DE69432640D1 - Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays - Google Patents

Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays

Info

Publication number
DE69432640D1
DE69432640D1 DE69432640T DE69432640T DE69432640D1 DE 69432640 D1 DE69432640 D1 DE 69432640D1 DE 69432640 T DE69432640 T DE 69432640T DE 69432640 T DE69432640 T DE 69432640T DE 69432640 D1 DE69432640 D1 DE 69432640D1
Authority
DE
Germany
Prior art keywords
metal chelate
compositions containing
containing metal
analyte
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69432640T
Other languages
English (en)
Other versions
DE69432640T2 (de
Inventor
F Ullman
Sharat Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Siemens Healthcare Diagnostics Products GmbH
Original Assignee
Dade Behring Marburg GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dade Behring Marburg GmbH filed Critical Dade Behring Marburg GmbH
Publication of DE69432640D1 publication Critical patent/DE69432640D1/de
Application granted granted Critical
Publication of DE69432640T2 publication Critical patent/DE69432640T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/06—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/5436—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand physically entrapped within the solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/585—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with a particulate label, e.g. coloured latex
    • G01N33/586—Liposomes, microcapsules or cells
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/807—Apparatus included in process claim, e.g. physical support structures
    • Y10S436/808—Automated or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/13—Tracers or tags

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69432640T 1993-11-22 1994-11-21 Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays Expired - Lifetime DE69432640T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/156,181 US5578498A (en) 1991-05-22 1993-11-22 Metal chelate containing compositions for use in chemiluminescent assays
US156181 1993-11-22
PCT/US1994/013193 WO1995014928A1 (en) 1993-11-22 1994-11-21 Metal chelate containing compositions for use in chemiluminescent assays

Publications (2)

Publication Number Publication Date
DE69432640D1 true DE69432640D1 (de) 2003-06-12
DE69432640T2 DE69432640T2 (de) 2004-03-25

Family

ID=22558459

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432640T Expired - Lifetime DE69432640T2 (de) 1993-11-22 1994-11-21 Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays

Country Status (7)

Country Link
US (9) US5578498A (de)
EP (2) EP0730738B1 (de)
JP (1) JP3426241B2 (de)
AT (1) ATE239917T1 (de)
CA (1) CA2177143C (de)
DE (1) DE69432640T2 (de)
WO (1) WO1995014928A1 (de)

Families Citing this family (116)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395506B1 (en) * 1991-04-18 2002-05-28 Becton, Dickinson And Company Device for monitoring cells
US5578498A (en) 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) * 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
WO1994002486A1 (en) * 1992-07-20 1994-02-03 Syntex (U.S.A.) Inc. Novel chemiluminescent compounds and methods of use
US6002000A (en) * 1992-07-20 1999-12-14 Dade Behring Marburg Gmbh Chemiluminescent compounds and methods of use
EP0720659A1 (de) * 1993-09-23 1996-07-10 Zeneca Limited Nuklein säure nachweis mittels energieübertragung
EP0881879B1 (de) * 1996-02-19 2003-06-18 Schaffer, Moshe Photoempfindliche zusammensetzung
ES2270459T3 (es) * 1996-05-01 2007-04-01 Dade Behring Marburg Gmbh Composiciones quimioluminiscentes y su uso en la deteccion de peroxido de hidrogeno.
US6028025A (en) * 1996-10-21 2000-02-22 Massachusetts Institute Of Technology Metalloporphyrin oxidation catalyst covalently coupled to an inorganic surface and method making same
US6753191B2 (en) 1996-11-06 2004-06-22 University Of Pittsburgh Polymerized crystalline colloidal array chemical sensing materials for use in high ionic strength solutions
US5898004A (en) * 1996-11-06 1999-04-27 University Of Pittsburgh Of The Commonwealth System Of Higher Education Polymerized crystalline colloidal array sensors
US5854078A (en) 1996-11-06 1998-12-29 University Of Pittsburgh Polymerized crystalline colloidal array sensor methods
US5772926A (en) * 1997-05-13 1998-06-30 Lumigen, Inc. Chemiluminescent reactions using dihydroxyaromatic compounds and heterocyclic enol phosphates
WO1999006821A1 (de) * 1997-08-01 1999-02-11 Presens Precision Sensing Gmbh Verfahren und vorrichtung zur referenzierung von fluoreszenzintensitätssignalen
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6322980B1 (en) * 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US20040248150A1 (en) * 1999-04-02 2004-12-09 Sharat Singh Methods employing oligonucleotide-binding e-tag probes
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US6673550B2 (en) 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US20030235832A1 (en) * 2000-06-21 2003-12-25 Ahmed Chenna Multiplexed analysis by chromatographic separation of molecular tags
US7037654B2 (en) 1999-04-30 2006-05-02 Aclara Biosciences, Inc. Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
DE19933104A1 (de) * 1999-07-15 2001-01-18 Ingo Klimant Phosphoreszierende Mikro- und Nanopartikel als Referenzstandard und Phosphoreszenzmarker
US6329205B1 (en) 1999-08-31 2001-12-11 Molecular Probes, Inc. Detection method using luminescent europium-based protein stains
WO2001032665A2 (en) * 1999-11-01 2001-05-10 Fluorrx, Inc. New ruthenium metal ligand complexes
US6703248B1 (en) * 1999-12-15 2004-03-09 Dade Behring Marburg Gmbh Particles for diagnostic and therapeutic use
EP1264181B1 (de) 2000-03-06 2007-06-06 Dade Behring Marburg GmbH Mit polysacchariden beschichtete träger, deren herstellung und verwendung
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US7255999B2 (en) * 2001-05-21 2007-08-14 Monogram Biosciences, Inc. Methods and compositions for analyzing proteins
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US7635571B2 (en) * 2000-12-07 2009-12-22 Siemens Healthcare Diagnostics Products Gmbh Amplified signal in binding assays
SG92833A1 (en) * 2001-03-27 2002-11-19 Sumitomo Chemical Co Polymeric light emitting substance and polymer light emitting device using the same
WO2002078906A2 (en) * 2001-03-29 2002-10-10 Cellect Technologies Corp. Methods devices and systems for sorting and separating particles
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
WO2002097112A2 (en) * 2001-05-26 2002-12-05 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
US20030089273A1 (en) * 2001-08-23 2003-05-15 Thomas Potrawa Europium-ammonium tetra chelates
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
CN1166422C (zh) * 2001-11-05 2004-09-15 北京源德生物医学工程股份有限公司 用于体外高能聚焦超声波治疗机的坐位架
US20050053939A1 (en) * 2001-11-09 2005-03-10 Ahmed Chenna Methods and compositions for enhancing detection in determinations employing cleavable electrophoretic tag reagents
US6949347B2 (en) * 2002-03-05 2005-09-27 Aclara Biosciences, Inc. Multiplex analysis using membrane-bound sensitizers
US20040229294A1 (en) 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
JP4443407B2 (ja) * 2002-07-25 2010-03-31 アクララ バイオサイエンシーズ， インコーポレイテッド レセプターオリゴマー形成の検出
US6783699B2 (en) 2002-10-17 2004-08-31 Medgene, Inc. Europium-containing fluorescent nanoparticles and methods of manufacture thereof
AU2003280667A1 (en) * 2002-10-31 2004-05-25 Reverse Proteomics Research Institute Co., Ltd. Method of immobilizing compound on solid phase support
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US7179542B2 (en) 2003-05-20 2007-02-20 Canon Kabushiki Kaisha Thiazole- and imidazole-fused phenanthroline molecules in organic light-emitting devices
EP1640429A4 (de) * 2003-05-22 2010-03-10 Mitsubishi Chem Corp Lichtemittierende vorrichtung und nachleuchtender leuchtstoff
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
CA2535510C (en) * 2003-08-11 2013-10-15 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
CA2543830A1 (en) * 2003-10-27 2005-05-19 Monogram Biosciences, Inc. Detecting human anti-therapeutic antibodies
WO2005062048A1 (de) * 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogenes nachweisverfahren
US7722842B2 (en) * 2003-12-31 2010-05-25 The Ohio State University Carbon dioxide sequestration using alkaline earth metal-bearing minerals
EP1766076B1 (de) * 2004-06-09 2015-12-02 PerkinElmer LAS, Inc. Verfahren zum zielmolekülnachweis mit siderophoren und verwandten zusammensetzungen
US7964407B2 (en) * 2004-07-21 2011-06-21 Bates Lynn S Methods of marking products using natural materials having genetically controlled micromorphological structures as markers
US7807468B2 (en) * 2004-07-21 2010-10-05 Bates Lynn S Methods of marking and testing pharmaceutical products
US20060040258A1 (en) * 2004-08-23 2006-02-23 Huiyan Guo Water-soluble conjugates and methods of preparation
RU2007114042A (ru) * 2004-09-17 2008-10-27 Чирон Корпорейшн (Us) Гомогенный люминесцентный способ анализа при сближении, опосредованного трехвалентным металлом
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US20060166376A1 (en) * 2005-01-21 2006-07-27 Craig Alan R Compositions for use as a signal generation component and methods of using same
CN100429197C (zh) * 2005-02-04 2008-10-29 博阳生物科技（上海）有限公司 双丁二酮化合物、铕配合物、含该配合物的组合物及其用途
US20060205090A1 (en) * 2005-03-14 2006-09-14 Newton Michael W Water-soluble conjugates for electrochemical detection
CN100445744C (zh) * 2005-04-25 2008-12-24 博阳生物科技（上海）有限公司 用于免疫分析的微球组合物或组件及免疫分析方法
US20080312092A1 (en) * 2005-07-08 2008-12-18 The University Of Denver Photoinduced Signal Amplification Through Externally Sensitized Photofragmentation in Masked Photosensitizers
WO2007070761A2 (en) * 2005-12-12 2007-06-21 Colorado Seminary, Which Owns And Operates The University Of Denver Method for encoding and screening combinatorial libraries
WO2008098100A2 (en) * 2007-02-07 2008-08-14 Perscitus Biosciences, Llc Detection of molecule proximity
WO2009026313A1 (en) * 2007-08-20 2009-02-26 Colorado Seminary, Which Owns And Operates The University Of Denver Photoinduced signal amplification through externally sensitized photofragmentation in masked photosensitizers and photoamplified fluorescence turn-off system
WO2009070772A1 (en) * 2007-11-27 2009-06-04 Monogram Biosciences, Inc. Enhanced method for detecting and/or quantifying an analyte in a sample
US10416162B2 (en) * 2007-12-20 2019-09-17 Monogram Biosciences, Inc. Her2 diagnostic methods
CN101251540B (zh) * 2008-03-26 2012-12-05 博阳生物科技（上海）有限公司 乙型肝炎病毒e抗原检测微粒、其制备及应用
CA2737946C (en) 2008-09-26 2016-11-15 The Ohio State University Conversion of carbonaceous fuels into carbon free energy carriers
EP2438442B1 (de) 2008-12-01 2017-08-09 Laboratory Corporation of America Holdings Verfahren und tests zur messung von p95 und/oder p95-komlexen in einer probe und für p95 spezifische antikörper
WO2010083470A1 (en) 2009-01-15 2010-07-22 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of her-3
EP2398868B1 (de) 2009-02-20 2016-06-15 Perkinelmer Biosignal, Inc. Multiplex-assayverfahren und zusammensetzungen
US9347947B2 (en) * 2009-03-12 2016-05-24 Siemens Healthcare Diagnostics Inc. Immunoassays employing non-particulate chemiluminescent reagent
JP5311662B2 (ja) * 2009-08-24 2013-10-09 キッコーマン株式会社 ペルオキシダーゼ化学発光反応の発光増強方法及びペルオキシダーゼ化学発光反応用発光増強剤
CN102597173A (zh) 2009-09-08 2012-07-18 俄亥俄州立大学研究基金会 具有原位co2捕集的合成燃料和化学品生产
CN102695670B (zh) 2009-09-08 2016-02-24 俄亥俄州立大学研究基金会 具有集成的碳捕集的重整/水裂解和用于发电的电化学系统的集成
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
US10088490B2 (en) 2010-08-20 2018-10-02 Siemens Healthcare Diagnostics Inc. Assay for analytes using multiple receptors
US10010847B2 (en) 2010-11-08 2018-07-03 Ohio State Innovation Foundation Circulating fluidized bed with moving bed downcomers and gas sealing between reactors
DE102011007546A1 (de) 2011-04-15 2012-10-18 Humboldt-Universität Zu Berlin Messvorrichtung für eine Messung einer Singulettsauerstoff-Lumineszenz
EP2707583B1 (de) 2011-05-11 2019-07-10 Ohio State Innovation Foundation Sauerstoffträgermaterialien
CA2835419C (en) 2011-05-11 2020-06-02 Ohio State Innovation Foundation Systems for converting fuel
ES2701929T3 (es) 2011-05-19 2019-02-26 Laboratory Corp America Holdings Métodos para determinar la probabilidad de supervivencia y para predecir la probabilidad de metástasis en el cáncer
EP2742352B1 (de) 2011-08-12 2018-02-28 Siemens Healthcare Diagnostics Inc. Nachweis von sexualhormonen
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
CN105358475B (zh) 2013-02-05 2018-12-04 俄亥俄州国家创新基金会 用于燃料转化的方法
US9616403B2 (en) 2013-03-14 2017-04-11 Ohio State Innovation Foundation Systems and methods for converting carbonaceous fuels
EP2981828A1 (de) 2013-04-05 2016-02-10 Laboratory Corporation of America Holdings Systeme und verfahren zur erleichterung der diagnose, prognose und behandlung von krebs auf basis der erkennung einer her3-aktivierung
US20140308751A1 (en) 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
US10124072B2 (en) 2013-09-18 2018-11-13 Caliper Life Sciences, Inc. In-vivo reactive species imaging
US20150238915A1 (en) 2014-02-27 2015-08-27 Ohio State Innovation Foundation Systems and methods for partial or complete oxidation of fuels
AU2015280292B2 (en) 2014-06-27 2019-08-01 Siemens Healthcare Diagnostics Inc. Binding partners specific for vitamin D epimers
US9746484B2 (en) 2014-06-27 2017-08-29 Siemens Healthcare Diagnostics Inc. Binding partners specific for vitamin D epimers in vitamin D assays
EP3427057A1 (de) 2016-03-07 2019-01-16 H. Hoffnabb-La Roche Ag Nachweis von antikörpern gegen p53
JP2019515252A (ja) 2016-03-15 2019-06-06 ラボラトリー コーポレイション オブ アメリカ ホールディングス 細胞間のタンパク質相互作用を評価する方法
EP3429738A4 (de) 2016-04-12 2019-09-18 Ohio State Innovation Foundation Chemical-looping-verfahren zur herstellung von synthesegas aus kohlenstoffhaltigen brennstoffen
KR20190025689A (ko) 2016-07-06 2019-03-11 프로테나 바이오사이언시즈 리미티드 전체 및 s129 인산화된 알파-시누클레인을 검출하기 위한 검정
US11090624B2 (en) 2017-07-31 2021-08-17 Ohio State Innovation Foundation Reactor system with unequal reactor assembly operating pressures
US10933146B2 (en) 2017-12-12 2021-03-02 Massachusetts Institute Of Technology Cell-permeable imaging sensors and uses thereof
US10549236B2 (en) 2018-01-29 2020-02-04 Ohio State Innovation Foundation Systems, methods and materials for NOx decomposition with metal oxide materials
CN110514651A (zh) 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 一种化学发光免疫分析测定方法及使用该方法的系统、试剂盒
US20210208080A1 (en) 2018-05-21 2021-07-08 Beyond Diagnostics (Shanghai) Co., Ltd Chemiluminescence analytical method and system and kit using same
KR102281252B1 (ko) * 2018-05-21 2021-07-23 (주)인벤티지랩 두타스테라이드를 포함하는 마이크로 입자 및 이의 제조 방법
JP7122454B2 (ja) 2018-07-30 2022-08-19 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド ビオチンアッセイを実施するためのキット、マイクロ流体デバイス、および方法
WO2020033500A1 (en) 2018-08-09 2020-02-13 Ohio State Innovation Foundation Systems, methods and materials for hydrogen sulfide conversion
US11453626B2 (en) 2019-04-09 2022-09-27 Ohio State Innovation Foundation Alkene generation using metal sulfide particles
CN112500434B (zh) * 2020-11-20 2021-10-22 复旦大学 基于铱配合物的光扳机分子及应用

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3340716A (en) * 1964-11-10 1967-09-12 Reynolds Metals Co Method of producing wrought structure
US3720622A (en) * 1970-01-02 1973-03-13 American Cyanamid Co Generation of light from the decomposition of dioxetaneones in the presence of a fluorescer
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US3947264A (en) * 1974-04-09 1976-03-30 Uniroyal, Inc. Substituted 2,3-dihydro-,4-oxathiin plant growth stunting agents
US4043792A (en) * 1974-04-09 1977-08-23 Uniroyal, Inc. Plant growth regulation using certain substituted 2,3-dihydro-1,4-oxathiins
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4199559A (en) 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
CA1121647A (en) 1977-11-09 1982-04-13 Norman L. Betz Feed intake limiting acidulated fat for animals
US4529561A (en) 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4220450A (en) 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
US4380580A (en) 1978-04-10 1983-04-19 Miles Laboratories, Inc. Heterogenous chemiluminescent specific binding assay
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
AU517292B2 (en) 1978-06-20 1981-07-23 Syva Co. Fluorescence quenching system
US4226993A (en) 1978-07-24 1980-10-07 Miles Laboratories, Inc. Amino-functionalized phthalhydrazides
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4576912A (en) 1978-11-30 1986-03-18 Technicon Instruments Corporation Fluoroimmunoassaying
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
CA1130297A (en) * 1980-05-02 1982-08-24 Michael A. Puttock Method of making 2,3-dihydro-5,6-diphenyl- 1,4-oxathiin
US4483921A (en) 1981-01-12 1984-11-20 Collaborative Research, Inc. Immunoassay with antigen or antibody labeled liposomes sequestering enzyme
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
CA1180647A (en) * 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4654300A (en) 1982-04-02 1987-03-31 Syntex (U.S.A.) Inc. Fluorescent microbead quenching assay
US4483929A (en) 1982-05-03 1984-11-20 Liposome Technology Incorporated Liposomes with glycolipid-linked antibodies
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4568649A (en) 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4652533A (en) 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
JPS6036962A (ja) 1983-08-09 1985-02-26 Toray Ind Inc 生物学的検査用微粒子
EP0144914A3 (de) 1983-12-12 1986-08-13 Miles Inc. Hybridisierungstest mittels markierter Paare von hybridbindenden Reagenzien
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
DE3785591T2 (de) 1986-01-10 1993-09-02 Amoco Corp Kompetitiver homogener test.
EP0259453A1 (de) 1986-03-04 1988-03-16 Cambridge Biotech Corporation Nachweis von nukleinsäure durch partikel-agglutination
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
US4959182A (en) 1986-07-17 1990-09-25 Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5616729A (en) 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US4857652A (en) * 1986-07-17 1989-08-15 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4978614A (en) 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
WO1988000695A1 (en) 1986-07-24 1988-01-28 Quest Systems, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US4891324A (en) 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US4806485A (en) * 1987-02-27 1989-02-21 Cooperative Institute For Research In Environmental Sciences Univers. Of Colorado Method of improving the detection limits of UV-VIS absorbing compounds in HPLC by the use of a singlet oxygen trap
US5070158A (en) 1987-03-12 1991-12-03 Hewlett-Packard Company Covalently labeled siloxane polymers
US5017473A (en) 1987-05-26 1991-05-21 Becton, Dickinson And Company Homogeneous chemiluminescence immunoassay using a light absorbing material
US4822878A (en) 1987-06-30 1989-04-18 Viomedics, Inc. Cyclic anhydride derivatives of chromophors
SE8703682L (sv) * 1987-09-24 1989-03-25 Wallac Oy Homogen bestaemningsmetod som utnyttjar affinitetsreaktioner
US4943525A (en) 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
US4910303A (en) * 1988-05-26 1990-03-20 Texaco Chemical Company Process for preparing oxazine derivatives
AU636110B2 (en) 1988-06-08 1993-04-22 Nichols Institute Diagnostics Assays utilizing sensitizer-induced production of detectable signal
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
US5061445A (en) 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5019496A (en) 1989-02-17 1991-05-28 Gerald Oster Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay
EP0441948A4 (en) 1989-09-06 1992-06-03 Tropix, Inc. Synthesis of stable, water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
WO1991005063A1 (en) 1989-10-05 1991-04-18 Exoxemis, Inc. Haloperoxidase acid optimum chemiluminescence assay system
EP0476545B1 (de) 1990-09-14 1997-05-07 Tosoh Corporation Verfahren und Kit für Immunoassay
FI88654C (fi) * 1991-03-15 1993-06-10 Datacity Center Oy Fluorescenshoejningsmetod
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US6251581B1 (en) 1991-05-22 2001-06-26 Dade Behring Marburg Gmbh Assay method utilizing induced luminescence
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
DE69233146T2 (de) * 1991-05-22 2004-04-29 Dade Behring Marburg Gmbh Partikel, die eine Zusammensetzung beinhalten, die eine chemilumineszierende Verbindung umfassen
US5257970A (en) 1992-04-09 1993-11-02 Health Research, Inc. In situ photodynamic therapy
ATE162892T1 (de) 1992-07-31 1998-02-15 Behringwerke Ag Photoaktivierbare chemiluminizierende matrices
FR2707658B1 (fr) 1993-07-12 1995-11-24 Prolabo Sa Latex fluorescent comportant au moins deux fluorochromes, procédé d'obtention et application dudit latex comme marqueur, notamment en biologie.
ES2135597T3 (es) 1993-09-03 1999-11-01 Dade Behring Marburg Gmbh Inmunoensayos fluorescentes de canalizacion del oxigeno.

Also Published As

Publication number Publication date
US6180354B1 (en) 2001-01-30
US6916667B2 (en) 2005-07-12
EP0730738B1 (de) 2003-05-07
US20050214875A1 (en) 2005-09-29
CA2177143C (en) 2007-09-18
EP0730738A1 (de) 1996-09-11
US7229842B2 (en) 2007-06-12
US20020058280A1 (en) 2002-05-16
WO1995014928A1 (en) 1995-06-01
US5578498A (en) 1996-11-26
US6692975B2 (en) 2004-02-17
JPH09505888A (ja) 1997-06-10
EP1091211A1 (de) 2001-04-11
JP3426241B2 (ja) 2003-07-14
US5780646A (en) 1998-07-14
US5811311A (en) 1998-09-22
US20040121490A1 (en) 2004-06-24
US5536834A (en) 1996-07-16
CA2177143A1 (en) 1995-06-01
ATE239917T1 (de) 2003-05-15
US6340599B1 (en) 2002-01-22
DE69432640T2 (de) 2004-03-25

Similar Documents

Publication Publication Date Title
DE69432640D1 (de) Metall-chelat enthaltende zusammensetzungen zur verwendung in chemilumineszierenden assays
ATE244581T1 (de) Fibrindichtungsmittelzusammensetzungen und verfahren zu deren verwendung
CA2002101A1 (en) Electrochemiluminescent assays
AU667131B2 (en) Cyanoacrylate adhesives with cured thermal properties utilizing substituted aromatic additive
DE60231115D1 (de) Zusammensetzung zum reparieren von wänden mit geringer staubentwicklung
DK158995C (da) Blanding til bestemmelse af naervaerelsen af en forbindelse i en proeve samt teststrimmel impraegneret med blandingen
TR199902796T2 (xx) Toz deterjan bile�imleri.
EP0078703A3 (de) Markierte Pyroglu-L-Phe-L-Arg-Derivate, Substrate und Methoden zur Bestimmung von Kallikrein
AU573277B2 (en) Cyanoacrylate and silacrown compound adhesive composition
DE3382380D1 (de) Aktivierte 'aryl-beendete' fluoreszierende verbindungen und testverfahren und systeme in denen dieselben als fluorogenische ausgangsmaterialien verwendet werden.
DK506083D0 (da) Bismaleimidholdige termohaerdende materialer og polymere
KR850006202A (ko) 자기 피복 조성물 및 자기 기록 대체(磁氣被覆組成勿 및 磁氣記錄媒體)
DE69302719T2 (de) Kalibrator und Verwendung davon in einer Immuntest
JPS5712420A (en) Magnetic recording medium
KR880005584A (ko) 광학 기록 매체와 그 제조방법
JPS57177054A (en) Synthetic resin composition having improved durability of fluorescence
JP3140722B2 (ja) ブチルゴム粘着剤組成物及びそれを用いた粘着テープ又はシート
ES2073051T3 (es) Betunes modificados con polimeros conteniendo compuestos metalicos.
KR850002289A (ko) 다른 단백질 가수분해효소의 존재하에 카텝신 b의 검출방법 및 유용한 그 화합물
DK120087D0 (da) 2,3-naphthalendicarboxaldehyder til analysebrug
KR840002014A (ko) 조기경화억제제(prevulcanization inhibitors)
JPS5712414A (en) Magnetic recording medium
JPS5712417A (en) Magnetic recording medium
SU610821A1 (ru) В жущее
KR880010095A (ko) 형광체 조성물

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SIEMENS HEALTHCARE DIAGNOSTICS PRODUCTS GMBH, , DE