DE69523566T2 - Dichte-gradientmedien zur trennung von zellen - Google Patents
Dichte-gradientmedien zur trennung von zellenInfo
- Publication number
- DE69523566T2 DE69523566T2 DE69523566T DE69523566T DE69523566T2 DE 69523566 T2 DE69523566 T2 DE 69523566T2 DE 69523566 T DE69523566 T DE 69523566T DE 69523566 T DE69523566 T DE 69523566T DE 69523566 T2 DE69523566 T2 DE 69523566T2
- Authority
- DE
- Germany
- Prior art keywords
- density gradient
- cell separation
- gradient media
- gradient medium
- medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Ecology (AREA)
- Food Science & Technology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/189,509 US5489386A (en) | 1994-01-31 | 1994-01-31 | Density gradient medium for the separation of cells |
PCT/US1995/000956 WO1995020429A1 (en) | 1994-01-31 | 1995-01-23 | Density gradient medium for separating cells |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69523566D1 DE69523566D1 (de) | 2001-12-06 |
DE69523566T2 true DE69523566T2 (de) | 2002-09-05 |
Family
ID=22697630
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69523566T Expired - Fee Related DE69523566T2 (de) | 1994-01-31 | 1995-01-23 | Dichte-gradientmedien zur trennung von zellen |
Country Status (9)
Country | Link |
---|---|
US (1) | US5489386A (de) |
EP (1) | EP0739229B1 (de) |
JP (1) | JP3017291B2 (de) |
AT (1) | ATE207777T1 (de) |
AU (1) | AU680738B2 (de) |
CA (1) | CA2182367C (de) |
DE (1) | DE69523566T2 (de) |
DK (1) | DK0739229T3 (de) |
WO (1) | WO1995020429A1 (de) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FI940823A0 (fi) * | 1994-02-22 | 1994-02-22 | Orion Yhtymae Oy | Analysatorkyvett foer turbidimetriska och nefelometriska bestaemningar av helblodsprov |
ES2189869T3 (es) * | 1995-03-08 | 2003-07-16 | Bioseparations Inc | Procedimiento para el enriquecimiento de poblaciones de celulas raras. |
US5639669A (en) * | 1995-06-07 | 1997-06-17 | Ledley; Robert | Separation of fetal cells from maternal blood |
AUPN883396A0 (en) * | 1996-03-21 | 1996-04-18 | Australian Red Cross Society (Western Australian Division) | Centrifugation support |
US6210889B1 (en) | 1998-01-28 | 2001-04-03 | The Universite Laval | Method for enrichment of fetal cells from maternal blood and use of same in determination of fetal sex and detection of chromosomal abnormalities |
US6535393B2 (en) * | 1998-12-04 | 2003-03-18 | Micron Technology, Inc. | Electrical device allowing for increased device densities |
IT1311989B1 (it) * | 1999-03-30 | 2002-03-22 | Giammaria Sitar | Procedimento per isolare cellule fetali presenti nel sangue perifericomaterno. |
US7135335B2 (en) * | 1999-05-28 | 2006-11-14 | Stemcell Technologies Inc. | Method for separating cells using immunorosettes |
US7947236B2 (en) | 1999-12-03 | 2011-05-24 | Becton, Dickinson And Company | Device for separating components of a fluid sample |
US6593145B2 (en) | 2001-03-07 | 2003-07-15 | The Texas A&M University System | Density gradient solutions of metal ion chelate complexes |
US7316932B2 (en) * | 2001-10-01 | 2008-01-08 | Stemcell Technologies Inc. | Method for separating cells |
US7653260B2 (en) * | 2004-06-17 | 2010-01-26 | Carl Zeis MicroImaging GmbH | System and method of registering field of view |
US8582924B2 (en) * | 2004-06-30 | 2013-11-12 | Carl Zeiss Microimaging Gmbh | Data structure of an image storage and retrieval system |
