DE69535204D1 - CDNA für humane Methyllentetrahydrofolatreduktase - Google Patents

CDNA für humane Methyllentetrahydrofolatreduktase

Info

Publication number
DE69535204D1
DE69535204D1 DE69535204T DE69535204T DE69535204D1 DE 69535204 D1 DE69535204 D1 DE 69535204D1 DE 69535204 T DE69535204 T DE 69535204T DE 69535204 T DE69535204 T DE 69535204T DE 69535204 D1 DE69535204 D1 DE 69535204D1
Authority
DE
Germany
Prior art keywords
human
patients
mthfr
cdna
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69535204T
Other languages
English (en)
Other versions
DE69535204T2 (de
Inventor
Rima Rozen
Philippe Goyette
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
McGill University
Original Assignee
McGill University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by McGill University filed Critical McGill University
Publication of DE69535204D1 publication Critical patent/DE69535204D1/de
Application granted granted Critical
Publication of DE69535204T2 publication Critical patent/DE69535204T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0026—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5)
    • C12N9/0028—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on CH-NH groups of donors (1.5) with NAD or NADP as acceptor (1.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69535204T 1994-05-26 1995-05-25 CDNA für humane Methyllentetrahydrofolatreduktase Expired - Lifetime DE69535204T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9410620 1994-05-26
GB9410620A GB9410620D0 (en) 1994-05-26 1994-05-26 cDNA for human mehylenetetrahydrofolate reductase
PCT/CA1995/000314 WO1995033054A1 (en) 1994-05-26 1995-05-25 cDNA FOR HUMAN METHYLENETETRAHYDROFOLATE REDUCTASE

Publications (2)

Publication Number Publication Date
DE69535204D1 true DE69535204D1 (de) 2006-10-12
DE69535204T2 DE69535204T2 (de) 2007-07-19

Family

ID=10755786

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69535204T Expired - Lifetime DE69535204T2 (de) 1994-05-26 1995-05-25 CDNA für humane Methyllentetrahydrofolatreduktase

Country Status (9)

Country Link
US (4) US6074821A (de)
EP (2) EP1752539A2 (de)
AT (1) ATE338130T1 (de)
AU (1) AU2519895A (de)
CA (1) CA2191220C (de)
DE (1) DE69535204T2 (de)
ES (1) ES2271946T3 (de)
GB (1) GB9410620D0 (de)
WO (1) WO1995033054A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9410620D0 (en) * 1994-05-26 1994-07-13 Univ Mcgill cDNA for human mehylenetetrahydrofolate reductase
US6566065B1 (en) * 1994-05-26 2003-05-20 Mcgill University Method of diagnosing schizophrenia by detecting a mutation in the (MTHFR) gene
EP1097222A1 (de) * 1998-07-15 2001-05-09 E.I. Du Pont De Nemours And Company Enzyme des tetrahydrofolatmetabolismus
US20050191691A1 (en) * 1998-07-20 2005-09-01 Variagenics, Inc., A Delaware Corporation Gene sequence variances in genes related to folate metabolism having utility in determining the treatment of disease
US6759200B1 (en) 1998-07-20 2004-07-06 Nuvelo, Inc. Thymidine phosphorylase gene sequence variances having utility in determining the treatment of disease
US6664062B1 (en) 1998-07-20 2003-12-16 Nuvelo, Inc. Thymidylate synthase gene sequence variances having utility in determining the treatment of disease
JP2003502014A (ja) * 1999-03-01 2003-01-21 マクギル ユニバーシティ ヒトメチレンテトラヒドロ葉酸還元酵素のｃＤＮＡ
US20010025030A1 (en) * 1999-03-01 2001-09-27 Rima Rozen cDNA for human methylenetetrahydrofolate reductase and uses thereof
EP1652936A3 (de) * 1999-03-01 2006-06-14 McGILL UNIVERSITY cDNA von menschlicher Methylentetrahydrofolatreductase
US6912492B1 (en) * 1999-05-25 2005-06-28 University Of Medicine & Dentistry Of New Jersey Methods for diagnosing, preventing, and treating developmental disorders due to a combination of genetic and environmental factors
FR2811321A1 (fr) * 2000-07-04 2002-01-11 Bio Merieux Amplificateur d'une region ribonucleique cible d'un arn ribosomal 16s ou adn pour un tel arn d'une espece eubacterienne et detection de telles especes
US7054758B2 (en) * 2001-01-30 2006-05-30 Sciona Limited Computer-assisted means for assessing lifestyle risk factors
CN1155722C (zh) * 2001-04-02 2004-06-30 四川宇康生物技术有限公司 孕前基因报警诊断试剂盒及其检测方法
JP4174203B2 (ja) * 2001-10-11 2008-10-29 オキサゲン リミティッド 骨損傷の受け易さを判定する方法
US7319145B2 (en) * 2001-12-03 2008-01-15 Rima Rozen Methylenetetrahydrofolate reductase inhibitors and use thereof
US20030198985A1 (en) * 2002-02-22 2003-10-23 Hogan Kirk J. Assay for nitrous oxide neurologic syndrome
EP1490076A4 (de) * 2002-03-11 2010-01-06 Lipomics Technologies Inc Neue metabolische targets und marker
KR20030081967A (ko) * 2002-04-15 2003-10-22 최병옥 뇌경색의 예측 또는 예방을 위한 ｍｔｈｆｒ 677ｔｔ유전자형
WO2004022713A2 (en) 2002-09-05 2004-03-18 Techlab, Inc. Method for distinguishing ulcerative colitis from crohn's disease by detecting the presence of fecal anti-neutrophil cytoplasmic antibodies (anca)
CN102027134A (zh) * 2008-03-27 2011-04-20 加利福尼亚大学董事会 参与代谢途径的基因的受损等位基因以及用于检测和使用其的方法
EP2780467B1 (de) 2011-11-14 2018-10-17 Alfasigma S.p.A. Assays und verfahren zur auswahl eines behandlungsplans für einen patienten mit depressionen und behandlungsverfahren dafür

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9410620D0 (en) * 1994-05-26 1994-07-13 Univ Mcgill cDNA for human mehylenetetrahydrofolate reductase
US5972614A (en) 1995-12-06 1999-10-26 Genaissance Pharmaceuticals Genome anthologies for harvesting gene variants
US6008221A (en) 1996-11-06 1999-12-28 Bristol-Myers Squibb Company Method for treating Alzheimer's disease with folic acid
CA2335649A1 (en) 1998-07-20 2000-01-27 Variagenics, Inc. Gene sequence variances with utility in determining the treatment of disease

Also Published As

Publication number Publication date
ES2271946T3 (es) 2007-04-16
EP0755450B1 (de) 2006-08-30
ATE338130T1 (de) 2006-09-15
AU2519895A (en) 1995-12-21
US20030157530A1 (en) 2003-08-21
DE69535204T2 (de) 2007-07-19
US6218120B1 (en) 2001-04-17
US6074821A (en) 2000-06-13
EP1752539A2 (de) 2007-02-14
GB9410620D0 (en) 1994-07-13
US6528259B1 (en) 2003-03-04
CA2191220A1 (en) 1995-12-07
EP0755450A1 (de) 1997-01-29
WO1995033054A1 (en) 1995-12-07
CA2191220C (en) 2012-03-13

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