DE69535353D1 - Langlebige anisotropie-(polarisations-)sonden für die klinische chemie, immunoassays, affinitätsassays und die biomedizinische forschung - Google Patents

Langlebige anisotropie-(polarisations-)sonden für die klinische chemie, immunoassays, affinitätsassays und die biomedizinische forschung

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Publication number
DE69535353D1
DE69535353D1 DE69535353T DE69535353T DE69535353D1 DE 69535353 D1 DE69535353 D1 DE 69535353D1 DE 69535353 T DE69535353 T DE 69535353T DE 69535353 T DE69535353 T DE 69535353T DE 69535353 D1 DE69535353 D1 DE 69535353D1
Authority
DE
Germany
Prior art keywords
sample
polarization
immunoassays
anisotropy
probes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535353T
Other languages
English (en)
Other versions
DE69535353T2 (de
Inventor
R Lakowicz
Henryk Szmacinski
Ewald Terpetschnig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Application granted granted Critical
Publication of DE69535353D1 publication Critical patent/DE69535353D1/de
Publication of DE69535353T2 publication Critical patent/DE69535353T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69535353T 1994-10-28 1995-10-27 Langlebige anisotropie-(polarisations-)sonden für die klinische chemie, immunoassays, affinitätsassays und die biomedizinische forschung Expired - Lifetime DE69535353T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/330,743 US5660991A (en) 1994-10-28 1994-10-28 Long lifetime anisotropy (polarization) probes for clinical chemistry, immunoassays, affinity assays and biomedical research
US330743 1994-10-28
PCT/US1995/014143 WO1996013722A1 (en) 1994-10-28 1995-10-27 Long lifetime anisotropy (polarization) probes for clinical chemistry, immunoassays, affinity assays and biomedical research

Publications (2)

Publication Number Publication Date
DE69535353D1 true DE69535353D1 (de) 2007-02-08
DE69535353T2 DE69535353T2 (de) 2008-07-03

Family

ID=23291126

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535353T Expired - Lifetime DE69535353T2 (de) 1994-10-28 1995-10-27 Langlebige anisotropie-(polarisations-)sonden für die klinische chemie, immunoassays, affinitätsassays und die biomedizinische forschung

Country Status (8)