US20060051265A1 (en) * | 2004-09-08 | 2006-03-09 | Health Research, Inc. | Apparatus and method for sorting microstructures in a fluid medium |
US7971730B2 (en) | 2005-08-10 | 2011-07-05 | The Regents Of The University Of California | Collection tubes apparatus, systems and methods |
US9248447B2 (en) * | 2005-08-10 | 2016-02-02 | The Regents Of The University Of California | Polymers for use in centrifugal separation of liquids |
US7673758B2 (en) * | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Collection tubes apparatus, systems, and methods |
US7674388B2 (en) * | 2005-08-10 | 2010-03-09 | The Regents Of The University Of California | Photopolymer serum separator |
US20070238088A1 (en) * | 2006-03-29 | 2007-10-11 | General Electric Company | Hydrophilic functionalized colloidal silica compositions, methods of making, and uses therefor |
EP2156370B1 (de) * | 2007-05-14 | 2011-10-12 | Historx, Inc. | Abteilungsauftrennung durch pixelcharakterisierung unter verwendung von bilddatenclusterung |
WO2008156669A1 (en) * | 2007-06-15 | 2008-12-24 | Historx, Inc. | Method and system for standardizing microscope instruments |
CA2604317C (en) | 2007-08-06 | 2017-02-28 | Historx, Inc. | Methods and system for validating sample images for quantitative immunoassays |
CA2596204C (en) * | 2007-08-07 | 2019-02-26 | Historx, Inc. | Method and system for determining an optimal dilution of a reagent |
US7978258B2 (en) * | 2007-08-31 | 2011-07-12 | Historx, Inc. | Automatic exposure time selection for imaging tissue |
CA2731156C (en) | 2008-07-21 | 2013-09-24 | Becton, Dickinson And Company | Density phase separation device |
MX339267B (es) | 2008-07-21 | 2016-05-18 | Becton Dickinson Co | Dispositivo de separacion de fase por densidad. |
AU2009274096B2 (en) | 2008-07-21 | 2012-08-02 | Becton, Dickinson And Company | Density phase separation device |
WO2010012002A1 (en) * | 2008-07-25 | 2010-01-28 | Saryna Medical Corporation | Methods and systems for genetic analysis of fetal nucleated red blood cells |
CN102165489B (zh) * | 2008-09-16 | 2015-11-25 | 赫斯托克斯公司 | 生物标志物表达的可再现量化 |
PL2918344T3 (pl) | 2009-05-15 | 2021-12-13 | Becton, Dickinson And Company | Urządzenie do oddzielania faz gęstości |
US9272083B2 (en) | 2009-05-29 | 2016-03-01 | Endocellutions, Inc. | Apparatus and methods for aspirating and separating components of different densities from a physiological fluid containing cells |
AU2011208382B2 (en) | 2010-01-21 | 2015-02-26 | Biocep Ltd. | Magnetic separation of rare cells |
NL1037672C2 (nl) * | 2010-02-01 | 2011-08-03 | Eurotrol B V | Werkwijze voor het bepalen van de betrouwbaarheid van een inrichting voor het meten van de concentratie van een stof in volledig bloed, werkwijze voor het behandelen van volledig bloed, houder en kit. |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
WO2012023298A1 (ja) * | 2010-08-20 | 2012-02-23 | 国立大学法人北陸先端科学技術大学院大学 | 血球の密度変化を利用した密度勾配遠心による有核赤血球の回収法 |
JP6208473B2 (ja) | 2012-06-20 | 2017-10-04 | アークレイ株式会社 | 血液成分を含む試料の処理方法 |
US9669405B2 (en) | 2012-10-22 | 2017-06-06 | The Regents Of The University Of California | Sterilizable photopolymer serum separator |
US9217697B2 (en) | 2012-11-30 | 2015-12-22 | Rarecyte, Inc. | Apparatus, system, and method for collecting a target material |
