DE69509377T2 - Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten - Google Patents

Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten

Info

Publication number
DE69509377T2
DE69509377T2 DE69509377T DE69509377T DE69509377T2 DE 69509377 T2 DE69509377 T2 DE 69509377T2 DE 69509377 T DE69509377 T DE 69509377T DE 69509377 T DE69509377 T DE 69509377T DE 69509377 T2 DE69509377 T2 DE 69509377T2
Authority
DE
Germany
Prior art keywords
anthracycline derivatives
anticancer
formula
trifluormethylated
daunomycin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69509377T
Other languages
English (en)
Other versions
DE69509377D1 (de
Inventor
Tomio New Fuji Mansio Takeuchi
Sumio Umezawa
Tsutomu Tsuchiya
Yasushi Takagi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Application granted granted Critical
Publication of DE69509377D1 publication Critical patent/DE69509377D1/de
Publication of DE69509377T2 publication Critical patent/DE69509377T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C31/00—Saturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C31/34—Halogenated alcohols
    • C07C31/42—Polyhydroxylic acyclic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/178—Unsaturated ethers containing hydroxy or O-metal groups
    • C07C43/1786—Unsaturated ethers containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69509377T 1994-03-11 1995-03-10 Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten Expired - Fee Related DE69509377T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6771494 1994-03-11

Publications (2)

Publication Number Publication Date
DE69509377D1 DE69509377D1 (de) 1999-06-02
DE69509377T2 true DE69509377T2 (de) 1999-11-18

Family

ID=13352911

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69509377T Expired - Fee Related DE69509377T2 (de) 1994-03-11 1995-03-10 Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten

Country Status (7)

Country Link
US (2) US5719130A (de)
EP (1) EP0749976B1 (de)
AT (1) ATE179426T1 (de)
CA (1) CA2185247A1 (de)
DE (1) DE69509377T2 (de)
ES (1) ES2131819T3 (de)
WO (1) WO1995024412A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0912590A (ja) * 1995-06-23 1997-01-14 Microbial Chem Res Found ４−アミノ−２，４，６−トリデオキシ−２−フルオロ−マンノピラノシル基を有する新規アンスラサイクリン誘導体
JPH10175992A (ja) * 1996-12-16 1998-06-30 Microbial Chem Res Found ４−アミノ−２，４，６−トリデオキシ−２−フルオロ−α−Ｌ−タロピラノシル基を有する新規アンスラサイクリン誘導体
US6197809B1 (en) 1998-12-23 2001-03-06 Ardenia Investments Ltd. Compounds for the treatment of cancer
US20040254099A1 (en) * 1999-04-21 2004-12-16 Adherex Technologies, Inc. Compounds and methods for modulating beta-catenin mediated gene expression
US6303576B1 (en) * 1999-04-21 2001-10-16 Adherex Technologies Inc. Compounds and methods for modulating β-catenin mediated gene expression
US20040038904A1 (en) * 2002-05-21 2004-02-26 Angela Ogden Method of treating multiple sclerosis
CA2867381C (en) 2012-03-16 2016-09-20 The Johns Hopkins University Controlled release formulations for the delivery of hif-1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0631298B2 (ja) * 1985-12-18 1994-04-27 財団法人微生物化学研究会 新規アンスラサイクリン誘導体，抗腫瘍剤，及び製造法
JPH0742304B2 (ja) * 1986-12-05 1995-05-10 財団法人微生物化学研究会 新規なアンスラサイクリン誘導体およびその製造法
JPH06797B2 (ja) * 1987-01-30 1994-01-05 財団法人相模中央化学研究所 １４−フルオロダウノルビシン誘導体
KR100211417B1 (ko) * 1990-11-30 1999-10-01 유충식 L-탈로피라노시드 유도체 및 그의 제조방법

Also Published As

Publication number Publication date
ATE179426T1 (de) 1999-05-15
DE69509377D1 (de) 1999-06-02
WO1995024412A1 (fr) 1995-09-14
EP0749976B1 (de) 1999-04-28
CA2185247A1 (en) 1995-09-14
US5801257A (en) 1998-09-01
EP0749976A4 (de) 1997-03-19
EP0749976A1 (de) 1996-12-27
US5719130A (en) 1998-02-17
ES2131819T3 (es) 1999-08-01

Similar Documents

Publication Publication Date Title
BE904431A (fr) Nouveaux derives morpholino de la daunorubicine et de la doxorubicine.
CA2332054A1 (en) Platinum complex, its preparation and therapeutic application
MY103365A (en) 4-demethoxy-4-amino-anthracyclines
IL89199A0 (en) 3'-deamino-4'-deoxy-4'-amino anthracyclines,their preparation and pharmaceutical compositions containing them
DE69509377D1 (de) Anthracyclin-derivate, die ein trifluormethylierte zuckereinheiten enthalten
CA1136618A (en) Antitumor anthracycline derivatives
UA27108A1 (uk) Аhтрацикліhові глікозиди та їх фармацевтичhо прийhятhі кислотhо-адитивhі солі, спосіб їх одержаhhя, похідhі 1,6-дийод-3-оксапеhтаhу та спосіб їх одержаhhя
EP0287353A3 (de) Chirale Synthese von Anthracyclinen von substituierten Anthrachinonen
KR960705577A (ko) 안트라사이클린 유도체(Anthracycline derivatives)
HUT46936A (en) Process for producing cyclooktaamilose
US4303785A (en) Antitumor anthracycline antibiotics
ES8302733A1 (es) Un procedimiento para preparar nuevos derivados de antraci- clina
MY102186A (en) Antitumor anthracycline glycosides, their preparation intermediate thereof, and compositions and use thereof
NZ232305A (en) Daunorubicin and doxorubicin derivatives; compositions for treating tumours
DE3064485D1 (en) Anthracycline glycosides, process for their preparation and therapeutical composition containing them
AU626503B2 (en) Rhodomycins with a modified carbohydrate unit
IE873301L (en) Anthracycline glycosides
ATE71105T1 (de) 4-substituierte anthracyclinone und anthracyclinonglycoside und ihre herstellung.
US4562177A (en) 3'-Amino-2' halo-anthracycline antibiotics
SE8702409L (sv) Nya antracykliner
Messana et al. Constituents of brosimopsis oblongifolia. 3: Structure of a new diels-alder type adduct, brosimone a
US5510469A (en) 2-acyloxy-4-morpholinyl anthracyclines
DE3374013D1 (en) Novel anthracycline derivatives, a process for preparing the same by a microorganism strain, the novel strain streptomyces cyaneus, and use of the anthracycline derivatives as medicaments
MX9706283A (es) Nuevos antibioticos de polieno, 3874 hi a h6, procedimientos para su preparacion y empleo.
FI113541B (fi) Menetelmä antrasykliinidisakkaridien valmistamiseksi

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee