FR2760455B1 - (-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique - Google Patents

(-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique

Info

Publication number
FR2760455B1
FR2760455B1 FR9702713A FR9702713A FR2760455B1 FR 2760455 B1 FR2760455 B1 FR 2760455B1 FR 9702713 A FR9702713 A FR 9702713A FR 9702713 A FR9702713 A FR 9702713A FR 2760455 B1 FR2760455 B1 FR 2760455B1
Authority
FR
France
Prior art keywords
antidiarrheic
cinnamyl
cyclopropylmethyl
dichloro
piperidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9702713A
Other languages
English (en)
Other versions
FR2760455A1 (fr
Inventor
Alain Calvet
Maria Chovet
Svein G Dahl
Henry Jacobelli
Pierre Riviere
Vassilia Theodorou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut de Recherche Jouveinal
Original Assignee
Institut de Recherche Jouveinal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9702713A priority Critical patent/FR2760455B1/fr
Application filed by Institut de Recherche Jouveinal filed Critical Institut de Recherche Jouveinal
Priority to US09/367,579 priority patent/US6440997B2/en
Priority to IL13071698A priority patent/IL130716A/en
Priority to KR1019997008058A priority patent/KR20000075973A/ko
Priority to AU70367/98A priority patent/AU749902B2/en
Priority to ZA981849A priority patent/ZA981849B/xx
Priority to JP53819398A priority patent/JP2001513802A/ja
Priority to PCT/EP1998/001564 priority patent/WO1998039296A1/fr
Priority to CA002277839A priority patent/CA2277839A1/fr
Priority to NZ336575A priority patent/NZ336575A/en
Priority to EP98916993A priority patent/EP0968187A1/fr
Priority to BR9808823-8A priority patent/BR9808823A/pt
Publication of FR2760455A1 publication Critical patent/FR2760455A1/fr
Application granted granted Critical
Publication of FR2760455B1 publication Critical patent/FR2760455B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
FR9702713A 1997-03-05 1997-03-05 (-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique Expired - Fee Related FR2760455B1 (fr)

Priority Applications (12)

Application Number Priority Date Filing Date Title
FR9702713A FR2760455B1 (fr) 1997-03-05 1997-03-05 (-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique
CA002277839A CA2277839A1 (fr) 1997-03-05 1998-03-04 (-)e-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethyl-piperidine et son utilisation comme antidiarrheique
KR1019997008058A KR20000075973A (ko) 1997-03-05 1998-03-04 (-)ｅ-2-(3,4-디클로로신나밀)-1-시클로프로필메틸피페리딘및 그의 지사제로서의 용도
AU70367/98A AU749902B2 (en) 1997-03-05 1998-03-04 (-)E-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethyl-piperidine and its antidiarrhoeal use
ZA981849A ZA981849B (en) 1997-03-05 1998-03-04 (-)E-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethylpiperidine and its antidiarrhoeal use
JP53819398A JP2001513802A (ja) 1997-03-05 1998-03-04 （−）ｅ−２−（３，４−ジクロロシンナミル）−１−シクロプロピルメチル−ピペリジンおよび止瀉薬としてのその使用
US09/367,579 US6440997B2 (en) 1997-03-05 1998-03-04 −E-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethylpiperidine, and its antidiarrhoeal use
IL13071698A IL130716A (en) 1997-03-05 1998-03-04 (-) E - 2 (-4,3 dichlorocinamyl) - 1 cyclopropylmethyl-piperidine and its use in the preparation of anti-diarrheal preparations
NZ336575A NZ336575A (en) 1997-03-05 1998-03-04 (-)E-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethyl-piperidine for treating diarrhoea
EP98916993A EP0968187A1 (fr) 1997-03-05 1998-03-04 (-)e-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethyl-piperidine et son utilisation comme antidiarrheique
BR9808823-8A BR9808823A (pt) 1997-03-05 1998-03-04 (-)e-2- (3,4-diclorocinamil) -1-ciclopropilmetil-piperidina e seu uso antidiarréico
PCT/EP1998/001564 WO1998039296A1 (fr) 1997-03-05 1998-03-04 (-)e-2-(3,4-dichlorocinnamyl)-1-cyclopropylmethyl-piperidine et son utilisation comme antidiarrheique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9702713A FR2760455B1 (fr) 1997-03-05 1997-03-05 (-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique

Publications (2)

Publication Number Publication Date
FR2760455A1 FR2760455A1 (fr) 1998-09-11
FR2760455B1 true FR2760455B1 (fr) 1999-04-16

Family

ID=9504511

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9702713A Expired - Fee Related FR2760455B1 (fr) 1997-03-05 1997-03-05 (-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique

Country Status (12)

Country Link
US (1) US6440997B2 (fr)
EP (1) EP0968187A1 (fr)
JP (1) JP2001513802A (fr)
KR (1) KR20000075973A (fr)
AU (1) AU749902B2 (fr)
BR (1) BR9808823A (fr)
CA (1) CA2277839A1 (fr)
FR (1) FR2760455B1 (fr)
IL (1) IL130716A (fr)
NZ (1) NZ336575A (fr)
WO (1) WO1998039296A1 (fr)
ZA (1) ZA981849B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1138327A1 (fr) * 2000-03-29 2001-10-04 Warner-Lambert Company Utilisation de dérivés 2-(arylalkenyl)azacycloalkanes pour traiter les désordres gastrointestinaux liés au stress
FR2833945B1 (fr) * 2001-12-21 2004-03-12 Warner Lambert Co N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5849760A (en) * 1993-12-09 1998-12-15 Institut De Recherche Jouveinal 2-(arylalkenyl)azacycloalkane derivatives as ligands for sigma receptors

Also Published As

Publication number Publication date
CA2277839A1 (fr) 1998-09-11
AU7036798A (en) 1998-09-22
EP0968187A1 (fr) 2000-01-05
BR9808823A (pt) 2000-07-04
IL130716A (en) 2004-02-19
US6440997B2 (en) 2002-08-27
AU749902B2 (en) 2002-07-04
NZ336575A (en) 2001-10-26
WO1998039296A1 (fr) 1998-09-11
IL130716A0 (en) 2000-06-01
JP2001513802A (ja) 2001-09-04
US20010008897A1 (en) 2001-07-19
KR20000075973A (ko) 2000-12-26
FR2760455A1 (fr) 1998-09-11
ZA981849B (en) 1998-09-01

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Effective date: 20061130