FR2833945B1 - N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation - Google Patents

N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation

Info

Publication number
FR2833945B1
FR2833945B1 FR0116785A FR0116785A FR2833945B1 FR 2833945 B1 FR2833945 B1 FR 2833945B1 FR 0116785 A FR0116785 A FR 0116785A FR 0116785 A FR0116785 A FR 0116785A FR 2833945 B1 FR2833945 B1 FR 2833945B1
Authority
FR
France
Prior art keywords
azacycloalcanes
cyclopropylmethyl
preparation
methods
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0116785A
Other languages
English (en)
Other versions
FR2833945A1 (fr
Inventor
Henry Jacobelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority to FR0116785A priority Critical patent/FR2833945B1/fr
Priority to MXPA02012190A priority patent/MXPA02012190A/es
Priority to EP02027456A priority patent/EP1321461A1/fr
Priority to US10/319,363 priority patent/US6787563B2/en
Priority to BR0205410-8A priority patent/BR0205410A/pt
Priority to CA002414905A priority patent/CA2414905A1/fr
Priority to JP2002369656A priority patent/JP2003238530A/ja
Publication of FR2833945A1 publication Critical patent/FR2833945A1/fr
Application granted granted Critical
Publication of FR2833945B1 publication Critical patent/FR2833945B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Hydrogenated Pyridines (AREA)
FR0116785A 2001-12-21 2001-12-21 N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation Expired - Fee Related FR2833945B1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR0116785A FR2833945B1 (fr) 2001-12-21 2001-12-21 N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation
MXPA02012190A MXPA02012190A (es) 2001-12-21 2002-12-09 N-(ciclopropilmetil) azacicloalcanos, composiciones que los contienen y metodos para su preparacion.
EP02027456A EP1321461A1 (fr) 2001-12-21 2002-12-10 N-(Cyclopropylméthyl)-azacycloalcanes, compositions les contenant et procédés de préparation
US10/319,363 US6787563B2 (en) 2001-12-21 2002-12-13 Crystalline 3-{4-methyl-3-[methyl-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-amino]-piperidin-1-yl}-3-oxo-propionitrile citrate
BR0205410-8A BR0205410A (pt) 2001-12-21 2002-12-17 N-(ciclopropilmetil) aza cicloalcanos, composições contendo os mesmos e processos de preparação
CA002414905A CA2414905A1 (fr) 2001-12-21 2002-12-20 N-(cyclopropylmethyl)azacycloalcanes, compositions contenant ces composes et methodes pour les preparer
JP2002369656A JP2003238530A (ja) 2001-12-21 2002-12-20 Ｎ−（シクロプロピルメチル）アザシクロアルカン、それらを含有する組成物およびそれらの製造方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0116785A FR2833945B1 (fr) 2001-12-21 2001-12-21 N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation

Publications (2)

Publication Number Publication Date
FR2833945A1 FR2833945A1 (fr) 2003-06-27
FR2833945B1 true FR2833945B1 (fr) 2004-03-12

Family

ID=8870932

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0116785A Expired - Fee Related FR2833945B1 (fr) 2001-12-21 2001-12-21 N-cyclopropylmethyl-azacycloalcanes, compositions les contenant et procedes de preparation

Country Status (7)

Country Link
US (1) US6787563B2 (fr)
EP (1) EP1321461A1 (fr)
JP (1) JP2003238530A (fr)
BR (1) BR0205410A (fr)
CA (1) CA2414905A1 (fr)
FR (1) FR2833945B1 (fr)
MX (1) MXPA02012190A (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0507863A4 (en) * 1989-12-28 1993-07-07 Virginia Commonwealth University Sigma receptor ligands and the use thereof
FR2713639B1 (fr) * 1993-12-09 1996-08-30 Irj Nouveaux dérivés de 2-arylalkényl-azacycloalkanes ligands aux récepteurs sigma, leur procédé de préparation et leur application en thérapeutique.
FR2760455B1 (fr) * 1997-03-05 1999-04-16 Jouveinal Inst Rech (-)e-2-(3,4-dichloro-cinnamyl)-1-cyclopropylmethyl- piperidine, son utilite antidiarrheique
FR2760454B1 (fr) 1997-03-05 1999-04-30 Jouveinal Inst Rech (r) n-(1-cyclopropylmethyl-pyrrolidine-2ylmethyl)-benzamide et son utilite comme antidiarrheique

Also Published As

Publication number Publication date
FR2833945A1 (fr) 2003-06-27
MXPA02012190A (es) 2004-10-29
US20030139448A1 (en) 2003-07-24
CA2414905A1 (fr) 2003-06-21
US6787563B2 (en) 2004-09-07
BR0205410A (pt) 2004-07-20
JP2003238530A (ja) 2003-08-27
EP1321461A1 (fr) 2003-06-25

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Legal Events

Date Code Title Description
ST Notification of lapse

Effective date: 20070831