DE69432300D1 - Biologische klebstoffzusammensetzung und verfahren zum fördern der haftung zwischen flächengewebe - Google Patents

Biologische klebstoffzusammensetzung und verfahren zum fördern der haftung zwischen flächengewebe

Info

Publication number
DE69432300D1
DE69432300D1 DE69432300T DE69432300T DE69432300D1 DE 69432300 D1 DE69432300 D1 DE 69432300D1 DE 69432300 T DE69432300 T DE 69432300T DE 69432300 T DE69432300 T DE 69432300T DE 69432300 D1 DE69432300 D1 DE 69432300D1
Authority
DE
Germany
Prior art keywords
adhesive composition
tissue
biological adhesive
liability
promoting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69432300T
Other languages
English (en)
Other versions
DE69432300T2 (de
Inventor
Dr Juergensen
Daniel Aeschlimann
B Hunziker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Orthogene Inc
Original Assignee
Orthogene Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orthogene Inc filed Critical Orthogene Inc
Application granted granted Critical
Publication of DE69432300D1 publication Critical patent/DE69432300D1/de
Publication of DE69432300T2 publication Critical patent/DE69432300T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/104—Aminoacyltransferases (2.3.2)
    • C12N9/1044—Protein-glutamine gamma-glutamyltransferase (2.3.2.13), i.e. transglutaminase or factor XIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/10—Polypeptides; Proteins
    • A61L24/106—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A61L2300/254—Enzymes, proenzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/834—Urine; urinary system
    • Y10S530/835—Kidney
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/84—Bones; tendons; teeth; cartilage
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/841—Muscles; heart
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/842—Skin; hair; nails; sebaceous glands; cerumen
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/843—Digestive system
    • Y10S530/846—Liver
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/85—Reproductive organs or embryos

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Adhesives Or Adhesive Processes (AREA)
DE69432300T 1993-06-03 1994-06-03 Biologische klebstoffzusammensetzung und verfahren zum fördern der haftung zwischen flächengewebe Expired - Fee Related DE69432300T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71528 1979-08-31
US08/071,528 US5549904A (en) 1993-06-03 1993-06-03 Biological adhesive composition and method of promoting adhesion between tissue surfaces
PCT/US1994/006208 WO1994028949A1 (en) 1993-06-03 1994-06-03 Biological adhesive composition and method of promoting adhesion between tissue surfaces

Publications (2)

Publication Number Publication Date
DE69432300D1 true DE69432300D1 (de) 2003-04-24
DE69432300T2 DE69432300T2 (de) 2004-02-12

Family

ID=22101910

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432300T Expired - Fee Related DE69432300T2 (de) 1993-06-03 1994-06-03 Biologische klebstoffzusammensetzung und verfahren zum fördern der haftung zwischen flächengewebe

Country Status (10)

Country Link
US (2) US5549904A (de)
EP (1) EP0702572B1 (de)
JP (1) JP3483255B2 (de)
AT (1) ATE234643T1 (de)
AU (2) AU7051194A (de)
CA (1) CA2163250A1 (de)
DE (1) DE69432300T2 (de)
ES (1) ES2194869T3 (de)
TW (1) TW404836B (de)
WO (1) WO1994028949A1 (de)

Families Citing this family (115)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5936035A (en) * 1988-11-21 1999-08-10 Cohesion Technologies, Inc. Biocompatible adhesive compositions
US7189410B1 (en) * 1990-11-27 2007-03-13 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6054122A (en) 1990-11-27 2000-04-25 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
US6117425A (en) 1990-11-27 2000-09-12 The American National Red Cross Supplemented and unsupplemented tissue sealants, method of their production and use
US6197325B1 (en) 1990-11-27 2001-03-06 The American National Red Cross Supplemented and unsupplemented tissue sealants, methods of their production and use
JPH07328108A (ja) * 1994-06-10 1995-12-19 Ajinomoto Co Inc 生体組織接着剤及び血液凝固剤
WO1996010089A1 (fr) * 1994-09-29 1996-04-04 Ajinomoto Co., Inc. Modification d'un peptide et d'une proteine
US6833408B2 (en) * 1995-12-18 2004-12-21 Cohesion Technologies, Inc. Methods for tissue repair using adhesive materials
US7883693B2 (en) 1995-12-18 2011-02-08 Angiodevice International Gmbh Compositions and systems for forming crosslinked biomaterials and methods of preparation of use
PT876165E (pt) * 1995-12-18 2006-10-31 Angiotech Biomaterials Corp Composicoes de polimeros reticulados e processos para a sua utilizacao
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
CA2300194A1 (en) * 1997-08-15 1999-02-25 Children's Medical Center Corporation Osteopontin coated surfaces and methods of use
US6114119A (en) * 1997-08-29 2000-09-05 Wisconsin Alumni Research Foundation Transglutaminase and gene encoding same
JP2001521786A (ja) * 1997-10-30 2001-11-13 ザ ジュネラル ホスピタル コーポレーション 単離軟骨細胞を使用した軟骨性基質の接着
US20030099620A1 (en) * 1997-10-30 2003-05-29 The General Hospital Corporation Bonding of cartilaginous matrices using isolated chondrocytes
US6190896B1 (en) 1997-11-14 2001-02-20 Bassam M. Fraij Active human cellular transglutaminase
EP1066051A4 (de) * 1998-03-26 2002-05-02 Gen Hospital Corp Sciellin und seine verwendungen
US20020022588A1 (en) * 1998-06-23 2002-02-21 James Wilkie Methods and compositions for sealing tissue leaks
US6190815B1 (en) * 1998-08-11 2001-02-20 Xerox Corporation Toner compositions
US7241730B2 (en) * 1998-08-27 2007-07-10 Universitat Zurich Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides
US6197061B1 (en) 1999-03-01 2001-03-06 Koichi Masuda In vitro production of transplantable cartilage tissue cohesive cartilage produced thereby, and method for the surgical repair of cartilage damage
US6463335B1 (en) 1999-10-04 2002-10-08 Medtronic, Inc. Temporary medical electrical lead having electrode mounting pad with biodegradable adhesive
WO2001054748A1 (en) 2000-01-25 2001-08-02 Edwards Lifesciences Corporation Delivery systems for treatment of restenosis and anastomotic intimal hyperplasia
GB0011356D0 (en) * 2000-05-12 2000-06-28 Univ Nottingham Trent Medical implant materials
US6685626B2 (en) 2001-02-02 2004-02-03 Regeneration Technologies, Inc. Compositions, devices, methods, and kits for induction of adhesions
US20060094112A1 (en) * 2001-03-07 2006-05-04 Omotunde Babalola Biological scaffold
ATE502660T1 (de) * 2001-07-16 2011-04-15 Depuy Products Inc Poröses freisetzungsgerüst und verfahren
US7858679B2 (en) * 2001-07-20 2010-12-28 Northwestern University Polymeric compositions and related methods of use
US8815793B2 (en) * 2001-07-20 2014-08-26 Northwestern University Polymeric compositions and related methods of use
US7618937B2 (en) * 2001-07-20 2009-11-17 Northwestern University Peptidomimetic polymers for antifouling surfaces
CA2460539C (en) * 2001-09-15 2013-10-29 Rush-Presbyterian-St. Luke's Medical Center Stratified cartilage tissue and methods to engineer same
US20030165473A1 (en) * 2001-11-09 2003-09-04 Rush-Presbyterian-St. Luke's Medical Center Engineered intervertebral disc tissue
ES2223227B1 (es) * 2002-05-31 2006-04-16 Consejo Sup. Investig. Cientificas Secuencia de nucleotidos de maiz codificante de una proteina con actividad transglutaminasa, y su uso.
US8911831B2 (en) * 2002-07-19 2014-12-16 Northwestern University Surface independent, surface-modifying, multifunctional coatings and applications thereof
US20080171012A1 (en) * 2007-01-11 2008-07-17 Phillip Messersmith Fouling Resistant Coatings and Methods of Making Same
US7163545B2 (en) * 2002-07-29 2007-01-16 Mayo Foundation For Medical Education And Research Spinal cord surgical implant
