DE69426835T2 - Derivate von 2-arylalkenyl-azacyclo alkan als sigma rezeptor-liganden, verfahren zu ihrer herstellung und ihrer therapeutischer anwendung - Google Patents
Derivate von 2-arylalkenyl-azacyclo alkan als sigma rezeptor-liganden, verfahren zu ihrer herstellung und ihrer therapeutischer anwendungInfo
- Publication number
- DE69426835T2 DE69426835T2 DE69426835T DE69426835T DE69426835T2 DE 69426835 T2 DE69426835 T2 DE 69426835T2 DE 69426835 T DE69426835 T DE 69426835T DE 69426835 T DE69426835 T DE 69426835T DE 69426835 T2 DE69426835 T2 DE 69426835T2
- Authority
- DE
- Germany
- Prior art keywords
- azacyclo
- alkan
- arylalkenyl
- derivatives
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000003982 sigma receptor ligand Substances 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9314814A FR2713639B1 (fr) | 1993-12-09 | 1993-12-09 | Nouveaux dérivés de 2-arylalkényl-azacycloalkanes ligands aux récepteurs sigma, leur procédé de préparation et leur application en thérapeutique. |
PCT/FR1994/001439 WO1995015948A1 (fr) | 1993-12-09 | 1994-12-09 | Nouveaux derives de 2-arylalkenyl-azacycloalkanes ligands aux recepteurs sigma, leur procede de preparation et leur application en therapeutique |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69426835D1 DE69426835D1 (de) | 2001-04-12 |
DE69426835T2 true DE69426835T2 (de) | 2001-08-16 |
Family
ID=9453762
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69426835T Expired - Fee Related DE69426835T2 (de) | 1993-12-09 | 1994-12-09 | Derivate von 2-arylalkenyl-azacyclo alkan als sigma rezeptor-liganden, verfahren zu ihrer herstellung und ihrer therapeutischer anwendung |
Country Status (9)
Country | Link |
---|---|
US (2) | US5849760A (de) |
EP (2) | EP0734379B1 (de) |
JP (1) | JP3594310B2 (de) |
AU (1) | AU1245495A (de) |
CA (1) | CA2177739A1 (de) |
DE (1) | DE69426835T2 (de) |
ES (1) | ES2157315T3 (de) |
FR (1) | FR2713639B1 (de) |
WO (1) | WO1995015948A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2751645B1 (fr) * | 1996-07-29 | 1998-12-24 | Sanofi Sa | Amines pour la fabrication de medicaments destines a empecher la proliferation de cellules tumorales |
FR2760455B1 (fr) * | 1997-03-05 | 1999-04-16 | Jouveinal Inst Rech | (-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique |
EP1138327A1 (de) * | 2000-03-29 | 2001-10-04 | Warner-Lambert Company | Verwendung von 2-(Arylalkenyl)Azacycloalkan derivativen zur Behandlung von Magen-Darmstörungen, die durch Stress verursacht sind |
GB0007842D0 (en) * | 2000-03-31 | 2000-05-17 | Spruce Barbara | Sigma receptor ligands and their medical uses |
AU2002332659A1 (en) * | 2001-08-21 | 2003-03-03 | Sepracor, Inc. | 2-substituted piperidines that are ligands for monoamine receptors and transporters |
FR2833945B1 (fr) * | 2001-12-21 | 2004-03-12 | Warner Lambert Co | N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation |
DE60318306T2 (de) | 2002-03-29 | 2008-12-11 | Eisai R&D Management Co., Ltd. | (1-indanon)-(1,2,3,6-tetrahydropyridin)derivat |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
EP1942879A1 (de) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス,インコーポレイティド | アンジオテンシン調節による神経新生 |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
AU2008310201A1 (en) | 2007-10-13 | 2009-04-16 | Shenzhen New Electric Science And Technology Co., Ltd | Multimedia acoustics system having audio frequency digital interface |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US9675587B2 (en) | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
IL300858A (en) | 2020-09-17 | 2023-04-01 | Meletios Therapeutics | Compounds for the treatment of viral infection |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2636625B1 (fr) * | 1988-09-01 | 1990-11-09 | Jouveinal Sa | Benzylamines disubstituees, leur procede de preparation, leur utilisation comme medicament et leurs intermediaires de synthese |
US5109002A (en) * | 1989-09-08 | 1992-04-28 | Du Pont Merck Pharmaceutical Company | Antipsychotic 1-cycloalkylpiperidines |
WO1991006297A1 (en) * | 1989-10-27 | 1991-05-16 | The Du Pont Merck Pharmaceutical Company | (n-phthalimidoalkyl) piperidines |
JPH05503517A (ja) * | 1989-12-18 | 1993-06-10 | バージニア・コモンウェルス・ユニバーシティ | シグマレセプターリガンド及びその用途 |
IE66180B1 (en) * | 1990-02-26 | 1995-12-13 | Jouveinal Sa | N-Cycloalkylalkylamines their process of preparation their use as a medicament and their synthesis intermediates |
US5231099A (en) * | 1991-04-15 | 1993-07-27 | Du Pont Merck Pharmaceutical Company | Use of sigma receptor antagonists to enhance the effects of antipsychotic drugs |
GB9113031D0 (en) * | 1991-06-17 | 1991-08-07 | Smithkline Beecham Plc | Compounds |
WO1993009094A1 (en) * | 1991-10-30 | 1993-05-13 | The Du Pont Merck Pharmaceutical Company | Ether derivatives of alkyl piperidines and pyrrolidines as antipsychotic agents |
JPH07503461A (ja) * | 1992-01-28 | 1995-04-13 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | カルシウムチャンネル拮抗薬としての化合物 |
GB9202238D0 (en) * | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
-
1993
- 1993-12-09 US US08/652,567 patent/US5849760A/en not_active Expired - Fee Related
- 1993-12-09 FR FR9314814A patent/FR2713639B1/fr not_active Expired - Fee Related
-
1994
- 1994-12-09 AU AU12454/95A patent/AU1245495A/en not_active Abandoned
- 1994-12-09 EP EP95903385A patent/EP0734379B1/de not_active Expired - Lifetime
- 1994-12-09 ES ES95903385T patent/ES2157315T3/es not_active Expired - Lifetime
- 1994-12-09 WO PCT/FR1994/001439 patent/WO1995015948A1/fr active IP Right Grant
- 1994-12-09 CA CA002177739A patent/CA2177739A1/fr not_active Abandoned
- 1994-12-09 EP EP99114215A patent/EP0995436A3/de not_active Withdrawn
- 1994-12-09 JP JP51600895A patent/JP3594310B2/ja not_active Expired - Fee Related
- 1994-12-09 DE DE69426835T patent/DE69426835T2/de not_active Expired - Fee Related
-
1998
- 1998-09-02 US US09/145,918 patent/US6013656A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP0995436A3 (de) | 2003-11-05 |
CA2177739A1 (fr) | 1995-06-15 |
JPH09508893A (ja) | 1997-09-09 |
WO1995015948A1 (fr) | 1995-06-15 |
EP0734379B1 (de) | 2001-03-07 |
US6013656A (en) | 2000-01-11 |
FR2713639A1 (fr) | 1995-06-16 |
US5849760A (en) | 1998-12-15 |
EP0734379A1 (de) | 1996-10-02 |
EP0995436A2 (de) | 2000-04-26 |
JP3594310B2 (ja) | 2004-11-24 |
AU1245495A (en) | 1995-06-27 |
FR2713639B1 (fr) | 1996-08-30 |
ES2157315T3 (es) | 2001-08-16 |
DE69426835D1 (de) | 2001-04-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: PFIZER HOLDING FRANCE, PARIS, FR |
|
8339 | Ceased/non-payment of the annual fee |