ATE228026T1 - Methode zur erreicherung von populationen seltener zellen - Google Patents

Methode zur erreicherung von populationen seltener zellen

Info

Publication number
ATE228026T1
ATE228026T1 AT96910382T AT96910382T ATE228026T1 AT E228026 T1 ATE228026 T1 AT E228026T1 AT 96910382 T AT96910382 T AT 96910382T AT 96910382 T AT96910382 T AT 96910382T AT E228026 T1 ATE228026 T1 AT E228026T1
Authority
AT
Austria
Prior art keywords
erythrocytes
blood sample
fetal nucleated
centrifuged
achievement
Prior art date
Application number
AT96910382T
Other languages
English (en)
Inventor
David W Sammons
Michael Manley
Joseph G Utermohlen
Garland E Twitty
Original Assignee
Bioseparations Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/401,131 external-priority patent/US5676849A/en
Application filed by Bioseparations Inc filed Critical Bioseparations Inc
Application granted granted Critical
Publication of ATE228026T1 publication Critical patent/ATE228026T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/491—Blood by separating the blood components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02—Separation of non-miscible liquids
    • B01D17/0202—Separation of non-miscible liquids by ab- or adsorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02—Separation of non-miscible liquids
    • B01D17/0217—Separation of non-miscible liquids by centrifugal force
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/06—Separation of liquids from each other by electricity
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/08—Thickening liquid suspensions by filtration
    • B01D17/085—Thickening liquid suspensions by filtration with membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D21/00—Separation of suspended solid particles from liquids by sedimentation
    • B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
    • B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
    • B01D17/02—Separation of non-miscible liquids
    • B01D17/04—Breaking emulsions
    • B01D17/047—Breaking emulsions with separation aids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2221/00—Applications of separation devices
    • B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Thermal Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Ecology (AREA)
  • Electrochemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT96910382T 1995-03-08 1996-03-07 Methode zur erreicherung von populationen seltener zellen ATE228026T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/401,131 US5676849A (en) 1994-10-21 1995-03-08 Method for enrichment of fetal cell population from maternal whole blood samples
PCT/US1995/013631 WO1996012945A1 (en) 1994-10-21 1995-10-20 Method for separating nucleated fetal erythrocytes
PCT/US1996/003165 WO1996027420A1 (en) 1995-03-08 1996-03-07 Method for enriching rare cell population

Publications (1)

Publication Number Publication Date
ATE228026T1 true ATE228026T1 (de) 2002-12-15

Family

ID=23586432

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96910382T ATE228026T1 (de) 1995-03-08 1996-03-07 Methode zur erreicherung von populationen seltener zellen

Country Status (6)

Country Link
EP (1) EP0813442B1 (de)
JP (1) JPH11502106A (de)
AT (1) ATE228026T1 (de)
DE (1) DE69624908T2 (de)
ES (1) ES2189869T3 (de)
WO (1) WO1996027420A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2813891B1 (fr) * 2000-09-14 2005-01-14 Immunotech Sa Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications
US8980568B2 (en) 2001-10-11 2015-03-17 Aviva Biosciences Corporation Methods and compositions for detecting non-hematopoietic cells from a blood sample
US8986944B2 (en) 2001-10-11 2015-03-24 Aviva Biosciences Corporation Methods and compositions for separating rare cells from fluid samples
EP1524321B2 (de) * 2003-10-16 2014-07-23 Sequenom, Inc. Nicht invasiver Nachweis fötaler genetischer Merkmale
US20090305236A1 (en) * 2005-05-11 2009-12-10 Genetic Technologies Limited Methods of enriching fetal cells
CA2657621A1 (en) 2006-07-14 2008-01-17 Aviva Biosciences Corporation Methods and compositions for detecting rare cells from a biological sample
US9334477B2 (en) 2010-08-20 2016-05-10 Japan Advanced Institute Of Science And Technology Method for collecting nucleated red blood cells via density-gradient centrifugation utilizing changes in blood cell density
ITRM20120028A1 (it) * 2012-01-25 2013-07-26 Natalia Malara Metodo per isolare cellule tumorali circolanti.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925572A (en) * 1987-10-20 1990-05-15 Pall Corporation Device and method for depletion of the leukocyte content of blood and blood components
US5192553A (en) * 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US5336387A (en) * 1990-09-11 1994-08-09 Bioseparations, Inc. Electrical separator apparatus and method of counterflow gradient focusing
US5439571A (en) * 1991-11-19 1995-08-08 Bioseparations, Inc. Apparatus and method for enhanced resolution continuous flow zone electrophoresis
US5457024A (en) * 1993-01-22 1995-10-10 Aprogenex, Inc. Isolation of fetal erythrocytes
US5432054A (en) * 1994-01-31 1995-07-11 Applied Imaging Method for separating rare cells from a population of cells
US5489386A (en) * 1994-01-31 1996-02-06 Applied Imaging Density gradient medium for the separation of cells

Also Published As

Publication number Publication date
EP0813442A1 (de) 1997-12-29
EP0813442A4 (de) 1998-09-09
JPH11502106A (ja) 1999-02-23
ES2189869T3 (es) 2003-07-16
DE69624908D1 (de) 2003-01-02
WO1996027420A1 (en) 1996-09-12
EP0813442B1 (de) 2002-11-20
DE69624908T2 (de) 2003-07-03

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Legal Events

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