DE69432644D1 - Kombination eines Angiotensin-II antagonistisch wirkendes Benzimidazols mit ein Diuretikum - Google Patents
Kombination eines Angiotensin-II antagonistisch wirkendes Benzimidazols mit ein DiuretikumInfo
- Publication number
- DE69432644D1 DE69432644D1 DE69432644T DE69432644T DE69432644D1 DE 69432644 D1 DE69432644 D1 DE 69432644D1 DE 69432644 T DE69432644 T DE 69432644T DE 69432644 T DE69432644 T DE 69432644T DE 69432644 D1 DE69432644 D1 DE 69432644D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- group
- angiotensin
- compound
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/42—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of mineralocorticosteroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Ophthalmology & Optometry (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13552493 | 1993-06-07 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432644D1 true DE69432644D1 (de) | 2003-06-12 |
DE69432644T2 DE69432644T2 (de) | 2003-11-27 |
Family
ID=15153791
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435022T Expired - Lifetime DE69435022T2 (de) | 1993-06-07 | 1994-06-07 | Kombination von Angiotensin-II antagonistisch wirkenden Benzimidazolen mit Diuretika |
DE69434560T Expired - Lifetime DE69434560T2 (de) | 1993-06-07 | 1994-06-07 | Kombination eines Angiotensin-II antagonistisch wirkenden Benzimidazols mit Manidipin zur Behandlung von Bluthochdruck |
DE69435021T Expired - Lifetime DE69435021T2 (de) | 1993-06-07 | 1994-06-07 | Kombination eines Angiotensin-II antagonistisch wirkenden Benzimidazols mit einem Diuretikum |
DE69432644T Expired - Lifetime DE69432644T2 (de) | 1993-06-07 | 1994-06-07 | Kombination eines Angiotensin-II antagonistisch wirkendes Benzimidazols mit ein Diuretikum |
Family Applications Before (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69435022T Expired - Lifetime DE69435022T2 (de) | 1993-06-07 | 1994-06-07 | Kombination von Angiotensin-II antagonistisch wirkenden Benzimidazolen mit Diuretika |
DE69434560T Expired - Lifetime DE69434560T2 (de) | 1993-06-07 | 1994-06-07 | Kombination eines Angiotensin-II antagonistisch wirkenden Benzimidazols mit Manidipin zur Behandlung von Bluthochdruck |
DE69435021T Expired - Lifetime DE69435021T2 (de) | 1993-06-07 | 1994-06-07 | Kombination eines Angiotensin-II antagonistisch wirkenden Benzimidazols mit einem Diuretikum |
Country Status (9)
Country | Link |
---|---|
EP (6) | EP2277520A3 (de) |
AT (4) | ATE372115T1 (de) |
CA (1) | CA2125251C (de) |
CY (1) | CY2370B1 (de) |
DE (4) | DE69435022T2 (de) |
DK (1) | DK0753301T3 (de) |
ES (1) | ES2193217T3 (de) |
PT (1) | PT753301E (de) |
SG (1) | SG45336A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1995033456A2 (en) * | 1994-06-07 | 1995-12-14 | Telor Ophthalmic Pharmaceuticals, Inc. | Reducing intraocular pressure using aryloxy- and aryl-acetic acids |
US5763491A (en) * | 1994-12-09 | 1998-06-09 | The Regents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
US6228873B1 (en) | 1994-12-09 | 2001-05-08 | The Regents Of The University Of California | Method for enhancing outflow of aqueous humor in treatment of glaucoma |
DK0800384T3 (da) * | 1994-12-14 | 2001-04-17 | Enbalt Trading Ltd | Pharmaceutiske tabletformuleringer til direkte kompression |
JPH11507627A (ja) * | 1995-06-07 | 1999-07-06 | ジー.ディー.サール アンド カンパニー | 充血性心不全症を処置するためのエポキシ−ステロイド系アルドステロン拮抗物質とアンギオテンシンii拮抗物質との組合せ治療 |
JPH11509838A (ja) * | 1995-06-07 | 1999-08-31 | ジー.ディー.サール アンド カンパニー | 充血性心不全症を処置するためのスピロノラクトン化合物とアンギオテンシンii拮抗物質との組合わせ治療 |
WO1996040256A1 (en) * | 1995-06-07 | 1996-12-19 | G.D. Searle & Co. | Method to treat cardiofibrosis with a combination of an angiotensin ii antagonist and spironolactone |
ES2175385T5 (es) * | 1996-04-05 | 2006-06-01 | Takeda Chemical Industries, Ltd. | Combinacion farmaceutica que contiene un compuesto que tiene actividad antagonista de angiotensina ii y un compuesto que aumenta la sensibilidad a la insulina. |
WO1999012534A1 (fr) * | 1997-09-10 | 1999-03-18 | Ono Pharmaceutical Co., Ltd. | Regulateurs des recepteurs actives par le proliferateur des peroxisomes |
SK285863B6 (sk) * | 1998-07-10 | 2007-10-04 | Novartis Ag | Kombinovaná farmaceutická kompozícia obsahujúca AT1-antagonistu valsartan a amlodipín |
JP4000505B2 (ja) * | 1999-12-01 | 2007-10-31 | 第一三共株式会社 | 緑内障を治療するための併用剤 |
WO2001055093A1 (fr) * | 2000-01-25 | 2001-08-02 | Japan Tobacco Inc. | Composes a base de n-arylhydrazide et leur utilisation en tant que medicaments |
US20040102502A1 (en) * | 2000-10-25 | 2004-05-27 | Toshifumi Watanabe | Preventing/remedies for portal hypertension |
US20040087484A1 (en) * | 2000-12-01 | 2004-05-06 | Sahota Pritam Singh | Combination of organic compounds |
US20050032854A1 (en) * | 2001-12-03 | 2005-02-10 | Kiminori Kawahara | Insulin resistance improving agents |
US7015210B2 (en) | 2001-12-12 | 2006-03-21 | Pharmacia Corporation | Methods of treating ophthalmic disorders with epoxy-steroidal aldosterone receptor antagonists |
EG24716A (en) | 2002-05-17 | 2010-06-07 | Novartis Ag | Combination of organic compounds |
BRPI0406987A (pt) * | 2003-01-31 | 2006-01-10 | Sankyo Co | Medicamento para a prevenção e/ou tratamento de arteriosclerose, medicamentos para a inibição de proliferação de células do músculo liso vascular, de formação de neoìntima dos vasos sanguìneos e de remodelação vascular, medicamento para a prevenção de restenose que segue intervenção coronária percutânea, e, medicamentos para a profilaxia e/ou tratamento de hipertensão ou doenças causadas por hipertensão ou doenças causadas por hipertensão, de doenças cardìacas, de angina do peito, de infarto miocárdico, de arritmia, de morte súbita, de insuficiência cardìaca, de hipertrofia cardìaca, de doenças renais, de nefropatia diabética, de glomerulonefrite, de nefrosclerose, de doenças cerebrovasculares, de infarto cerebral, e de hemorragia cerebral |
US7732467B2 (en) | 2003-05-15 | 2010-06-08 | Alzheimer's Institute Of America, Inc. | Method for reducing amyloid deposition, amyloid neurotoxicity and microgliosis |
GB0322552D0 (en) | 2003-09-26 | 2003-10-29 | Astrazeneca Uk Ltd | Therapeutic treatment |
NZ584729A (en) | 2007-10-05 | 2012-12-21 | Alzheimer S Inst Of America Inc | Method for reducing amyloid deposition, amyloid neurotoxicity, and microgliosis with (-)-nilvadipine enantiomer |
CA2732018C (en) | 2008-07-31 | 2017-07-04 | Takeda Pharmaceutical Company Limited | Solid pharmaceutical composition |
UY32126A (es) | 2008-09-25 | 2010-04-30 | Takeda Pharmaceutical | Composición farmacéutica sólida |
DE102008059206A1 (de) | 2008-11-27 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Pharmazeutische Darreichungsform enthaltend Nifedipin oder Nisoldipin und einen Angiotensin-II Antagonisten und/oder ein Diuretikum |
WO2010075347A2 (en) * | 2008-12-23 | 2010-07-01 | Takeda Pharmaceutical Company Limited | Methods of treating hypertension with at least one angiotensin ii receptor blocker and chlorthalidone |
MX2011011011A (es) * | 2009-04-30 | 2011-11-02 | Takeda Pharmaceutical | Preparacion solida. |
TR201004754A1 (tr) * | 2010-06-11 | 2012-01-23 | Sanovel �La� San. Ve T�C. A.�. | Yeni Farmasötik Kombinasyonlar |
MX2014013320A (es) | 2012-05-07 | 2015-08-10 | Bayer Pharma AG | Procedimiento de fabricacion de una forma de dosificacion farmaceutica que comprende nifedipina y candesartan cilexetilo. |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2016710A1 (en) * | 1989-05-15 | 1990-11-15 | Prasun K. Chakravarty | Substituted benzimidazoles as angiotensin ii antagonists |
IL95975A (en) | 1989-10-24 | 1997-06-10 | Takeda Chemical Industries Ltd | N-benzyl- 2-alkylbenzimidazole derivatives, their production and pharmaceutical compositions containing them |
US5196444A (en) * | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
EP0461039B1 (de) * | 1990-06-08 | 1998-09-16 | Hoechst Marion Roussel | Benzimidazol-Derivate, Verfahren und Zwischenprodukte zu ihrer Herstellung, ihre Anwendung als Arzneimittel und diese enthaltende pharmazeutische Zusammensetzungen |
DE69131021T2 (de) * | 1990-12-14 | 1999-08-12 | Smithkline Beecham Corp | Angiotensin-ii-rezeptor blockierende zusammensetzungen |
FR2673427B1 (fr) * | 1991-03-01 | 1993-06-18 | Sanofi Elf | Derives heterocycliques diazotes n-substitues par un groupement biphenylmethyle, leur preparation, les compositions pharmaceutiques en contenant. |
IL102183A (en) * | 1991-06-27 | 1999-11-30 | Takeda Chemical Industries Ltd | The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them |
TW300219B (de) * | 1991-09-14 | 1997-03-11 | Hoechst Ag | |
TW284688B (de) * | 1991-11-20 | 1996-09-01 | Takeda Pharm Industry Co Ltd | |
GB2270841A (en) * | 1992-09-09 | 1994-03-30 | Merck & Co Inc | Compositions for Treating vascular restenosis |
WO1994009778A1 (en) * | 1992-10-26 | 1994-05-11 | Merck & Co., Inc. | Combinations of angiotensin-ii receptor antagonists and diuretics |
DE69534339T2 (de) * | 1994-02-08 | 2006-05-24 | Novartis Ag | Behandlung von normaldruckglaukom mit valsartan |
-
1994
- 1994-06-06 CA CA002125251A patent/CA2125251C/en not_active Expired - Lifetime
- 1994-06-07 AT AT03001569T patent/ATE372115T1/de not_active IP Right Cessation
- 1994-06-07 DE DE69435022T patent/DE69435022T2/de not_active Expired - Lifetime
- 1994-06-07 ES ES96115146T patent/ES2193217T3/es not_active Expired - Lifetime
- 1994-06-07 PT PT96115146T patent/PT753301E/pt unknown
- 1994-06-07 EP EP10178599A patent/EP2277520A3/de not_active Withdrawn
- 1994-06-07 EP EP07014995A patent/EP1844774A3/de not_active Ceased
- 1994-06-07 EP EP03001570A patent/EP1306089B1/de not_active Expired - Lifetime
- 1994-06-07 DE DE69434560T patent/DE69434560T2/de not_active Expired - Lifetime
- 1994-06-07 EP EP94108687A patent/EP0628313B1/de not_active Expired - Lifetime
- 1994-06-07 EP EP03001569A patent/EP1306088B1/de not_active Expired - Lifetime
- 1994-06-07 EP EP96115146A patent/EP0753301B1/de not_active Revoked
- 1994-06-07 SG SG1996003825A patent/SG45336A1/en unknown
- 1994-06-07 AT AT03001570T patent/ATE372116T1/de not_active IP Right Cessation
- 1994-06-07 DK DK96115146T patent/DK0753301T3/da active
- 1994-06-07 DE DE69435021T patent/DE69435021T2/de not_active Expired - Lifetime
- 1994-06-07 AT AT94108687T patent/ATE311188T1/de not_active IP Right Cessation
- 1994-06-07 DE DE69432644T patent/DE69432644T2/de not_active Expired - Lifetime
- 1994-06-07 AT AT96115146T patent/ATE239471T1/de active
-
2003
- 2003-08-04 CY CY0300054A patent/CY2370B1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
ATE372115T1 (de) | 2007-09-15 |
DK0753301T3 (da) | 2003-07-21 |
CA2125251A1 (en) | 1994-12-08 |
CY2370B1 (en) | 2004-06-04 |
EP0753301B1 (de) | 2003-05-07 |
EP0753301A1 (de) | 1997-01-15 |
ATE239471T1 (de) | 2003-05-15 |
DE69435021T2 (de) | 2008-05-29 |
EP2277520A2 (de) | 2011-01-26 |
EP0628313A1 (de) | 1994-12-14 |
DE69435021D1 (de) | 2007-10-18 |
DE69434560T2 (de) | 2006-06-08 |
EP2277520A3 (de) | 2011-08-24 |
EP1306089B1 (de) | 2007-09-05 |
EP0628313B1 (de) | 2005-11-30 |
ATE372116T1 (de) | 2007-09-15 |
ATE311188T1 (de) | 2005-12-15 |
DE69435022T2 (de) | 2008-05-29 |
EP1306088A1 (de) | 2003-05-02 |
DE69434560D1 (de) | 2006-01-05 |
PT753301E (pt) | 2003-08-29 |
EP1844774A2 (de) | 2007-10-17 |
ES2193217T3 (es) | 2003-11-01 |
EP1844774A3 (de) | 2008-08-20 |
DE69432644T2 (de) | 2003-11-27 |
CA2125251C (en) | 2005-04-26 |
EP1306088B1 (de) | 2007-09-05 |
SG45336A1 (en) | 1998-01-16 |
DE69435022D1 (de) | 2007-10-18 |
EP1306089A1 (de) | 2003-05-02 |
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