DE69431808T2 - Verfahren zur immunmodulation durch adoptive übertragung von antigenspezifischenzytotoxischen t-zellen - Google Patents

Verfahren zur immunmodulation durch adoptive übertragung von antigenspezifischenzytotoxischen t-zellen

Info

Publication number
DE69431808T2
DE69431808T2 DE69431808T DE69431808T DE69431808T2 DE 69431808 T2 DE69431808 T2 DE 69431808T2 DE 69431808 T DE69431808 T DE 69431808T DE 69431808 T DE69431808 T DE 69431808T DE 69431808 T2 DE69431808 T2 DE 69431808T2
Authority
DE
Germany
Prior art keywords
antigen
cells
ctls
immunolmodulation
antique
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69431808T
Other languages
English (en)
Other versions
DE69431808D1 (de
Inventor
Claudio Bordignon
Fulvio Mavilio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Roche Diagnostics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Diagnostics GmbH filed Critical Roche Diagnostics GmbH
Publication of DE69431808D1 publication Critical patent/DE69431808D1/de
Application granted granted Critical
Publication of DE69431808T2 publication Critical patent/DE69431808T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/464838—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/32—Amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/23—Interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE69431808T 1994-05-16 1994-05-16 Verfahren zur immunmodulation durch adoptive übertragung von antigenspezifischenzytotoxischen t-zellen Expired - Lifetime DE69431808T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP1994/001573 WO1995031208A1 (en) 1994-05-16 1994-05-16 Method of immunomodulation by means of adoptive transfer of antigen-specific cytotoxic t-cells

Publications (2)

Publication Number Publication Date
DE69431808D1 DE69431808D1 (de) 2003-01-09
DE69431808T2 true DE69431808T2 (de) 2003-09-18

Family

ID=8165855

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69431808T Expired - Lifetime DE69431808T2 (de) 1994-05-16 1994-05-16 Verfahren zur immunmodulation durch adoptive übertragung von antigenspezifischenzytotoxischen t-zellen

Country Status (11)

Country Link
EP (1) EP0804210B1 (de)
JP (1) JP3288708B2 (de)
KR (1) KR100219258B1 (de)
AT (1) ATE228368T1 (de)
AU (1) AU691501B2 (de)
DE (1) DE69431808T2 (de)
DK (1) DK0804210T3 (de)
ES (1) ES2186686T3 (de)
NO (1) NO319331B1 (de)
PT (1) PT804210E (de)
WO (1) WO1995031208A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063375A (en) * 1996-09-10 2000-05-16 Medical University Of South Carolina Semiallogeneic cell hybrids and related methods for treating cancer
GB0224442D0 (en) 2002-10-21 2002-11-27 Molmed Spa A delivery system
KR100882445B1 (ko) 2007-03-16 2009-02-09 울산대학교 산학협력단 항―４－１ｂｂ 항체를 이용한 항원 특이적 자가유래ｃｄ８＋ｔ 세포의 분리 및 증식 방법
GB201121308D0 (en) 2011-12-12 2012-01-25 Cell Medica Ltd Process
PL3591047T3 (pl) 2012-02-09 2022-12-05 Baylor College Of Medicine Mieszanki peptydowe do wytwarzania wielowirusowych ctl o szerokiej swoistości
EP4290238A2 (de) 2015-09-18 2023-12-13 Baylor College of Medicine Identifizierung immunogener antigene aus einem pathogen und korrelation mit klinischer wirksamkeit

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69114299T3 (de) * 1990-09-14 2005-09-15 The Johns Hopkins University Verfahren und zusammensetzungen für gentherapie und stärkung des immunsystems.
US5529774A (en) * 1991-08-13 1996-06-25 The Regents Of The University Of California In vivo transfer of the HSV-TK gene implanted retroviral producer cells

Also Published As

Publication number Publication date
DE69431808D1 (de) 2003-01-09
JPH09507643A (ja) 1997-08-05
WO1995031208A1 (en) 1995-11-23
JP3288708B2 (ja) 2002-06-04
NO964896D0 (no) 1996-11-18
AU6928194A (en) 1995-12-05
ES2186686T3 (es) 2003-05-16
EP0804210A1 (de) 1997-11-05
DK0804210T3 (da) 2003-03-10
PT804210E (pt) 2003-04-30
KR100219258B1 (ko) 1999-09-01
AU691501B2 (en) 1998-05-21
EP0804210B1 (de) 2002-11-27
ATE228368T1 (de) 2002-12-15
NO964896L (no) 1996-11-18
NO319331B1 (no) 2005-07-18

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