DE69533223D1 - Zusammensetzungen und verfahren zur stimulierung der proliferation und der differenzierung von menschlichen fetalen und erwachsenen pankreatischen zellen ex vivo - Google Patents

Zusammensetzungen und verfahren zur stimulierung der proliferation und der differenzierung von menschlichen fetalen und erwachsenen pankreatischen zellen ex vivo

Info

Publication number
DE69533223D1
DE69533223D1 DE69533223T DE69533223T DE69533223D1 DE 69533223 D1 DE69533223 D1 DE 69533223D1 DE 69533223 T DE69533223 T DE 69533223T DE 69533223 T DE69533223 T DE 69533223T DE 69533223 D1 DE69533223 D1 DE 69533223D1
Authority
DE
Germany
Prior art keywords
cells
differentiation
human
fetals
vivo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69533223T
Other languages
English (en)
Other versions
DE69533223T2 (de
Inventor
Jeffrey Rubin
Timo Pyry Juhani Otonkoski
Gillian M Beattie
Alberto Hayek
Vito Quaranta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Whittier Inst Diabetes & Endoc
US Department of Health and Human Services
Original Assignee
Whittier Inst Diabetes & Endoc
US Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Whittier Inst Diabetes & Endoc, US Department of Health and Human Services filed Critical Whittier Inst Diabetes & Endoc
Publication of DE69533223D1 publication Critical patent/DE69533223D1/de
Application granted granted Critical
Publication of DE69533223T2 publication Critical patent/DE69533223T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/12—Hepatocyte growth factor [HGF]

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69533223T 1994-04-29 1995-04-28 Zusammensetzungen und Verfahren zur Stimulation der Proliferation und Differenzierung von humanen fötalen und adulten Pankreaszellen ex vivo Expired - Lifetime DE69533223T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US235394 1988-08-23
US08/235,394 US5587309A (en) 1994-04-29 1994-04-29 Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
PCT/US1995/005521 WO1995029989A1 (en) 1994-04-29 1995-04-28 COMPOSITIONS AND METHOD OF STIMULATING THE PROLIFERATION AND DIFFERENTIATION OF HUMAN FETAL AND ADULT PANCREATIC CELLS $i(EX VIVO)

Publications (2)

Publication Number Publication Date
DE69533223D1 true DE69533223D1 (de) 2004-08-05
DE69533223T2 DE69533223T2 (de) 2005-07-14

Family

ID=22885314

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69533223T Expired - Lifetime DE69533223T2 (de) 1994-04-29 1995-04-28 Zusammensetzungen und Verfahren zur Stimulation der Proliferation und Differenzierung von humanen fötalen und adulten Pankreaszellen ex vivo

Country Status (8)

Country Link
US (2) US5587309A (de)
EP (1) EP0765385B1 (de)
JP (1) JP3996950B2 (de)
AT (1) ATE270323T1 (de)
AU (1) AU695390B2 (de)
CA (1) CA2189052A1 (de)
DE (1) DE69533223T2 (de)
WO (1) WO1995029989A1 (de)

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US6558952B1 (en) * 1992-12-14 2003-05-06 Waratah Pharmaceuticals, Inc. Treatment for diabetes
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
EP0808364B1 (de) * 1995-02-10 2005-11-30 The Regents of the University of California Menschliche pancreas zellinien: entwicklungen und anwendungen
US5723333A (en) * 1995-02-10 1998-03-03 Regents Of The University Of California Human pancreatic cell lines: developments and uses
US6110743A (en) * 1995-02-10 2000-08-29 The Regents Of The University Of California Development and use of human pancreatic cell lines
WO1997016536A1 (en) * 1995-10-30 1997-05-09 Vivorx, Inc. Method for ex vivo proliferation and differentiation of adult pancreatic islet cells, media useful therefor and uses thereof
US6110707A (en) * 1996-01-19 2000-08-29 Board Of Regents, The University Of Texas System Recombinant expression of proteins from secretory cell lines
US6043092A (en) * 1996-03-18 2000-03-28 University Of Pittsburgh Cell culture media for mammalian cells
US5672361A (en) * 1996-03-29 1997-09-30 Desmos, Inc. Laminin 5 for growth of pancreatic islet cells
US5874306A (en) * 1996-12-12 1999-02-23 The Regents Of The University Of California Culturing human pancreatic endocrine cells in medium containing extracellular matrix from human bladder carcinoma cells
SE9700983D0 (sv) * 1997-03-18 1997-03-18 Ascendia Ab Stimulering, odling och preservation av pankreas- och andra celler
CA2216055A1 (en) * 1997-09-19 1999-03-19 Mcgill University A medium to promote islet cell survival
US20040037818A1 (en) * 1998-07-30 2004-02-26 Brand Stephen J. Treatment for diabetes
US6322962B1 (en) 1998-08-14 2001-11-27 Board Of Regents, The University Of Texas System Sterol-regulated Site-1 protease and assays of modulators thereof
KR19990014353A (ko) * 1998-10-17 1999-02-25 윤태욱 췌도의 대량 배양증식방법
US6506599B1 (en) * 1999-10-15 2003-01-14 Tai-Wook Yoon Method for culturing langerhans islets and islet autotransplantation islet regeneration
AU781750B2 (en) * 1999-02-04 2005-06-09 Mcgill University Platform for the differentiation of cells
US6946293B1 (en) 1999-02-10 2005-09-20 Es Cell International Pte Ltd. Progenitor cells, methods and uses related thereto
IL144654A0 (en) * 1999-02-10 2002-05-23 Curis Inc Pancreatic progenitor cells, methods and uses related thereto
US6303355B1 (en) 1999-03-22 2001-10-16 Duke University Method of culturing, cryopreserving and encapsulating pancreatic islet cells
US6365385B1 (en) 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
DE60039160D1 (de) * 1999-04-06 2008-07-24 Genentech Inc Verwendung von erbb-rezeptorliganden zur behandlung von diabetes
US20090047325A1 (en) * 1999-04-30 2009-02-19 Neurotrophincell Pty. Limited Xenotransplant for cns therapy
WO2000066155A1 (en) 1999-04-30 2000-11-09 La Jolla Institute For Allergy And Immunology Methods for preventing reactivation of latent virus and controlling virus replication
ES2346400T3 (es) * 1999-04-30 2010-10-15 Neurotrophincell Pty Ltd Xenotransplante para la terapia del snc.
US20050265977A1 (en) * 1999-04-30 2005-12-01 Elliott Robert B Xenotransplant for CNS therapy
US6815203B1 (en) 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells
WO2000078929A1 (en) * 1999-06-23 2000-12-28 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells
DK1248640T3 (da) * 2000-01-20 2007-02-12 Diabcell Pty Ltd Xenotransplantation af svineöer og deres fremstilling
US6610535B1 (en) 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
US6436704B1 (en) * 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US7790690B2 (en) 2000-10-11 2010-09-07 U.S. Department Of Veterans Affairs Glucose sensitive regulator of insulin transcription
WO2002032437A1 (en) * 2000-10-17 2002-04-25 Diatranz Limited Preparation and xenotransplantation or porcine islets
US6972195B2 (en) * 2002-09-27 2005-12-06 Rongxiang Xu Composition and method for culturing potentially regenerative cells and functional tissue-organs in vitro
US6642003B2 (en) 2001-08-02 2003-11-04 Cedars-Sinai Medical Center Human glucose-dependent insulin-secreting cell line
WO2003027270A1 (en) * 2001-09-28 2003-04-03 Diabcell Pty Limited Growing xenotransplant material in culture
KR20030033638A (ko) * 2001-10-24 2003-05-01 (주)한국췌도이식연구소 인공 췌도 세포 및 이의 용도
NZ515310A (en) * 2001-11-07 2004-08-27 Diabcell Pty Ltd Methods of treatment and delivery modes
GB2415432B (en) * 2001-12-07 2006-09-06 Geron Corp Islet cells from human embryonic stem cells
US20030138949A1 (en) * 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US20040005301A1 (en) * 2002-02-12 2004-01-08 Goldman Steven A. Identification and high-yield isolation of human pancreatic islet progenitor and stem cells
US7141240B2 (en) * 2002-03-12 2006-11-28 Cedars-Sinai Medical Center Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
JP2005527224A (ja) * 2002-05-24 2005-09-15 ワラタ ファーマシューティカルズ， インコーポレイテッド 糖尿病の処置
US20030228287A1 (en) * 2002-06-07 2003-12-11 Regents Of The University Of California Maintenance of islet cells
ES2320754T3 (es) * 2002-10-22 2009-05-28 Waratah Pharmaceuticals, Inc. Tratamiento de la diabetes.
WO2004106921A2 (en) * 2003-05-27 2004-12-09 Mcgill University In vitro platform for screening agents inducing islet cell neogenesis
CA2529573A1 (en) * 2003-06-24 2004-12-29 Diabcell Pty Limited Porcine islets cultured with porcine sertoli cells for xenotransplantation
JP5128935B2 (ja) 2004-03-31 2013-01-23 ジェネンテック， インコーポレイテッド ヒト化抗ＴＧＦ−β抗体
KR100660473B1 (ko) * 2004-04-02 2006-12-22 학교법인연세대학교 췌장 선방세포로부터 이행분화된 췌장 전구세포주
JP2005306749A (ja) * 2004-04-19 2005-11-04 Kringle Pharma Inc Ｈｇｆ含有臓器保存液
NZ540597A (en) * 2005-06-08 2007-02-23 Neurotrophincell Pty Ltd A method for preventing the onset of type I diabetes comprising administering an implantable composition comprising living choroid plexus cells
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
WO2013010045A1 (en) 2011-07-12 2013-01-17 Biotime Inc. Novel methods and formulations for orthopedic cell therapy
US20150174202A1 (en) * 2011-09-28 2015-06-25 The Board Of Trustees Of The Leland Stanford Junior University Methods and Compositions for Modulating Beta Cell Proliferation
GB201611123D0 (en) 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
IT201800000534A1 (it) * 2018-01-03 2019-07-03 Procedimenti per la promozione della crescita cellulare degli isolotti pancreatici.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0363125A3 (de) * 1988-10-03 1990-08-16 Hana Biologics Inc. Produkt, enthaltend vermehrungsfähige Bauchspeicheldrüsen-Endokrinezellen, und Verfahren
US5362716A (en) * 1989-12-27 1994-11-08 The United States Of America As Represented By The Department Of Health And Human Services Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines
US5510263A (en) * 1993-04-05 1996-04-23 Desmos, Inc. Growth of pancreatic islet-like cell clusters
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo

Also Published As

Publication number Publication date
ATE270323T1 (de) 2004-07-15
JP3996950B2 (ja) 2007-10-24
US5587309A (en) 1996-12-24
EP0765385B1 (de) 2004-06-30
CA2189052A1 (en) 1995-11-09
DE69533223T2 (de) 2005-07-14
AU2433695A (en) 1995-11-29
AU695390B2 (en) 1998-08-13
WO1995029989A1 (en) 1995-11-09
EP0765385A1 (de) 1997-04-02
JPH10503923A (ja) 1998-04-14
US5888705A (en) 1999-03-30

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