WO1998024811A3 - Vascular endothelial growth factor - Google Patents

Vascular endothelial growth factor Download PDF

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Publication number
WO1998024811A3
WO1998024811A3 PCT/US1997/020888 US9720888W WO9824811A3 WO 1998024811 A3 WO1998024811 A3 WO 1998024811A3 US 9720888 W US9720888 W US 9720888W WO 9824811 A3 WO9824811 A3 WO 9824811A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth factor
growth factors
vascular endothelial
endothelial growth
amino acid
Prior art date
Application number
PCT/US1997/020888
Other languages
French (fr)
Other versions
WO1998024811A2 (en
Inventor
Teresa Gilbert
Darrel C Conklin
Charles E Hart
Sean Nygaard
Paul O Sheppard
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Priority to AU54399/98A priority Critical patent/AU5439998A/en
Publication of WO1998024811A2 publication Critical patent/WO1998024811A2/en
Publication of WO1998024811A3 publication Critical patent/WO1998024811A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Growth factors, their component polypeptides, methods of making them, polynucleotides encoding them, and methods of using them are disclosed. The growth factors are homodimeric or heterodimeric proteins having component polypeptide chains that each comprises a sequence of amino acid residues that is at least 80 % identical in amino acid sequence to residues 109 to 197 of SEQ ID NO:2. The growth factors are mitogenic for fibroblasts and smooth muscle cells, and may be used therapeutically or in vitro to stimulate cell growth, or to develop inhibitors of cell growth.
PCT/US1997/020888 1996-12-06 1997-11-20 Vascular endothelial growth factor WO1998024811A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU54399/98A AU5439998A (en) 1996-12-06 1997-11-20 Vascular endothelial growth factor

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US75965796A 1996-12-06 1996-12-06
US08/759,657 1996-12-06
US93345597A 1997-09-18 1997-09-18
US08/933,455 1997-09-18

Publications (2)

Publication Number Publication Date
WO1998024811A2 WO1998024811A2 (en) 1998-06-11
WO1998024811A3 true WO1998024811A3 (en) 1998-10-01

Family

ID=27116713

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020888 WO1998024811A2 (en) 1996-12-06 1997-11-20 Vascular endothelial growth factor

Country Status (2)

Country Link
AU (1) AU5439998A (en)
WO (1) WO1998024811A2 (en)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7153827B1 (en) 1994-03-08 2006-12-26 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 and methods of use
US5932540A (en) 1994-03-08 1999-08-03 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
US6734285B2 (en) 1994-03-08 2004-05-11 Human Genome Sciences, Inc. Vascular endothelial growth factor 2 proteins and compositions
US7186688B1 (en) 1994-03-08 2007-03-06 Human Genome Sciences, Inc. Methods of stimulating angiogenesis in a patient by administering vascular endothelial growth factor 2
US7109308B1 (en) 1994-03-08 2006-09-19 Human Genome Sciences, Inc. Antibodies to human vascular endothelial growth factor 2
ES2249762T3 (en) 1994-03-08 2006-04-01 Human Genome Sciences, Inc. GROWTH FACTOR OF THE VASCULAR ENDOTELIUM 2.
US6608182B1 (en) 1994-03-08 2003-08-19 Human Genome Sciences, Inc. Human vascular endothelial growth factor 2
US6040157A (en) 1994-03-08 2000-03-21 Human Genome Sciences, Inc. Vascular endothelial growth factor 2
PT848755E (en) 1995-09-08 2003-12-31 Genentech Inc PROTEIN RELATED TO VEGF
DE69634412T3 (en) 1995-09-29 2013-07-04 Vegenics Pty Ltd REGULATED GENES AND ITS USES
US6828426B1 (en) 1996-07-15 2004-12-07 Chugai Seiyaku Kabushiki Kaisha VEGF-like factor
DK0956339T3 (en) 1996-08-23 2006-01-30 Licentia Oy Recombinant vascular endothelial cell growth factor D (VEGF-D)
GB9624899D0 (en) 1996-11-29 1997-01-15 Schlumberger Ltd Method and apparatus for measuring flow in a horizontal borehole
JP2003517265A (en) 1997-12-24 2003-05-27 ルードヴィッヒ インスティテュート フォー キャンサー リサーチ Expression vectors and cell lines expressing vascular endothelial growth factor D and methods of treating melanoma
US6958147B1 (en) 1998-10-26 2005-10-25 Licentia Ltd Use of VEGF-C to prevent restenosis
JP4739526B2 (en) * 1998-12-07 2011-08-03 ザイモジェネティクス， インコーポレイテッド Growth factor homolog zvegf3
PT1140175E (en) * 1998-12-21 2006-06-30 Ludwig Inst Cancer Res ANTIBODIES FOR VEGF-D TRUNCATED AND ITS UTILIZATIONS
DK1141293T3 (en) * 1998-12-22 2007-11-12 Janssen Pharmaceutica Nv Vascular endothelial growth factor-X
US6783953B1 (en) 1998-12-22 2004-08-31 Janssen Pharmaceutica N.V. Vascular endothelial growth factor-X
US7223724B1 (en) 1999-02-08 2007-05-29 Human Genome Sciences, Inc. Use of vascular endothelial growth factor to treat photoreceptor cells
MXPA01011158A (en) * 1999-05-03 2004-06-03 Zymogenetics Inc Growth factor homolog zvegf4.
US6475796B1 (en) 1999-05-20 2002-11-05 Scios, Inc. Vascular endothelial growth factor variants
US7273751B2 (en) 2000-08-04 2007-09-25 Human Genome Science, Inc. Vascular endothelial growth factor-2
US7026462B2 (en) 2000-12-07 2006-04-11 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
US7067317B2 (en) 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
EP2228389B1 (en) 2001-04-13 2015-07-08 Human Genome Sciences, Inc. Antibodies against vascular endothelial growth factor 2
US7402312B2 (en) 2001-04-13 2008-07-22 Human Genome Sciences, Inc. Antibodies to vascular endothelial growth factor 2 (VEGF-2)
US7358085B2 (en) 2005-02-28 2008-04-15 Sangamo Biosciences, Inc. Anti-angiogenic methods and compositions

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026736A1 (en) * 1995-03-01 1996-09-06 Ludwig Institute For Cancer Research Vascular endothelial growth factor-b
WO1997012972A2 (en) * 1995-09-29 1997-04-10 Universita'degli Studi Di Siena Regulated genes and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996026736A1 (en) * 1995-03-01 1996-09-06 Ludwig Institute For Cancer Research Vascular endothelial growth factor-b
WO1997012972A2 (en) * 1995-09-29 1997-04-10 Universita'degli Studi Di Siena Regulated genes and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
NILSSON, B. ET AL.: "Expression and purification of recombinant insulin-like growth factors from Escherichia coli", METHODS IN ENZYMOLOGY, vol. 198, 1991, pages 3 - 16, XP002073019 *
ORLANDINI, M. ET AL.: "Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 93, October 1996 (1996-10-01), WASHINGTON US, pages 11675 - 11680, XP002029340 *
YAMADA, Y. ET AL.: "Molecular cloning of a novel Vascular Endothelial Growth Factor, VEGF-D", GENOMICS, vol. 42, no. 3, 15 June 1997 (1997-06-15), pages 483 - 488, XP002073018 *

Also Published As

Publication number Publication date
WO1998024811A2 (en) 1998-06-11
AU5439998A (en) 1998-06-29

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