DE69433714D1 - Kalzium - receptor aktive arylalkylamine - Google Patents

Kalzium - receptor aktive arylalkylamine

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Publication number
DE69433714D1
DE69433714D1 DE69433714T DE69433714T DE69433714D1 DE 69433714 D1 DE69433714 D1 DE 69433714D1 DE 69433714 T DE69433714 T DE 69433714T DE 69433714 T DE69433714 T DE 69433714T DE 69433714 D1 DE69433714 D1 DE 69433714D1
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Germany
Prior art keywords
calcium receptor
receptor active
arylalkylamine
molecules
inorganic ion
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Expired - Lifetime
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DE69433714T
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English (en)
Other versions
DE69433714T2 (de
Inventor
F Nemeth
Wagenen C Van
F Balandrin
G Delmar
T Moe
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Shire NPS Pharmaceuticals Inc
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NPS Pharmaceuticals Inc
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Publication of DE69433714D1 publication Critical patent/DE69433714D1/de
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Publication of DE69433714T2 publication Critical patent/DE69433714T2/de
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DE69433714T 1991-08-23 1994-10-21 Kalzium - receptor aktive arylalkylamine Expired - Lifetime DE69433714T2 (de)

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US74945191A 1991-08-23 1991-08-23
US83404492A 1992-02-11 1992-02-11
US93416192A 1992-08-21 1992-08-21
US1712793A 1993-02-12 1993-02-12
US938993A 1993-02-23 1993-02-23
US14124893A 1993-10-22 1993-10-22
US141248 1993-10-22
US29282794A 1994-08-19 1994-08-19
US292827 1994-08-19
PCT/US1994/012117 WO1995011221A1 (en) 1991-08-23 1994-10-21 Calcium receptor-active arylalkyl amines