Country Link
US (1) US5660991A (de)
EP (1) EP0788601B1 (de)
JP (1) JPH10508103A (de)
AT (1) ATE349696T1 (de)
AU (1) AU686490B2 (de)
CA (1) CA2203772A1 (de)
DE (1) DE69535353T2 (de)
WO (1) WO1996013722A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6699717B1 (en) * 1997-02-12 2004-03-02 The University Of Maryland Baltimore County Method using luminescent transition metal-ligand complex for detecting polar solvents
EP0957365B1 (de) * 1997-09-05 2006-02-01 Matsushita Electric Industrial Co., Ltd. Fluoreszierende polarisation
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
AU1824899A (en) * 1997-12-15 1999-07-05 Joseph R Lakowicz Method and composition for characterizing a sample containing a sample lipid andan assay kit
US6200752B1 (en) * 1998-01-14 2001-03-13 Joseph R. Lakowicz Method and composition for detecting the presence of a nucleic acid sequence in a sample
US6214628B1 (en) * 1998-01-14 2001-04-10 Joseph R. Lakowicz Method of conducting an assay of a sample containing an analyte of interest
US6140136A (en) * 1998-09-18 2000-10-31 Syntron Bioresearch, Inc. Analytical test device and method of use
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6597946B2 (en) 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
WO2000028307A1 (en) * 1998-11-11 2000-05-18 University Of Maryland, Baltimore Polarization based sensing
US6395556B1 (en) * 1998-11-11 2002-05-28 Joseph R. Lakowicz Polarization based sensing
WO2001032665A2 (en) * 1999-11-01 2001-05-10 Fluorrx, Inc. New ruthenium metal ligand complexes
US20020072625A1 (en) * 1999-12-10 2002-06-13 Johnson David Kenneth Materials and methods for measuring chelate: anti-chelate binding by fluorescence polarization immunoassay
WO2001049874A1 (en) 2000-01-06 2001-07-12 Caliper Technologies Corp. Methods and systems for monitoring intracellular binding reactions
US6498941B1 (en) 2000-03-09 2002-12-24 Advanced Cardiovascular Systems, Inc. Catheter based probe and method of using same for detecting chemical analytes
US6440389B1 (en) * 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
DE10133859B4 (de) * 2001-07-12 2011-02-24 Continental Teves Ag & Co. Ohg Vorrichtung zum Stabilisieren eines Fahrzeugs
US20030215391A1 (en) * 2001-07-19 2003-11-20 Carlos Rabito Fluorescent agents for real-time measurement of organ function
US6989273B2 (en) * 2002-02-08 2006-01-24 Canon Kabushiki Kaisha Light emissive iridium (III) complexes
WO2003089043A2 (en) * 2002-04-19 2003-10-30 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
ES2313140T3 (es) * 2005-03-23 2009-03-01 F. Hoffmann-La Roche Ag Procedimiento para la determinacion de la concentracion de glucosa, mediante polarizacion de la fluorescencia.
US20080225265A1 (en) * 2007-03-17 2008-09-18 Mi Research, Inc. Method and apparatus for finding macromolecule crystallization conditions
WO2014059281A1 (en) * 2012-10-11 2014-04-17 The Regents Of The University Of Michigan Fluorescence polarization assay for detecting high molecular weight molecules in biological fluids
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
KR102257912B1 (ko) 2013-03-13 2021-05-27 메소 스케일 테크놀러지즈, 엘엘시 개선된 분석 방법
EP2944958A1 (de) 2014-04-04 2015-11-18 Techno-Path (Distribution) Verfahren zur Vorhersage von phänotypischer Instabilität in einer Zelle
CN106796218B (zh) 2014-05-15 2020-10-13 中尺度技术有限责任公司 改进的测定方法
JP6629830B2 (ja) 2014-07-15 2020-01-15 バリタセル リミテッド 試料中の抗体濃度を測定する方法
EP3075844A1 (de) 2015-04-01 2016-10-05 Valitacell Limited Verfahren zur bestimmung einer zusammengesetzten oder funktionellen eigenschaft eines zellkulturmediums

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816419A (en) * 1983-08-01 1989-03-28 University Of Health Sciences/The Chicago Medical School Fluorescence ligand binding assay using charge-matched dye and solvent components
US5310687A (en) * 1984-10-31 1994-05-10 Igen, Inc. Luminescent metal chelate labels and means for detection
JPH0650315B2 (ja) * 1985-11-08 1994-06-29 株式会社日立製作所 免疫分析用試薬および免疫分析方法
US5239057A (en) * 1987-03-27 1993-08-24 Abbott Laboratories Fluorescence polarization assay for cyclosporin a and metabolites and related immunogens and antibodies
EP0312897A1 (de) * 1987-10-21 1989-04-26 Abbott Laboratories Thyroid-Hormon-Test und Furosemid verwendendes Reagenssystem
ATE180057T1 (de) * 1988-11-03 1999-05-15 Igen Int Inc Elektrochemilumineszente testverfahren

Also Published As

Publication number Publication date
AU686490B2 (en) 1998-02-05
WO1996013722A1 (en) 1996-05-09
EP0788601B1 (de) 2006-12-27
EP0788601A1 (de) 1997-08-13
DE69535353T2 (de) 2008-07-03
AU4279796A (en) 1996-05-23
ATE349696T1 (de) 2007-01-15
CA2203772A1 (en) 1996-05-09
US5660991A (en) 1997-08-26
JPH10508103A (ja) 1998-08-04
EP0788601A4 (de) 2000-04-12

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