US7208171B2 (en) * 2002-10-31 2007-04-24 Northwestern University Injectable and bioadhesive polymeric hydrogels as well as related methods of enzymatic preparation
DE60331367D1 (de) * 2002-12-30 2010-04-01 Angiotech Int Ag Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung
WO2004060405A2 (en) * 2002-12-30 2004-07-22 Angiotech International Ag Tissue reactive compounds and compositions and uses thereof
JP2004283371A (ja) * 2003-03-20 2004-10-14 Nagoya Industrial Science Research Inst 医用材料
US7067123B2 (en) 2003-04-29 2006-06-27 Musculoskeletal Transplant Foundation Glue for cartilage repair
US7901457B2 (en) 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
WO2005046528A1 (en) 2003-10-06 2005-05-26 3F Therapeutics, Inc. Minimally invasive valve replacement system
US20050075730A1 (en) 2003-10-06 2005-04-07 Myers Keith E. Minimally invasive valve replacement system
EP2335650B1 (de) 2003-12-11 2012-10-03 Isto Technologies Inc. Teilchenförmiges Knorpelsystem
KR101148445B1 (ko) 2004-04-28 2012-07-05 안지오디바이스 인터내셔널 게엠베하 가교된 생합성물질을 형성하기 위한 조성물 및 시스템, 및 이와 관련된 제조 및 사용 방법
US7670282B2 (en) 2004-06-14 2010-03-02 Pneumrx, Inc. Lung access device
US20050281798A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting sites of damaged lung tissue using composition
WO2006009688A2 (en) * 2004-06-16 2006-01-26 Pneumrx, Inc. Intra-bronchial lung volume reduction system
US7468350B2 (en) 2004-06-16 2008-12-23 Pneumrx, Inc. Glue composition for lung volume reduction
US20050281739A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue using compositions
US7608579B2 (en) * 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
US7553810B2 (en) * 2004-06-16 2009-06-30 Pneumrx, Inc. Lung volume reduction using glue composition
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US20050281740A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue
US20050288796A1 (en) * 2004-06-23 2005-12-29 Hani Awad Native soft tissue matrix for therapeutic applications
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
CA2570261C (en) 2004-07-08 2014-06-10 Pneumrx, Inc. Pleural effusion treatment device, method and material
EP1796602A4 (de) 2004-09-17 2016-10-19 Angiotech Pharm Inc Multifunktionelle verbindungen zur erzeugung vernetzter biomaterialien sowie herstellungs- und verwendungsverfahren dafür
US7837740B2 (en) 2007-01-24 2010-11-23 Musculoskeletal Transplant Foundation Two piece cancellous construct for cartilage repair
US20060111778A1 (en) * 2004-10-29 2006-05-25 Michalow Alexander E Methods of promoting healing of cartilage defects and method of causing stem cells to differentiate by the articular chondrocyte pathway
WO2006058195A2 (en) 2004-11-23 2006-06-01 Pneumrx, Inc. Steerable device for accessing a target site and methods
US7815926B2 (en) * 2005-07-11 2010-10-19 Musculoskeletal Transplant Foundation Implant for articular cartilage repair
US8480757B2 (en) 2005-08-26 2013-07-09 Zimmer, Inc. Implants and methods for repair, replacement and treatment of disease
EP1926459B1 (de) 2005-09-19 2015-01-07 Histogenics Corporation Zellunterstützende matrix mit eng definierter, gleichmässig senkrecht und nicht zufällig organisierter porosität und porendichte und verfahren zur herstellung davon
US7732539B2 (en) * 2006-02-16 2010-06-08 National Science Foundation Modified acrylic block copolymers for hydrogels and pressure sensitive wet adhesives
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
WO2007137653A1 (en) * 2006-05-26 2007-12-06 Baxter International Inc. Injectable fibrin composition for bone augmentation
JP5315233B2 (ja) * 2006-05-26 2013-10-16 バクスター・インターナショナル・インコーポレイテッド 注入可能な骨空隙充填剤
DE102006033167A1 (de) * 2006-07-10 2008-01-24 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung eines vernetzenden medizinischen Klebers
DE102006033168A1 (de) 2006-07-10 2008-01-17 Gelita Ag Verwendung von Gelatine und einem Vernetzungsmittel zur Herstellung einer vernetzenden therapeutischen Zusammensetzung
EP2064251B1 (de) 2006-08-04 2017-10-25 Kensey Nash Corporation Biomimetische verbindungen und syntheseverfahren dafür
WO2008091386A2 (en) * 2006-08-04 2008-07-31 Northwestern University Biomimetic modular adhesive complex: material, methods and applications therefore
US20100297218A1 (en) * 2006-09-20 2010-11-25 Pneumrx, Inc. Tissue adhesive compositions and methods thereof
DK176786B1 (da) * 2006-12-08 2009-08-24 Dat Schaub A M B A A process for joining of pieces of natural casing
