DE69510925D1 - Isolierung von zellmaterial mittels mikroskopischer darstellung - Google Patents
Isolierung von zellmaterial mittels mikroskopischer darstellungInfo
- Publication number
- DE69510925D1 DE69510925D1 DE69510925T DE69510925T DE69510925D1 DE 69510925 D1 DE69510925 D1 DE 69510925D1 DE 69510925 T DE69510925 T DE 69510925T DE 69510925 T DE69510925 T DE 69510925T DE 69510925 D1 DE69510925 D1 DE 69510925D1
- Authority
- DE
- Germany
- Prior art keywords
- cells
- zone
- tissue sample
- interest
- insulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000009413 insulation Methods 0.000 title 1
- 238000000034 method Methods 0.000 abstract 2
- 230000001413 cellular effect Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/32—Micromanipulators structurally combined with microscopes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/286—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q involving mechanical work, e.g. chopping, disintegrating, compacting, homogenising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/04—Devices for withdrawing samples in the solid state, e.g. by cutting
- G01N1/08—Devices for withdrawing samples in the solid state, e.g. by cutting involving an extracting tool, e.g. core bit
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2806—Means for preparing replicas of specimens, e.g. for microscopal analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/028—Sampling from a surface, swabbing, vaporising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/2813—Producing thin layers of samples on a substrate, e.g. smearing, spinning-on
- G01N2001/2833—Collecting samples on a sticky, tacky, adhesive surface
- G01N2001/284—Collecting samples on a sticky, tacky, adhesive surface using local activation of adhesive, i.e. Laser Capture Microdissection
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N2035/00178—Special arrangements of analysers
- G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/808—Optical sensing apparatus
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/203,780 US5843644A (en) | 1994-03-01 | 1994-03-01 | Isolation of cellular material under microscopic visualization using an adhesive/extraction reagent tipped probe |
PCT/US1995/002432 WO1995023960A1 (en) | 1994-03-01 | 1995-03-01 | Isolation of cellular material under microscopic visualization |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69510925D1 true DE69510925D1 (de) | 1999-08-26 |
DE69510925T2 DE69510925T2 (de) | 2000-02-17 |
Family
ID=22755276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69510925T Expired - Fee Related DE69510925T2 (de) | 1994-03-01 | 1995-03-01 | Isolierung von zellmaterial mittels mikroskopischer darstellung |
Country Status (11)
Country | Link |
---|---|
US (1) | US5843644A (de) |
EP (1) | EP0748439B1 (de) |
JP (1) | JP3732510B2 (de) |
KR (1) | KR100388941B1 (de) |
CN (1) | CN1143413A (de) |
AT (1) | ATE182405T1 (de) |
AU (1) | AU691263B2 (de) |
DE (1) | DE69510925T2 (de) |
ES (1) | ES2138727T3 (de) |
MX (1) | MXPA96003822A (de) |
WO (1) | WO1995023960A1 (de) |
Families Citing this family (72)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5843657A (en) * | 1994-03-01 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation of cellular material under microscopic visualization |
US6251467B1 (en) * | 1994-03-01 | 2001-06-26 | The United States Of America As Represented By The Department Of Health And Human Services | Isolation of cellular material under microscopic visualization |
CA2198774A1 (en) * | 1994-09-23 | 1996-03-28 | Sydney D. Finkelstein | Topographic genotyping |
US6040139A (en) * | 1995-09-19 | 2000-03-21 | Bova; G. Steven | Laser cell purification system |
WO1997029354A1 (de) * | 1996-02-05 | 1997-08-14 | Bayer Aktiengesellschaft | Verfahren und vorrichtung zum sortieren und zur gewinnung von planar ausgebrachten biologischen objekten wie biologische zellen bzw. zellorganellen, histologischen schnitten, chromosomenteilchen etc. mit laserstrahlen |
US5859699A (en) * | 1997-02-07 | 1999-01-12 | Arcturus Engineering, Inc. | Laser capture microdissection analysis vessel |
US6469779B2 (en) | 1997-02-07 | 2002-10-22 | Arcturus Engineering, Inc. | Laser capture microdissection method and apparatus |
US6495195B2 (en) | 1997-02-14 | 2002-12-17 | Arcturus Engineering, Inc. | Broadband absorbing film for laser capture microdissection |
US6100051A (en) * | 1997-06-27 | 2000-08-08 | The United States Of America As Represented By The Department Of Health And Human Services | Method utilizing convex geometry for laser capture microdissection |
US7075640B2 (en) * | 1997-10-01 | 2006-07-11 | Arcturus Bioscience, Inc. | Consumable for laser capture microdissection |
US5985085A (en) * | 1997-10-01 | 1999-11-16 | Arcturus Engineering, Inc. | Method of manufacturing consumable for laser capture microdissection |
SE9704186D0 (sv) * | 1997-11-14 | 1997-11-14 | Astra Ab | New composition of matter |
US6358749B1 (en) | 1997-12-02 | 2002-03-19 | Ozo Diversified Automation, Inc. | Automated system for chromosome microdissection and method of using same |
US6720191B1 (en) | 1998-02-03 | 2004-04-13 | The United States Of America As Represented By The Department Of Health And Human Services | Mechanical handling systems for laser capture microdissection |
DE19815400C2 (de) | 1998-04-06 | 2002-02-07 | Max Planck Gesellschaft | Vorrichtung zur Probenaufnahme aus polymeren Trägermaterialien |
DE69920718T2 (de) * | 1998-07-30 | 2005-10-20 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Präzisions-laseranheftungs-mikrodissektion mittels kurzer impulsdauer |
JP3582390B2 (ja) * | 1999-01-13 | 2004-10-27 | 松下電器産業株式会社 | 微細物体の自動探索装置 |
US6969614B1 (en) * | 1999-02-16 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for the isolation and analysis of cellular protein content |
EP1210577A2 (de) | 1999-04-29 | 2002-06-05 | Arcturus Engineering, Inc. | Verwendung von laminierungstechnik bei der vorbereitung von proben zur laseranheftungs-mikrodissektion |
US6690470B1 (en) | 1999-11-04 | 2004-02-10 | Arcturus Engineering, Inc. | Automated laser capture microdissection |
US6929907B2 (en) | 1999-12-31 | 2005-08-16 | North Carolina State University | Methods and compositions for determining the purity of chemically synthesized nucleic acids |
AU2001238462A1 (en) * | 2000-02-16 | 2001-08-27 | Arcturus Engineering, Inc. | Transfer film for laser microcapture |
DE10015157A1 (de) | 2000-03-27 | 2001-10-18 | P A L M Gmbh | Verfahren zur Bearbeitung einer biologischen Masse und Steuersystem für eine Vorrichtung zur Bearbeitung einer biologischen Masse |
WO2001079810A1 (fr) * | 2000-04-13 | 2001-10-25 | Seiko Instruments Inc. | Appareil a faisceaux d'ions focalises et procede de detachement d'un morceau d'echantillon |
DE10018251C2 (de) * | 2000-04-13 | 2003-08-14 | Leica Microsystems | Laserschneid-Vorrichtung mit Mikroskop |
EP1279020B1 (de) * | 2000-04-26 | 2016-03-16 | Life Technologies Corporation | Vorrichtung und verfahren zur extraktion und flüssiger behandlung von proben nach einer laseranheftungs-mikrodissektion (lcm) |
US6699721B1 (en) * | 2000-05-09 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Surface coatings for hot-melt adhesive film |
DE10102134A1 (de) * | 2001-01-18 | 2002-08-01 | Christoph Viebahn | Glasschneidegerät für Objektträger |
US20030228639A1 (en) * | 2001-03-19 | 2003-12-11 | Wright George L | Prostate cancer markers |
DE10119461C2 (de) * | 2001-04-17 | 2003-06-12 | Ufz Leipzighalle Gmbh | Verfahren und Vorrichtung zum Heraustrennen von Analysematerial aus einem Holzbohrkern |
US20020182647A1 (en) * | 2001-04-30 | 2002-12-05 | Emmert-Buck Michael R. | Histoscreen method |
US7229595B2 (en) * | 2001-06-15 | 2007-06-12 | Molecular Devices Corporation | Filtration column devices and methods of filtering therewith |
US7749388B2 (en) * | 2001-06-15 | 2010-07-06 | Life Technologies Corporation | Low volume filtration column devices and methods of filtering therewith |
US7556733B2 (en) * | 2001-06-15 | 2009-07-07 | Mds Analytical Technologies (Us) Inc. | Low volume filtration column devices and methods of filtering therewith |
US20040038240A1 (en) * | 2001-07-13 | 2004-02-26 | Akhouri Sinha | Method and materials for assessing cancer aggressiveness |
DE10152404C5 (de) * | 2001-10-24 | 2017-06-08 | Carl Zeiss Microscopy Gmbh | Laser-Mikrodissektionssystem |
US8722357B2 (en) | 2001-11-05 | 2014-05-13 | Life Technologies Corporation | Automated microdissection instrument |
US10156501B2 (en) | 2001-11-05 | 2018-12-18 | Life Technologies Corporation | Automated microdissection instrument for determining a location of a laser beam projection on a worksurface area |
WO2003072710A2 (en) * | 2002-02-21 | 2003-09-04 | Eastern Virginia Medical School | Protein biomarkers that distinguish prostate cancer from non-malignant cells |
DE10217858C1 (de) * | 2002-04-22 | 2003-10-02 | Fraunhofer Ges Forschung | Verfahren zur Trennung einer in einer Probe enthaltenen Zellgruppe in Einzelzellen |
AU2003270687B2 (en) | 2002-09-13 | 2008-05-08 | Life Technologies Corporation | Interactive and automated tissue image analysis with global training database and variable-abstraction processing in cytological specimen classification and laser capture microdissection applications |
AT412239B (de) * | 2002-10-31 | 2004-11-25 | Oridis Biomed Forschungs Und E | Verfahren und vorrichtung zur manipulation mit proben |
AU2003256803B2 (en) * | 2003-01-24 | 2009-09-17 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target activated microtransfer |
US7695752B2 (en) * | 2003-01-24 | 2010-04-13 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target activated microtransfer |
EP1676116B8 (de) * | 2003-10-21 | 2012-07-04 | Leica Microsystems CMS GmbH | Verfahren zur automatischen erzeugung von laser-schnittlinien in der laser-mikrodissektion |
DE102004051508B4 (de) * | 2003-10-21 | 2006-09-21 | Leica Microsystems Cms Gmbh | Verfahren zur automatischen Erzeugung von Laser-Schnittlinien in der Laser-Mikrodissektion |
US7132242B2 (en) * | 2003-11-10 | 2006-11-07 | Hewlett-Packard Development Company, L.P. | Method and device for targeted delivery of materials to selected single cells |
US8012693B2 (en) * | 2003-12-16 | 2011-09-06 | 3M Innovative Properties Company | Analysis of chemically crosslinked cellular samples |
DE102004005100A1 (de) * | 2004-02-02 | 2005-08-25 | Euroimmun Medizinische Labordiagnostika Gmbh | Verfahren zur Herstellung Festphasen-gebundener Bioreagenzien |
DE102004022484B4 (de) | 2004-05-07 | 2007-12-20 | P.A.L.M. Microlaser Technologies Ag | Mikroskoptisch |
DE102004023262B8 (de) | 2004-05-11 | 2013-01-17 | Carl Zeiss Microimaging Gmbh | Verfahren zur Bearbeitung einer Masse mittels Laserbestrahlung und Steuersystem |
EP1787101B1 (de) | 2004-09-09 | 2014-11-12 | Life Technologies Corporation | Vorrichtung und verfahren zur lasermikrodissektion |
WO2006047483A2 (en) * | 2004-10-22 | 2006-05-04 | Redpath Integrated Pathology, Inc. | Dynamic genomic deletion expansion and formulation of molecular marker panels for integrated molecular pathology diagnosis and characterization of tissue, cellular fluid, and pure fluid specimens |
AU2006261624B2 (en) * | 2005-06-16 | 2012-02-02 | Solventum Intellectual Properties Company | Method of classifying chemically crosslinked cellular samples using mass spectra |
DE102005061561A1 (de) * | 2005-12-22 | 2007-06-28 | P.A.L.M. Microlaser Technologies Ag | Laser-Mikrodissektionsverfahren, Steuersystem für eine Laser-Mikrodissektionsvorrichtung und Trägervorrichtung |
CN100528100C (zh) * | 2006-12-29 | 2009-08-19 | 山东省寄生虫病防治研究所 | 中国昆虫形态鉴别仪 |
US8818018B2 (en) | 2009-01-24 | 2014-08-26 | Hewlett-Packard Development Company, L.P. | System and method for enhancing security printing |
US8774488B2 (en) | 2010-03-11 | 2014-07-08 | Cellscape Corporation | Method and device for identification of nucleated red blood cells from a maternal blood sample |
CN103443609B (zh) | 2011-01-24 | 2016-01-20 | N·B·阿迪 | 用于从材料样品中提取材料的装置、系统和方法 |
US8934698B2 (en) * | 2011-06-22 | 2015-01-13 | The Johns Hopkins University | System and device for characterizing cells |
US20130130265A1 (en) * | 2011-11-17 | 2013-05-23 | Bhairavi Parikh | Methods and devices for obtaining and analyzing cells |
US9341628B2 (en) | 2012-11-30 | 2016-05-17 | Interpace Diagnostics Corporation | Methods for measuring carcinoembryonic antigen |
US9429560B2 (en) * | 2013-09-06 | 2016-08-30 | IonOptix LLC | Cell grabber with unitary construction |
WO2015199976A1 (en) | 2014-06-24 | 2015-12-30 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Target activated microdissection |
US11091810B2 (en) * | 2015-01-27 | 2021-08-17 | BioSpyder Technologies, Inc. | Focal gene expression profiling of stained FFPE tissues with spatial correlation to morphology |
US9625355B2 (en) | 2014-12-01 | 2017-04-18 | General Electric Company | Extraction of materials from regions of interest in a sample |
EP3250901A1 (de) | 2015-01-31 | 2017-12-06 | Roche Diagnostics GmbH | Systeme und verfahren zur meso-dissektion |
CN115493907A (zh) * | 2015-01-31 | 2022-12-20 | 豪夫迈·罗氏有限公司 | 用于中间解剖的系统和方法 |
CN108449995B (zh) | 2015-11-06 | 2022-02-01 | 文塔纳医疗系统公司 | 代表性诊断 |
EP3538863B1 (de) | 2016-11-09 | 2022-12-21 | F. Hoffmann-La Roche AG | Automatisiertes gewebedissektionsinstrument und verfahren zur verwendung davon |
CN111089775B (zh) * | 2019-12-04 | 2020-12-29 | 南京航空航天大学 | 一种陶瓷基小复合材料垂直冷镶嵌装置及镶嵌方法 |
WO2022201416A1 (ja) * | 2021-03-25 | 2022-09-29 | 日本電気株式会社 | 検査支援装置、検査支援方法、および記録媒体 |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1074885B (de) * | 1960-02-04 | Gewerkschaft Brigitta Hannover | Vorrichtung zum Auslesen von Mikrofossilien aus Sedimenten oder fein zer trummertem Gestein | |
US2659981A (en) * | 1951-08-13 | 1953-11-24 | Jefferson R Beckham | Scribing gauge |
US3989591A (en) * | 1973-01-15 | 1976-11-02 | Liotta Lance A | Test method for separating and/or isolating bacteria and tissue cells |
SE371885B (de) * | 1973-08-28 | 1974-12-02 | Lkb Produkter Ab | |
DE2644281C2 (de) * | 1976-09-30 | 1979-02-01 | Battelle-Institut E.V., 6000 Frankfurt | Verfahren und Vorrichtung zur Entnahme und Gewinnung von Probenmaterial, insbesondere für wissenschaftliche oder diagnostische Untersuchungen |
US4485706A (en) * | 1980-10-27 | 1984-12-04 | Disharoon Dale R | Methods and apparatus for cutting a substrate |
US4366245A (en) * | 1980-12-03 | 1982-12-28 | Maurice Lalonde | Method for the isolation of symbiotic microorganisms from host plants using an osmium tetraoxide fixative |
US4500509A (en) * | 1981-03-11 | 1985-02-19 | Lawrence Kass | Metachromatic dye sorption and fluorescent light emmisive means for differential determination of developmental stages of neutrophilic granulocytic cells and other leukocytes |
US4629687A (en) * | 1982-07-29 | 1986-12-16 | Board Of Trustees Of Michigan State University | Positive selection sorting of cells |
US4624915A (en) * | 1982-07-29 | 1986-11-25 | Board Of Trustees Of Michigan State University | Positive selection sorting of cells |
US4545831A (en) * | 1982-09-13 | 1985-10-08 | The Mount Sinai School Of Medicine | Method for transferring a thin tissue section |
US4635791A (en) * | 1983-01-31 | 1987-01-13 | Bio-Innovations | Container package for staining biological specimens |
DE3376359D1 (en) * | 1983-02-25 | 1988-05-26 | Stocker Winfried | Processes and devices for examinations on immobilised biological material |
US4619899A (en) * | 1983-06-30 | 1986-10-28 | Institut Biokhimii I Fiziologii Mikroorganizmov Akademii Nauk Ssr | Method and device for performing microoperations on cells |
US4628026A (en) * | 1983-11-15 | 1986-12-09 | Dietlind Gardell | Method and apparatus for automated double fluorochromization analysis in lymphocytotoxicity testing |
US4649109A (en) * | 1984-02-16 | 1987-03-10 | Brandeis University | Methods for isolating mutant microorganisms from parental populations |
US4665021A (en) * | 1984-09-21 | 1987-05-12 | Schnaper H William | Diagnostic method of screening for immune deficiency in a nephrotic patient by determination of SIRS in the urine |
US4767717A (en) * | 1985-05-02 | 1988-08-30 | Baisden C Robert | Method of detecting and quantitating cell malignancy in biological tissue |
JPS6285840A (ja) * | 1985-10-11 | 1987-04-20 | Kureha Chem Ind Co Ltd | 走査型電子顕微鏡を用いた試料処理方法および装置 |
US4741043B1 (en) * | 1985-11-04 | 1994-08-09 | Cell Analysis Systems Inc | Method of and apparatus for image analyses of biological specimens |
US5281517A (en) * | 1985-11-04 | 1994-01-25 | Cell Analysis Systems, Inc. | Methods for immunoploidy analysis |
US5023172A (en) * | 1986-07-14 | 1991-06-11 | The Research Foundation Of State University Of New York | Predictive assay for tumor control |
DE3718066A1 (de) * | 1987-05-29 | 1988-12-08 | Zeiss Carl Fa | Verfahren zur mikroinjektion in zellen bzw. zum absaugen aus einzelnen zellen oder ganzer zellen aus zellkulturen |
US5188963A (en) * | 1989-11-17 | 1993-02-23 | Gene Tec Corporation | Device for processing biological specimens for analysis of nucleic acids |
US4960224A (en) * | 1989-03-24 | 1990-10-02 | Thomas Boenisch | Closure and container for regent and slides |
US5252487A (en) * | 1989-05-19 | 1993-10-12 | Cell Analysis Systems, Inc. | Method and apparatus for determining the amount of oncogene protein product in a cell sample |
GB8915759D0 (en) * | 1989-07-10 | 1989-08-31 | Shandon Scient Ltd | Cell block preparation |
US5264341A (en) * | 1989-08-30 | 1993-11-23 | Eli Lilly And Company | Selective cloning for high monoclonal antibody secreting hybridomas |
JPH0648975B2 (ja) * | 1989-10-02 | 1994-06-29 | 俊郎 樋口 | 微小インジェクション装置及びそのインジェクション制御方法 |
FR2659981B1 (fr) * | 1990-03-22 | 1992-07-24 | Vef Sa | Procede et dispositif d'analyse bacteriologique. |
US5235522A (en) * | 1990-10-10 | 1993-08-10 | Cell Analysis Systems, Inc. | Method and apparatus for automated analysis of biological specimens |
US5218645A (en) * | 1991-03-29 | 1993-06-08 | Cell Analysis Systems, Inc. | Method and apparatus for separating cell objects for analysis |
US5428690A (en) * | 1991-09-23 | 1995-06-27 | Becton Dickinson And Company | Method and apparatus for automated assay of biological specimens |
JP3067347B2 (ja) * | 1991-10-30 | 2000-07-17 | 株式会社島津製作所 | ゲル状ビーズの選別装置 |
-
1994
- 1994-03-01 US US08/203,780 patent/US5843644A/en not_active Expired - Fee Related
-
1995
- 1995-03-01 DE DE69510925T patent/DE69510925T2/de not_active Expired - Fee Related
- 1995-03-01 ES ES95911965T patent/ES2138727T3/es not_active Expired - Lifetime
- 1995-03-01 KR KR1019960704792A patent/KR100388941B1/ko not_active IP Right Cessation
- 1995-03-01 EP EP95911965A patent/EP0748439B1/de not_active Expired - Lifetime
- 1995-03-01 JP JP52296395A patent/JP3732510B2/ja not_active Expired - Fee Related
- 1995-03-01 AU AU19337/95A patent/AU691263B2/en not_active Ceased
- 1995-03-01 CN CN95191912A patent/CN1143413A/zh active Pending
- 1995-03-01 MX MXPA96003822A patent/MXPA96003822A/es unknown
- 1995-03-01 WO PCT/US1995/002432 patent/WO1995023960A1/en active IP Right Grant
- 1995-03-01 AT AT95911965T patent/ATE182405T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
KR100388941B1 (ko) | 2003-10-08 |
DE69510925T2 (de) | 2000-02-17 |
CN1143413A (zh) | 1997-02-19 |
AU1933795A (en) | 1995-09-18 |
AU691263B2 (en) | 1998-05-14 |
JPH10500205A (ja) | 1998-01-06 |
ATE182405T1 (de) | 1999-08-15 |
EP0748439B1 (de) | 1999-07-21 |
US5843644A (en) | 1998-12-01 |
ES2138727T3 (es) | 2000-01-16 |
JP3732510B2 (ja) | 2006-01-05 |
MXPA96003822A (es) | 2004-08-17 |
EP0748439A1 (de) | 1996-12-18 |
WO1995023960A1 (en) | 1995-09-08 |
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