WO2014120797A1 (en) | 2013-01-29 | 2014-08-07 | Endocellutions, Inc. | Cell concentration devices and methods |
US9694359B2 (en) | 2014-11-13 | 2017-07-04 | Becton, Dickinson And Company | Mechanical separator for a biological fluid |
WO2018137186A1 (en) * | 2017-01-25 | 2018-08-02 | Yantai Ausbio Laboratories Co., Ltd. | Equipment and methods for automated sample processing for diagnostic purposes |
USD898184S1 (en) | 2019-01-29 | 2020-10-06 | Handi-Craft Company | Breast pump valve |
KR200492521Y1 (ko) * | 2019-02-11 | 2020-10-30 | 주식회사 이리농수산자재 | 농산물 랩핑용 결속부재 |
US11738288B2 (en) | 2020-06-29 | 2023-08-29 | Jacques Chammas | Automated system and method to isolate specific cells from blood or bone marrow |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4049692A (en) * | 1974-12-16 | 1977-09-20 | Corning Glass Works | Stabilized blood separating composition |
US4101422A (en) * | 1977-05-11 | 1978-07-18 | Emery Industries, Inc. | Copolyesters useful in blood separation assemblies |
US4386003A (en) * | 1981-09-17 | 1983-05-31 | Sherwood Medical Industries Inc. | Blood separating composition |
US4416778A (en) * | 1981-10-20 | 1983-11-22 | Neocyte, Inc. | Means for preparing neocyte enriched blood |
US4797475A (en) * | 1983-05-20 | 1989-01-10 | The Regents Of The University Of California | Method and composition for isolating white cell elements |
US4818418A (en) * | 1984-09-24 | 1989-04-04 | Becton Dickinson And Company | Blood partitioning method |
US4751001A (en) * | 1984-09-24 | 1988-06-14 | Becton Dickinson And Company | Blood partitioning apparatus |
US5053134A (en) * | 1984-12-04 | 1991-10-01 | Becton Dickinson And Company | Lymphocyte collection tube |
US4917801A (en) * | 1984-12-04 | 1990-04-17 | Becton Dickinson And Company | Lymphocyte collection tube |
US5260186A (en) * | 1986-03-10 | 1993-11-09 | Boris Cercek | Provision of density specific blood cells for the structuredness of the cytoplasmic matrix (SCM) test |
US4927750A (en) * | 1986-04-09 | 1990-05-22 | Jeanette Simpson | Cell separation process |
US4835097A (en) * | 1986-10-15 | 1989-05-30 | Saunders Alexander M | Method for ascertaining the history of a condition of the body from a single blood sample |
EP0353587A3 (de) * | 1988-07-26 | 1992-07-29 | Nippon Paint Co., Ltd. | Abdichtungsmittel für Serumabtrennung und dafür gebrauchte feine Harzteilchen |
ATE162631T1 (de) * | 1989-11-13 | 1998-02-15 | Childrens Medical Center | Ein nichtinvasives verfahren zur trennung und zum nachweis von fetaler dna |
EP0526584A1 (de) * | 1990-04-23 | 1993-02-10 | Cellpro Incorporated | Verfahren zur einreicherung von fetalen zellen aus mütterlichem blut |
DE4222573C1 (de) * | 1992-05-16 | 1993-08-12 | Dorothee Dr. 4400 Muenster De Ahlert | |
US5275933A (en) * | 1992-09-25 | 1994-01-04 | The Board Of Trustees Of The Leland Stanford Junior University | Triple gradient process for recovering nucleated fetal cells from maternal blood |
-
1994
- 1994-01-31 US US08/189,509 patent/US5489386A/en not_active Expired - Lifetime
-
1995
- 1995-01-23 JP JP7520133A patent/JP3017291B2/ja not_active Expired - Lifetime
- 1995-01-23 AT AT95910120T patent/ATE207777T1/de active
- 1995-01-23 CA CA002182367A patent/CA2182367C/en not_active Expired - Fee Related
- 1995-01-23 DK DK95910120T patent/DK0739229T3/da active
- 1995-01-23 EP EP95910120A patent/EP0739229B1/de not_active Expired - Lifetime
- 1995-01-23 DE DE69523566T patent/DE69523566T2/de not_active Expired - Fee Related
- 1995-01-23 AU AU18337/95A patent/AU680738B2/en not_active Ceased
- 1995-01-23 WO PCT/US1995/000956 patent/WO1995020429A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0739229A4 (de) | 1997-12-03 |
EP0739229B1 (de) | 2001-10-31 |
ATE207777T1 (de) | 2001-11-15 |
CA2182367C (en) | 2002-07-09 |
JP3017291B2 (ja) | 2000-03-06 |
CA2182367A1 (en) | 1995-08-03 |
AU1833795A (en) | 1995-08-15 |
JPH09508971A (ja) | 1997-09-09 |
AU680738B2 (en) | 1997-08-07 |
DE69523566D1 (de) | 2001-12-06 |
WO1995020429A1 (en) | 1995-08-03 |
US5489386A (en) | 1996-02-06 |
EP0739229A1 (de) | 1996-10-30 |
DK0739229T3 (da) | 2002-02-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69523566D1 (de) | Dichte-gradientmedien zur trennung von zellen | |
Kovach et al. | Erythroid cell development in fetal mice: ultrastructural characteristics and hemoglobin synthesis | |
IL110364A0 (en) | Enriching and identifying fetal nucleated erythrocytes in maternal blood for in situ hybridization | |
MX9301243A (es) | Filtro y metodo para obtener plaquetas. | |
RU99110373A (ru) | Использование антител против эмбрионального гемоглобина для идентификации плодных клеток | |
US4725406A (en) | Apparatus and method for diagnostic analysis of biological fluids | |
CA2469878A1 (en) | Blood cell separating system | |
BR9306867A (pt) | Enriquecimento e identificação de células fetais do sangue materno para a hibridização in situ | |
EP0257759A3 (de) | Teilchen zum Kalibrieren von Durchflusszytometriegeräten und anderen Analysevorrichtungen | |
FI932150A0 (fi) | Analyssystem foer glykerande blodproteiner | |
DE69513188T2 (de) | Vorrichtung und verfahren zur trennung von zellen | |
GB9518156D0 (en) | Method of isolating cells | |
BR8100378A (pt) | Aparelho e processo para ensaios de separacao,classificacao e compatibilidade de celulas vermelhas do sangue | |
WO1996042015A3 (en) | Reagent and method for differential determination of leukocytes in blood | |
DE69501326T2 (de) | Differentielle expansion von fötalen stamzellen im mütterlichen kreislauf zur verwendung in der pränatalen genetischen analyse | |
DK0974056T3 (da) | Prænatale in vitro-diagnostiske fremgangsmåder | |
Ito et al. | Isolation and characterization of fetal nucleated red blood cells from maternal blood as a target for single cell sequencing‐based non‐invasive genetic testing | |
ATE49659T1 (de) | Probe zur identifizierung von hla d. | |
Miller et al. | Comparison of acid phosphatase ACP1 variants by isoelectric focusing and conventional electrophoresis: identification of three new alleles, ACP1* N, ACP1* P and ACP1* S | |
ATE228026T1 (de) | Methode zur erreicherung von populationen seltener zellen | |
Foraker et al. | Glycogen in invasive squamous carcinoma of the uterine cervix | |
WO1997030354A3 (en) | Foetal cell analysis | |
Saunders et al. | Method for separating rare cells from a population of cells | |
Duck-Chong et al. | Sedimentation of lung-derived phospholipid during low-speed centrifugation of amniotic fluid. | |
IT8783430A0 (it) | Dispositivo atto ad effettuare in modo automatico il prelievo e la distribuzione standardizzata di campioni analitici in piastre contenenti terreni di coltura. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |