DE69612568D1 - 17-seitenkette-alknyl- und 20-oxopregna-derivate von vitamin d, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon - Google Patents
17-seitenkette-alknyl- und 20-oxopregna-derivate von vitamin d, ein verfahren zu ihrer herstellung und pharmazeutische präparate davonInfo
- Publication number
- DE69612568D1 DE69612568D1 DE69612568T DE69612568T DE69612568D1 DE 69612568 D1 DE69612568 D1 DE 69612568D1 DE 69612568 T DE69612568 T DE 69612568T DE 69612568 T DE69612568 T DE 69612568T DE 69612568 D1 DE69612568 D1 DE 69612568D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- oxopregna
- alknyl
- vitamin
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- XMDLIEZJERQGEY-ZHFUSYIKSA-N (1r,3s,5z)-5-[(2e)-2-[(1s,3as,7ar)-1-ethyl-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical class C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)CC)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C XMDLIEZJERQGEY-ZHFUSYIKSA-N 0.000 abstract 1
- 230000003509 anti-fertility effect Effects 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- 230000001028 anti-proliverative effect Effects 0.000 abstract 1
- 239000003418 antiprogestin Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000001506 immunosuppresive effect Effects 0.000 abstract 1
- 229940125721 immunosuppressive agent Drugs 0.000 abstract 1
- 239000003018 immunosuppressive agent Substances 0.000 abstract 1
- 230000003623 progesteronic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9526208.5A GB9526208D0 (en) | 1995-12-21 | 1995-12-21 | Chemical compounds |
| PCT/GB1996/003218 WO1997023453A1 (en) | 1995-12-21 | 1996-12-23 | 17-side chain alkynyl-and 20-oxopregna-derivatives of vitamin d, methods for their production and pharmaceutical compositions thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69612568D1 true DE69612568D1 (de) | 2001-05-23 |
| DE69612568T2 DE69612568T2 (de) | 2001-09-06 |
Family
ID=10785847
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69612568T Expired - Fee Related DE69612568T2 (de) | 1995-12-21 | 1996-12-23 | 17-seitenkette-alknyl- und 20-oxopregna-derivate von vitamin d, ein verfahren zu ihrer herstellung und pharmazeutische präparate davon |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6372926B2 (de) |
| EP (1) | EP0874815B1 (de) |
| JP (1) | JP2000503636A (de) |
| KR (1) | KR19990076664A (de) |
| CN (1) | CN1086694C (de) |
| AT (1) | ATE200663T1 (de) |
| AU (1) | AU710680B2 (de) |
| CA (1) | CA2241011A1 (de) |
| CZ (1) | CZ290930B6 (de) |
| DE (1) | DE69612568T2 (de) |
| DK (1) | DK0874815T3 (de) |
| ES (1) | ES2155948T3 (de) |
| GB (1) | GB9526208D0 (de) |
| GR (1) | GR3036132T3 (de) |
| HU (1) | HUP9903786A3 (de) |
| IL (1) | IL125027A0 (de) |
| NO (1) | NO982816L (de) |
| NZ (1) | NZ324775A (de) |
| PT (1) | PT874815E (de) |
| WO (1) | WO1997023453A1 (de) |
| ZA (1) | ZA9610874B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003087048A2 (en) * | 2002-04-11 | 2003-10-23 | Instytut Farmaceutyczny | Preparation of 24 alkyl analogs of cholecalciferol and non-racemic compounds |
| US7253293B2 (en) * | 2004-01-06 | 2007-08-07 | Andrzej Slominski | Enzymatic method to produce 7-dehydropregnenolone, vitamin D3-like compounds and derivatives thereof |
| CA2571710A1 (en) | 2004-06-24 | 2006-11-02 | Nicholas Valiante | Small molecule immunopotentiators and assays for their detection |
| US20080280860A1 (en) * | 2005-03-23 | 2008-11-13 | Bioxell S.P.A. | Use of Vitamin D Compounds to Treat Endometriosis |
| TW200714580A (en) * | 2005-10-14 | 2007-04-16 | Formosa Lab Inc | Process for preparing vitamin D analogs |
| SG173119A1 (en) * | 2009-01-27 | 2011-08-29 | Berg Biosystems Llc | Vitamin d3 and analogs thereof for alleviating side effects associated with chemotherapy |
| BR112012003372A2 (pt) | 2009-08-14 | 2019-09-24 | Berg Biosystems Llc | vitamina d3 e análogos da mesma para o tratamento de alopecia. |
| JP5563324B2 (ja) * | 2010-02-03 | 2014-07-30 | フォーモサ・ラボラトリーズ・インコーポレーテッド | マキサカルシトール中間体およびその製造方法 |
| EP3003497B1 (de) | 2013-05-29 | 2024-02-14 | BPGbio, Inc. | Verhinderung oder verringerung von chemotherapieinduzierter alopezie mit vitamin d |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6034543B2 (ja) | 1977-07-01 | 1985-08-09 | 中外製薬株式会社 | ビタミンｄ誘導体 |
| GB9214202D0 (en) * | 1992-07-03 | 1992-08-12 | Leo Pharm Prod Ltd | Chemical compounds |
| GB9220439D0 (en) * | 1992-09-28 | 1992-11-11 | Leo Pharm Prod Ltd | Chemical compounds |
| US5397776A (en) * | 1993-08-20 | 1995-03-14 | Wisconsin Alumni Research Foundation | Vitamin D compounds with anti-progesterone activity |
-
1995
- 1995-12-21 GB GBGB9526208.5A patent/GB9526208D0/en active Pending
-
1996
- 1996-12-23 KR KR1019980704776A patent/KR19990076664A/ko not_active Application Discontinuation
- 1996-12-23 DE DE69612568T patent/DE69612568T2/de not_active Expired - Fee Related
- 1996-12-23 EP EP96943236A patent/EP0874815B1/de not_active Expired - Lifetime
- 1996-12-23 NZ NZ324775A patent/NZ324775A/xx unknown
- 1996-12-23 AU AU12025/97A patent/AU710680B2/en not_active Ceased
- 1996-12-23 JP JP9523433A patent/JP2000503636A/ja not_active Ceased
- 1996-12-23 HU HU9903786A patent/HUP9903786A3/hu unknown
- 1996-12-23 CA CA002241011A patent/CA2241011A1/en not_active Abandoned
- 1996-12-23 CZ CZ19981947A patent/CZ290930B6/cs not_active IP Right Cessation
- 1996-12-23 IL IL12502796A patent/IL125027A0/xx not_active IP Right Cessation
- 1996-12-23 US US09/051,483 patent/US6372926B2/en not_active Expired - Fee Related
- 1996-12-23 CN CN96180032A patent/CN1086694C/zh not_active Expired - Fee Related
- 1996-12-23 WO PCT/GB1996/003218 patent/WO1997023453A1/en not_active Application Discontinuation
- 1996-12-23 ZA ZA9610874A patent/ZA9610874B/xx unknown
- 1996-12-23 AT AT96943236T patent/ATE200663T1/de not_active IP Right Cessation
- 1996-12-23 ES ES96943236T patent/ES2155948T3/es not_active Expired - Lifetime
- 1996-12-23 DK DK96943236T patent/DK0874815T3/da active
- 1996-12-23 PT PT96943236T patent/PT874815E/pt unknown
-
1998
- 1998-06-18 NO NO982816A patent/NO982816L/no not_active Application Discontinuation
-
2001
- 2001-06-27 GR GR20010400985T patent/GR3036132T3/el not_active IP Right Cessation
-
2002
- 2002-03-07 US US10/091,594 patent/US20020188142A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ZA9610874B (en) | 1997-06-18 |
| NZ324775A (en) | 1999-02-25 |
| CZ194798A3 (cs) | 1998-11-11 |
| JP2000503636A (ja) | 2000-03-28 |
| CN1086694C (zh) | 2002-06-26 |
| ES2155948T3 (es) | 2001-06-01 |
| GR3036132T3 (en) | 2001-09-28 |
| US20020010163A1 (en) | 2002-01-24 |
| NO982816L (no) | 1998-08-21 |
| CN1209120A (zh) | 1999-02-24 |
| GB9526208D0 (en) | 1996-02-21 |
| US6372926B2 (en) | 2002-04-16 |
| CA2241011A1 (en) | 1997-07-03 |
| EP0874815A1 (de) | 1998-11-04 |
| US20020188142A1 (en) | 2002-12-12 |
| EP0874815B1 (de) | 2001-04-18 |
| NO982816D0 (no) | 1998-06-18 |
| AU1202597A (en) | 1997-07-17 |
| ATE200663T1 (de) | 2001-05-15 |
| PT874815E (pt) | 2001-07-31 |
| IL125027A0 (en) | 1999-01-26 |
| KR19990076664A (ko) | 1999-10-15 |
| HUP9903786A3 (en) | 2000-09-28 |
| WO1997023453A1 (en) | 1997-07-03 |
| DK0874815T3 (da) | 2002-03-04 |
| CZ290930B6 (cs) | 2002-11-13 |
| DE69612568T2 (de) | 2001-09-06 |
| AU710680B2 (en) | 1999-09-30 |
| HUP9903786A2 (hu) | 2000-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |