DE69624908T2 - Methode zur erreicherung von populationen seltener zellen - Google Patents
Methode zur erreicherung von populationen seltener zellenInfo
- Publication number
- DE69624908T2 DE69624908T2 DE69624908T DE69624908T DE69624908T2 DE 69624908 T2 DE69624908 T2 DE 69624908T2 DE 69624908 T DE69624908 T DE 69624908T DE 69624908 T DE69624908 T DE 69624908T DE 69624908 T2 DE69624908 T2 DE 69624908T2
- Authority
- DE
- Germany
- Prior art keywords
- erythrocytes
- blood sample
- fetal nucleated
- rare cells
- centrifuged
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/49—Blood
- G01N33/491—Blood by separating the blood components
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0202—Separation of non-miscible liquids by ab- or adsorption
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/0217—Separation of non-miscible liquids by centrifugal force
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/06—Separation of liquids from each other by electricity
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/08—Thickening liquid suspensions by filtration
- B01D17/085—Thickening liquid suspensions by filtration with membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D21/00—Separation of suspended solid particles from liquids by sedimentation
- B01D21/26—Separation of sediment aided by centrifugal force or centripetal force
- B01D21/262—Separation of sediment aided by centrifugal force or centripetal force by using a centrifuge
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D17/00—Separation of liquids, not provided for elsewhere, e.g. by thermal diffusion
- B01D17/02—Separation of non-miscible liquids
- B01D17/04—Breaking emulsions
- B01D17/047—Breaking emulsions with separation aids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2221/00—Applications of separation devices
- B01D2221/10—Separation devices for use in medical, pharmaceutical or laboratory applications, e.g. separating amalgam from dental treatment residues
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Thermal Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Ecology (AREA)
- Electrochemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/401,131 US5676849A (en) | 1994-10-21 | 1995-03-08 | Method for enrichment of fetal cell population from maternal whole blood samples |
PCT/US1995/013631 WO1996012945A1 (en) | 1994-10-21 | 1995-10-20 | Method for separating nucleated fetal erythrocytes |
PCT/US1996/003165 WO1996027420A1 (en) | 1995-03-08 | 1996-03-07 | Method for enriching rare cell population |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69624908D1 DE69624908D1 (de) | 2003-01-02 |
DE69624908T2 true DE69624908T2 (de) | 2003-07-03 |
Family
ID=23586432
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69624908T Expired - Fee Related DE69624908T2 (de) | 1995-03-08 | 1996-03-07 | Methode zur erreicherung von populationen seltener zellen |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0813442B1 (de) |
JP (1) | JPH11502106A (de) |
AT (1) | ATE228026T1 (de) |
DE (1) | DE69624908T2 (de) |
ES (1) | ES2189869T3 (de) |
WO (1) | WO1996027420A1 (de) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2813891B1 (fr) * | 2000-09-14 | 2005-01-14 | Immunotech Sa | Reactif multifonctionnel pour erythrocytes mettant en jeu des carbamates et applications |
US8980568B2 (en) | 2001-10-11 | 2015-03-17 | Aviva Biosciences Corporation | Methods and compositions for detecting non-hematopoietic cells from a blood sample |
US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
ATE435301T1 (de) * | 2003-10-16 | 2009-07-15 | Sequenom Inc | Nicht invasiver nachweis fötaler genetischer merkmale |
CA2651367A1 (en) * | 2005-05-11 | 2006-11-16 | Genetic Technologies Limited | Methods of enriching fetal cells |
CN101583722A (zh) * | 2006-07-14 | 2009-11-18 | 阿维瓦生物科学股份有限公司 | 从生物学样品检测稀有细胞的方法和组合物 |
WO2012023298A1 (ja) * | 2010-08-20 | 2012-02-23 | 国立大学法人北陸先端科学技術大学院大学 | 血球の密度変化を利用した密度勾配遠心による有核赤血球の回収法 |
ITRM20120028A1 (it) * | 2012-01-25 | 2013-07-26 | Natalia Malara | Metodo per isolare cellule tumorali circolanti. |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4925572A (en) * | 1987-10-20 | 1990-05-15 | Pall Corporation | Device and method for depletion of the leukocyte content of blood and blood components |
US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
US5336387A (en) * | 1990-09-11 | 1994-08-09 | Bioseparations, Inc. | Electrical separator apparatus and method of counterflow gradient focusing |
US5439571A (en) * | 1991-11-19 | 1995-08-08 | Bioseparations, Inc. | Apparatus and method for enhanced resolution continuous flow zone electrophoresis |
US5457024A (en) * | 1993-01-22 | 1995-10-10 | Aprogenex, Inc. | Isolation of fetal erythrocytes |
US5432054A (en) * | 1994-01-31 | 1995-07-11 | Applied Imaging | Method for separating rare cells from a population of cells |
US5489386A (en) * | 1994-01-31 | 1996-02-06 | Applied Imaging | Density gradient medium for the separation of cells |
-
1996
- 1996-03-07 ES ES96910382T patent/ES2189869T3/es not_active Expired - Lifetime
- 1996-03-07 EP EP96910382A patent/EP0813442B1/de not_active Expired - Lifetime
- 1996-03-07 WO PCT/US1996/003165 patent/WO1996027420A1/en active IP Right Grant
- 1996-03-07 DE DE69624908T patent/DE69624908T2/de not_active Expired - Fee Related
- 1996-03-07 AT AT96910382T patent/ATE228026T1/de not_active IP Right Cessation
- 1996-03-07 JP JP8527058A patent/JPH11502106A/ja not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
EP0813442A4 (de) | 1998-09-09 |
JPH11502106A (ja) | 1999-02-23 |
ES2189869T3 (es) | 2003-07-16 |
DE69624908D1 (de) | 2003-01-02 |
EP0813442A1 (de) | 1997-12-29 |
WO1996027420A1 (en) | 1996-09-12 |
ATE228026T1 (de) | 2002-12-15 |
EP0813442B1 (de) | 2002-11-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee |