DE69611360D1 - Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren - Google Patents
Succinamid-derivate und ihre verwendung als metallproteinase-inhibitorenInfo
- Publication number
- DE69611360D1 DE69611360D1 DE69611360T DE69611360T DE69611360D1 DE 69611360 D1 DE69611360 D1 DE 69611360D1 DE 69611360 T DE69611360 T DE 69611360T DE 69611360 T DE69611360 T DE 69611360T DE 69611360 D1 DE69611360 D1 DE 69611360D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- date oct
- sec
- proteinase inhibitors
- metal proteinase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Lubricants (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9507799.6A GB9507799D0 (en) | 1995-04-18 | 1995-04-18 | Metalloproteinase inhibitors |
PCT/GB1996/000930 WO1996033161A1 (en) | 1995-04-18 | 1996-04-18 | Derivatives of succinamide and their use as metalloproteinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69611360D1 true DE69611360D1 (de) | 2001-02-01 |
DE69611360T2 DE69611360T2 (de) | 2001-06-13 |
Family
ID=10773096
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69611360T Expired - Fee Related DE69611360T2 (de) | 1995-04-18 | 1996-04-18 | Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren |
DE69609957T Expired - Fee Related DE69609957T2 (de) | 1995-04-18 | 1996-04-18 | Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69609957T Expired - Fee Related DE69609957T2 (de) | 1995-04-18 | 1996-04-18 | Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren |
Country Status (9)
Country | Link |
---|---|
US (2) | US5840939A (de) |
EP (2) | EP0821666B1 (de) |
JP (2) | JPH11503748A (de) |
AT (2) | ATE198319T1 (de) |
AU (1) | AU5343696A (de) |
DE (2) | DE69611360T2 (de) |
ES (2) | ES2153959T3 (de) |
GB (1) | GB9507799D0 (de) |
WO (2) | WO1996033161A1 (de) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6548084B2 (en) | 1995-07-20 | 2003-04-15 | Smithkline Beecham Plc | Controlled release compositions |
AU1812197A (en) * | 1996-03-01 | 1997-09-16 | Sankyo Company Limited | Hydroxamic acid derivatives |
US5840974A (en) * | 1996-12-04 | 1998-11-24 | Britisch Biotech Pharmaceuticals, Ltd. | Metalloproteinase inhibitors |
ZA9818B (en) * | 1997-01-07 | 1998-07-02 | Abbott Lab | C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion |
US5952320A (en) * | 1997-01-07 | 1999-09-14 | Abbott Laboratories | Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion |
US5985911A (en) * | 1997-01-07 | 1999-11-16 | Abbott Laboratories | C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion |
BR9813719A (pt) * | 1998-01-09 | 2000-10-17 | Pfizer | Agentes terapêuticos |
GB9810464D0 (en) | 1998-05-16 | 1998-07-15 | British Biotech Pharm | Hydroxamic acid derivatives |
GB9813451D0 (en) * | 1998-06-22 | 1998-08-19 | Smithkline Beecham Plc | Novel compounds |
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
WO2000038618A2 (en) | 1998-12-24 | 2000-07-06 | Du Pont Pharmaceuticals Company | SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION |
US6297337B1 (en) | 1999-05-19 | 2001-10-02 | Pmd Holdings Corp. | Bioadhesive polymer compositions |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
EP1222176A1 (de) | 1999-10-08 | 2002-07-17 | Bristol-Myers Squibb Pharma Company | Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein |
US6797820B2 (en) * | 1999-12-17 | 2004-09-28 | Vicuron Pharmaceuticals Inc. | Succinate compounds, compositions and methods of use and preparation |
AU2001239791A1 (en) | 2000-02-17 | 2001-08-27 | Du Pont Pharmaceuticals Company | Succinoylamino carbocycles and heterocycles as inhibitors of abeta protein production |
US6803383B2 (en) * | 2000-03-27 | 2004-10-12 | The Scripps Research Institute | Inhibition of angiogenesis and tumor growth |
US6495540B2 (en) | 2000-03-28 | 2002-12-17 | Bristol - Myers Squibb Pharma Company | Lactams as inhibitors of A-β protein production |
MXPA02009755A (es) | 2000-04-03 | 2003-03-27 | Bristol Myers Squibb Pharma Co | Lactamas ciclicas como inhibidores de la produccion de proteina a-beta. |
CN1434803A (zh) | 2000-04-03 | 2003-08-06 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为Aβ蛋白质产生抑制剂的环内酰胺 |
CA2404273A1 (en) | 2000-04-11 | 2001-10-18 | Bristol-Myers Squibb Pharma Company | Substituted lactams as inhibitors of a.beta. protein production |
AR028606A1 (es) * | 2000-05-24 | 2003-05-14 | Smithkline Beecham Corp | Nuevos inhibidores de mmp-2/mmp-9 |
AU783857B2 (en) | 2000-06-01 | 2005-12-15 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a beta protein production |
WO2002028829A2 (en) * | 2000-09-25 | 2002-04-11 | Questcor Pharmaceuticals, Inc. | Peptide deformylase inhibitors |
US20050112261A1 (en) * | 2003-11-21 | 2005-05-26 | Davis Robert J. | Churros and method for making same |
KR101155335B1 (ko) * | 2005-01-07 | 2012-06-11 | 엘지전자 주식회사 | 이동통신 단말기의 멀티미디어 메시지 동작방법 |
JP5064503B2 (ja) | 2006-08-21 | 2012-10-31 | エフ.ホフマン−ラ ロシュ アーゲー | Glyt1に対する阻害剤としての二環芳香族置換アミド |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2058797A1 (en) * | 1991-02-01 | 1992-08-02 | Michael John Broadhurst | Amino acid derivatives |
AU666727B2 (en) * | 1992-06-25 | 1996-02-22 | F. Hoffmann-La Roche Ag | Hydroxamic acid derivatives |
GB9215665D0 (en) * | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
WO1994021625A1 (en) * | 1993-03-16 | 1994-09-29 | British Biotech Pharmaceuticals Limited | Hydroxamic acid derivatives as metalloproteinase inhibitors |
WO1995004033A1 (en) * | 1993-08-02 | 1995-02-09 | Celltech Limited | Succinamide derivatives, processes for their preparation and their use as gelatinase and collagenase inhibitors |
DK0822186T3 (da) * | 1994-01-20 | 2000-06-26 | British Biotech Pharm | L-tert-leucin-2-pyridylamid |
-
1995
- 1995-04-18 GB GBGB9507799.6A patent/GB9507799D0/en active Pending
-
1996
- 1996-04-18 US US08/930,619 patent/US5840939A/en not_active Expired - Fee Related
- 1996-04-18 US US08/930,620 patent/US5908851A/en not_active Expired - Fee Related
- 1996-04-18 ES ES96910104T patent/ES2153959T3/es not_active Expired - Lifetime
- 1996-04-18 ES ES96910138T patent/ES2150116T3/es not_active Expired - Lifetime
- 1996-04-18 AT AT96910104T patent/ATE198319T1/de not_active IP Right Cessation
- 1996-04-18 WO PCT/GB1996/000930 patent/WO1996033161A1/en active IP Right Grant
- 1996-04-18 WO PCT/GB1996/000965 patent/WO1996033165A1/en active IP Right Grant
- 1996-04-18 EP EP96910104A patent/EP0821666B1/de not_active Expired - Lifetime
- 1996-04-18 JP JP8531572A patent/JPH11503748A/ja active Pending
- 1996-04-18 DE DE69611360T patent/DE69611360T2/de not_active Expired - Fee Related
- 1996-04-18 AT AT96910138T patent/ATE195723T1/de not_active IP Right Cessation
- 1996-04-18 DE DE69609957T patent/DE69609957T2/de not_active Expired - Fee Related
- 1996-04-18 EP EP96910138A patent/EP0821668B1/de not_active Expired - Lifetime
- 1996-04-18 AU AU53436/96A patent/AU5343696A/en not_active Abandoned
- 1996-04-18 JP JP8531557A patent/JPH11503746A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
ATE195723T1 (de) | 2000-09-15 |
US5908851A (en) | 1999-06-01 |
EP0821666B1 (de) | 2000-12-27 |
ATE198319T1 (de) | 2001-01-15 |
AU5343696A (en) | 1996-11-07 |
US5840939A (en) | 1998-11-24 |
DE69611360T2 (de) | 2001-06-13 |
GB9507799D0 (en) | 1995-05-31 |
DE69609957D1 (de) | 2000-09-28 |
EP0821668A1 (de) | 1998-02-04 |
EP0821666A1 (de) | 1998-02-04 |
ES2150116T3 (es) | 2000-11-16 |
DE69609957T2 (de) | 2001-03-01 |
JPH11503746A (ja) | 1999-03-30 |
JPH11503748A (ja) | 1999-03-30 |
WO1996033165A1 (en) | 1996-10-24 |
EP0821668B1 (de) | 2000-08-23 |
WO1996033161A1 (en) | 1996-10-24 |
ES2153959T3 (es) | 2001-03-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |