DE69611360D1 - Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren - Google Patents

Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren

Info

Publication number
DE69611360D1
DE69611360D1 DE69611360T DE69611360T DE69611360D1 DE 69611360 D1 DE69611360 D1 DE 69611360D1 DE 69611360 T DE69611360 T DE 69611360T DE 69611360 T DE69611360 T DE 69611360T DE 69611360 D1 DE69611360 D1 DE 69611360D1
Authority
DE
Germany
Prior art keywords
pct
date oct
sec
proteinase inhibitors
metal proteinase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69611360T
Other languages
English (en)
Other versions
DE69611360T2 (de
Inventor
Paul Beckett
Andrew Miller
Marie Spavold
Mark Whittaker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
British Biotech Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Biotech Pharmaceuticals Ltd filed Critical British Biotech Pharmaceuticals Ltd
Application granted granted Critical
Publication of DE69611360D1 publication Critical patent/DE69611360D1/de
Publication of DE69611360T2 publication Critical patent/DE69611360T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Lubricants (AREA)
DE69611360T 1995-04-18 1996-04-18 Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren Expired - Fee Related DE69611360T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9507799.6A GB9507799D0 (en) 1995-04-18 1995-04-18 Metalloproteinase inhibitors
PCT/GB1996/000930 WO1996033161A1 (en) 1995-04-18 1996-04-18 Derivatives of succinamide and their use as metalloproteinase inhibitors

Publications (2)

Publication Number Publication Date
DE69611360D1 true DE69611360D1 (de) 2001-02-01
DE69611360T2 DE69611360T2 (de) 2001-06-13

Family

ID=10773096

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69609957T Expired - Fee Related DE69609957T2 (de) 1995-04-18 1996-04-18 Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren
DE69611360T Expired - Fee Related DE69611360T2 (de) 1995-04-18 1996-04-18 Succinamid-derivate und ihre verwendung als metallproteinase-inhibitoren

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69609957T Expired - Fee Related DE69609957T2 (de) 1995-04-18 1996-04-18 Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren

Country Status (9)

Country Link
US (2) US5908851A (de)
EP (2) EP0821668B1 (de)
JP (2) JPH11503748A (de)
AT (2) ATE195723T1 (de)
AU (1) AU5343696A (de)
DE (2) DE69609957T2 (de)
ES (2) ES2153959T3 (de)
GB (1) GB9507799D0 (de)
WO (2) WO1996033161A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6548084B2 (en) 1995-07-20 2003-04-15 Smithkline Beecham Plc Controlled release compositions
WO1997031892A1 (fr) * 1996-03-01 1997-09-04 Sankyo Company, Limited Derives d'acide hydroxamique
US5840974A (en) * 1996-12-04 1998-11-24 Britisch Biotech Pharmaceuticals, Ltd. Metalloproteinase inhibitors
US5985911A (en) * 1997-01-07 1999-11-16 Abbott Laboratories C-terminal ketone inhibitors of matrix metalloproteinases and TNFα secretion
ZA9818B (en) * 1997-01-07 1998-07-02 Abbott Lab C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion
US5952320A (en) * 1997-01-07 1999-09-14 Abbott Laboratories Macrocyclic inhibitors of matrix metalloproteinases and TNFα secretion
EA002971B1 (ru) * 1998-01-09 2002-12-26 Пфайзер Инк. Ингибиторы металлопротеаз матрикса, способы их получения, фармкомпозиция, применение и способ лечения
GB9810464D0 (en) * 1998-05-16 1998-07-15 British Biotech Pharm Hydroxamic acid derivatives
GB9813451D0 (en) 1998-06-22 1998-08-19 Smithkline Beecham Plc Novel compounds
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
US6288261B1 (en) 1998-12-18 2001-09-11 Abbott Laboratories Inhibitors of matrix metalloproteinases
WO2000038618A2 (en) 1998-12-24 2000-07-06 Du Pont Pharmaceuticals Company SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6297337B1 (en) 1999-05-19 2001-10-02 Pmd Holdings Corp. Bioadhesive polymer compositions
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
WO2001027108A1 (en) 1999-10-08 2001-04-19 Bristol-Myers Squibb Pharma Company AMINO LACTAM SULFONAMIDES AS INHIBITORS OF Aβ PROTEIN PRODUCTION
US6797820B2 (en) * 1999-12-17 2004-09-28 Vicuron Pharmaceuticals Inc. Succinate compounds, compositions and methods of use and preparation
JP2003523345A (ja) 2000-02-17 2003-08-05 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Ａβタンパク質産生の阻害剤としてのスクシノイルアミノ炭素環および複素環
US6803383B2 (en) * 2000-03-27 2004-10-12 The Scripps Research Institute Inhibition of angiogenesis and tumor growth
US6495540B2 (en) 2000-03-28 2002-12-17 Bristol - Myers Squibb Pharma Company Lactams as inhibitors of A-β protein production
EP1268434A1 (de) 2000-04-03 2003-01-02 Bristol-Myers Squibb Pharma Company Zyklische lactame als a-beta proteinproduktionsinhibitoren
EP1268433A1 (de) 2000-04-03 2003-01-02 Bristol-Myers Squibb Pharma Company Zyklische lactame als a-beta-proteinproduktionsinhibitoren
CA2404273A1 (en) 2000-04-11 2001-10-18 Bristol-Myers Squibb Pharma Company Substituted lactams as inhibitors of a.beta. protein production
AR028606A1 (es) * 2000-05-24 2003-05-14 Smithkline Beecham Corp Nuevos inhibidores de mmp-2/mmp-9
CN1386118A (zh) 2000-06-01 2002-12-18 布里斯托尔-迈尔斯斯奎布药品公司 作为Aβ蛋白产生抑制剂的被环状琥珀酸酯取代的内酰胺类化合物
AU2002230385A1 (en) * 2000-09-25 2002-04-15 Questcor Pharmaceuticals, Inc. Peptide deformylase inhibitors
US20050112261A1 (en) * 2003-11-21 2005-05-26 Davis Robert J. Churros and method for making same
KR101155335B1 (ko) * 2005-01-07 2012-06-11 엘지전자 주식회사 이동통신 단말기의 멀티미디어 메시지 동작방법
CA2661459A1 (en) 2006-08-21 2008-02-28 F. Hoffmann-La Roche Ag Di-aromatic substituted amides as inhibitors for glyt1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2058797A1 (en) * 1991-02-01 1992-08-02 Michael John Broadhurst Amino acid derivatives
AU666727B2 (en) * 1992-06-25 1996-02-22 F. Hoffmann-La Roche Ag Hydroxamic acid derivatives
GB9215665D0 (en) * 1992-07-23 1992-09-09 British Bio Technology Compounds
GB9223904D0 (en) * 1992-11-13 1993-01-06 British Bio Technology Inhibition of cytokine production
NZ262447A (en) * 1993-03-16 1996-07-26 British Biotech Pharm Hydroxamic acid derivatives and their use as pharmaceutical agents
WO1995004033A1 (en) * 1993-08-02 1995-02-09 Celltech Limited Succinamide derivatives, processes for their preparation and their use as gelatinase and collagenase inhibitors
DK0822186T3 (da) * 1994-01-20 2000-06-26 British Biotech Pharm L-tert-leucin-2-pyridylamid

Also Published As

Publication number Publication date
ATE195723T1 (de) 2000-09-15
EP0821668B1 (de) 2000-08-23
DE69611360T2 (de) 2001-06-13
US5840939A (en) 1998-11-24
WO1996033161A1 (en) 1996-10-24
GB9507799D0 (en) 1995-05-31
JPH11503746A (ja) 1999-03-30
EP0821666A1 (de) 1998-02-04
ES2150116T3 (es) 2000-11-16
JPH11503748A (ja) 1999-03-30
DE69609957D1 (de) 2000-09-28
ATE198319T1 (de) 2001-01-15
WO1996033165A1 (en) 1996-10-24
AU5343696A (en) 1996-11-07
EP0821668A1 (de) 1998-02-04
DE69609957T2 (de) 2001-03-01
EP0821666B1 (de) 2000-12-27
ES2153959T3 (es) 2001-03-16
US5908851A (en) 1999-06-01

Similar Documents

Publication Publication Date Title
DE69609957D1 (de) Succinamid-derivate und ihre verwendung als metalloproteinaseinhibitoren
DE69409525D1 (de) Acetamidderivate und ihre verwendung als modifizierungsmittel des verhaltens der verdauung
PT100606A (pt) Derivados fluoroalcoxibenzilamino de heterociclos contendo azoto
BG104138A (en) 2-aminopyridines containing substituents with condensed rings as nos inhibitors
ATE365551T1 (de) Fusionierte heteroaryl-derivative zur verwendung als p38 kinase inhibitoren zur behandlung von u.a rheumatischer arthritis
DK0683780T3 (da) Imidazopyridiner og deres anvendelse til behandling af mave-tarm-sygdomme
PT1045690E (pt) Benzenossulfonamidas inibidoras da pde-iv e seu uso terapeutico
AU1070895A (en) Indole-derived arylpiperazines as ligands for 5HT1-like receptors 5HT1B and 5HT1D
ATE155133T1 (de) Piperazinderivate als 5-ht antagonisten
DE69924292D1 (de) Pyrazol verbindungen und ihre verwendung
NO305176B1 (no) N-substituerte 3-azabicyklo [3.2.0] heptanderivater og anvendelse derav
ATE178886T1 (de) 1-aryl-2-acylamino-ethan-verbindungen und ihre verwendung als neurokinin- insbesondere als neurokinin-1-antagonisten
DK0696278T3 (da) Herbicidtvirkende substituerede 1-phenyl- eller 1-pyridinylbenzotriazoler
MX9303605A (es) Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
DK0720598T3 (da) Phenoxyphenylcyclopentenyl-hydroxyurinstoffer
ATE145206T1 (de) Oxindol 1-(n-(alkoxycarbonyl)>carboxamide und 1- (n-carboxamido>carboxamide als antiinflammatorische wirkstoffe
DE69405760D1 (de) 4-aza-pregnan-5-alpha-reductase isozym 1 inhibitoren
ATE176225T1 (de) Heterocyclische benzolsulfonyliminderivate als inhibitoren der il-1 wirkung
SE9402241L (sv) Inhibitor
DE69711221D1 (de) Metalloproteinase-inhibitoren
ATE177098T1 (de) Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
EP1325918A4 (de) Herzmuskelzellen-apoptose hemmstoffe und behandlung/vorbeugung von herzkrankheiten
DE69425823D1 (de) Substituierte chinolinderivate, und ihre verwendung als inhibitoren der magensekretion
ATE206127T1 (de) Inhibitoren retroviraler proteasen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee