DE69608804T2 - Di- und trivalente kleine moleküle als selektininhibitoren - Google Patents

Di- und trivalente kleine moleküle als selektininhibitoren

Info

Publication number
DE69608804T2
DE69608804T2 DE69608804T DE69608804T DE69608804T2 DE 69608804 T2 DE69608804 T2 DE 69608804T2 DE 69608804 T DE69608804 T DE 69608804T DE 69608804 T DE69608804 T DE 69608804T DE 69608804 T2 DE69608804 T2 DE 69608804T2
Authority
DE
Germany
Prior art keywords
bis
mmol
carboxymethylphenyl
phenyl
dmannopyranosyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69608804T
Other languages
German (de)
English (en)
Other versions
DE69608804D1 (de
Inventor
Huong Bui
Brian Dupre
M. Kassir
M. Keller
P. Kogan
L. Scott
L. Wheeler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Encysive Pharmaceuticals Inc
Original Assignee
Texas Biotechnology Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp
Publication of DE69608804D1 publication Critical patent/DE69608804D1/de
Application granted granted Critical
Publication of DE69608804T2 publication Critical patent/DE69608804T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)
DE69608804T 1995-06-29 1996-06-26 Di- und trivalente kleine moleküle als selektininhibitoren Expired - Lifetime DE69608804T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US278495P 1995-06-29 1995-06-29
US53395P 1995-06-29 1995-06-29
PCT/US1996/011032 WO1997001335A1 (en) 1995-06-29 1996-06-26 Di- and trivalent small molecule selectin inhibitors

Publications (2)

Publication Number Publication Date
DE69608804D1 DE69608804D1 (de) 2000-07-13
DE69608804T2 true DE69608804T2 (de) 2000-11-02

Family

ID=26667782

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69608804T Expired - Lifetime DE69608804T2 (de) 1995-06-29 1996-06-26 Di- und trivalente kleine moleküle als selektininhibitoren

Country Status (21)

Country Link
EP (1) EP0840606B1 (enExample)
JP (1) JP4046351B2 (enExample)
KR (1) KR100438136B1 (enExample)
CN (1) CN1149082C (enExample)
AT (1) ATE193647T1 (enExample)
AU (1) AU704596B2 (enExample)
BR (1) BR9608873A (enExample)
CA (1) CA2221991C (enExample)
CZ (1) CZ290072B6 (enExample)
DE (1) DE69608804T2 (enExample)
DK (1) DK0840606T3 (enExample)
ES (1) ES2146886T3 (enExample)
FI (1) FI974618A7 (enExample)
GR (1) GR3034289T3 (enExample)
HU (1) HU224590B1 (enExample)
NO (1) NO310623B1 (enExample)
PL (1) PL185372B1 (enExample)
PT (1) PT840606E (enExample)
RU (1) RU2165931C2 (enExample)
UA (1) UA52607C2 (enExample)
WO (1) WO1997001335A1 (enExample)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1020944C (zh) * 1990-01-30 1993-05-26 阿图尔-费希尔股份公司费希尔厂 紧固件
AU6024998A (en) * 1997-01-15 1998-08-07 Glycomed Incorporated Aryl c-glycoside compounds and sulfated esters thereof
WO1999029706A2 (en) * 1997-12-08 1999-06-17 Glycomed Incorporated DISALICYLATE ANALOG BASED SIALYL LEWISx MIMETICS
AU5625499A (en) * 1998-09-04 2000-03-27 Altana Pharma Ag Novel pyranoses
PH12000002657B1 (en) 1999-10-12 2006-02-21 Bristol Myers Squibb Co C-aryl glucoside SGLT2 inhibitors
GB9924990D0 (en) * 1999-10-21 1999-12-22 Glaxo Group Ltd Medicaments
US6683056B2 (en) 2000-03-30 2004-01-27 Bristol-Myers Squibb Company O-aryl glucoside SGLT2 inhibitors and method
US6555519B2 (en) 2000-03-30 2003-04-29 Bristol-Myers Squibb Company O-glucosylated benzamide SGLT2 inhibitors and method
US6936590B2 (en) 2001-03-13 2005-08-30 Bristol Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
AU2003249641B2 (en) 2002-05-16 2009-08-20 Glycomimetics, Inc. Compounds and methods for inhibiting selectin-mediated function
DE602004011272T2 (de) 2003-11-19 2008-12-24 Glycomimetics, Inc. Spezifischer antagonist sowohl für e- als auch p-selektine
EP1577289A1 (en) 2004-03-18 2005-09-21 Revotar Biopharmaceuticals AG Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders
US7517980B2 (en) 2005-08-09 2009-04-14 Glycomimetics, Inc. Glycomimetric inhibitors of the PA-IL lectin, PA-IIL lectin or both the lectins from Pseudomonas
EP1934236B1 (en) 2005-09-02 2012-11-21 GlycoMimetics, Inc. Heterobifunctional pan-selectin inhibitors
EP1764095A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel nitrocatechol derivatives having selectin ligand activity
EP1764093A1 (en) 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel aromatic compounds and their use in medical applications
EP1764096A1 (en) * 2005-09-20 2007-03-21 Revotar Biopharmaceuticals AG Novel phloroglucinol derivatives having selectin ligand activity
KR100827674B1 (ko) * 2006-05-23 2008-05-07 (주)한빛테크 자동트립 장치와 그 제어방법
EP1903049A1 (en) 2006-09-08 2008-03-26 Revotar Biopharmaceuticals AG Crystalline forms of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyloxy)-phenyl] hexane
EP1897533A1 (en) * 2006-09-08 2008-03-12 Revotar Biopharmaceuticals AG Use of 1,6-Bis [3-(3-carboxymethylphenyl)-4-(2-alpha -D-mannopyranosyl-oxy)-phenyl] hexane for the preparation of cosmetic compositions
EP1958637A1 (en) * 2007-02-14 2008-08-20 Revotar Biopharmaceuticals AG Pharmaceutical composition for the treatment of IL-8 mediated diseases
US8217064B2 (en) 2007-12-20 2012-07-10 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
US8895510B2 (en) 2008-04-08 2014-11-25 Glycomimetics, Inc. Pan-selectin inhibitor with enhanced pharmacokinetic activity
RU2012152633A (ru) * 2010-05-07 2014-06-20 Ревотар Биофармасьютикалз Аг Способ получения бимосиамозы
US8921328B2 (en) 2010-09-14 2014-12-30 Glycomimetics, Inc. E-selectin antagonists
KR102055958B1 (ko) 2011-12-22 2019-12-13 글리코미메틱스, 인크. E-셀렉틴 길항제 화합물, 조성물, 및 이용 방법
ES2668045T3 (es) 2012-12-07 2018-05-16 Glycomimetics, Inc. Compuestos, composiciones y métodos que usan antagonistas de la E-selectina para la movilización de las células hematopoyéticas
ES2754549T3 (es) 2014-12-03 2020-04-20 Glycomimetics Inc Inhibidores heterobifuncionales de E-selectinas y receptores de quimioquinas CXCR4
EP3497131B1 (en) 2016-08-08 2022-03-09 GlycoMimetics, Inc. Combination of t-cell checkpoint inhibitors with inhibitors of e-selectin or cxcr4, or with heterobifunctional inhibitors of both e-selectin and cxcr4.
US11197877B2 (en) 2017-03-15 2021-12-14 Glycomimetics. Inc. Galactopyranosyl-cyclohexyl derivauves as E-selectin antagonists

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH19293A (en) * 1982-11-15 1986-03-04 Pfizer Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof
NZ224501A (en) * 1987-05-06 1990-01-29 Adir Tylosin and carbomycin oxime derivatives and pharmaceutical compositions
US5075289A (en) * 1988-06-07 1991-12-24 Abbott Laboratories 9-r-azacyclic erythromycin antibiotics
CA2064985A1 (en) * 1991-04-05 1992-10-06 Robert R. Wilkening 8a-aza-8a-homoertyhromycin cyclic lactams
CA2129140A1 (en) * 1992-01-31 1993-08-05 Akira Hasegawa Lewis-type sugar chain derivative
US5444050A (en) * 1994-04-29 1995-08-22 Texas Biotechnology Corporation Binding of E-selectin or P-selectin to sialyl Lewisx or sialyl-Lewisa
US5498775A (en) * 1994-11-07 1996-03-12 American Home Products Corporation Polyanionic benzylglycosides as inhibitors of smooth muscle cell proliferation

Also Published As

Publication number Publication date
FI974618L (fi) 1997-12-23
BR9608873A (pt) 1999-07-06
CN1196678A (zh) 1998-10-21
FI974618A0 (fi) 1997-12-23
RU2165931C2 (ru) 2001-04-27
JPH11508885A (ja) 1999-08-03
NO976074D0 (no) 1997-12-23
AU6292396A (en) 1997-01-30
JP4046351B2 (ja) 2008-02-13
ATE193647T1 (de) 2000-06-15
DE69608804D1 (de) 2000-07-13
HU224590B1 (hu) 2005-11-28
WO1997001335A1 (en) 1997-01-16
KR100438136B1 (ko) 2004-08-25
CA2221991A1 (en) 1997-01-16
FI974618A7 (fi) 1997-12-23
CZ407597A3 (cs) 1998-07-15
UA52607C2 (uk) 2003-01-15
DK0840606T3 (da) 2000-08-07
HUP9802602A2 (hu) 1999-02-01
PL324330A1 (en) 1998-05-25
KR19990028441A (ko) 1999-04-15
GR3034289T3 (en) 2000-12-29
EP0840606A4 (enExample) 1998-05-13
CN1149082C (zh) 2004-05-12
EP0840606A1 (en) 1998-05-13
ES2146886T3 (es) 2000-08-16
PL185372B1 (pl) 2003-04-30
AU704596B2 (en) 1999-04-29
HUP9802602A3 (en) 1999-08-30
EP0840606B1 (en) 2000-06-07
CZ290072B6 (cs) 2002-05-15
PT840606E (pt) 2000-11-30
NO976074L (no) 1998-03-02
NO310623B1 (no) 2001-07-30
CA2221991C (en) 2007-09-18

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Legal Events

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