DE69431919T2 - 2-(pyrazol-3-yl)carbapenemderivate - Google Patents

2-(pyrazol-3-yl)carbapenemderivate

Info

Publication number
DE69431919T2
DE69431919T2 DE69431919T DE69431919T DE69431919T2 DE 69431919 T2 DE69431919 T2 DE 69431919T2 DE 69431919 T DE69431919 T DE 69431919T DE 69431919 T DE69431919 T DE 69431919T DE 69431919 T2 DE69431919 T2 DE 69431919T2
Authority
DE
Germany
Prior art keywords
pyrazol
carbapenem derivatives
carbapenem
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69431919T
Other languages
English (en)
Other versions
DE69431919D1 (de
Inventor
Steven Coulton
Jeremy David Hinks
Eric Hunt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
SmithKline Beecham Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939322284A external-priority patent/GB9322284D0/en
Priority claimed from GB9410929A external-priority patent/GB9410929D0/en
Application filed by SmithKline Beecham Ltd filed Critical SmithKline Beecham Ltd
Publication of DE69431919D1 publication Critical patent/DE69431919D1/de
Application granted granted Critical
Publication of DE69431919T2 publication Critical patent/DE69431919T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69431919T 1993-10-29 1994-10-25 2-(pyrazol-3-yl)carbapenemderivate Expired - Fee Related DE69431919T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939322284A GB9322284D0 (en) 1993-10-29 1993-10-29 Novel compounds
GB9410929A GB9410929D0 (en) 1994-06-01 1994-06-01 Novel compounds
PCT/GB1994/002347 WO1995011905A1 (en) 1993-10-29 1994-10-25 2-(pyrazol-3-yl)carbapenem derivatives

Publications (2)

Publication Number Publication Date
DE69431919D1 DE69431919D1 (de) 2003-01-30
DE69431919T2 true DE69431919T2 (de) 2003-11-13

Family

ID=26303758

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431919T Expired - Fee Related DE69431919T2 (de) 1993-10-29 1994-10-25 2-(pyrazol-3-yl)carbapenemderivate

Country Status (22)

Country Link
US (1) US5612477A (de)
EP (1) EP0725783B1 (de)
JP (1) JP3703146B2 (de)
KR (1) KR960705827A (de)
CN (1) CN1167486A (de)
AP (1) AP9600800A0 (de)
AT (1) ATE229957T1 (de)
AU (1) AU697108B2 (de)
BG (1) BG100551A (de)
BR (1) BR9407889A (de)
CA (1) CA2175054C (de)
CZ (1) CZ122996A3 (de)
DE (1) DE69431919T2 (de)
ES (1) ES2188621T3 (de)
FI (1) FI961817A (de)
HU (1) HUT75519A (de)
NO (1) NO961654L (de)
NZ (1) NZ274878A (de)
OA (1) OA10287A (de)
PL (1) PL314173A1 (de)
SK (1) SK53696A3 (de)
WO (1) WO1995011905A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020147333A1 (en) 1993-10-29 2002-10-10 Smithkline Beecham P.L.C. 2-(pyrazol-3-yl)carbapenem derivatives
WO1996034869A1 (en) * 1995-05-03 1996-11-07 Smithkline Beecham Plc Esters of carbapenems
EP0785937A1 (de) * 1994-10-14 1997-07-30 Smithkline Beecham Plc 2-(imidazol-4-yl)carbapenemderivate, ihre zwischenprodukte und verwendung als antibakterielle mittel
IL118092A0 (en) * 1995-05-03 1996-09-12 Smithkline Beecham Plc Antibacterial compounds their preparation and pharmaceutical compositions containing them
GB0400329D0 (en) * 2004-01-08 2004-02-11 Glaxo Group Ltd Novel processes
GB0400405D0 (en) * 2004-01-09 2004-02-11 Glaxo Group Ltd Novel processes
JP2007039383A (ja) * 2005-08-03 2007-02-15 Dainippon Sumitomo Pharma Co Ltd アリールカルバペネム化合物の製造方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1593524A (en) * 1976-11-19 1981-07-15 Merck & Co Inc 1-carba-2-penem-3-carboxylic acids
US4260627A (en) * 1978-10-24 1981-04-07 Merck & Co., Inc. 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids
CA2030342A1 (en) * 1989-11-21 1991-05-22 Susumu Nakagawa Process for producing 2-carbon-substituted carbapenem derivatives
CA2036960A1 (en) * 1990-02-26 1991-08-27 Thomas A. Rano Novel synthesis of carbapenem intermediates
JP3233434B2 (ja) * 1992-04-01 2001-11-26 塩野義製薬株式会社 カルバペネム誘導体

Also Published As

Publication number Publication date
NO961654L (no) 1996-06-11
JPH09504285A (ja) 1997-04-28
FI961817A (fi) 1996-06-28
AU7997594A (en) 1995-05-22
PL314173A1 (en) 1996-08-19
ATE229957T1 (de) 2003-01-15
NO961654D0 (no) 1996-04-25
DE69431919D1 (de) 2003-01-30
EP0725783B1 (de) 2002-12-18
JP3703146B2 (ja) 2005-10-05
CA2175054A1 (en) 1995-05-04
CN1167486A (zh) 1997-12-10
OA10287A (en) 1997-10-07
ES2188621T3 (es) 2003-07-01
NZ274878A (en) 1998-02-26
FI961817A0 (fi) 1996-04-29
AU697108B2 (en) 1998-09-24
WO1995011905A1 (en) 1995-05-04
HU9601097D0 (en) 1996-07-29
CA2175054C (en) 2005-07-12
EP0725783A1 (de) 1996-08-14
CZ122996A3 (en) 1996-10-16
KR960705827A (ko) 1996-11-08
US5612477A (en) 1997-03-18
AP9600800A0 (en) 1996-04-30
HUT75519A (en) 1997-05-28
SK53696A3 (en) 1996-10-02
BG100551A (en) 1997-01-31
BR9407889A (pt) 1996-10-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee