DE69434420D1 - Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren - Google Patents

Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren

Info

Publication number
DE69434420D1
DE69434420D1 DE69434420T DE69434420T DE69434420D1 DE 69434420 D1 DE69434420 D1 DE 69434420D1 DE 69434420 T DE69434420 T DE 69434420T DE 69434420 T DE69434420 T DE 69434420T DE 69434420 D1 DE69434420 D1 DE 69434420D1
Authority
DE
Germany
Prior art keywords
fibroblast growth
amino acid
growth factors
beta
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434420T
Other languages
English (en)
Inventor
Andrew Peter Seddon
Lu-Yuan Li
Peter Boehlen
Magdalena Eisinger
Avner Yayon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Wyeth Holdings LLC
Wyeth LLC
Original Assignee
Yeda Research and Development Co Ltd
Wyeth Holdings LLC
Wyeth LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/290,373 external-priority patent/US5491220A/en
Application filed by Yeda Research and Development Co Ltd, Wyeth Holdings LLC, Wyeth LLC filed Critical Yeda Research and Development Co Ltd
Application granted granted Critical
Publication of DE69434420D1 publication Critical patent/DE69434420D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
DE69434420T 1993-09-24 1994-09-23 Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren Expired - Lifetime DE69434420D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12697393A 1993-09-24 1993-09-24
US08/290,373 US5491220A (en) 1993-09-24 1994-08-15 Surface loop structural analogues of fibroblast growth factors
PCT/US1994/010800 WO1995008630A1 (en) 1993-09-24 1994-09-23 Surface loop structural analogues of fibroblast growth factors

Publications (1)

Publication Number Publication Date
DE69434420D1 true DE69434420D1 (de) 2005-08-11

Family

ID=26825210

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69434420T Expired - Lifetime DE69434420D1 (de) 1993-09-24 1994-09-23 Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren

Country Status (8)

Country Link
EP (1) EP0730651B1 (de)
JP (1) JPH09503661A (de)
AT (1) ATE299181T1 (de)
AU (1) AU687455B2 (de)
CA (1) CA2172137C (de)
DE (1) DE69434420D1 (de)
NZ (1) NZ274667A (de)
WO (1) WO1995008630A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1334981B1 (de) * 1994-10-13 2011-01-26 Swedish Orphan Biovitrum AB (publ) Methode zur Reinigung von Keratinozyten-Wachstumfaktoren
WO1996011951A2 (en) * 1994-10-13 1996-04-25 Amgen Inc. Keratinocyte growth factor analogs
AU722626B2 (en) * 1996-05-20 2000-08-10 Abburi Ramaiah Cosmetic preparation
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
WO1999055861A2 (en) * 1998-04-28 1999-11-04 Eisai Co., Ltd. Fibroblast growth factor mutein compositions and methods of use therefor
IL139380A0 (en) * 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
IL149562A0 (en) * 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
KR102650035B1 (ko) 2015-11-27 2024-03-20 마자리코바 우니베지타 내열성 fgf2 폴리펩타이드 및 그 용도
KR102428940B1 (ko) * 2019-11-25 2022-08-03 한국해양과학기술원 온도안정성 및 단백질 분해효소 저항성을 향상시킨 fgf2 폴리펩타이드 및 그 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途

Also Published As

Publication number Publication date
AU7878494A (en) 1995-04-10
EP0730651A4 (de) 1997-12-03
WO1995008630A1 (en) 1995-03-30
EP0730651A1 (de) 1996-09-11
ATE299181T1 (de) 2005-07-15
JPH09503661A (ja) 1997-04-15
AU687455B2 (en) 1998-02-26
EP0730651B1 (de) 2005-07-06
CA2172137C (en) 1999-12-14
NZ274667A (en) 1997-03-24

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