ATE236128T1 - N-alkylacridancarboxylderivate, geeignet für die detektion von chemilumineszenz - Google Patents

N-alkylacridancarboxylderivate, geeignet für die detektion von chemilumineszenz

Info

Publication number
ATE236128T1
ATE236128T1 AT94107632T AT94107632T ATE236128T1 AT E236128 T1 ATE236128 T1 AT E236128T1 AT 94107632 T AT94107632 T AT 94107632T AT 94107632 T AT94107632 T AT 94107632T AT E236128 T1 ATE236128 T1 AT E236128T1
Authority
AT
Austria
Prior art keywords
chemiluminescence
alkylacridanecarboxyl
derivatives
detection
compounds
Prior art date
Application number
AT94107632T
Other languages
English (en)
Inventor
Hashem Akhavan-Tafti
Renuka Desilva
Katsuaki Sugioka
Original Assignee
Lumigen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lumigen Inc filed Critical Lumigen Inc
Application granted granted Critical
Publication of ATE236128T1 publication Critical patent/ATE236128T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/02—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with only hydrogen, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/06—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
AT94107632T 1993-05-17 1994-05-17 N-alkylacridancarboxylderivate, geeignet für die detektion von chemilumineszenz ATE236128T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/061,810 US5491072A (en) 1993-05-17 1993-05-17 N-alkylacridan carboxyl derivatives useful for chemiluminescent detection

Publications (1)

Publication Number Publication Date
ATE236128T1 true ATE236128T1 (de) 2003-04-15

Family

ID=22038290

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94107632T ATE236128T1 (de) 1993-05-17 1994-05-17 N-alkylacridancarboxylderivate, geeignet für die detektion von chemilumineszenz

Country Status (8)

Country Link
US (1) US5491072A (de)
EP (1) EP0625510B1 (de)
JP (1) JP3231777B2 (de)
AT (1) ATE236128T1 (de)
AU (1) AU666814B2 (de)
CA (1) CA2123235C (de)
DE (1) DE69432382T2 (de)
WO (1) WO1994026927A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6414152B1 (en) * 1981-12-11 2002-07-02 University Of Wales College Of Medicine Of Heath Park Luminescent labelling material and procedures
US7122671B1 (en) * 1979-07-19 2006-10-17 University College Cardiff Consultants Limited Luminescent labelling materials and procedures
US5686258A (en) * 1993-05-17 1997-11-11 Lumigen, Inc. Chemiluminescent detection of hydrolytic enzymes using an acridan
US5723295A (en) * 1993-05-17 1998-03-03 Lumigen, Inc. Methods, acridan compounds and kits for producing light
US5593845A (en) * 1993-05-17 1997-01-14 Lumigen, Inc. Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
DE69528661T2 (de) * 1994-09-02 2003-07-10 Lumigen, Inc. Verfahren und testsätze zur erzeugung von licht von einer acridan-verbindung
US5843666A (en) * 1994-09-02 1998-12-01 Lumigen, Inc. Chemiluminescent detection methods using dual enzyer-labeled binding partners
US5731148A (en) * 1995-06-07 1998-03-24 Gen-Probe Incorporated Adduct protection assay
WO1997005287A1 (en) * 1995-07-31 1997-02-13 Charm Sciences, Inc. Chemiluminescent method of monitoring products after heat treatment
CN1173954C (zh) * 1996-01-16 2004-11-03 鲁米根公司 与磷酸酶反应产生化学发光的化合物、组合物和方法
PT915851E (pt) * 1996-07-16 2002-09-30 Staat Nl Verteg Door Min Welzi Esteres dibenzodihidropiridinecarboxilicos e seu uso no ensaio dos metodos quimiluminiscente
AU9102398A (en) * 1997-09-12 1999-04-05 Lumigen, Inc. Novel compounds for generating chemiluminescence with a peroxidase
US5922558A (en) * 1997-09-12 1999-07-13 Lumigen, Inc. Methods and compositions for generating chemiluminescence with a peroxidase
EP1254252A4 (de) * 2000-01-28 2006-06-07 Brij P Giri Stabilisierte formeln für chemilumineszente assays
US7186568B1 (en) 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
WO2003053934A1 (en) 2001-12-20 2003-07-03 Lumigen, Inc. Improved compounds for generating chemiluminescence with a peroxidase
US6872828B2 (en) 2001-12-20 2005-03-29 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
JP2004535423A (ja) 2001-06-01 2004-11-25 エフ．ホフマン−ラ　ロシュ　アーゲー 化学発光手順のための新規化合物
US6723851B2 (en) * 2001-10-31 2004-04-20 Quest Diagnostics Investment Incorporated Chemiluminescent compounds and use thereof
US6897036B2 (en) * 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US7781229B2 (en) * 2004-04-14 2010-08-24 Michigan Diagnostics, Llc Ultra-sensitive chemiluminescent substrates for enzymes and their conjugates
US7799534B2 (en) 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7906293B2 (en) * 2007-04-09 2011-03-15 Abbott Laboratories Acridinium phenyl esters useful in the analysis of biological
US20100240070A1 (en) * 2007-11-07 2010-09-23 Beckman Coulter, Inc. Nonseparation Assay Methods Using Peroxide Generating Enzymes
ES2622977T3 (es) * 2009-02-27 2017-07-10 Beckman Coulter, Inc. Ensayos homogéneos con fase de disolución
AU2010217839A1 (en) * 2009-02-27 2011-09-15 Beckman Coulter, Inc. Non separation assays with selective signal inhibitors
JP5311662B2 (ja) * 2009-08-24 2013-10-09 キッコーマン株式会社 ペルオキシダーゼ化学発光反応の発光増強方法及びペルオキシダーゼ化学発光反応用発光増強剤
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
CN112400113B (zh) 2018-07-13 2022-04-15 3M创新有限公司 特异性结合化学发光测定法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2510431A (en) * 1946-11-02 1950-06-06 Goodrich Co B F Insecticidal composition comprising a dodecahydro acridane
US2645594A (en) * 1948-10-19 1953-07-14 Abbott Lab Antiseptic acridane compounds
CH451144A (de) * 1961-12-18 1968-05-15 Siegfried Ag Verfahren zur Herstellung von Salzen von 10-Aminoalkyl-5,5-dialkylacridanen
US3917603A (en) * 1970-05-13 1975-11-04 Ciba Geigy Corp Methyl(9-methyl-acaidan-9-yl)-ketones
US3830919A (en) * 1971-06-17 1974-08-20 Colgate Palmolive Co Antimicrobial haidressing
US3962252A (en) * 1973-02-28 1976-06-08 Mead Johnson & Company 10-imidoylacridans
US4094981A (en) * 1976-03-26 1978-06-13 Mead Johnson & Company Smooth muscle relaxant employing 10-imidoylacridans
GB1461877A (en) * 1974-02-12 1977-01-19 Wellcome Found Assay method utilizing chemiluminescence
US4263398A (en) * 1978-10-23 1981-04-21 Morton-Norwich Products, Inc. 9-(P-diethylaminophenyl)-9-chloro-10-phenylacridan agar medium
GB2112779B (en) * 1981-12-11 1986-10-15 Welsh Nat School Med Aryl acridinium esters as luminescent labelling materials
US4687747A (en) * 1984-07-02 1987-08-18 Mallinckrodt, Inc. Phenanthridinium ester as a labelling compound in luminometric immunoassay
DE3628573C2 (de) * 1986-08-22 1994-10-13 Hoechst Ag Chemilumineszierende Acridinderivate, Verfahren zu deren Herstellung und ihre Verwendung in Lumineszenzimmunoassays
US4918192A (en) * 1986-10-06 1990-04-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5110932A (en) * 1986-10-06 1992-05-05 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US4745181A (en) * 1986-10-06 1988-05-17 Ciba Corning Diagnostics Corp. Polysubstituted aryl acridinium esters
US5284951A (en) * 1987-12-31 1994-02-08 London Diagnostics, Inc. Hydrolytically stable chemiluminescent labels and their conjugates, and assays therefrom
NZ227506A (en) * 1987-12-31 1992-06-25 London Diagnostics Inc Specific binding assays using chemiluminescent compounds
AU634716B2 (en) * 1988-08-01 1993-03-04 Ciba Corning Diagnostics Corp. Method for detection of an analyte using acridinium esters and liposomes
US5132204A (en) * 1989-05-31 1992-07-21 Chiron Corporation Chemiluminescent double-triggered 1, 2-dioxetanes
JPH0767394B2 (ja) * 1991-03-20 1995-07-26 三洋化成工業株式会社 化学発光増強剤、化学発光利用検出・定量法及びキット

Also Published As

Publication number Publication date
JP3231777B2 (ja) 2001-11-26
EP0625510B1 (de) 2003-04-02
JPH08500125A (ja) 1996-01-09
AU666814B2 (en) 1996-02-22
EP0625510A3 (de) 1997-03-05
WO1994026927A1 (en) 1994-11-24
AU6302594A (en) 1994-12-01
US5491072A (en) 1996-02-13
EP0625510A2 (de) 1994-11-23
DE69432382T2 (de) 2004-02-12
DE69432382D1 (de) 2003-05-08
CA2123235A1 (en) 1994-11-18
CA2123235C (en) 1999-09-21

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