DE69432589D1 - Substrate für die übertragung von fluoreszenzenergie - Google Patents

Substrate für die übertragung von fluoreszenzenergie

Info

Publication number
DE69432589D1
DE69432589D1 DE69432589T DE69432589T DE69432589D1 DE 69432589 D1 DE69432589 D1 DE 69432589D1 DE 69432589 T DE69432589 T DE 69432589T DE 69432589 T DE69432589 T DE 69432589T DE 69432589 D1 DE69432589 D1 DE 69432589D1
Authority
DE
Germany
Prior art keywords
substrates
transfer
fluorescent energy
fluorescent
energy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69432589T
Other languages
English (en)
Other versions
DE69432589T2 (de
Inventor
Andrew John Garman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Q FUTURES LTD., CHESTER, CHESHIRE, GB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of DE69432589D1 publication Critical patent/DE69432589D1/de
Publication of DE69432589T2 publication Critical patent/DE69432589T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE69432589T 1993-05-27 1994-05-27 Substrate für die übertragung von fluoreszenzenergie Expired - Fee Related DE69432589T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9310978 1993-05-27
GB939310978A GB9310978D0 (en) 1993-05-27 1993-05-27 Compounds
PCT/GB1994/001153 WO1994028166A1 (en) 1993-05-27 1994-05-27 Fluorescence energy transfer substrates

Publications (2)

Publication Number Publication Date
DE69432589D1 true DE69432589D1 (de) 2003-06-05
DE69432589T2 DE69432589T2 (de) 2004-04-01

Family

ID=10736238

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432589T Expired - Fee Related DE69432589T2 (de) 1993-05-27 1994-05-27 Substrate für die übertragung von fluoreszenzenergie

Country Status (7)

Country Link
US (1) US6291201B1 (de)
EP (1) EP0700447B1 (de)
JP (1) JP3645566B2 (de)
AU (1) AU6801794A (de)
DE (1) DE69432589T2 (de)
GB (2) GB9310978D0 (de)
WO (1) WO1994028166A1 (de)

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US6028190A (en) 1994-02-01 2000-02-22 The Regents Of The University Of California Probes labeled with energy transfer coupled dyes
US5605809A (en) * 1994-10-28 1997-02-25 Oncoimmunin, Inc. Compositions for the detection of proteases in biological samples and methods of use thereof
US5777079A (en) * 1994-11-10 1998-07-07 The Regents Of The University Of California Modified green fluorescent proteins
US5625048A (en) 1994-11-10 1997-04-29 The Regents Of The University Of California Modified green fluorescent proteins
US5843658A (en) * 1995-03-10 1998-12-01 Hamamatsu Photonics K.K. Method of measuring oligonucleotide decomposing activity
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
EP1019528B1 (de) * 1996-01-04 2003-10-29 Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno Methode zur bestimmung von proteolytischen enzyme unter benutzung von fluoreszenzgelöschten substraten
ATE196652T1 (de) * 1996-01-18 2000-10-15 Aventis Pharma Gmbh In kunstlisches rekombinantes substrat ragg-1 und nativem aggrecan zum studium der proteolytischen wirkung von 'aggrecanase' in zellkultursystemen
US6803188B1 (en) * 1996-01-31 2004-10-12 The Regents Of The University Of California Tandem fluorescent protein constructs
US6900304B2 (en) 1996-01-31 2005-05-31 The Regents Of The University Of California Emission ratiometric indicators of phosphorylation
US5945526A (en) 1996-05-03 1999-08-31 Perkin-Elmer Corporation Energy transfer dyes with enhanced fluorescence
US7388092B2 (en) 1996-05-03 2008-06-17 Applera Corporation Oligonucleotides and analogs labeled with energy transfer dyes
US5925558A (en) * 1996-07-16 1999-07-20 The Regents Of The University Of California Assays for protein kinases using fluorescent protein substrates
US5912137A (en) 1996-07-16 1999-06-15 The Regents Of The University Of California Assays for protein kinases using fluorescent
US6124128A (en) * 1996-08-16 2000-09-26 The Regents Of The University Of California Long wavelength engineered fluorescent proteins
CA2266543C (en) * 1996-09-24 2003-12-09 Cadus Pharmaceutical Corporation Methods and compositions for identifying receptor effectors
US5998204A (en) * 1997-03-14 1999-12-07 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
US6197928B1 (en) 1997-03-14 2001-03-06 The Regents Of The University Of California Fluorescent protein sensors for detection of analytes
DE19717904A1 (de) * 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
WO1998050579A1 (en) * 1997-05-01 1998-11-12 Minnesota Mining And Manufacturing Company Fluorogenic protease substrates based on dye-dimerization
US6495664B1 (en) 1998-07-24 2002-12-17 Aurora Biosciences Corporation Fluorescent protein sensors of post-translational modifications
DE19840545A1 (de) * 1998-08-28 2000-03-09 Jerini Biotools Gmbh Festphasengebundene Peptide mit intramolekularem Fluoreszenz-Energie-Transfer zur Identifizierung von Substraten und Inhibitoren von Proteasen
US6410255B1 (en) 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US6358684B1 (en) 1999-08-27 2002-03-19 Pe Corporation UV excitable fluorescent energy transfer dyes
US20060040319A1 (en) * 2000-01-14 2006-02-23 Tom Muir Multiple sensor-containing active modified polypeptides, preparation and uses thereof
AU2001262906A1 (en) 2000-02-11 2001-08-20 Cellomics, Inc. Peptide biosensors for anthrax protease
JP3829252B2 (ja) 2001-06-08 2006-10-04 独立行政法人理化学研究所 蛍光蛋白質
ZA200402235B (en) * 2001-08-23 2005-08-29 Qtk Biosystems Llc Bio-sensing platforms for detection and quantitation of biological molecules.
US7208285B2 (en) * 2001-08-28 2007-04-24 Allergan, Inc. Fret protease assays for botulinum serotype A/E toxins
US7332567B2 (en) * 2001-08-28 2008-02-19 Allergan, Inc. Fret protease assays for clostridial toxins
AU2002363530A1 (en) * 2001-11-07 2003-05-19 Sensor Technologies Llc Method of identifying energy transfer sensors for analytes
GB0208989D0 (en) 2002-04-19 2002-05-29 Amersham Biosciences Uk Ltd Methods for measuring enzyme activity
CA2493993A1 (en) * 2002-08-01 2004-02-12 Sensor Technologies Llc Method of measuring molecular interactions
US20070020630A1 (en) 2003-03-27 2007-01-25 Trotta Christopher R Methods of identifying compounds that target trna splicing endonuclease and uses of said compounds as anti-proliferative agents
EP2363025A1 (de) 2003-03-27 2011-09-07 PTC Therapeutics, Inc. Betrachtung von Enzymen des TRNA-Splice-Wegs zur Identifikation von Antifungalen und/oder Proliferationshemmenden Molekülen
US20050095174A1 (en) * 2003-10-31 2005-05-05 Wolf David E. Semipermeable sensors for detecting analyte
AU2004305039A1 (en) * 2003-12-12 2005-07-07 Qtl Biosystems Llc Metal ion mediated fluorescence superquenching assays, kits and reagents
US8227621B2 (en) * 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
JP2009521666A (ja) * 2005-10-12 2009-06-04 アラーガン、インコーポレイテッド 共鳴エネルギー移動後の偏光解消（ｄａｒｅｔ）を用いる分子または細胞より小さい部分の相互作用力のアッセイ
US7858386B2 (en) * 2006-03-07 2010-12-28 The United States Of America As Represented By The Secretary Of The Navy Method of controlling quantum dot photoluminescence and other intrinsic properties through biological specificity
US20110098309A1 (en) * 2007-07-12 2011-04-28 Acumen Pharmaceuticals, Inc. Methods of inhibiting the formation of amyloid-beta diffusable ligands using acylhydrazide compounds
US9006283B2 (en) 2007-07-12 2015-04-14 Acumen Pharmaceuticals, Inc. Methods of modifying amyloid β oligomers using non-peptidic compounds
US8962677B2 (en) * 2007-07-12 2015-02-24 Acumen Pharmaceuticals, Inc. Methods of restoring cognitive ability using non-peptidic compounds
US9217024B2 (en) 2007-12-18 2015-12-22 Acumen Pharmaceuticals, Inc. ADDL receptor polypeptides, polynucleotides and host cells for recombinant production
WO2009117726A2 (en) * 2008-03-21 2009-09-24 The Regents Of The University Of California High-sensitive fluorescent energy transfer assay using fluorescent amino acids and fluoresent proteins
WO2011087789A2 (en) 2009-12-22 2011-07-21 Becton, Dickinson And Company Methods for the detection of microorganisms
WO2018112154A1 (en) * 2016-12-15 2018-06-21 Codiak Biosciences, Inc. Methods of measuring exosomes using intrinsic fluorescence
WO2019212946A1 (en) 2018-04-30 2019-11-07 Ribon Therapeutics Inc. Screening methods for parp modulators

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5173434A (en) * 1990-11-05 1992-12-22 Baxter Diagnostics Inc. Measurement of color reactions by monitoring a change of fluorescence
EP0428000A1 (de) * 1989-11-03 1991-05-22 Abbott Laboratories Fluorogene Substrate zum Nachweis von proteolytischer Enzymaktivität
WO1991009310A1 (en) 1989-12-12 1991-06-27 Lidak Pharmaceuticals Free fatty acid determination
US5011910A (en) 1989-12-28 1991-04-30 Washington University Reagent and method for determining activity of retroviral protease
DK93990D0 (da) 1990-04-17 1990-04-17 Carlsberg As Fluorogene peptider og deres anvendelse ved bestemmelse af enzymatisk aktivitet
DE69130171T2 (de) * 1990-07-02 1999-06-24 Univ California Bestimmung von analyten durch übertragung von fluoreszenzenergie

Also Published As

Publication number Publication date
GB9310978D0 (en) 1993-07-14
EP0700447A1 (de) 1996-03-13
WO1994028166A1 (en) 1994-12-08
GB9410737D0 (en) 1994-07-13
GB2278356A (en) 1994-11-30
DE69432589T2 (de) 2004-04-01
EP0700447B1 (de) 2003-05-02
JPH09504778A (ja) 1997-05-13
US6291201B1 (en) 2001-09-18
AU6801794A (en) 1994-12-20
JP3645566B2 (ja) 2005-05-11

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: Q FUTURES LTD., CHESTER, CHESHIRE, GB

8328 Change in the person/name/address of the agent

Representative=s name: JANNIG & REPKOW PATENTANWAELTE, 86199 AUGSBURG

8339 Ceased/non-payment of the annual fee