DE69612575D1 - Hocheffiziente Übersetzung von mRNA Molukülen - Google Patents

Hocheffiziente Übersetzung von mRNA Molukülen

Info

Publication number
DE69612575D1
DE69612575D1 DE69612575T DE69612575T DE69612575D1 DE 69612575 D1 DE69612575 D1 DE 69612575D1 DE 69612575 T DE69612575 T DE 69612575T DE 69612575 T DE69612575 T DE 69612575T DE 69612575 D1 DE69612575 D1 DE 69612575D1
Authority
DE
Germany
Prior art keywords
highly efficient
mrna molecules
efficient translation
translation
mrna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69612575T
Other languages
English (en)
Other versions
DE69612575T2 (de
Inventor
David W Andrews
Akaterini Vassilakos
Martin John Glenton Hughes
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McMaster University
Original Assignee
McMaster University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McMaster University filed Critical McMaster University
Application granted granted Critical
Publication of DE69612575D1 publication Critical patent/DE69612575D1/de
Publication of DE69612575T2 publication Critical patent/DE69612575T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69612575T 1995-02-10 1996-02-12 Hocheffiziente Übersetzung von mRNA Molukülen Expired - Fee Related DE69612575T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/386,921 US5824497A (en) 1995-02-10 1995-02-10 High efficiency translation of mRNA molecules

Publications (2)

Publication Number Publication Date
DE69612575D1 true DE69612575D1 (de) 2001-05-31
DE69612575T2 DE69612575T2 (de) 2001-10-18

Family

ID=23527635

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69612575T Expired - Fee Related DE69612575T2 (de) 1995-02-10 1996-02-12 Hocheffiziente Übersetzung von mRNA Molukülen

Country Status (4)

Country Link
US (2) US5824497A (de)
EP (1) EP0726319B1 (de)
CA (1) CA2169317A1 (de)
DE (1) DE69612575T2 (de)

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WO2007024708A2 (en) 2005-08-23 2007-03-01 The Trustees Of The University Of Pennsylvania Rna containing modified nucleosides and methods of use thereof
DE102005046490A1 (de) * 2005-09-28 2007-03-29 Johannes-Gutenberg-Universität Mainz Modifikationen von RNA, die zu einer erhöhten Transkriptstabilität und Translationseffizienz führen
US10155038B2 (en) 2007-02-02 2018-12-18 Yale University Cells prepared by transient transfection and methods of use thereof
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US9249423B2 (en) 2007-02-02 2016-02-02 Yale University Method of de-differentiating and re-differentiating somatic cells using RNA
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US10837020B2 (en) 2009-04-22 2020-11-17 Massachusetts Institute Of Technology Innate immune suppression enables repeated delivery of long RNA molecules
KR102171849B1 (ko) 2009-12-07 2020-10-30 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 세포 리프로그래밍을 위한 정제된 변형 ｒｎａ를 포함하는 ｒｎａ 제제
US8586363B2 (en) * 2009-12-10 2013-11-19 Regents Of The University Of Minnesota TAL effector-mediated DNA modification
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RS63244B1 (sr) 2011-12-16 2022-06-30 Modernatx Inc Kompozicije modifikovane mrna
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CA2912665C (en) 2013-05-15 2021-03-02 Robert Kruse Intracellular translation of circular rna
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US9931394B2 (en) 2015-03-23 2018-04-03 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
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CA3051252A1 (en) 2017-02-01 2018-08-09 Modernatx, Inc. Immunomodulatory therapeutic mrna compositions encoding activating oncogene mutation peptides
US11485972B2 (en) 2017-05-18 2022-11-01 Modernatx, Inc. Modified messenger RNA comprising functional RNA elements
WO2018232006A1 (en) 2017-06-14 2018-12-20 Modernatx, Inc. Polynucleotides encoding coagulation factor viii
JP7423521B2 (ja) 2017-11-22 2024-01-29 モダーナティエックス・インコーポレイテッド フェニルケトン尿症の治療用のフェニルアラニンヒドロキシラーゼをコードするポリヌクレオチド
US11859215B2 (en) 2017-11-22 2024-01-02 Modernatx, Inc. Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
EP3714045A1 (de) 2017-11-22 2020-09-30 Modernatx, Inc. Für propionyl-coa-carboxylase-alpha- und beta-untereinheiten codierende polynukleotide zur behandlung von propionazidämie
US20210163928A1 (en) 2018-04-11 2021-06-03 Modernatx, Inc. Messenger rna comprising functional rna elements
US20220184185A1 (en) 2018-07-25 2022-06-16 Modernatx, Inc. Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
MA53545A (fr) 2018-09-02 2021-07-14 Modernatx Inc Polynucléotides codant pour l'acyl-coa déshydrogénase à très longue chaîne pour le traitement de l'insuffisance en acyl-coa déshydrogénase à très longue chaîne
US20220243182A1 (en) 2018-09-13 2022-08-04 Modernatx, Inc. Polynucleotides encoding branched-chain alpha-ketoacid dehydrogenase complex e1-alpha, e1-beta, and e2 subunits for the treatment of maple syrup urine disease
MX2021003015A (es) 2018-09-13 2021-07-15 Modernatx Inc Polinucleotidos que codifican glucosa-6-fosfatasa para el tratamiento de la glucogenosis.
US20220401584A1 (en) 2018-09-14 2022-12-22 Modernatx, Inc. Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
MA53734A (fr) 2018-09-27 2021-08-04 Modernatx Inc Polynucléotides codant pour l'arginase 1 pour le traitement d'une déficience en arginase
JP2022532078A (ja) 2019-05-08 2022-07-13 アストラゼネカ アクチボラグ 皮膚及び創傷のための組成物並びにその使用の方法
MA56517A (fr) 2019-06-24 2022-04-27 Modernatx Inc Arn messager comprenant des éléments d'arn fonctionnels et leurs utilisations
WO2021076805A1 (en) 2019-10-15 2021-04-22 Moderna TX, Inc. Mrnas encoding immune modulating polypeptides and uses thereof
JP2022552378A (ja) 2019-10-15 2022-12-15 モデルナティエックス インコーポレイテッド パーキンソン病を治療するための顆粒球マクロファージコロニー刺激因子をコードするｍＲＮＡ
JP7451705B2 (ja) * 2019-11-26 2024-03-18 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー タンパク質発現用ｍＲＮＡ構造体及びその用途
US20230112857A1 (en) 2020-01-10 2023-04-13 Modernatx, Inc. Methods of making tolerogenic dendritic cells
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JP2023527875A (ja) 2020-06-01 2023-06-30 モダーナティエックス・インコーポレイテッド フェニルアラニンヒドロキシラーゼバリアント及びその使用
CN116194151A (zh) 2020-06-23 2023-05-30 摩登纳特斯有限公司 包含具有延长的半衰期的mRNA治疗剂的LNP组合物
US20240216288A1 (en) 2021-03-24 2024-07-04 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
JP2024512026A (ja) 2021-03-24 2024-03-18 モデルナティエックス インコーポレイテッド オルニチントランスカルバミラーゼ欠損症の治療を目的とした脂質ナノ粒子及びオルニチントランスカルバミラーゼをコードするポリヌクレオチド
US20240207444A1 (en) 2021-03-24 2024-06-27 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
WO2022204371A1 (en) 2021-03-24 2022-09-29 Modernatx, Inc. Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
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WO2022250430A1 (ko) * 2021-05-25 2022-12-01 한국생명공학연구원 단백질 발현용 mRNA 제조방법 및 이에 의해 제조된 mRNA의 용도
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Also Published As

Publication number Publication date
EP0726319A2 (de) 1996-08-14
US5807707A (en) 1998-09-15
EP0726319B1 (de) 2001-04-25
DE69612575T2 (de) 2001-10-18
US5824497A (en) 1998-10-20
EP0726319A3 (de) 1997-10-22
CA2169317A1 (en) 1996-08-11

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8339 Ceased/non-payment of the annual fee