US7935363B2 (en) 2006-12-12 2011-05-03 Synthasome, Inc. Composite material for tissue repair
BRPI0718328A2 (pt) 2006-12-15 2011-10-11 Lifebond Ltd composição, curativo hemostático e dispositivo médico para a inserção em um corpo de um ser humano ou de um mamìfero inferior
US8133484B2 (en) * 2006-12-15 2012-03-13 Lifebond Ltd Hemostatic materials and dressing
US8163549B2 (en) 2006-12-20 2012-04-24 Zimmer Orthobiologics, Inc. Method of obtaining viable small tissue particles and use for tissue repair
US20080154233A1 (en) * 2006-12-20 2008-06-26 Zimmer Orthobiologics, Inc. Apparatus for delivering a biocompatible material to a surgical site and method of using same
US8383092B2 (en) * 2007-02-16 2013-02-26 Knc Ner Acquisition Sub, Inc. Bioadhesive constructs
US8673286B2 (en) 2007-04-09 2014-03-18 Northwestern University DOPA-functionalized, branched, poly(aklylene oxide) adhesives
US10278947B2 (en) 2007-02-28 2019-05-07 Orthopeutics, L.P. Crosslinker enhanced repair of connective tissues
US8435551B2 (en) 2007-03-06 2013-05-07 Musculoskeletal Transplant Foundation Cancellous construct with support ring for repair of osteochondral defects
AU2008240191B2 (en) 2007-04-12 2013-09-19 Zimmer, Inc. Compositions and methods for tissue repair
EP2142224B1 (de) 2007-04-23 2016-03-23 Baxter International Inc. Fibrinzusammensetzungen mit strontiumverbindungen
CA2717725A1 (en) 2008-03-05 2009-09-11 Musculoskeletal Transplant Foundation Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles
US20110112573A1 (en) * 2008-06-18 2011-05-12 Orahn Preiss Bloom Methods and devices for use with sealants
EP2543394A1 (de) * 2008-06-18 2013-01-09 Lifebond Ltd Verfahren zur enzymatischen Vernetzung eines Proteins
AU2009261559B2 (en) 2008-06-18 2014-01-16 Lifebond Ltd Improved cross-linked compositions
US9173669B2 (en) 2008-09-12 2015-11-03 Pneumrx, Inc. Enhanced efficacy lung volume reduction devices, methods, and systems
WO2010083051A2 (en) * 2009-01-15 2010-07-22 ProChon Biotech, Ltd. Cartilage particle tissue mixtures optionally combined with a cancellous construct
WO2010135352A1 (en) 2009-05-18 2010-11-25 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
US9597430B2 (en) * 2009-07-31 2017-03-21 Synthasome, Inc. Synthetic structure for soft tissue repair
US20110130465A1 (en) * 2009-12-01 2011-06-02 Nerites Corporation Coatings for prevention of biofilms
DK2515957T3 (en) 2009-12-22 2015-11-09 Lifebond Ltd CHANGE OF ENZYMATIC CIRCULATORS FOR MANAGEMENT OF CHARACTERISTICS BY CIRCUIT MATRIX
US9163212B2 (en) 2010-01-25 2015-10-20 Warsaw Orthopedic, Inc. Osteogenic cell delivery matrix
ES2567174T3 (es) 2010-08-05 2016-04-20 Lifebond Ltd Composición seca en apósitos y adhesivos para heridas
US9549760B2 (en) * 2010-10-29 2017-01-24 Kyphon Sarl Reduced extravasation of bone cement
EP2637707A4 (de) 2010-11-09 2014-10-01 Kensey Nash Corp Haftverbindungen und anwendungsverfahren für herniereparatur
EP2765925A1 (de) * 2011-10-11 2014-08-20 Zimmer Knee Creations, Inc. Verfahren und instrumente zur subchondralen behandlung von osteoarthritis bei kleinen gelenken
US8999376B2 (en) 2012-02-03 2015-04-07 Xcede Technologies, Inc. Tissue patch
US20140178343A1 (en) 2012-12-21 2014-06-26 Jian Q. Yao Supports and methods for promoting integration of cartilage tissue explants
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
US10077420B2 (en) 2014-12-02 2018-09-18 Histogenics Corporation Cell and tissue culture container
US9833538B2 (en) 2015-08-07 2017-12-05 Xcede Technologies, Inc. Adhesive compositions and related methods
US9540548B1 (en) 2015-08-07 2017-01-10 Xcede Technologies, Inc. Adhesive compositions and related methods
WO2017027378A1 (en) 2015-08-07 2017-02-16 Xcede Technologies, Inc. Adhesive compositions and related methods
WO2017223462A1 (en) * 2016-06-24 2017-12-28 President And Fellows Of Harvard College Composition and method for adhering biomaterials to a target surface
CA3051245A1 (en) 2017-01-30 2018-08-02 Lifecell Corporation Tissue matrix materials and enzymatic adhesives
EP3573673B1 (de) * 2017-01-30 2021-08-18 LifeCell Corporation Gewebezusammensetzung umfassend muskelmatrix und verhafren zu ihrer herstellung
WO2018140853A1 (en) 2017-01-30 2018-08-02 Lifecell Corporation Transglutaminase treated products
US11998654B2 (en) 2018-07-12 2024-06-04 Bard Shannon Limited Securing implants and medical devices

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2949407A1 (de) * 1979-12-07 1981-06-11 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gewinnung von (alpha) -2-sb-glykoprotein
DE3113986A1 (de) * 1981-04-07 1982-10-21 Robert Bosch Gmbh, 7000 Stuttgart Vorrichtung zur regelung der leerlaufdrehzahl einer brennkraftmaschine
US4582794A (en) * 1982-09-15 1986-04-15 The University Of Arizona Foundation Method of determining polyamine content of biological fluids
US4728643A (en) * 1984-11-02 1988-03-01 The General Hospital Corporation Method of treating psoriasis
US5037816A (en) * 1984-11-02 1991-08-06 The General Hospital Corporation Method of treating psoriasis
AU2423988A (en) * 1987-08-17 1989-03-09 Liposome Company, Inc., The A sponge enzyme having transglutaminase-like activity
US4968713A (en) * 1989-07-31 1990-11-06 Merck & Co., Inc. Certain imidazole compounds as transglutaminase inhibitors
WO1992012238A1 (en) * 1991-01-04 1992-07-23 The Board Of Regents, University Of Texas System Cloning and expression of tissue transglutaminases
US5206023A (en) * 1991-01-31 1993-04-27 Robert F. Shaw Method and compositions for the treatment and repair of defects or lesions in cartilage
US5270300A (en) * 1991-09-06 1993-12-14 Robert Francis Shaw Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone

Also Published As

Publication number Publication date
US5736132A (en) 1998-04-07
ES2194869T3 (es) 2003-12-01
EP0702572B1 (de) 2003-03-19
EP0702572A1 (de) 1996-03-27
ATE234643T1 (de) 2003-04-15
WO1994028949A1 (en) 1994-12-22
AU7051194A (en) 1995-01-03
DE69432300T2 (de) 2004-02-12
TW404836B (en) 2000-09-11
AU8305598A (en) 1999-04-29
JP3483255B2 (ja) 2004-01-06
US5549904A (en) 1996-08-27
JPH08510943A (ja) 1996-11-19
CA2163250A1 (en) 1994-12-22

Similar Documents

Publication Publication Date Title
DE69432300D1 (de) Biologische klebstoffzusammensetzung und verfahren zum fördern der haftung zwischen flächengewebe
ATE153389T1 (de) Zusammensetzung und verfahren zur behandlung von phosphatierten metalloberflächen
CA2130114A1 (en) Method of Treating Nonferrous Metal Surfaces by Means of an Acid Activating Agent and an Organophosphate or Organophosphonate and Substrates Treated by Such Method
ATE242647T1 (de) Verfahren zur immobilisierung von mediatormolekülen auf anorganischen und metallischen implantatmaterialien
ATE299396T1 (de) Verfahren zur verbesserung der aktivität von katalysatoren
DE69736981D1 (de) In vitro verfahren zum einbringen von nukleinsäuren in eine zelle
ATE5898T1 (de) Verfahren zur enzymatischen glucoseoxidation.
ATE282097T1 (de) Zusammensetzung und verfahren zur behandlung von konversions-beschichteten metalloberflächen
ATE283900T1 (de) Verfahren zur behandlung von metallen mit einer mischung von ureido-silanen und multisilylierten funktionellen silanen
DE69012861D1 (de) Biologische Behandlung einer artifiziellen Oberfläche.
FI904521A0 (fi) Komposition foer inducering av sammanbindning.
DK0620722T3 (da) Fremgangsmåde til klæbning til hårdt væv
DE68923680D1 (de) Oberflächenbehandlung zur Verbesserung des Haftvermögens von Anstrichen an Polydicyclopentadienen.
DE3581650D1 (de) Derivat von p-aminophenol mit mucrosekretolytischer fluessiger und antipyretischer wirksamkeit, dessen verfahren zur herstellung und dessen pharmazeutische zusammensetzungen.
ATE324474T1 (de) Verfahren zur verbesserung des haftens von primern auf substraten
TR199802706T2 (xx) Bir bitki hastal���n�n iyile�tirilmesi i�in y�ntem.
ATE335551T1 (de) Verfahren zur funktionalisierung fester oberflächen
ATA137793A (de) Verfahren zur oberflächenbehandlung von zu beschichtenden werkstücken
DE68904578D1 (de) Enzym zur alpha-amidierung von c-termini und verfahren zu dessen herstellung.
ATE91711T1 (de) Verfahren zur enzymatischen hydrolyse von alpha- aminoadipinyl-monoaminoverbindungen.
JPS6485141A (en) Manufacture of catalyst with surface layer of noble metal carried by silica
DE69704885T2 (de) Zusammensetzung und Verfahren zur Leimung von flächigen Strukturen
ATE39117T1 (de) Verfahren und zwischenprodukte fuer sorbinil.
SE8601421D0 (sv) Haarbehandlungsmittel und verfahren zur kosmetischen behandlung von haaren und haarboden
ATE206009T1 (de) Verfahren sowie wirkstoff zur verhinderung von mikrobiellem wachstum an oberflächen sowie masse zur oberflächenbeschichtung oder -veredelung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee