DE69429507D1 - Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung - Google Patents

Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung

Info

Publication number
DE69429507D1
DE69429507D1 DE69429507T DE69429507T DE69429507D1 DE 69429507 D1 DE69429507 D1 DE 69429507D1 DE 69429507 T DE69429507 T DE 69429507T DE 69429507 T DE69429507 T DE 69429507T DE 69429507 D1 DE69429507 D1 DE 69429507D1
Authority
DE
Germany
Prior art keywords
biologically active
particles
production
active substances
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69429507T
Other languages
English (en)
Other versions
DE69429507T2 (de
Inventor
Viktor Alexeevich Volkonsky
Sergei V Chernyakov
Sergei D Dvuhsherstnov
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
FeRx Inc
Original Assignee
FeRx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FeRx Inc filed Critical FeRx Inc
Application granted granted Critical
Publication of DE69429507D1 publication Critical patent/DE69429507D1/de
Publication of DE69429507T2 publication Critical patent/DE69429507T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
DE69429507T 1993-01-29 1994-01-26 Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung Expired - Fee Related DE69429507T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1136393A 1993-01-29 1993-01-29
PCT/US1994/000892 WO1994016683A1 (en) 1993-01-29 1994-01-26 Magnetically responsive composition for carrying biologically active substances and methods of production and use

Publications (2)

Publication Number Publication Date
DE69429507D1 true DE69429507D1 (de) 2002-01-31
DE69429507T2 DE69429507T2 (de) 2002-05-16

Family

ID=21750068

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69429507T Expired - Fee Related DE69429507T2 (de) 1993-01-29 1994-01-26 Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung

Country Status (12)

Country Link
US (3) US5549915A (de)
EP (1) EP0683665B1 (de)
JP (2) JP3145120B2 (de)
AT (1) ATE210967T1 (de)
AU (1) AU6165394A (de)
CA (1) CA2154913C (de)
DE (1) DE69429507T2 (de)
DK (1) DK0683665T3 (de)
ES (1) ES2165385T3 (de)
HK (1) HK1013256A1 (de)
PT (1) PT683665E (de)
WO (1) WO1994016683A1 (de)

Families Citing this family (45)

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US6200547B1 (en) * 1994-01-26 2001-03-13 Ferx Incorporated Magnetically responsive compositions for carrying biologically active substances and methods of production and use
ATE210967T1 (de) * 1993-01-29 2002-01-15 Ferx Inc Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung
US6482436B1 (en) 1993-01-29 2002-11-19 Ferx Incorporated Magnetically responsive composition
US5958458A (en) * 1994-06-15 1999-09-28 Dumex-Alpharma A/S Pharmaceutical multiple unit particulate formulation in the form of coated cores
US5985312A (en) * 1996-01-26 1999-11-16 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6368586B1 (en) 1996-01-26 2002-04-09 Brown University Research Foundation Methods and compositions for enhancing the bioadhesive properties of polymers
US6488615B1 (en) 2000-03-31 2002-12-03 Ferx Incorporated Permanent magnet keeper-shield assembly
US7090636B2 (en) * 2000-03-31 2006-08-15 Fe Rx Incorporated Permanent magnet keeper-shield assembly
EP1428228A4 (de) * 2001-02-26 2008-04-30 Univ Utah Res Found Magnetaktivierte partikel zur adsorption von gelösten stoffen aus lösung
US6921283B2 (en) * 2001-08-27 2005-07-26 Trompeter Electronics, Inc. BNC connector having visual indication
FR2832598B1 (fr) * 2001-11-26 2006-01-27 Oreal Article de conditionnement et/ou d'application d'un produit
WO2003059325A1 (en) * 2002-01-09 2003-07-24 Ferx Incorporated Magnetic delivery compositions
US20030219785A1 (en) * 2002-02-01 2003-11-27 Vanderbilt University Targeted drug delivery methods
US8097185B2 (en) * 2002-02-26 2012-01-17 University Of Utah Research Foundation Magnetic activated carbon particles for adsorption of solutes from solution
CA2549994A1 (en) * 2002-12-18 2004-08-12 Hough Ear Institute Otologic nanotechnology
US7723311B2 (en) * 2003-06-18 2010-05-25 Nanobiomagnetics, Inc. Delivery of bioactive substances to target cells
US8651113B2 (en) * 2003-06-18 2014-02-18 Swr&D Inc. Magnetically responsive nanoparticle therapeutic constructs and methods of making and using
US7344491B1 (en) 2003-11-26 2008-03-18 Nanobiomagnetics, Inc. Method and apparatus for improving hearing
ES2264839B1 (es) * 2003-11-24 2007-10-01 Universidad De Zaragoza (Inst Denanociencia De Ar Agom. Farmacoterapia parenteral focalizada mediante el implante de imanes permanentes en los organos diana.
DE10359252A1 (de) * 2003-12-17 2005-07-28 Siemens Ag Navigierte Wärmebehandlung von Tumoren mit enzymumhüllten Eisenpartikeln
US20070100457A1 (en) * 2004-03-04 2007-05-03 Hyde Edward R Jr Paramagnetic liquid interface
CN1976681A (zh) * 2004-03-26 2007-06-06 弗尔克斯破产财产公司 可磁性靶向丝裂霉素c组合物及其使用方法
US20060024378A1 (en) * 2004-08-02 2006-02-02 Mehta Rakesh H Magnetically responsive carbon nano-structures for transporting biologically active substances, and methods relating thereto
US20070281007A1 (en) * 2004-08-27 2007-12-06 Jacob Jules S Mucoadhesive Oral Formulations of High Permeability, High Solubility Drugs
WO2008001851A1 (en) * 2006-06-28 2008-01-03 Ihi Corporation Drug, drug induction device, magnetic detector and method of designing drug
US8568286B2 (en) * 2006-06-14 2013-10-29 Cardiac Pacemakers, Inc. Methods to position therapeutic agents using a magnetic field
US20080097606A1 (en) * 2006-10-19 2008-04-24 Cragg Andrew H Knee joint prosthesis and hyaluronate compositions for treatment of osteoarthritis
US20090169484A1 (en) 2007-12-28 2009-07-02 Ihi Corporation Iron-salen complex
JP5433155B2 (ja) * 2008-02-20 2014-03-05 株式会社Ｉｈｉ 磁性を有する薬剤、薬剤の誘導システム、並びに磁気検出装置
JP2009274962A (ja) * 2008-05-12 2009-11-26 Yoshihiro Ishikawa 鉄サレン錯体、磁性を有する薬剤、薬剤の誘導システム、並びに磁気検出装置
EP2357166B1 (de) 2008-11-20 2020-01-15 IHI Corporation Automagnetische metall-salen-komplexverbindung
CN102791323B (zh) 2009-12-25 2014-10-15 株式会社Ihi 使用磁体的药物传递控制装置
JP5554408B2 (ja) 2010-06-01 2014-07-23 株式会社Ｉｈｉ 蛍光色素材料及びその使用方法
US8740872B2 (en) 2010-10-19 2014-06-03 The Board Of Regents Of The University Of Oklahoma Magnetically-targeted treatment for cardiac disorders
US10398668B2 (en) 2010-10-19 2019-09-03 The Board Of Regents Of The University Of Oklahoma Glutamate treatment of cardiovascular disorders
US9744235B2 (en) 2010-10-19 2017-08-29 The Board Of Regents Of The University Of Oklahoma Treatment of cardiovascular disorders with targeted nanoparticles
JP2012176905A (ja) * 2011-02-25 2012-09-13 Ihi Corp 金属サレン錯体化合物
RU2546663C2 (ru) * 2010-12-21 2015-04-10 АйЭйчАй КОРПОРЕЙШН Комплексное соединение металл-сален и способ его получения
JP2012131737A (ja) * 2010-12-21 2012-07-12 Ihi Corp 金属サレン錯体化合物及びその製造方法
JP2012167067A (ja) 2011-02-15 2012-09-06 Ihi Corp 自己磁性金属サレン錯体化合物
JP5873656B2 (ja) 2011-06-13 2016-03-01 株式会社Ihi 金属サレン錯体化合物、局所麻酔薬剤及び抗悪性腫瘍薬剤
JP6017766B2 (ja) 2011-07-26 2016-11-02 株式会社Ihi 新規な金属サレン錯体化合物の抗がん剤
CN104010660A (zh) 2011-10-04 2014-08-27 株式会社Ihi 金属Salen配位化合物响应性药剂以及金属Salen配位化合物的体内行为控制系统
JP5694549B2 (ja) * 2011-10-06 2015-04-01 株式会社Ihi 液剤
SG11201702260RA (en) 2014-09-26 2017-04-27 Ihi Corp Anti-cancer agent and cancer cell killing method

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US3718594A (en) * 1970-11-30 1973-02-27 Eastman Kodak Co Method of preparing magnetically responsive carrier particles
US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
US4345588A (en) * 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4247406A (en) * 1979-04-23 1981-01-27 Widder Kenneth J Intravascularly-administrable, magnetically-localizable biodegradable carrier
US4331654A (en) * 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
EP0093757A1 (de) * 1981-11-12 1983-11-16 Ulf SCHRÖDER Verfahren zur herstellung von magnetisch beeinflussbaren nanopartikeln für intravaskulare anwendung
JPS59122429A (ja) * 1982-12-28 1984-07-14 Japan Synthetic Rubber Co Ltd 生物学的物質の担体用磁性粒子
US4652257A (en) * 1985-03-21 1987-03-24 The United States Of America As Represented By The Secretary Of The Navy Magnetically-localizable, polymerized lipid vesicles and method of disrupting same
US4849209A (en) * 1985-06-07 1989-07-18 Cadema Medical Products, Inc. Treatment of arthritis, including rheumatoid arthritis with 166 Holmium radionuclide
US4818614A (en) * 1985-07-29 1989-04-04 Shiseido Company Ltd. Modified powder
US4690130A (en) * 1985-12-19 1987-09-01 Mirell Stuart G Electromagnetic therapy control system
US4871716A (en) * 1986-02-04 1989-10-03 University Of Florida Magnetically responsive, hydrophilic microspheres for incorporation of therapeutic substances and methods of preparation thereof
JPH01122037U (de) * 1988-02-12 1989-08-18
SU1722256A3 (ru) * 1989-11-02 1992-03-23 Viktor A Volkonskij Cпocoб пoлучehия maгhиtoупpabляemoй диcпepcии
ATE210967T1 (de) * 1993-01-29 2002-01-15 Ferx Inc Magnetisch reagierende zusammensetzung als träger für biologisch aktive substanzen und verfahren für ihre herstellung und verwendung

Also Published As

Publication number Publication date
EP0683665A4 (de) 1996-04-17
DE69429507T2 (de) 2002-05-16
AU6165394A (en) 1994-08-15
CA2154913C (en) 1999-10-19
EP0683665A1 (de) 1995-11-29
JP2001010978A (ja) 2001-01-16
ATE210967T1 (de) 2002-01-15
ES2165385T3 (es) 2002-03-16
JP3176600B2 (ja) 2001-06-18
CA2154913A1 (en) 1994-08-04
JP3145120B2 (ja) 2001-03-12
WO1994016683A1 (en) 1994-08-04
EP0683665B1 (de) 2001-12-19
PT683665E (pt) 2002-05-31
JPH08506111A (ja) 1996-07-02
DK0683665T3 (da) 2002-04-02
US5549915A (en) 1996-08-27
US5705195A (en) 1998-01-06
HK1013256A1 (en) 1999-08-20
US5651989A (en) 1997-07-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee