DE69415001T2 - Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern - Google Patents

Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern

Info

Publication number
DE69415001T2
DE69415001T2 DE69415001T DE69415001T DE69415001T2 DE 69415001 T2 DE69415001 T2 DE 69415001T2 DE 69415001 T DE69415001 T DE 69415001T DE 69415001 T DE69415001 T DE 69415001T DE 69415001 T2 DE69415001 T2 DE 69415001T2
Authority
DE
Germany
Prior art keywords
production
glycoprotein iib
intermediate connections
iiia blockers
iiia
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69415001T
Other languages
English (en)
Other versions
DE69415001D1 (de
Inventor
Lin-Hua Zhang
Philip Ma
William Frank Degrado
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
DuPont Merck Pharmaceutical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DuPont Merck Pharmaceutical Co filed Critical DuPont Merck Pharmaceutical Co
Publication of DE69415001D1 publication Critical patent/DE69415001D1/de
Application granted granted Critical
Publication of DE69415001T2 publication Critical patent/DE69415001T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69415001T 1993-03-29 1994-03-28 Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern Expired - Fee Related DE69415001T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3843493A 1993-03-29 1993-03-29
PCT/US1994/003221 WO1994022909A1 (en) 1993-03-29 1994-03-28 NOVEL PROCESSES AND INTERMEDIATE COMPOUNDS FOR THE PREPARATION OF PLATELET CLYCOPROTEIN IIb/IIIa INHIBITORS

Publications (2)

Publication Number Publication Date
DE69415001D1 DE69415001D1 (de) 1999-01-14
DE69415001T2 true DE69415001T2 (de) 1999-05-06

Family

ID=21899933

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415001T Expired - Fee Related DE69415001T2 (de) 1993-03-29 1994-03-28 Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern

Country Status (12)

Country Link
US (1) US5817749A (de)
EP (1) EP0691986B1 (de)
JP (1) JPH08509708A (de)
AT (1) ATE174036T1 (de)
AU (1) AU682857B2 (de)
CA (1) CA2159072A1 (de)
DE (1) DE69415001T2 (de)
DK (1) DK0691986T3 (de)
ES (1) ES2126748T3 (de)
GR (1) GR3029453T3 (de)
NZ (1) NZ263455A (de)
WO (1) WO1994022909A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
FR2636066B1 (fr) * 1988-09-02 1991-10-25 Centre Nat Rech Scient Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
DD289543A5 (de) * 1989-05-12 1991-05-02 Univ Halle Wittenberg Neue pharmakologisch-aktive cyclopeptide und verfahren zu ihrer herstellung
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
AU6470590A (en) * 1989-10-23 1991-04-26 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2036973A1 (en) * 1990-02-27 1991-08-28 Mark G. Bock Cyclic hexapeptide oxytocin antagonists
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
WO1992001709A1 (en) * 1990-07-24 1992-02-06 Eastman Kodak Company Process for synthesizing peptides
EP0555328A1 (de) * 1990-11-02 1993-08-18 Genentech, Inc. Blutplättchenaggregationshemmstoffe
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
WO1994015958A2 (en) * 1993-01-08 1994-07-21 Tanabe Seiyaku Co., Ltd. Peptide inhibitors of cell adhesion
JPH08509709A (ja) * 1993-03-29 1996-10-15 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー Ｎ▲上α▼−メチルアルギニンを含有する血小板糖たんぱく▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ抑制剤の製造方法およびそれに用いる中間体化合物
EP0691987A1 (de) * 1993-03-29 1996-01-17 The Du Pont Merck Pharmaceutical Company Zyklische verbindungen als inhibitoren des platelet-glykoproteins iib/iiia

Also Published As

Publication number Publication date
GR3029453T3 (en) 1999-05-28
WO1994022909A1 (en) 1994-10-13
AU682857B2 (en) 1997-10-23
DK0691986T3 (da) 1999-08-16
DE69415001D1 (de) 1999-01-14
NZ263455A (en) 1997-10-24
CA2159072A1 (en) 1994-10-13
EP0691986B1 (de) 1998-12-02
ATE174036T1 (de) 1998-12-15
AU6415794A (en) 1994-10-24
JPH08509708A (ja) 1996-10-15
ES2126748T3 (es) 1999-04-01
EP0691986A1 (de) 1996-01-17
US5817749A (en) 1998-10-06

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: DU PONT PHARMACEUTICALS CO., WILMINGTON, DEL., US

8339 Ceased/non-payment of the annual fee
8327 Change in the person/name/address of the patent owner

Owner name: BRISTOL-MYERS SQUIBB PHARMA CO., PRINCETON, N.J.,