HK1012620A1 - Calcium receptor-active arylalkyl amines. - Google Patents

Calcium receptor-active arylalkyl amines.

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Publication number
HK1012620A1
HK1012620A1 HK98113872A HK98113872A HK1012620A1 HK 1012620 A1 HK1012620 A1 HK 1012620A1 HK 98113872 A HK98113872 A HK 98113872A HK 98113872 A HK98113872 A HK 98113872A HK 1012620 A1 HK1012620 A1 HK 1012620A1
Authority
HK
Hong Kong
Prior art keywords
calcium receptor
arylalkyl amines
active
receptor
molecules
Prior art date
Application number
HK98113872A
Other languages
English (en)
Inventor
Edward F Nemeth
Van Bradford C Wagenen
Manuel F Balandrin
Eric G Delmar
Scott T Moe
Original Assignee
Nps Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nps Pharma Inc filed Critical Nps Pharma Inc
Publication of HK1012620A1 publication Critical patent/HK1012620A1/xx

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    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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HK98113872A 1991-08-23 1998-12-17 Calcium receptor-active arylalkyl amines. HK1012620A1 (en)

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US74945191A 1991-08-23 1991-08-23
US83404492A 1992-02-11 1992-02-11
US93416192A 1992-08-21 1992-08-21
US1712793A 1993-02-12 1993-02-12
US938993A 1993-02-23 1993-02-23
US14124893A 1993-10-22 1993-10-22
US29282794A 1994-08-19 1994-08-19
PCT/US1994/012117 WO1995011221A1 (en) 1991-08-23 1994-10-21 Calcium receptor-active arylalkyl amines

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Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763569A (en) * 1991-08-23 1998-06-09 The Brigham And Women's Hospital, Inc Calcium receptor-active molecules
US6313146B1 (en) 1991-08-23 2001-11-06 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5858684A (en) * 1991-08-23 1999-01-12 The Brigham And Women's Hospital, Inc. Method of screening calcium receptor-active molecules
US5962314A (en) * 1993-02-23 1999-10-05 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
DE122005000033I1 (de) 1994-10-21 2005-09-29 Nps Pharma Inc Kalzium-Rezeptor aktive Verbindungen.
US6057346A (en) * 1994-12-12 2000-05-02 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of retroviral LTR promoters by calcium response modifiers
US6084084A (en) * 1996-02-21 2000-07-04 Nps Pharmaceuticals, Inc. Human metabotropic glutamate receptor
US6818660B2 (en) 1996-04-09 2004-11-16 Nps Pharmaceuticals, Inc. Calcilytic compounds
IL126458A (en) 1996-04-09 2004-06-20 Nps Pharma Inc Calcium receptor inhibiting calcilytic compounds
EP1258471B1 (en) * 1996-05-01 2007-01-24 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
ATE430123T1 (de) * 1996-05-01 2009-05-15 Nps Pharma Inc Inorganische am ionen-rezeptor aktive verbindungen
EP1770083B1 (en) * 1996-05-01 2009-04-29 Nps Pharmaceuticals, Inc. Inorganic ion receptor-active compounds
WO1997042951A1 (en) * 1996-05-16 1997-11-20 Board Of Regents, The University Of Texas System Methods of identifying modulators of perivascular sensory nerve ca2+ receptors
WO1998001417A1 (fr) 1996-07-08 1998-01-15 Kirin Beer Kabushiki Kaisha Composes actifs comme recepteurs du calcium
TW483881B (en) 1996-12-03 2002-04-21 Nps Pharma Inc Calcilytic compounds
US7202261B2 (en) 1996-12-03 2007-04-10 Nps Pharmaceuticals, Inc. Calcilytic compounds
FR2812875B1 (fr) * 2000-08-08 2003-12-12 Centre Nat Rech Scient Nouvelles diamines possedant une activite modulatrice des casr et leur mode de preparation
US7176322B2 (en) * 2002-05-23 2007-02-13 Amgen Inc. Calcium receptor modulating agents
US6908935B2 (en) 2002-05-23 2005-06-21 Amgen Inc. Calcium receptor modulating agents
US6849761B2 (en) 2002-09-05 2005-02-01 Wyeth Substituted naphthoic acid derivatives useful in the treatment of insulin resistance and hyperglycemia
ES2401769T5 (es) 2003-09-12 2020-07-01 Amgen Inc Formulación de disolución rápida de cinacalcet HCl
WO2005065050A2 (ja) 2003-12-25 2005-07-21 Asahi Kasei Pharma Corporation ２環化合物
ES2561111T3 (es) 2004-05-28 2016-02-24 Mitsubishi Tanabe Pharma Corporation Arilalquilaminas y procedimiento para la producción de las mismas
US7361789B1 (en) 2004-07-28 2008-04-22 Amgen Inc. Dihydronaphthalene compounds, compositions, uses thereof, and methods for synthesis
FR2885129B1 (fr) 2005-04-29 2007-06-15 Proskelia Sas Nouveaux derives de l'ureee substituee parun thiazole ou benzothiazole, leur procede de preparation, leur application a titre de medicaments, les compositions pharmaceutiques les renfermant et utilisation.
ES2400693T3 (es) * 2005-09-02 2013-04-11 Amgen Inc. Regulación del equilibrio de fluido intestinal usando calcimiméticos
US7875609B2 (en) 2005-11-25 2011-01-25 Galapagos Sasu Urea derivatives, processes for their preparation, their use as medicaments, and pharmaceutical compositions containing them
WO2007112280A1 (en) 2006-03-23 2007-10-04 Amgen Inc. Methods and compositions for making and using polymorphs of cinacalcet
CA2648939C (en) * 2006-04-20 2014-07-08 Amgen Inc. Stable emulsion formulations
CA2681582C (en) 2007-03-30 2015-07-14 Amgen Inc. Methods of treating bowel disorders
EP2269646A4 (en) 2008-02-25 2011-06-29 Ajinomoto Kk PROPHYLACTIC OR THERAPEUTIC AGENT FOR DIABETES OR OBESITY
WO2009119554A1 (ja) 2008-03-24 2009-10-01 味の素株式会社 消化管の重炭酸分泌促進剤
JP5533648B2 (ja) 2008-04-17 2014-06-25 味の素株式会社 免疫賦活剤
WO2010042642A1 (en) * 2008-10-08 2010-04-15 Amgen Inc. Calcium receptor modulating agents
WO2010104882A1 (en) 2009-03-10 2010-09-16 Amgen Inc. Methods of modulating sperm motility
RU2595720C2 (ru) * 2009-04-09 2016-08-27 Когнишн Терапьютикс, Инк. Ингибиторы снижения когнитивных способностей
US8765676B2 (en) 2009-05-27 2014-07-01 Leo Pharma A/S Calcium sensing receptor modulating compounds and pharmaceutical use thereof
US8785494B2 (en) 2009-05-27 2014-07-22 Leo-Pharma A/S Calcium sensing receptor modulating compounds and pharmaceutical use thereof
BR112012002246A2 (pt) 2009-07-31 2019-09-24 Cognition Therapeutics Inc composto, composto ou sal farmaceutico aceitavel deste, composição farmaceutica, metodo para inibir, tratar e/ou reduzir o declinio cognitivol e/ou doença de akzhmer em um paciente
JP5968881B2 (ja) 2010-06-30 2016-08-10 レオ ファーマ アクティーゼルスカブ カルシウム模倣化合物の新規多形
US9056814B2 (en) 2010-06-30 2015-06-16 Leo Pharma A/S Polymorphic form of a calcimimetic compound
RU2013128950A (ru) 2010-11-26 2015-01-10 Лео Фарма А/С Замещенные циклопентилазины в качестве casr-активных соединений
EP2643290A1 (en) 2010-11-26 2013-10-02 Leo Pharma A/S Calcium-sensing receptor-active compounds
RU2013128973A (ru) 2010-11-26 2015-01-10 Лео Фарма А/С Соединения, активные в отношении кальций-чувствительных рецепторов
CN103228619A (zh) 2010-11-26 2013-07-31 利奥制药有限公司 钙传感受体活性化合物
GB201217330D0 (en) 2012-09-28 2012-11-14 Univ Cardiff Therapeutic for treating inflammatory lung disorders
RU2692258C2 (ru) 2014-01-31 2019-06-24 Когнишн Терапьютикс, Инк. Композиции изоиндолина и способы лечения нейродегенеративного заболевания
EP3116487A1 (en) 2014-03-14 2017-01-18 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Pharmaceutical composition of cinacalcet
WO2018213281A1 (en) 2017-05-15 2018-11-22 Cognition Therapeutics, Inc. Compositions for treating neurodegenerative diseases
EP4108233A1 (en) 2021-06-24 2022-12-28 Faran S.A. Oral solution comprising a cinacalcet salt

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5001251A (en) * 1988-01-15 1991-03-19 E. R. Squibb & Sons, Inc. Optical resolution of DL-3-acylthio-2-methylpropanoic acid
DK0508307T3 (da) * 1991-04-08 1995-12-27 Sumitomo Chemical Co Optisk aktive sekundære aminforbindelser, fremgangsmåde til fremstilling af en optisk aktiv sekundær aminforbindelse og fremgangsmåde til fremstilling af en optisk aktiv carboxylsyre ved anvendelse af denne forbindelse
RU2147574C1 (ru) * 1991-08-23 2000-04-20 Эн-Пи-Эс Фармасьютикалз, Инк. Арилалкиламины, композиции, способы лечения и диагностики, способы идентификации соединения
JP3175339B2 (ja) * 1992-10-07 2001-06-11 住友化学工業株式会社 光学活性アミン化合物、その製法、その中間体及びその用途
EP0637237B1 (en) * 1993-02-23 2004-05-19 Brigham And Women's Hospital, Inc. Calcium receptor-active molecules

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