DE69427496D1 - Neue Prosequenz zur Sekretion heterologer Proteine aus Hefezellen - Google Patents

Neue Prosequenz zur Sekretion heterologer Proteine aus Hefezellen

Info

Publication number
DE69427496D1
DE69427496D1 DE69427496T DE69427496T DE69427496D1 DE 69427496 D1 DE69427496 D1 DE 69427496D1 DE 69427496 T DE69427496 T DE 69427496T DE 69427496 T DE69427496 T DE 69427496T DE 69427496 D1 DE69427496 D1 DE 69427496D1
Authority
DE
Germany
Prior art keywords
heterologous proteins
new
secretion
pro sequence
prosequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69427496T
Other languages
English (en)
Other versions
DE69427496T2 (de
Inventor
Tilman Achstetter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Application granted granted Critical
Publication of DE69427496D1 publication Critical patent/DE69427496D1/de
Publication of DE69427496T2 publication Critical patent/DE69427496T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Insects & Arthropods (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
DE69427496T 1993-01-11 1994-01-11 Neue Prosequenz zur Sekretion heterologer Proteine aus Hefezellen Expired - Fee Related DE69427496T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9300171A FR2700338B1 (fr) 1993-01-11 1993-01-11 Nouvelle séquence pro permettant la secrétion de protéines hétérologues à partir d'une cellule de levure.

Publications (2)

Publication Number Publication Date
DE69427496D1 true DE69427496D1 (de) 2001-07-26
DE69427496T2 DE69427496T2 (de) 2002-06-06

Family

ID=9442934

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69427496T Expired - Fee Related DE69427496T2 (de) 1993-01-11 1994-01-11 Neue Prosequenz zur Sekretion heterologer Proteine aus Hefezellen

Country Status (8)

Country Link
EP (1) EP0607080B1 (de)
AT (1) ATE202381T1 (de)
DE (1) DE69427496T2 (de)
DK (1) DK0607080T3 (de)
ES (1) ES2157963T3 (de)
FR (1) FR2700338B1 (de)
GR (1) GR3036648T3 (de)
PT (1) PT607080E (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69427403T2 (de) * 1993-06-29 2002-06-06 Transgene Sa Peptide-familie, genannt xenoxine
FR2714908A1 (fr) * 1994-01-11 1995-07-13 Transgene Sa Famille de peptides appelés xénoxines.
CN1062017C (zh) * 1995-09-01 2001-02-14 中国科学院遗传研究所 防御素基因的植物表达载体质粒
GB9724307D0 (en) * 1997-11-17 1998-01-14 Zeneca Ltd Improvements relating to protein accumulation
FR2777568B1 (fr) 1998-04-15 2002-10-31 Rhone Poulenc Agrochimie Gene codant pour l'heliomicine, proteine obtenue, vecteur le contenant, organismes transformes obtenus et procede de preparation
RU2460795C1 (ru) * 2011-07-06 2012-09-10 Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") Способ микробиологического синтеза секретируемого соматотропина человека и штамм дрожжей saccharomyces cerevisiae - продуцент секретируемого соматотропина человека

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL83435A (en) * 1986-09-23 1993-01-14 Miles Lab Dna construct for expression of genes in yeast, an expression vector containing it and yeast transformed with said expression vector
FR2633296B1 (fr) * 1988-06-24 1991-11-15 Centre Nat Rech Scient Molecules peptidiques a action sur les germes a gram positif
FR2646437B1 (fr) * 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant

Also Published As

Publication number Publication date
ATE202381T1 (de) 2001-07-15
DK0607080T3 (da) 2001-10-01
DE69427496T2 (de) 2002-06-06
EP0607080B1 (de) 2001-06-20
FR2700338B1 (fr) 1995-03-31
ES2157963T3 (es) 2001-09-01
EP0607080A1 (de) 1994-07-20
GR3036648T3 (en) 2001-12-31
FR2700338A1 (fr) 1994-07-13
PT607080E (pt) 2001-10-31

Similar Documents

Publication Publication Date Title
KR920012442A (ko) 피치아 파스토리스 산성 인산효소 유전자의 dna 단편 및 이를 사용하는 방법
ATE286136T1 (de) Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen
ES532825A0 (es) Un metodo de sintetizar un polipeptido seleccionado
EP2175028A3 (de) Stressbedingte Phosphataseproteine und Verfahren zu deren Verwendung für Pflanzen
WO2001045492A3 (en) Protein kinase stress-related proteins and methods of use in plants
DK0894126T3 (da) Alkalisk phosphatase-deficient trådformet svamp
ATE386101T1 (de) Expressionsplasmide, durch einen osmb promoter reguliert
ATA192895A (de) Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
DK1332222T3 (da) Stofskifteændringer i fermenteringer der udtrykker rekombinante proteiner
DE69427496D1 (de) Neue Prosequenz zur Sekretion heterologer Proteine aus Hefezellen
ES2067703T3 (es) Cepa de saccharomyces cerevisiae productora de una proteina heterologa y procedimiento de preparacion de dicha proteina heterologa mediante fermentacion de dicha cepa.
DK0396436T3 (da) Gærstammer til fremstilling af modne heterologe proteiner, især hirudin
EP2281892A3 (de) Verfahren zur Herstellung von Polypeptiden in atmungsdefizienten Trichoderma Zellen
ATE312939T1 (de) Verfahren zur rekombinanten herstellung von polypeptiden
WO2003020914A3 (en) Protein phosphatase stress-related polypeptides and methods of use in plants
EE03074B1 (et) Rekombinantsed eukarüootsed rakud, nende saamiseks vajalikud DNA järjestused, meetod eukarüootsete rakkude konstrueerimiseks ja sekreteeritavate valkude ning biomassi tootmismeetod
DE59901930D1 (de) Expressionssystem zur produktion von proteinen
ATE288495T1 (de) Phosphoglycerat-kinase-1-promotor aus rhizopus oryzae und dessen verwendung
WO2004046359A3 (en) Method of controlling gene expression in plants or plant cells
WO2000037492A3 (en) Human hepatoma-derived growth factor homologous (huhdgfh) ____
DE60024596D1 (de) Sequenzen zur verbesserung der sekretionseffizienz von nicht-sekretierten proteinen in säugetier- und insektenzellen
ATE336585T1 (de) Modifikation von kryptischen splicemotiven heterologer gene zur expression in pilzen
KR970010967A (ko) 인체 칼시토닌 전구체의 분비 생산용 발현벡터 및 이를 이용한 인체 칼시토닌 전구체의 제조방법
KR960037831A (ko) 효모로부터 인간 리포코틴-i 단백질을 고발현 분비시키기 위한 플라스미드 벡터
KR950032618A (ko) 인간 리포코틴 분비 생산을 위한 효모용 발현 벡터

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee