DE69505365D1 - Immunologisches verfahren zum nachweis von glykosaminoglykan-aktiviertem antithrombin iii; die entsprechenden monoklonalen antikörper und deren herstellung - Google Patents

Immunologisches verfahren zum nachweis von glykosaminoglykan-aktiviertem antithrombin iii; die entsprechenden monoklonalen antikörper und deren herstellung

Info

Publication number
DE69505365D1
DE69505365D1 DE69505365T DE69505365T DE69505365D1 DE 69505365 D1 DE69505365 D1 DE 69505365D1 DE 69505365 T DE69505365 T DE 69505365T DE 69505365 T DE69505365 T DE 69505365T DE 69505365 D1 DE69505365 D1 DE 69505365D1
Authority
DE
Germany
Prior art keywords
iii
agent
activated
pct
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69505365T
Other languages
English (en)
Other versions
DE69505365T2 (de
Inventor
Jean-Claude Lormeau
Blandine Mille
Francis Paolucci
Bernard Pau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Innovations SAS
Original Assignee
Pasteur Sanofi Diagnostics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Sanofi Diagnostics SA filed Critical Pasteur Sanofi Diagnostics SA
Publication of DE69505365D1 publication Critical patent/DE69505365D1/de
Application granted granted Critical
Publication of DE69505365T2 publication Critical patent/DE69505365T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69505365T 1994-04-14 1995-04-10 Immunologisches verfahren zum nachweis von glykosaminoglykan-aktiviertem antithrombin iii; die entsprechenden monoklonalen antikörper und deren herstellung Expired - Fee Related DE69505365T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404469A FR2718849B1 (fr) 1994-04-14 1994-04-14 Procédé d'immunodosage de l'antithrombine III activée par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procédé d'obtention.
PCT/FR1995/000456 WO1995028644A1 (fr) 1994-04-14 1995-04-10 Procede d'immunodosage de l'antithrombine iii activee par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procede d'obtention

Publications (2)

Publication Number Publication Date
DE69505365D1 true DE69505365D1 (de) 1998-11-19
DE69505365T2 DE69505365T2 (de) 1999-05-06

Family

ID=9462114

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69505365T Expired - Fee Related DE69505365T2 (de) 1994-04-14 1995-04-10 Immunologisches verfahren zum nachweis von glykosaminoglykan-aktiviertem antithrombin iii; die entsprechenden monoklonalen antikörper und deren herstellung

Country Status (9)

Country Link
US (1) US5891647A (de)
EP (1) EP0755518B1 (de)
AT (1) ATE172305T1 (de)
AU (1) AU2311595A (de)
CA (1) CA2187670A1 (de)
DE (1) DE69505365T2 (de)
ES (1) ES2125011T3 (de)
FR (1) FR2718849B1 (de)
WO (1) WO1995028644A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
PL363047A1 (en) * 2000-09-08 2004-11-15 Hamilton Civic Hospitals Research Development Inc. Antithrombotic compositions
DE10239821A1 (de) * 2002-08-29 2004-03-11 Roche Diagnostics Gmbh Verbesserung der Spezifität bei der Bestimmung von Antithrombin
US8617820B2 (en) * 2007-08-28 2013-12-31 Ortho-Clinical Diagnostics, Inc. Use of glycosaminoglycans to reduce non-specific binding in immunoassays
EP2452196B1 (de) * 2009-07-08 2017-09-06 Bio-Rad Laboratories, Inc. Reinigung monoklonaler antikörper
RU2015143696A (ru) 2013-03-14 2017-04-19 Байер Хелскеа Ллк МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА ПРОТИВ АНТИТРОМБИНА β

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7602423A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Bepaling van heparine in bloedplasma.
DE2804590A1 (de) 1978-02-03 1979-08-09 Licentia Gmbh Schalteranordnung zur stummschaltung in einem rundfunkempfaenger
FR2564468B1 (fr) * 1984-05-16 1994-12-23 Choay Sa Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques
FR2535306A1 (fr) * 1982-10-28 1984-05-04 Martinez Antoine Procede de synthese organique d'oligosaccharides correspondant a des fragments de muco-polysaccharides naturels, nouveaux oligosaccharides obtenus et leurs applications biologiques
BE896543A (fr) * 1983-04-22 1983-08-16 Wallone Region Ensembles d'anticorps monoclonaux deriges contre les proteines humaines impliquees dans la coagulation et la fibrinolyse du sang
DE3804590A1 (de) * 1987-02-25 1988-09-08 Miles Inc Diagnostische sonden zum nachweis von elastase-modifiziertem antithrombin und verfahren zur behandlung
EP0341927B1 (de) * 1988-05-10 1993-07-14 AMERSHAM INTERNATIONAL plc Biosensoren
FR2645647B1 (fr) * 1989-04-07 1991-07-05 Stago Diagnostica Procede de dosage de complexes antithrombine-proteases
JPH0694713A (ja) * 1991-07-31 1994-04-08 Masashi Funayama アンチトロンビンｉｉｉ活性の測定方法とそれを用いたアンチトロンビンｉｉｉ活性の測定キット

Also Published As

Publication number Publication date
AU2311595A (en) 1995-11-10
EP0755518A1 (de) 1997-01-29
CA2187670A1 (fr) 1995-10-26
FR2718849B1 (fr) 1996-06-14
ES2125011T3 (es) 1999-02-16
ATE172305T1 (de) 1998-10-15
FR2718849A1 (fr) 1995-10-20
DE69505365T2 (de) 1999-05-06
EP0755518B1 (de) 1998-10-14
US5891647A (en) 1999-04-06
WO1995028644A1 (fr) 1995-10-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee