecular weight heparin
IE64511B1 (en) 1988-03-11 1995-08-09 Takeda Chemical Industries Ltd Automated synthesizing apparatus
US5262053A (en) * 1988-07-15 1993-11-16 Filtrox-Werk Ag Filtration process, use of stabilizers installation for a filtration process, and procedure for operating said installation
US5683916A (en) * 1988-10-31 1997-11-04 Hemasure Inc. Membrane affinity apparatus and purification methods related thereto
US5023077A (en) * 1989-01-24 1991-06-11 Aphton Corporation Immunogenic compositions and methods for the treatment and prevention of gastric and duodenal ulcer disease
US4986918A (en) * 1989-11-08 1991-01-22 Romicon Inc. Membrane separation system and method of operation
FR2666245B1 (fr) * 1990-08-31 1992-10-23 Lyonnaise Eaux Procede de commande des modes de fonctionnement d'un appareil automatique de filtration d'eau sur membranes tubulaires.
IL95561A0 (en) 1990-09-02 1991-06-30 Weizmann Kiryat Membrane Prod Method for the purification and concentration of biologically active materials
US5256294A (en) 1990-09-17 1993-10-26 Genentech, Inc. Tangential flow filtration process and apparatus
US5132015A (en) * 1990-10-04 1992-07-21 Rohm And Haas Company Flow control for ultra filtration systems
US5171767A (en) * 1991-05-06 1992-12-15 Rohm And Haas Company Utrafiltration process for the recovery of polymeric latices from whitewater
US5227071A (en) * 1992-01-17 1993-07-13 Madison Chemical Company, Inc. Method and apparatus for processing oily wastewater
US5188733A (en) 1992-02-26 1993-02-23 Trustees Of Boston University Apparatus and process for effecting sequential peptide syntheses
GB9210980D0 (en) * 1992-05-22 1992-07-08 Dow Danmark Cassette membrane system and method of use for low pressure separations
US5380495A (en) * 1993-08-27 1995-01-10 Chang; Heng-Wei Solid phase peptide synthesizer
US5525235A (en) * 1994-05-17 1996-06-11 Energy Biosystems Corporation Method for separating a petroleum containing emulsion
US6359114B1 (en) 1995-06-07 2002-03-19 Aphton Corp. System for method for the modification and purification of proteins
US6027853A (en) * 1998-01-16 2000-02-22 Olin Microelectronic Chemicals, Inc. Process for preparing a radiation-sensitive composition

Also Published As

Publication number Publication date
WO1996040733A1 (en) 1996-12-19
EP0832097B1 (de) 2001-10-31
JPH11507348A (ja) 1999-06-29
US6359114B1 (en) 2002-03-19
PT832097E (pt) 2002-04-29
DK0832097T3 (da) 2001-11-19
AU6102996A (en) 1996-12-30
DE69616546T2 (de) 2002-05-02
ATE207931T1 (de) 2001-11-15
ES2163025T3 (es) 2002-01-16
EP0832097A1 (de) 1998-04-01
AU698179B2 (en) 1998-10-29
JP3752695B2 (ja) 2006-03-08
US20020095028A1 (en) 2002-07-18

Similar Documents

Publication Publication Date Title
DE69616546D1 (de) Vorrichtung zur reinigung und modifizierung von peptiden
DE29680236U1 (de) Vorrichtung zur Abbildung von Gas
DE68900599D1 (de) Geraet zur erweiterung von gefaessen und system zum einbringen desselben.
DE69533085D1 (de) Vorrichtung zur lokalisierung von vibrierenden medizinischen elementen
DE69820877D1 (de) Vorrichtung zur durchführung von nachweisen an reaktionsstellen
DE3880812D1 (de) Membranverfahren und vorrichtung zur gastrocknung.
EP0305929A3 (de) Membranen mit gebundenen Oligonukleotiden oder Peptiden
DE59611511D1 (de) Verfahren zur redundanzreduktion bei der codierung von mehrkanaligen signalen und vorrichtung zur dekodierung von redundanzreduzierten, mehrkanaligen signalen
DE3879082T2 (de) Modul und Vorrichtung zur Anreicherung von Sauerstoff.
DE69300024T2 (de) Vorrichtung zur Erzeugung von Bezugsspannungen.
AP9901607A0 (en) Method and apparatus for continuous flow isoelectric focusing for
DE3789309D1 (de) Enzymatische membran, verfahren zur herstellung und trennung von peptiden.
DE69731267D1 (de) Vorrichtung zur Erzeugung von Schwingungen
DE69412739D1 (de) Polyimid-Membrane zur Gastrennung
DE58906909D1 (de) Vorrichtung zur abschliessenden fixierung von extremitäten.
DE68903429D1 (de) Vorrichtung zur trennung von gasmischungen.
DE19881185D2 (de) Vorrichtung zur Zerstörung bzw. Zertrümmerung von Konkrementen
DE3766741D1 (de) Vorrichtung zur erzeugung von ultrahochdruck.
DE29718733U1 (de) Vorrichtung zur Erzeugung von Sauerstoff bzw. Ozon-Sauerstoffgemisch
AU7193296A (en) Process for the ultrafiltration of biological matrices comprising peptides or proteins
DE29601518U1 (de) Vorrichtung zur Vermittlung von Informationen über den Bewegungsablauf von Fahrzeugen
DE68905273T2 (de) Vorrichtung zur herstellung von yoghurt.
DE69315730T2 (de) Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
DE69814044D1 (de) Authentifizierungssystem, authentifizierungsvorrichtung, vorrichtung zur erzeugung von authentifizierungsdaten und authentifizierungsverfahren
DE59705838D1 (de) Vorrichtung zur überkopfbehandlung von flaschen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: RECEPTOR BIOLOGIX, INC. (N.D.GES.D. STAATES DE, US