ATE299181T1 - Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren - Google Patents

Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren

Info

Publication number
ATE299181T1
ATE299181T1 AT94929876T AT94929876T ATE299181T1 AT E299181 T1 ATE299181 T1 AT E299181T1 AT 94929876 T AT94929876 T AT 94929876T AT 94929876 T AT94929876 T AT 94929876T AT E299181 T1 ATE299181 T1 AT E299181T1
Authority
AT
Austria
Prior art keywords
fibroblast growth
amino acid
growth factors
surface loop
beta
Prior art date
Application number
AT94929876T
Other languages
English (en)
Inventor
Andrew Peter Seddon
Lu-Yuan Li
Peter Boehlen
Magdalena Eisinger
Avner Yayon
Original Assignee
Wyeth Corp
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/290,373 external-priority patent/US5491220A/en
Application filed by Wyeth Corp, Yeda Res & Dev filed Critical Wyeth Corp
Application granted granted Critical
Publication of ATE299181T1 publication Critical patent/ATE299181T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/501—Fibroblast growth factor [FGF] acidic FGF [aFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Prostheses (AREA)
AT94929876T 1993-09-24 1994-09-23 Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren ATE299181T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12697393A 1993-09-24 1993-09-24
US08/290,373 US5491220A (en) 1993-09-24 1994-08-15 Surface loop structural analogues of fibroblast growth factors
PCT/US1994/010800 WO1995008630A1 (en) 1993-09-24 1994-09-23 Surface loop structural analogues of fibroblast growth factors

Publications (1)

Publication Number Publication Date
ATE299181T1 true ATE299181T1 (de) 2005-07-15

Family

ID=26825210

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94929876T ATE299181T1 (de) 1993-09-24 1994-09-23 Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren

Country Status (8)

Country Link
EP (1) EP0730651B1 (de)
JP (1) JPH09503661A (de)
AT (1) ATE299181T1 (de)
AU (1) AU687455B2 (de)
CA (1) CA2172137C (de)
DE (1) DE69434420D1 (de)
NZ (1) NZ274667A (de)
WO (1) WO1995008630A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2201762C (en) * 1994-10-13 2001-12-18 Eric W. Hsu Method for purifying keratinocyte growth factors
AU3893195A (en) * 1994-10-13 1996-05-06 Amgen, Inc. Keratinocyte growth factor analogs
AU722626B2 (en) * 1996-05-20 2000-08-10 Abburi Ramaiah Cosmetic preparation
US6743422B1 (en) 1996-10-15 2004-06-01 Amgen, Inc. Keratinocyte growth factor-2 products
US6274712B1 (en) 1997-12-23 2001-08-14 3-Dimensional Pharmaceuticals, Inc. Analogs of human basic fibroblast growth factor mutated at one or more of the positions glutamute 89, aspartate 101 or leucine 137
AU3170499A (en) * 1998-04-28 1999-11-16 Eisai Co. Ltd. Fibroblast growth factor mutein compositions and methods of use therefor
IL139380A0 (en) * 2000-10-31 2001-11-25 Prochon Biotech Ltd Active variants of fibroblast growth factor
IL149562A0 (en) * 2002-05-09 2002-11-10 Prochon Ltd Fgf variants and methods for use thereof
EP3380508B1 (de) * 2015-11-27 2020-07-22 Masarykova Univerzita Thermostabiles fgf2-polypeptid, verwendung davon und kulturmedium thermostabilem fgf2-polypeptid
EP4067374A4 (de) 2019-11-25 2024-03-06 Korea Institute of Ocean Science and Technology Fgf2-polypeptid mit verbesserter temperaturstabilität und proteaseresistenz und seine verwendung
KR102428940B1 (ko) * 2019-11-25 2022-08-03 한국해양과학기술원 온도안정성 및 단백질 분해효소 저항성을 향상시킨 fgf2 폴리펩타이드 및 그 용도

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2526965B2 (ja) * 1987-02-24 1996-08-21 武田薬品工業株式会社 ムテイン，ｄｎａおよびその用途

Also Published As

Publication number Publication date
EP0730651A4 (de) 1997-12-03
JPH09503661A (ja) 1997-04-15
EP0730651A1 (de) 1996-09-11
DE69434420D1 (de) 2005-08-11
WO1995008630A1 (en) 1995-03-30
AU687455B2 (en) 1998-02-26
CA2172137C (en) 1999-12-14
AU7878494A (en) 1995-04-10
EP0730651B1 (de) 2005-07-06
NZ274667A (en) 1997-03-24

Similar Documents

Publication Publication Date Title
ATE299181T1 (de) Strukturelle analoge oberflächenschlaufen der fibroblasten-wachstumsfaktoren
Darnall et al. Subunit constitution of proteins: a table
AU7180787A (en) Fibroblast growth factor
DE69021263D1 (de) Fibronektinbindungsprotein und dessen Herstellung.
EP1482044A3 (de) Hämatopoietisches Fusionsprotein multivariantes IL-3 enthaltend
ATE81779T1 (de) Peptidanalogedes insulinaehnlichen wachstumsfaktors-1 bei saeugetieren.
NZ335109A (en) Stable analogs of keratinocyte growth factor (KRF) useful for preventing alopecia, treating gastro-duodenal ulcers, bowel disease, liver function or general induction epithelial cell proliferation
EP0442724A3 (en) Modified hil-6
ATE372382T1 (de) Ein faktor viii-polypeptid mit faktor viii:c- aktivität
CA2075974A1 (en) Totally synthetic affinity reagents
CA2022752A1 (en) Hepatic parenchymal cell growth factor, gene encoding the same, process for producing the factor, and transformants producing the factor
PT84111A (de) Peptide mit vasorelaxierender natriuretischer und diuretischer wirkung verfahren zu ihrer herstellung diese enthaltende mittelund ihre verwendung
DE69131426D1 (de) Neue wasserlösliche polypeptide mit hoher affinität für alpha- und beta- interferone
ATE111520T1 (de) Tgf beta 1/beta2: ein chimärer transformierender wachstumsfaktor.
DE3853446D1 (de) Fibronectinbindungsprotein und dessen Herstellung.
DE69529674D1 (de) Biologisch aktive ligande der eph familie
NO971508L (no) Analoger av sur fibroblastvekstfaktor med forökt stabilitet og biologisk aktivitet
DE59409964D1 (de) Rekombinante D-Hydantoinase, Verfahren zur Herstellung und Verwendung
ATE109827T1 (de) Verfahren zur herstellung von peptiden, dazu zu verwendendes rekombinantes plasmid und mit diesem plasmid transformierte myelomzellen.
ATE46537T1 (de) Promotor und dessen verwendung.
TW264481B (en) Surface loop structural analogues of fibroblast growth factors
ES2044928T3 (es) Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
CA2067176A1 (en) Recombinant gene coding for a protein having an endochitinase activity
ATE254179T1 (de) Neue type-i-interferon varianten, ihre verfahren zur herstellung, und ihre verwendungen
ES8802185A1 (es) Un metodo para preparar un anticuerpo util para la deteccion de un factor de crecimiento epidermico

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties