DE69414678T2 - Polyiodierte verbindungen, ihre herstellung und ihre verwendung als kontrastmittel in der radiologie - Google Patents

Polyiodierte verbindungen, ihre herstellung und ihre verwendung als kontrastmittel in der radiologie

Info

Publication number
DE69414678T2
DE69414678T2 DE69414678T DE69414678T DE69414678T2 DE 69414678 T2 DE69414678 T2 DE 69414678T2 DE 69414678 T DE69414678 T DE 69414678T DE 69414678 T DE69414678 T DE 69414678T DE 69414678 T2 DE69414678 T2 DE 69414678T2
Authority
DE
Germany
Prior art keywords
approximately
pct
weight
compounds
polyiodized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414678T
Other languages
English (en)
Other versions
DE69414678D1 (de
Inventor
Dominique Meyer
Greneur Soizic Le
Lem Gael Le
Christian Simonot
Catherine Chambon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet SA filed Critical Guerbet SA
Publication of DE69414678D1 publication Critical patent/DE69414678D1/de
Application granted granted Critical
Publication of DE69414678T2 publication Critical patent/DE69414678T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes
DE69414678T 1993-03-22 1994-03-21 Polyiodierte verbindungen, ihre herstellung und ihre verwendung als kontrastmittel in der radiologie Expired - Fee Related DE69414678T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9303269A FR2703055B1 (fr) 1993-03-22 1993-03-22 Nouveaux composés polyiodés, leur préparation et leur utilisation en tant que produits de contraste pour la radiologie .
PCT/FR1994/000305 WO1994021600A1 (fr) 1993-03-22 1994-03-21 Nouveaux composes polyiodes, leur preparation et leur utilisation en tant que produits de contraste pour la radiologie

Publications (2)

Publication Number Publication Date
DE69414678D1 DE69414678D1 (de) 1998-12-24
DE69414678T2 true DE69414678T2 (de) 1999-07-22

Family

ID=9445205

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414678T Expired - Fee Related DE69414678T2 (de) 1993-03-22 1994-03-21 Polyiodierte verbindungen, ihre herstellung und ihre verwendung als kontrastmittel in der radiologie

Country Status (16)

