DE69432382D1 - N-Alkylacridancarboxylderivate, geeignet für die Detektion von Chemilumineszenz - Google Patents
N-Alkylacridancarboxylderivate, geeignet für die Detektion von ChemilumineszenzInfo
- Publication number
- DE69432382D1 DE69432382D1 DE69432382T DE69432382T DE69432382D1 DE 69432382 D1 DE69432382 D1 DE 69432382D1 DE 69432382 T DE69432382 T DE 69432382T DE 69432382 T DE69432382 T DE 69432382T DE 69432382 D1 DE69432382 D1 DE 69432382D1
- Authority
- DE
- Germany
- Prior art keywords
- chemiluminescence
- alkylacridancarboxylderivate
- detection
- compounds
- alkylacridan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
- C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/06—Oxygen atoms
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/81—Packaged device or kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61810 | 1987-06-15 | ||
US08/061,810 US5491072A (en) | 1993-05-17 | 1993-05-17 | N-alkylacridan carboxyl derivatives useful for chemiluminescent detection |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69432382D1 true DE69432382D1 (de) | 2003-05-08 |
DE69432382T2 DE69432382T2 (de) | 2004-02-12 |
Family
ID=22038290
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69432382T Expired - Lifetime DE69432382T2 (de) | 1993-05-17 | 1994-05-17 | N-Alkylacridancarboxylderivate, geeignet für die Detektion von Chemilumineszenz |
Country Status (8)
Country | Link |
---|---|
US (1) | US5491072A (de) |
EP (1) | EP0625510B1 (de) |
JP (1) | JP3231777B2 (de) |
AT (1) | ATE236128T1 (de) |
AU (1) | AU666814B2 (de) |
CA (1) | CA2123235C (de) |
DE (1) | DE69432382T2 (de) |
WO (1) | WO1994026927A1 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7122671B1 (en) * | 1979-07-19 | 2006-10-17 | University College Cardiff Consultants Limited | Luminescent labelling materials and procedures |
US6414152B1 (en) * | 1981-12-11 | 2002-07-02 | University Of Wales College Of Medicine Of Heath Park | Luminescent labelling material and procedures |
US5686258A (en) * | 1993-05-17 | 1997-11-11 | Lumigen, Inc. | Chemiluminescent detection of hydrolytic enzymes using an acridan |
US5593845A (en) * | 1993-05-17 | 1997-01-14 | Lumigen, Inc. | Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection |
US5723295A (en) * | 1993-05-17 | 1998-03-03 | Lumigen, Inc. | Methods, acridan compounds and kits for producing light |
CA2197669A1 (en) * | 1994-09-02 | 1996-03-14 | Hashem Akhavan-Tafti | Novel method and kits for producing light from an acridan compound |
US5843666A (en) * | 1994-09-02 | 1998-12-01 | Lumigen, Inc. | Chemiluminescent detection methods using dual enzyer-labeled binding partners |
US5731148A (en) * | 1995-06-07 | 1998-03-24 | Gen-Probe Incorporated | Adduct protection assay |
WO1997005287A1 (en) * | 1995-07-31 | 1997-02-13 | Charm Sciences, Inc. | Chemiluminescent method of monitoring products after heat treatment |
AU716233B2 (en) * | 1996-01-16 | 2000-02-24 | Lumigen, Inc. | Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes |
DE69711188T2 (de) * | 1996-07-16 | 2002-09-05 | Nederlanden Staat | Dibenzodihydropyridincarbonsäureester und ihre anwendung in chemolumineszenz-untersuchungsverfahren |
US5922558A (en) * | 1997-09-12 | 1999-07-13 | Lumigen, Inc. | Methods and compositions for generating chemiluminescence with a peroxidase |
WO1999014220A1 (en) * | 1997-09-12 | 1999-03-25 | Lumigen, Inc. | Novel compounds for generating chemiluminescence with a peroxidase |
CA2398812A1 (en) * | 2000-01-28 | 2001-08-02 | Brij Pal Giri | Novel stabilized formulations for chemiluminescent assays |
US7186568B1 (en) | 2000-06-26 | 2007-03-06 | Lumigen Inc. | Electrochemiluminescence from acridan compounds |
US6872828B2 (en) | 2001-12-20 | 2005-03-29 | Lumigen, Inc. | Compounds for generating chemiluminescence with a peroxidase |
DE60213986T2 (de) | 2001-06-01 | 2007-09-06 | Roche Diagnostics Gmbh | Neuen reagenzien in chemilumineszenz-nachweisverfahren |
US6723851B2 (en) * | 2001-10-31 | 2004-04-20 | Quest Diagnostics Investment Incorporated | Chemiluminescent compounds and use thereof |
AU2002352881B2 (en) | 2001-12-20 | 2008-11-06 | Lumigen, Inc. | Improved compounds for generating chemiluminescence with a peroxidase |
US6897036B2 (en) * | 2002-06-06 | 2005-05-24 | Lumigen, Inc. | Fluorescent detection of peroxidase enzymes |
US7390670B2 (en) | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
WO2006073424A2 (en) * | 2004-04-14 | 2006-07-13 | Giri Brij P | New ultra-sensitive chemiluminescent substrates for enzymes and their conjugates |
US7799534B2 (en) * | 2006-05-09 | 2010-09-21 | Beckman Coulter, Inc. | Nonseparation assay methods |
US7732153B2 (en) | 2006-05-09 | 2010-06-08 | Beckman Coulter, Inc. | Nonseparation assay methods |
US7906293B2 (en) * | 2007-04-09 | 2011-03-15 | Abbott Laboratories | Acridinium phenyl esters useful in the analysis of biological |
WO2009062027A1 (en) * | 2007-11-07 | 2009-05-14 | Beckman Coulter, Inc. | Nonseparation assay methods using peroxide generating enzymes |
JP5844643B2 (ja) | 2009-02-27 | 2016-01-20 | ベックマン コールター, インコーポレイテッド | 液相ホモジニアスアッセイ |
CA2753596A1 (en) * | 2009-02-27 | 2010-09-02 | Beckman Coulter, Inc. | Non separation assays with selective signal inhibitors |
JP5311662B2 (ja) * | 2009-08-24 | 2013-10-09 | キッコーマン株式会社 | ペルオキシダーゼ化学発光反応の発光増強方法及びペルオキシダーゼ化学発光反応用発光増強剤 |
US20110097723A1 (en) * | 2009-09-19 | 2011-04-28 | Qun Liu | Methods and reagents for analyte detection |
US11320424B2 (en) | 2018-07-13 | 2022-05-03 | 3M Innovative Properties Company | Specific binding chemiluminescent assay |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2510431A (en) * | 1946-11-02 | 1950-06-06 | Goodrich Co B F | Insecticidal composition comprising a dodecahydro acridane |
US2645594A (en) * | 1948-10-19 | 1953-07-14 | Abbott Lab | Antiseptic acridane compounds |
CH451144A (de) * | 1961-12-18 | 1968-05-15 | Siegfried Ag | Verfahren zur Herstellung von Salzen von 10-Aminoalkyl-5,5-dialkylacridanen |
US3917603A (en) * | 1970-05-13 | 1975-11-04 | Ciba Geigy Corp | Methyl(9-methyl-acaidan-9-yl)-ketones |
US3830919A (en) * | 1971-06-17 | 1974-08-20 | Colgate Palmolive Co | Antimicrobial haidressing |
US4094981A (en) * | 1976-03-26 | 1978-06-13 | Mead Johnson & Company | Smooth muscle relaxant employing 10-imidoylacridans |
US3962252A (en) * | 1973-02-28 | 1976-06-08 | Mead Johnson & Company | 10-imidoylacridans |
GB1461877A (en) * | 1974-02-12 | 1977-01-19 | Wellcome Found | Assay method utilizing chemiluminescence |
US4263398A (en) * | 1978-10-23 | 1981-04-21 | Morton-Norwich Products, Inc. | 9-(P-diethylaminophenyl)-9-chloro-10-phenylacridan agar medium |
GB2112779B (en) * | 1981-12-11 | 1986-10-15 | Welsh Nat School Med | Aryl acridinium esters as luminescent labelling materials |
US4687747A (en) * | 1984-07-02 | 1987-08-18 | Mallinckrodt, Inc. | Phenanthridinium ester as a labelling compound in luminometric immunoassay |
DE3645292C2 (de) * | 1986-08-22 | 1997-12-11 | Hoechst Ag | Chemilumineszenzimmunoassays und ein Verfahren zu ihrer Herstellung |
US4918192A (en) * | 1986-10-06 | 1990-04-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
US4745181A (en) * | 1986-10-06 | 1988-05-17 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
US5110932A (en) * | 1986-10-06 | 1992-05-05 | Ciba Corning Diagnostics Corp. | Polysubstituted aryl acridinium esters |
NZ227506A (en) * | 1987-12-31 | 1992-06-25 | London Diagnostics Inc | Specific binding assays using chemiluminescent compounds |
US5281712A (en) * | 1987-12-31 | 1994-01-25 | London Diagnostics, Inc. | Ammonium substituted chemiluminescent labels and their conjugates, and assays therefrom |
AU634716B2 (en) * | 1988-08-01 | 1993-03-04 | Ciba Corning Diagnostics Corp. | Method for detection of an analyte using acridinium esters and liposomes |
US5132204A (en) * | 1989-05-31 | 1992-07-21 | Chiron Corporation | Chemiluminescent double-triggered 1, 2-dioxetanes |
JPH0767394B2 (ja) * | 1991-03-20 | 1995-07-26 | 三洋化成工業株式会社 | 化学発光増強剤、化学発光利用検出・定量法及びキット |
-
1993
- 1993-05-17 US US08/061,810 patent/US5491072A/en not_active Expired - Lifetime
-
1994
- 1994-05-10 CA CA002123235A patent/CA2123235C/en not_active Expired - Fee Related
- 1994-05-12 AU AU63025/94A patent/AU666814B2/en not_active Ceased
- 1994-05-16 WO PCT/US1994/005437 patent/WO1994026927A1/en unknown
- 1994-05-16 JP JP52576694A patent/JP3231777B2/ja not_active Expired - Fee Related
- 1994-05-17 EP EP94107632A patent/EP0625510B1/de not_active Expired - Lifetime
- 1994-05-17 DE DE69432382T patent/DE69432382T2/de not_active Expired - Lifetime
- 1994-05-17 AT AT94107632T patent/ATE236128T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0625510A2 (de) | 1994-11-23 |
EP0625510A3 (de) | 1997-03-05 |
CA2123235A1 (en) | 1994-11-18 |
AU666814B2 (en) | 1996-02-22 |
JP3231777B2 (ja) | 2001-11-26 |
EP0625510B1 (de) | 2003-04-02 |
AU6302594A (en) | 1994-12-01 |
US5491072A (en) | 1996-02-13 |
CA2123235C (en) | 1999-09-21 |
DE69432382T2 (de) | 2004-02-12 |
WO1994026927A1 (en) | 1994-11-24 |
ATE236128T1 (de) | 2003-04-15 |
JPH08500125A (ja) | 1996-01-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |