ES2125011T3 - Procedimiento inmunologico de la antitrombina iii activada por un glicosaminoglicano, anticuerpos monoclonales correspondientes y su procedimiento de obtencion. - Google Patents

Procedimiento inmunologico de la antitrombina iii activada por un glicosaminoglicano, anticuerpos monoclonales correspondientes y su procedimiento de obtencion.

Info

Publication number
ES2125011T3
ES2125011T3 ES95916732T ES95916732T ES2125011T3 ES 2125011 T3 ES2125011 T3 ES 2125011T3 ES 95916732 T ES95916732 T ES 95916732T ES 95916732 T ES95916732 T ES 95916732T ES 2125011 T3 ES2125011 T3 ES 2125011T3
Authority
ES
Spain
Prior art keywords
iii
procedure
agent
pct
activated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95916732T
Other languages
English (en)
Inventor
Jean-Claude Lormeau
Blandine Georgette Renee Mille
Francis Egiste Joseph Paolucci
Bernard Pau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bio Rad Innovations SAS
Original Assignee
Pasteur Sanofi Diagnostics SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pasteur Sanofi Diagnostics SA filed Critical Pasteur Sanofi Diagnostics SA
Application granted granted Critical
Publication of ES2125011T3 publication Critical patent/ES2125011T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/38—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against protease inhibitors of peptide structure
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/811—Serine protease (E.C. 3.4.21) inhibitors
    • G01N2333/8121—Serpins
    • G01N2333/8128—Antithrombin III

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

LA INVENCION SE REFIERE A UN PROCEDIMIENTO DE DETERMINACION DE ANTITROMBINA III (AT III) ACTIVADA POR UN GLICOSAMINOGLICANO SULFATADO O UN OLIGOSACARIDO SULFATADO CUYO EFECTO IN VIVO SOBRE LA AT III ES ANALOGO AL DE LA HEPARINA, POR UNA INMUNODOSIFICACION DE TIPO SANDWICH EN FASE SOLIDA, CARACTERIZADO PORQUE SE EMPLEA; UN ANTICUERPO MONOCLONAL QUE RECONOCE EN SOLUCION MENOS EFICAZMENTE, LA AT III QUE LA AT III ACTIVADA POR UN GLICOSAMINOGLICANO SULFATADO O UNO DE LOS OLIGOSACARIDOS SULFATADOS, QUE TIENE UNA ACTIVIDAD SOBRE LA AT III ANALOGA A LA DE LA HEPARINA; Y UN ANTICUERPO MONOCLONAL QUE NO RECONOCE PRACTICAMENTE LA AT III NATIVA EN SOLUCION Y LA AT III ACTIVADA POR UNO DE DICHOS GLICOSAMINOGLICANOS SULFATADOS O DICHOS OLIGOSACARIDOS EN SOLUCION PERO QUE SI RECONOCE LA AT III DESNATURALIZADA.
ES95916732T 1994-04-14 1995-04-10 Procedimiento inmunologico de la antitrombina iii activada por un glicosaminoglicano, anticuerpos monoclonales correspondientes y su procedimiento de obtencion. Expired - Lifetime ES2125011T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9404469A FR2718849B1 (fr) 1994-04-14 1994-04-14 Procédé d'immunodosage de l'antithrombine III activée par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procédé d'obtention.
PCT/FR1995/000456 WO1995028644A1 (fr) 1994-04-14 1995-04-10 Procede d'immunodosage de l'antithrombine iii activee par un glycosaminoglycane, anticorps monoclonaux correspondants et leur procede d'obtention

Publications (1)

Publication Number Publication Date
ES2125011T3 true ES2125011T3 (es) 1999-02-16

Family

ID=9462114

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95916732T Expired - Lifetime ES2125011T3 (es) 1994-04-14 1995-04-10 Procedimiento inmunologico de la antitrombina iii activada por un glicosaminoglicano, anticuerpos monoclonales correspondientes y su procedimiento de obtencion.

Country Status (9)

Country Link
US (1) US5891647A (es)
EP (1) EP0755518B1 (es)
AT (1) ATE172305T1 (es)
AU (1) AU2311595A (es)
CA (1) CA2187670A1 (es)
DE (1) DE69505365T2 (es)
ES (1) ES2125011T3 (es)
FR (1) FR2718849B1 (es)
WO (1) WO1995028644A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020032444A (ko) * 1999-06-30 2002-05-03 잭 허쉬 응괴 연관된 응고 인자를 억제하는 헤파린 조성물
PL363047A1 (en) * 2000-09-08 2004-11-15 Hamilton Civic Hospitals Research Development Inc. Antithrombotic compositions
DE10239821A1 (de) * 2002-08-29 2004-03-11 Roche Diagnostics Gmbh Verbesserung der Spezifität bei der Bestimmung von Antithrombin
US8617820B2 (en) * 2007-08-28 2013-12-31 Ortho-Clinical Diagnostics, Inc. Use of glycosaminoglycans to reduce non-specific binding in immunoassays
EP2452196B1 (en) * 2009-07-08 2017-09-06 Bio-Rad Laboratories, Inc. Purification of monoclonal antibodies
RU2015143696A (ru) 2013-03-14 2017-04-19 Байер Хелскеа Ллк МОНОКЛОНАЛЬНЫЕ АНТИТЕЛА ПРОТИВ АНТИТРОМБИНА β

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7602423A (nl) * 1976-03-08 1977-09-12 Leuven Res & Dev Vzw Bepaling van heparine in bloedplasma.
DE2804590A1 (de) 1978-02-03 1979-08-09 Licentia Gmbh Schalteranordnung zur stummschaltung in einem rundfunkempfaenger
FR2564468B1 (fr) * 1984-05-16 1994-12-23 Choay Sa Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques
FR2535306A1 (fr) * 1982-10-28 1984-05-04 Martinez Antoine Procede de synthese organique d'oligosaccharides correspondant a des fragments de muco-polysaccharides naturels, nouveaux oligosaccharides obtenus et leurs applications biologiques
BE896543A (fr) * 1983-04-22 1983-08-16 Wallone Region Ensembles d'anticorps monoclonaux deriges contre les proteines humaines impliquees dans la coagulation et la fibrinolyse du sang
DE3804590A1 (de) * 1987-02-25 1988-09-08 Miles Inc Diagnostische sonden zum nachweis von elastase-modifiziertem antithrombin und verfahren zur behandlung
EP0341927B1 (en) * 1988-05-10 1993-07-14 AMERSHAM INTERNATIONAL plc Biological sensors
FR2645647B1 (fr) * 1989-04-07 1991-07-05 Stago Diagnostica Procede de dosage de complexes antithrombine-proteases
JPH0694713A (ja) * 1991-07-31 1994-04-08 Masashi Funayama アンチトロンビンｉｉｉ活性の測定方法とそれを用いたアンチトロンビンｉｉｉ活性の測定キット

Also Published As

Publication number Publication date
AU2311595A (en) 1995-11-10
EP0755518A1 (fr) 1997-01-29
CA2187670A1 (fr) 1995-10-26
FR2718849B1 (fr) 1996-06-14
ATE172305T1 (de) 1998-10-15
FR2718849A1 (fr) 1995-10-20
DE69505365D1 (de) 1998-11-19
DE69505365T2 (de) 1999-05-06
EP0755518B1 (fr) 1998-10-14
US5891647A (en) 1999-04-06
WO1995028644A1 (fr) 1995-10-26

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