Country Link
US (1) US5817873A (de)
EP (1) EP0648203B1 (de)
JP (1) JPH07507572A (de)
AT (1) ATE173462T1 (de)
AU (1) AU6285594A (de)
CA (1) CA2136243A1 (de)
DE (1) DE69414678T2 (de)
ES (1) ES2126101T3 (de)
FI (1) FI945464A0 (de)
FR (1) FR2703055B1 (de)
HU (1) HU218083B (de)
IL (1) IL108967A (de)
NO (1) NO307962B1 (de)
WO (1) WO1994021600A1 (de)
YU (1) YU13794A (de)
ZA (1) ZA941959B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4344464A1 (de) * 1993-12-22 1995-06-29 Schering Ag Kaskadenpolymere mit Iodaromaten
ATE181547T1 (de) * 1994-09-22 1999-07-15 Guerbet Sa Iodo-verbindungen, ihre herstellung und verwendung als kontrastmittel für röntgen- radiologie
US5709846A (en) * 1994-09-22 1998-01-20 Guerbet S.A. Iodinated derivatives, their preparation and their use as contrast agents in x-ray radiology
US5756066A (en) * 1995-06-07 1998-05-26 Schering Aktiengesellschaft Iodine-containing peptides
WO2007055580A1 (en) * 2005-11-10 2007-05-18 Ge Healthcare As Contrast agents and diagnostic compositions based on iodine-containing cyanuric acid derivatives
NO20055702D0 (no) 2005-12-02 2005-12-02 Amersham Health As Contrast agents
US20070148096A1 (en) * 2005-12-15 2007-06-28 Lars-Goran Wistrand Contrast Agents
JP5248329B2 (ja) 2006-02-14 2013-07-31 ジーイー・ヘルスケア・アクスイェ・セルスカプ 造影剤
EP1986993B1 (de) * 2006-02-14 2012-12-05 Ge Healthcare As Kontrastmittel
CN101379023A (zh) * 2006-02-15 2009-03-04 通用电气医疗集团股份有限公司 造影剂
EP2021317A1 (de) * 2006-05-11 2009-02-11 GE Healthcare AS Kontrastmittel
WO2007133088A1 (en) * 2006-05-11 2007-11-22 Ge Healthcare As Contrast agents
US7662859B2 (en) * 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
EP2129664A1 (de) * 2007-04-04 2009-12-09 GE Healthcare AS Trisubstituierte triazamakrozyklen-c-verbindungen und ihre verwendung als kontrastmittel
US20080260651A1 (en) * 2007-04-17 2008-10-23 Ge Healthcare As Contrast agents
NO20073382L (no) * 2007-06-29 2008-12-30 Ge Healthcare As Contrast Agents
MX2011004859A (es) 2008-11-07 2011-08-03 Massachusetts Inst Technology Lipidoides de aminoalcohol y usos de los mismos.
EP2691443B1 (de) 2011-03-28 2021-02-17 Massachusetts Institute of Technology Konjugierte lipomers und ihre verwendung
WO2014028487A1 (en) 2012-08-13 2014-02-20 Massachusetts Institute Of Technology Amine-containing lipidoids and uses thereof
US9315472B2 (en) * 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
WO2017165841A1 (en) 2016-03-25 2017-09-28 Nanoprobes, Inc. Iodine-based particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734953A (en) * 1969-08-11 1973-05-22 Squibb & Sons Inc Tris-triiodoisophthalamic acids and derivatives
NL7102816A (de) * 1970-03-12 1971-09-14
GB1346795A (en) * 1971-06-14 1974-02-13 Mallinckrodt Chemical Works Nitrilotriacyltriimino-tris-2,4,6-triidobenzoic acid compounds
AR207465A1 (es) * 1974-05-31 1976-10-08 Guerbet Lab Andre Procedimiento de preparacion de derivados de acido triiodoi2,4,6-(triiodo-2,4,6-benzoil)-amino-alcanoilaminobenzoico de acido triiodo-2,4,6-(triiodo-2,4,6-(triiodo-2,4,6-benzoil)-aminoalcanoilaminobenzoil)-amino-alcanoil-aminobenzoico y de acido triiodo-2,4,6-bis((triiodo-2,4,6-fenil)-carbamoil-metil)-aminoalcanoil-aminobenzoico
FR2511870A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants, composes utilisables a cet effet et produits opacifiants les contenant
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
DE3786000T3 (de) * 1986-08-18 1997-08-21 Dow Chemical Co Conjugate dichter Sterne.
FR2635327B1 (fr) * 1988-08-10 1990-11-16 Guerbet Sa Polymeres iodes, a squelette dextrane, leurs procedes de preparation et leurs applications comme produits de contraste
EP0436316A1 (de) * 1989-12-08 1991-07-10 Milos Sovak Röntgenkontrastmittel für verlängerte Opacifikation

Also Published As

Publication number Publication date
FR2703055A1 (fr) 1994-09-30
NO307962B1 (no) 2000-06-26
HU218083B (hu) 2000-05-28
US5817873A (en) 1998-10-06
WO1994021600A1 (fr) 1994-09-29
ES2126101T3 (es) 1999-03-16
DE69414678D1 (de) 1998-12-24
YU13794A (sh) 1997-08-22
FI945464A (fi) 1994-11-21
EP0648203B1 (de) 1998-11-18
FR2703055B1 (fr) 1995-07-07
NO944424D0 (no) 1994-11-18
IL108967A (en) 1999-01-26
ATE173462T1 (de) 1998-12-15
NO944424L (no) 1995-01-23
FI945464A0 (fi) 1994-11-21
ZA941959B (en) 1995-09-21
AU6285594A (en) 1994-10-11
JPH07507572A (ja) 1995-08-24
HUT71474A (en) 1995-11-28
CA2136243A1 (fr) 1994-09-29
EP0648203A1 (de) 1995-04-19
IL108967A0 (en) 1994-06-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee