DE69533067T2 - Hepatis e-virus antigene und dessen verwendungen - Google Patents
Hepatis e-virus antigene und dessen verwendungen Download PDFInfo
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- DE69533067T2 DE69533067T2 DE69533067T DE69533067T DE69533067T2 DE 69533067 T2 DE69533067 T2 DE 69533067T2 DE 69533067 T DE69533067 T DE 69533067T DE 69533067 T DE69533067 T DE 69533067T DE 69533067 T2 DE69533067 T2 DE 69533067T2
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- 238000003756 stirring Methods 0.000 description 1
- 239000012609 strong anion exchange resin Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000011191 terminal modification Methods 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- AAPLIUHOKVUFCC-UHFFFAOYSA-N trimethylsilanol Chemical compound C[Si](C)(C)O AAPLIUHOKVUFCC-UHFFFAOYSA-N 0.000 description 1
- 238000003211 trypan blue cell staining Methods 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 238000005199 ultracentrifugation Methods 0.000 description 1
- 241000701366 unidentified nuclear polyhedrosis viruses Species 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 229940125575 vaccine candidate Drugs 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000007919 viral pathogenicity Effects 0.000 description 1
- 210000000605 viral structure Anatomy 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 239000012610 weak anion exchange resin Substances 0.000 description 1
- 239000012130 whole-cell lysate Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/70—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
- C12Q1/701—Specific hybridization probes
- C12Q1/706—Specific hybridization probes for hepatitis
- C12Q1/707—Specific hybridization probes for hepatitis non-A, non-B Hepatitis, excluding hepatitis D
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
- G01N33/5767—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis non-A, non-B hepatitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/14011—Baculoviridae
- C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
- C12N2710/14141—Use of virus, viral particle or viral elements as a vector
- C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/28011—Hepeviridae
- C12N2770/28111—Hepevirus, e.g. hepatitis E virus
- C12N2770/28122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/28011—Hepeviridae
- C12N2770/28111—Hepevirus, e.g. hepatitis E virus
- C12N2770/28123—Virus like particles [VLP]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Communicable Diseases (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Public Health (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US327952 | 1981-12-07 | ||
| US32795294A | 1994-10-24 | 1994-10-24 | |
| US542634 | 1995-10-13 | ||
| US08/542,634 US6214970B1 (en) | 1988-06-17 | 1995-10-13 | Hepatitis E virus antigens and uses therefor |
| PCT/US1995/013703 WO1996012807A2 (en) | 1994-10-24 | 1995-10-23 | Hepatitis e virus antigens and uses therefor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69533067D1 DE69533067D1 (de) | 2004-06-24 |
| DE69533067T2 true DE69533067T2 (de) | 2005-05-12 |
Family
ID=26986149
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69533067T Expired - Lifetime DE69533067T2 (de) | 1994-10-24 | 1995-10-23 | Hepatis e-virus antigene und dessen verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US6214970B1 (enExample) |
| EP (1) | EP0787190B1 (enExample) |
| JP (2) | JPH10509588A (enExample) |
| AT (1) | ATE267256T1 (enExample) |
| AU (1) | AU4195696A (enExample) |
| DE (1) | DE69533067T2 (enExample) |
| ES (1) | ES2223054T3 (enExample) |
| WO (1) | WO1996012807A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0662133B1 (en) | 1992-09-18 | 2009-11-18 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Recombinant proteins of a pakistani strain of hepatitis e and their use in diagnostic methods and vaccines |
| US6787145B1 (en) | 1992-09-18 | 2004-09-07 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines |
| US6207416B1 (en) | 1992-09-18 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines |
| US6054567A (en) * | 1997-04-11 | 2000-04-25 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant proteins of a pakistani strain of hepatitis E and their use in diagnostic methods and vaccines |
| US6458562B1 (en) | 1998-04-09 | 2002-10-01 | The United States Of America As Represented By The Secretary Of Health And Human Services | Recombinant proteins of a Pakistani strain of hepatitis E and their use in diagnostic methods and vaccines |
| CA2283538A1 (en) * | 1999-09-30 | 2001-03-30 | Mun Hon Ng | New hev antigenic peptide and methods |
| CN101367869B (zh) | 2000-09-30 | 2012-12-05 | 北京万泰生物药业股份有限公司 | 用于预防、诊断及治疗戊型肝炎病毒的多肽,及它们作为诊断试剂和疫苗 |
| WO2003068163A2 (en) * | 2002-02-14 | 2003-08-21 | Novavax, Inc. | Optimization of gene sequences of chimeric virus-like particles for expression in insect cells |
| JP2005102689A (ja) * | 2003-09-08 | 2005-04-21 | Mitsubishi Kagaku Bio-Clinical Laboratories Inc | Ｅ型肝炎ウイルス様中空粒子 |
| US8906862B2 (en) | 2009-02-27 | 2014-12-09 | The Regents Of The University Of California | Multiple antigen delivery system using hepatitis E virus-like particle |
| JP5869885B2 (ja) * | 2009-02-27 | 2016-02-24 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｅ型肝炎ウイルス様粒子を用いた多抗原送達系 |
| US8906863B2 (en) | 2009-02-27 | 2014-12-09 | The Regents Of The University Of California | Proteolysis-resistant capsid of chimeric hepatitis E virus as an oral delivery vector |
| WO2017202973A1 (en) * | 2016-05-25 | 2017-11-30 | Intervet International B.V. | Hev vaccine |
| CN117083290A (zh) * | 2021-03-26 | 2023-11-17 | 港大科桥有限公司 | 戊型肝炎病毒样颗粒及其用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU644878B2 (en) | 1988-06-17 | 1993-12-23 | Genelabs Technologies, Inc. | Enterically transmitted non-A/non-B hepatitis viral agent and characteristic epitopes thereof |
| US6455492B1 (en) | 1988-06-17 | 2002-09-24 | Genelabs Technologies, Inc. | Hepatitis E virus vaccine and method |
| US5885768A (en) | 1988-06-17 | 1999-03-23 | The United States Of America As Represented By The Department Of Health And Human Services | Hepatitis E virus peptide antigen and antibodies |
| US5294548A (en) * | 1990-04-02 | 1994-03-15 | American Biogenetic Sciences, Inc | Recombianant Hepatitis a virus |
| EP0662133B1 (en) | 1992-09-18 | 2009-11-18 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Recombinant proteins of a pakistani strain of hepatitis e and their use in diagnostic methods and vaccines |
| AU694139B2 (en) | 1993-09-24 | 1998-07-16 | Macfarlane Burnet Centre For Medical Research Limited, The | Immunoreactive antigens of hepatitis E virus |
-
1995
- 1995-10-13 US US08/542,634 patent/US6214970B1/en not_active Expired - Fee Related
- 1995-10-23 ES ES95940546T patent/ES2223054T3/es not_active Expired - Lifetime
- 1995-10-23 AT AT95940546T patent/ATE267256T1/de not_active IP Right Cessation
- 1995-10-23 JP JP8514117A patent/JPH10509588A/ja not_active Withdrawn
- 1995-10-23 AU AU41956/96A patent/AU4195696A/en not_active Abandoned
- 1995-10-23 DE DE69533067T patent/DE69533067T2/de not_active Expired - Lifetime
- 1995-10-23 EP EP95940546A patent/EP0787190B1/en not_active Expired - Lifetime
- 1995-10-23 WO PCT/US1995/013703 patent/WO1996012807A2/en not_active Ceased
-
2001
- 2001-05-29 US US09/769,066 patent/US20020107360A1/en not_active Abandoned
-
2005
- 2005-12-07 JP JP2005354138A patent/JP4237747B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6214970B1 (en) | 2001-04-10 |
| WO1996012807A2 (en) | 1996-05-02 |
| EP0787190B1 (en) | 2004-05-19 |
| ATE267256T1 (de) | 2004-06-15 |
| ES2223054T3 (es) | 2005-02-16 |
| EP0787190A2 (en) | 1997-08-06 |
| AU4195696A (en) | 1996-05-15 |
| WO1996012807A3 (en) | 1996-05-30 |
| JP2006141400A (ja) | 2006-06-08 |
| DE69533067D1 (de) | 2004-06-24 |
| JP4237747B2 (ja) | 2009-03-11 |
| JPH10509588A (ja) | 1998-09-22 |
| US20020107360A1 (en) | 2002-08-08 |
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|---|---|---|---|
| 8364 | No opposition during term of opposition |