ATE155133T1 - Piperazinderivate als 5-ht antagonisten - Google Patents
Piperazinderivate als 5-ht antagonistenInfo
- Publication number
- ATE155133T1 ATE155133T1 AT94902964T AT94902964T ATE155133T1 AT E155133 T1 ATE155133 T1 AT E155133T1 AT 94902964 T AT94902964 T AT 94902964T AT 94902964 T AT94902964 T AT 94902964T AT E155133 T1 ATE155133 T1 AT E155133T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- date
- antagonists
- piperazine derivatives
- sec
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 239000003420 antiserotonin agent Substances 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
- 102100022738 5-hydroxytryptamine receptor 1A Human genes 0.000 abstract 1
- 101710138638 5-hydroxytryptamine receptor 1A Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002249 anxiolytic agent Substances 0.000 abstract 1
- 230000000949 anxiolytic effect Effects 0.000 abstract 1
- 229940005530 anxiolytics Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939300194A GB9300194D0 (en) | 1993-01-06 | 1993-01-06 | Piperazine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE155133T1 true ATE155133T1 (de) | 1997-07-15 |
Family
ID=10728386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94902964T ATE155133T1 (de) | 1993-01-06 | 1993-12-24 | Piperazinderivate als 5-ht antagonisten |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5622951A (de) |
| EP (1) | EP0677046B1 (de) |
| JP (1) | JPH08505381A (de) |
| AT (1) | ATE155133T1 (de) |
| AU (1) | AU5711594A (de) |
| DE (1) | DE69312091T2 (de) |
| DK (1) | DK0677046T3 (de) |
| ES (1) | ES2105617T3 (de) |
| GB (1) | GB9300194D0 (de) |
| GR (1) | GR3024430T3 (de) |
| IL (1) | IL108259A (de) |
| PH (1) | PH31304A (de) |
| WO (1) | WO1994015928A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5900415A (en) * | 1994-11-07 | 1999-05-04 | Pfizer Inc. | Certain substituted benzylamine derivatives; a new class of neuropeptide Y1 specific ligands |
| US5990114A (en) * | 1996-02-28 | 1999-11-23 | Recordati, S.A., Chemical And Pharmaceutical Company | Use of 5-HT1A receptor antagonists for the treatment of urinary incontinence |
| US6200994B1 (en) | 1999-01-07 | 2001-03-13 | American Home Products Corp | 1,4-Disubstituted cyclohexane derivatives for the treatment of depression |
| US6313126B1 (en) | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| ES2182775T3 (es) * | 1999-01-07 | 2003-03-16 | Wyeth Corp | Derivados de ciclohexano 1,4-disustituidos para el tratamiento de la depresion. |
| GB0316915D0 (en) | 2003-07-18 | 2003-08-20 | Glaxo Group Ltd | Compounds |
| AR047759A1 (es) * | 2003-09-26 | 2006-02-22 | Vertex Pharma | Derivados de fenil - piperazina como moduladores de receptores muscarnicos |
| JP4596792B2 (ja) * | 2004-02-24 | 2010-12-15 | あすか製薬株式会社 | ５−ｈｔ１ａ作動作用と５−ｈｔ３拮抗作用を併有する薬剤 |
| MX2007015165A (es) | 2005-06-03 | 2008-02-14 | Abbott Lab | Derivados de ciclobutil-amina. |
| US7576110B2 (en) | 2005-09-22 | 2009-08-18 | Abbott Laboratories | Benzothiazole cyclobutyl amine derivatives |
| MX2008016343A (es) | 2006-06-23 | 2009-01-19 | Abbott Lab | Derivados ciclopropil amina como moduladores del receptro de histamina h3. |
| US9108948B2 (en) | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| GB201017345D0 (en) * | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| JP6083818B2 (ja) | 2011-11-18 | 2017-02-22 | ヘプタレス セラピューティクス リミテッドＨｅｐｔａｒｅｓ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｌｉｍｉｔｅｄ | ムスカリンｍ１受容体アゴニスト |
| GB201404922D0 (en) | 2014-03-19 | 2014-04-30 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| EA037555B1 (ru) | 2015-04-02 | 2021-04-13 | Проксимэйджен, Элэлси | Применение 6-{4-[1-(пропан-2-ил)пиперидин-4-ил]-1,4-диазепан-1-ил}-n-(пиридин-4-ил)пиридин-2-карбоксамида для лечения раковых заболеваний цнс |
| GB201513743D0 (en) | 2015-08-03 | 2015-09-16 | Heptares Therapeutics Ltd | Muscarinic agonists |
| GB201519352D0 (en) | 2015-11-02 | 2015-12-16 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201617454D0 (en) | 2016-10-14 | 2016-11-30 | Heptares Therapeutics Limited | Pharmaceutical compounds |
| US10259787B2 (en) | 2016-10-14 | 2019-04-16 | Heptares Therapeutics Limited | Substituted cyclohexanes as muscarinic M1 receptor and/or M4 receptor agonists |
| GB201810239D0 (en) | 2018-06-22 | 2018-08-08 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819960D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB201819961D0 (en) | 2018-12-07 | 2019-01-23 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
| GB202020191D0 (en) | 2020-12-18 | 2021-02-03 | Heptares Therapeutics Ltd | Pharmaceutical compounds |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3354161A (en) * | 1964-07-16 | 1967-11-21 | Miles Lab | 8alpha-(4-phenyl-1-piperazyl)-4alpha, 5, 6, 7, 8alpha-hexahydro-4h-1-benzopyrans and process |
| US3309370A (en) * | 1964-07-16 | 1967-03-14 | Miles Lab | Bicycloalkyl piperazine derivatives and process |
| NL7314672A (de) * | 1972-11-11 | 1974-05-14 | ||
| UST100505I4 (en) * | 1980-03-17 | 1981-04-07 | Triazolo[4,3-a]pyridin-3(2H)-ones | |
| US4975445A (en) * | 1989-12-06 | 1990-12-04 | Warner-Lambert Company | Substituted cyclohexenes as central nervous system agents |
| US5047406A (en) * | 1989-12-06 | 1991-09-10 | Warner-Lambert Co. | Substituted cyclohexanols as central nervous system agents |
| FR2689893A1 (fr) * | 1992-04-09 | 1993-10-15 | Rhone Poulenc Rorer Sa | Dérivés de diphényl-1,1 hydroxy-3 (sila)cyclopentane, leur préparation et les médicaments les contenant. |
-
1993
- 1993-01-06 GB GB939300194A patent/GB9300194D0/en active Pending
- 1993-12-24 WO PCT/GB1993/002661 patent/WO1994015928A1/en not_active Ceased
- 1993-12-24 JP JP6515782A patent/JPH08505381A/ja active Pending
- 1993-12-24 AU AU57115/94A patent/AU5711594A/en not_active Abandoned
- 1993-12-24 DE DE69312091T patent/DE69312091T2/de not_active Expired - Fee Related
- 1993-12-24 DK DK94902964.9T patent/DK0677046T3/da active
- 1993-12-24 ES ES94902964T patent/ES2105617T3/es not_active Expired - Lifetime
- 1993-12-24 EP EP94902964A patent/EP0677046B1/de not_active Expired - Lifetime
- 1993-12-24 US US08/436,413 patent/US5622951A/en not_active Expired - Lifetime
- 1993-12-24 AT AT94902964T patent/ATE155133T1/de not_active IP Right Cessation
-
1994
- 1994-01-03 IL IL10825994A patent/IL108259A/en not_active IP Right Cessation
- 1994-01-05 PH PH47581A patent/PH31304A/en unknown
-
1997
- 1997-08-13 GR GR970402073T patent/GR3024430T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL108259A0 (en) | 1994-04-12 |
| ES2105617T3 (es) | 1997-10-16 |
| PH31304A (en) | 1998-07-06 |
| EP0677046A1 (de) | 1995-10-18 |
| AU5711594A (en) | 1994-08-15 |
| GR3024430T3 (en) | 1997-11-28 |
| EP0677046B1 (de) | 1997-07-09 |
| DK0677046T3 (da) | 1997-09-01 |
| WO1994015928A1 (en) | 1994-07-21 |
| DE69312091D1 (de) | 1997-08-14 |
| DE69312091T2 (de) | 1998-02-19 |
| US5622951A (en) | 1997-04-22 |
| IL108259A (en) | 1998-09-24 |
| GB9300194D0 (en) | 1993-03-03 |
| JPH08505381A (ja) | 1996-06-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |