DE69523116D1 - Verbessertes Verfahren zur kolorimetrischen Bestimmung der Konzentration der weissen Blutzellen in einer biologischen Flüssigkeit - Google Patents

Verbessertes Verfahren zur kolorimetrischen Bestimmung der Konzentration der weissen Blutzellen in einer biologischen Flüssigkeit

Info

Publication number
DE69523116D1
DE69523116D1 DE69523116T DE69523116T DE69523116D1 DE 69523116 D1 DE69523116 D1 DE 69523116D1 DE 69523116 T DE69523116 T DE 69523116T DE 69523116 T DE69523116 T DE 69523116T DE 69523116 D1 DE69523116 D1 DE 69523116D1
Authority
DE
Germany
Prior art keywords
concentration
blood cells
improved method
white blood
biological fluid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69523116T
Other languages
English (en)
Other versions
DE69523116T2 (de
Inventor
James Noffsinger
Michael J Pugia
Melvin D Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Inc
Original Assignee
Bayer AG
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG, Bayer Corp filed Critical Bayer AG
Publication of DE69523116D1 publication Critical patent/DE69523116D1/de
Application granted granted Critical
Publication of DE69523116T2 publication Critical patent/DE69523116T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2334/00—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases
    • C12Q2334/70—O-linked chromogens for determinations of hydrolase enzymes, e.g. glycosidases, phosphatases, esterases the product, e.g. phenol, naphthol being diazotised in situ, e.g. with Fast Red
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/966—Elastase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/963—Methods of stopping an enzyme reaction or stabilizing the test materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/97—Test strip or test slide

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Ecology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69523116T 1994-11-15 1995-11-02 Verbessertes Verfahren zur kolorimetrischen Bestimmung der Konzentration der weissen Blutzellen in einer biologischen Flüssigkeit Expired - Lifetime DE69523116T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33979794A 1994-11-15 1994-11-15

Publications (2)

Publication Number Publication Date
DE69523116D1 true DE69523116D1 (de) 2001-11-15
DE69523116T2 DE69523116T2 (de) 2002-01-31

Family

ID=23330640

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69523116T Expired - Lifetime DE69523116T2 (de) 1994-11-15 1995-11-02 Verbessertes Verfahren zur kolorimetrischen Bestimmung der Konzentration der weissen Blutzellen in einer biologischen Flüssigkeit

Country Status (6)

Country Link
US (1) US5663044A (de)
EP (1) EP0713093B1 (de)
JP (2) JP3784869B2 (de)
AU (1) AU679870B2 (de)
CA (1) CA2161574A1 (de)
DE (1) DE69523116T2 (de)

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US5846754A (en) * 1996-05-28 1998-12-08 Bayer Corporation Enzyme determination with protease inactivation
WO2000028070A2 (en) 1998-11-11 2000-05-18 Wheeler Ronald E Detection of prostatitis
US6348324B1 (en) 1999-01-21 2002-02-19 Hypoguard America Limited Composition and device for detecting leukocytes in urine
US6528652B1 (en) 1999-01-21 2003-03-04 Chronimed Composition and device for detecting leukocytes in urine
US6709868B2 (en) 2002-05-20 2004-03-23 Portascience Inc. Method and apparatus for measuring white blood cell count
US7041469B2 (en) * 2002-10-10 2006-05-09 Quidel Corporation Assays for trichomonal and other hydrolases
ZA200507485B (en) * 2003-03-17 2007-03-28 Unilever Plc Compositions useful to prevent in-grown hair arising from shaving
US7404949B2 (en) 2004-03-15 2008-07-29 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Methods and compositions useful to prevent in-grown hair arising from shaving
US8003399B2 (en) * 2005-08-31 2011-08-23 Kimberly-Clark Worldwide, Inc. Nitrite detection technique
US7504235B2 (en) * 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
US7727206B2 (en) * 2005-12-27 2010-06-01 Gorres Geoffrey H Device for monitoring a patient for a urinary tract infection
US8044257B2 (en) 2006-10-30 2011-10-25 Kimberly-Clark Worldwide, Inc. Absorbent article containing lateral flow assay device
US7935538B2 (en) 2006-12-15 2011-05-03 Kimberly-Clark Worldwide, Inc. Indicator immobilization on assay devices
US8043272B2 (en) * 2007-04-30 2011-10-25 Kimberly-Clark Worldwide, Inc. Collection and testing of infant urine using an absorbent article
US20080269707A1 (en) 2007-04-30 2008-10-30 Kimberly-Clark Worldwide, Inc. Lateral Flow Device for Attachment to an Absorbent Article
US8180421B2 (en) * 2007-12-12 2012-05-15 Kimberly-Clark Worldwide, Inc. Resonance energy transfer based detection of nosocomial infection
US9103796B2 (en) 2007-12-14 2015-08-11 Kimberly-Clark Worldwide, Inc. Multi-layered devices for analyte detection
CA2751161C (en) 2008-12-30 2018-10-02 Children's Medical Center Corporation Method of predicting acute appendicitis
ES2573804T3 (es) 2009-01-26 2016-06-10 Siemens Healthcare Diagnostics Inc. Método de detección de tiras reactivas para análisis de orina comprometidas por la humedad ambiental
US20150369747A1 (en) 2011-07-15 2015-12-24 Siemens Healthcare Diagnostics Inc. Device and method for detection of humidity-compromised urine test strips
US20190064165A1 (en) * 2016-03-22 2019-02-28 Parvizi Surgical Innovation, Llc Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay
US11104933B1 (en) 2016-03-22 2021-08-31 Cleu Diagnostics, Llc Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay
EP3432873A4 (de) * 2016-03-22 2020-01-08 Parvizi Surgical Innovation, LLC Zusammensetzungen und verfahren zur bestimmung des vorhandenseins von aktiven leukozytenzellen unter verwendung eines elektrochemischen tests
JP6965008B2 (ja) * 2016-03-30 2021-11-10 栄研化学株式会社 エステラーゼ及び／又はプロテアーゼ検出用試験片
JP6635345B2 (ja) * 2017-02-14 2020-01-22 学校法人慶應義塾 尿中のバイオマーカーを検出するための方法及び該方法に用いるためのキット
CN112111557A (zh) * 2020-09-22 2020-12-22 成都恩普瑞生物工程有限公司 一种不含表面活性剂的尿液分析质控液
WO2023126802A1 (en) 2022-01-03 2023-07-06 Sequana Medical Nv Implantable pump having infection monitoring feature

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GB1128371A (en) 1965-10-04 1968-09-25 Miles Lab Diagnostic composition
US3552928A (en) 1967-07-19 1971-01-05 Miles Lab Whole blood separation means and test system using same
US3846247A (en) 1972-09-27 1974-11-05 Warner Lambert Co Moisture barrier
DE2854987A1 (de) 1978-12-20 1980-06-26 Boehringer Mannheim Gmbh Diagnostische mittel zum nachweis proteolytischer enzyme und dafuer geeignete chromogene
DE2905531A1 (de) 1979-02-14 1981-01-08 Boehringer Mannheim Gmbh Diagnostisches mittel zum nachweis von leukozyten in koerperfluessigkeiten
DE3017721A1 (de) 1980-05-09 1981-11-26 Boehringer Mannheim Gmbh, 6800 Mannheim Mittel zum nachweis esterolytischer und/oder proteolytischer enzyme und dafuer geeignete substrate
EP0103628A4 (de) * 1982-03-11 1984-09-19 Arthur Babson Stabilisierung von diazoniumsalzelösungen.
US4554236A (en) * 1982-03-18 1985-11-19 American Hoechst Corporation Amino acid stabilizers for water soluble diazonium compound condensation products
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DE3413078A1 (de) 1984-04-06 1985-10-24 Miles Laboratories, Inc., Elkhart, Ind. Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
US4657855A (en) * 1984-04-06 1987-04-14 Miles Laboratories, Inc. Composition and test device for determining the presence of leukocytes, esterase and protease in a test sample
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Also Published As

Publication number Publication date
US5663044A (en) 1997-09-02
JP3784869B2 (ja) 2006-06-14
EP0713093A3 (de) 1996-10-02
EP0713093A2 (de) 1996-05-22
JP2006113076A (ja) 2006-04-27
CA2161574A1 (en) 1996-05-16
EP0713093B1 (de) 2001-10-10
JP3814630B2 (ja) 2006-08-30
JPH08220090A (ja) 1996-08-30
AU679870B2 (en) 1997-07-10
DE69523116T2 (de) 2002-01-31
AU3776095A (en) 1996-06-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS INC. (N.D.GES.D, US

8328 Change in the person/name/address of the agent

Representative=s name: MAIER, D., DIPL.-ING. UNIV., PAT.-ASS., 81739 MUEN