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Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
EP1275635A1 (de) 1994-10-21 2003-01-15 Nps Pharmaceuticals, Inc. Kalzium-Rezeptor aktive Verbindungen
US6057346A (en) * 1994-12-12 2000-05-02 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of retroviral LTR promoters by calcium response modifiers
US6084084A (en) * 1996-02-21 2000-07-04 Nps Pharmaceuticals, Inc. Human metabotropic glutamate receptor
EP0901459B1 (de) 1996-04-09 2005-06-29 Nps Pharmaceuticals, Inc. Calcylitische verbindungen
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
EP1770083B1 (de) * 1996-05-01 2009-04-29 Nps Pharmaceuticals, Inc. Inorganische am Ionen-Rezeptor aktive Verbindungen
ES2326004T3 (es) * 1996-05-01 2009-09-28 Nps Pharmaceuticals, Inc. Compuestos activos de receptor de ion inorganico.
EP1258471B1 (de) * 1996-05-01 2007-01-24 Nps Pharmaceuticals, Inc. Verbindungen, die auf anorganische Ionen-Rezeptoren wirken
US6184254B1 (en) 1996-05-16 2001-02-06 Board Of Regents, The University Of Texas System Methods of identifying modulators of perivascular sensory nerve Ca2+ receptors
JP4331264B2 (ja) 1996-07-08 2009-09-16 協和発酵キリン株式会社 カルシウムレセプター活性化合物
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
FR2812875B1 (fr) * 2000-08-08 2003-12-12 Centre Nat Rech Scient Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
US6908935B2 (en) 2002-05-23 2005-06-21 Amgen Inc. Calcium receptor modulating agents
US7176322B2 (en) 2002-05-23 2007-02-13 Amgen Inc. Calcium receptor modulating agents
US6849761B2 (en) 2002-09-05 2005-02-01 Wyeth Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia
ES2655435T3 (es) 2003-09-12 2018-02-20 Amgen Inc. Formulación de disolución rápida de cinacalcet
WO2005065050A2 (ja) 2003-12-25 2005-07-21 Asahi Kasei Pharma Corporation 2環化合物
JP4629036B2 (ja) 2004-05-28 2011-02-09 田辺三菱製薬株式会社 アリールアルキルアミン化合物及びその製法
US7361789B1 (en) 2004-07-28 2008-04-22 Amgen Inc. Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
FR2885129B1 (fr) 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
US8486381B2 (en) * 2005-09-02 2013-07-16 Amgen Inc. Methods of modulating intestinal fluid balance
ES2335360T3 (es) * 2005-11-25 2010-03-25 Galapagos Sas Derivados de urea utiles como moduladores de los receptores de calcio.
AU2007230724B2 (en) 2006-03-23 2014-01-30 Amgen Inc. Methods and compositions for making and using polymorphs of cinacalcet
KR20080110681A (ko) 2006-04-20 2008-12-18 암겐 인코포레이티드 안정적 에멀젼 조제물
CA2681582C (en) 2007-03-30 2015-07-14 Amgen Inc. Methods of treating bowel disorders
WO2009107660A1 (ja) 2008-02-25 2009-09-03 味の素株式会社 糖尿病又は肥満病の予防又は治療剤
WO2009119554A1 (ja) 2008-03-24 2009-10-01 味の素株式会社 消化管の重炭酸分泌促進剤
JP5533648B2 (ja) 2008-04-17 2014-06-25 味の素株式会社 免疫賦活剤
WO2010042642A1 (en) * 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
WO2010104882A1 (en) 2009-03-10 2010-09-16 Amgen Inc. Methods of modulating sperm motility
WO2010118055A1 (en) * 2009-04-09 2010-10-14 Cognition Therapeutics, Inc. Inhibitors of cognitive decline
US8785494B2 (en) 2009-05-27 2014-07-22 Leo-Pharma A/S Calcium sensing receptor modulating compounds and pharmaceutical use thereof
WO2010136037A1 (en) 2009-05-27 2010-12-02 Leo Pharma A/S Novel calcium sensing receptor modulating compounds and pharmaceutical use thereof
EP2458983B1 (de) 2009-07-31 2015-07-08 Cognition Therapeutics, Inc. Hemmer des kognitiven abbaus
RU2599788C2 (ru) 2010-06-30 2016-10-20 Лео Фарма А/С Новая полиморфная форма кальцимиметического соединения
EP2588445A1 (de) 2010-06-30 2013-05-08 Leo Pharma A/S Neue polymorphe form einer calcimimetischen verbindung
US20130261132A1 (en) 2010-11-26 2013-10-03 Leo Pharma A/S Calcium-sensing receptor-active compounds
JP2014508104A (ja) 2010-11-26 2014-04-03 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
US20130245084A1 (en) 2010-11-26 2013-09-19 Leo Pharma A/S Calcium-sensing receptor-active compounds
JP2014500882A (ja) 2010-11-26 2014-01-16 レオ ファーマ アクティーゼルスカブ カルシウム感知受容体活性化合物
GB201217330D0 (en) 2012-09-28 2012-11-14 Univ Cardiff Therapeutic for treating inflammatory lung disorders
EP4023294A1 (de) 2014-01-31 2022-07-06 Cognition Therapeutics, Inc. Isoindolinzusammensetzungen und verfahren zur behandlung der alzheimer-krankheit
WO2015136329A1 (en) 2014-03-14 2015-09-17 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Pharmaceutical composition of cinacalcet
BR112019023851A2 (pt) 2017-05-15 2020-08-18 Cognition Therapeutics, Inc. compostos, suas composições farmacêuticas e métodos para tratamento de doenças neurodegenerativas
EP4108233A1 (de) 2021-06-24 2022-12-28 Faran S.A. Orale lösung mit cinacalcet-salz

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001251A (en) * 1988-01-15 1991-03-19 E. R. Squibb & Sons, Inc. Optical resolution of DL-3-acylthio-2-methylpropanoic acid
DE69206306T2 (de) * 1991-04-08 1996-06-13 Sumitomo Chemical Co Optisch aktive Sekundär-Aminverbindung, Verfahren zur Herstellung einer optisch aktiven Sekundär-Aminverbindung und Verfahren zur Herstellung optisch aktiver Carbonsäure durch die Verwendung dieser Verbindung.
JP2728564B2 (ja) * 1991-08-23 1998-03-18 エヌピーエス・ファーマシウティカルズ・インコーポレイテッド カルシウム受容体活性化分子
JP3175339B2 (ja) * 1992-10-07 2001-06-11 住友化学工業株式会社 光学活性アミン化合物、その製法、その中間体及びその用途
RU2146132C1 (ru) * 1993-02-23 2000-03-10 Брихэм энд Уимен З Хоспитал, Инк. Фармацевтическая композиция, активная в отношении рецептора кальция, способ лечения пациента, способ анализа соединения оказывать влияние на активность рецептора неорганического иона, нуклеиновая кислота, кодирующая рецептор, рецептор кальция

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ATE264292T1 (de) 2004-04-15
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