DE69414678T2 - POLYIODIZED COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS CONTRAST AGENTS IN RADIOLOGY - Google Patents

POLYIODIZED COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS CONTRAST AGENTS IN RADIOLOGY

Info

Publication number
DE69414678T2
DE69414678T2 DE69414678T DE69414678T DE69414678T2 DE 69414678 T2 DE69414678 T2 DE 69414678T2 DE 69414678 T DE69414678 T DE 69414678T DE 69414678 T DE69414678 T DE 69414678T DE 69414678 T2 DE69414678 T2 DE 69414678T2
Authority
DE
Germany
Prior art keywords
approximately
pct
weight
compounds
polyiodized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414678T
Other languages
German (de)
Other versions
DE69414678D1 (en
Inventor
Dominique Meyer
Greneur Soizic Le
Lem Gael Le
Christian Simonot
Catherine Chambon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Guerbet SA
Original Assignee
Guerbet SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Guerbet SA filed Critical Guerbet SA
Publication of DE69414678D1 publication Critical patent/DE69414678D1/en
Application granted granted Critical
Publication of DE69414678T2 publication Critical patent/DE69414678T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/36—Systems containing two condensed rings the rings having more than two atoms in common
    • C07C2602/46—Systems containing two condensed rings the rings having more than two atoms in common the bicyclo ring system containing nine carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
    • C07C2603/74—Adamantanes

Abstract

PCT No. PCT/FR94/00305 Sec. 371 Date Nov. 1, 1994 Sec. 102(e) Date Nov. 1, 1994 PCT Filed Mar. 21, 1994 PCT Pub. No. WO94/21600 PCT Pub. Date Sep. 29, 1994The present invention relates to polyiodinated compounds with a single molecular weight having a molecular concentration of iodine of greater than approximately 20% by weight, and in particular greater than approximately 30% by weight, containing at least 9 iodine atoms and having a molecular weight above 2000 and below approximately 50,000, and in particular above 2000 and below approximately 20,000, said compounds possessing either a zero overall electrical charge or at least two anionic charges, and persisting in the vascular compartment at a value equal to at least approximately 30% by weight of the injected dose in a subject five minutes after intravascular administration in the said subject.
DE69414678T 1993-03-22 1994-03-21 POLYIODIZED COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS CONTRAST AGENTS IN RADIOLOGY Expired - Fee Related DE69414678T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9303269A FR2703055B1 (en) 1993-03-22 1993-03-22 New polyiodinated compounds, their preparation and their use as contrast agents for radiology.
PCT/FR1994/000305 WO1994021600A1 (en) 1993-03-22 1994-03-21 Novel polyiodinated compounds, preparation thereof and use thereof as radiological contrast agents

Publications (2)

Publication Number Publication Date
DE69414678D1 DE69414678D1 (en) 1998-12-24
DE69414678T2 true DE69414678T2 (en) 1999-07-22

Family

ID=9445205

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414678T Expired - Fee Related DE69414678T2 (en) 1993-03-22 1994-03-21 POLYIODIZED COMPOUNDS, THEIR PRODUCTION AND THEIR USE AS CONTRAST AGENTS IN RADIOLOGY

Country Status (16)

Country Link
US (1) US5817873A (en)
EP (1) EP0648203B1 (en)
JP (1) JPH07507572A (en)
AT (1) ATE173462T1 (en)
AU (1) AU6285594A (en)
CA (1) CA2136243A1 (en)
DE (1) DE69414678T2 (en)
ES (1) ES2126101T3 (en)
FI (1) FI945464A (en)
FR (1) FR2703055B1 (en)
HU (1) HU218083B (en)
IL (1) IL108967A (en)
NO (1) NO307962B1 (en)
WO (1) WO1994021600A1 (en)
YU (1) YU13794A (en)
ZA (1) ZA941959B (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4344464A1 (en) * 1993-12-22 1995-06-29 Schering Ag Cascade polymers with iodine aromatics
WO1996009280A1 (en) * 1994-09-22 1996-03-28 Guerbet S.A. Polyiodinated compounds, preparation and use thereof in x-ray radiology
DE69510527T2 (en) * 1994-09-22 2000-01-27 Guerbet Villepinte IODO DERIVATIVES THEIR PRODUCTION AND USE AS CONTRAST FOR X-RAY RADIOLOGY
US5756066A (en) * 1995-06-07 1998-05-26 Schering Aktiengesellschaft Iodine-containing peptides
US20080267884A1 (en) * 2005-11-10 2008-10-30 Oskar Axelsson Contrast Agents and Diagnostic Compositions Based on Iodine-Containing Cyanuric Acid Derivatives
NO20055702D0 (en) 2005-12-02 2005-12-02 Amersham Health As Contrast agents
US20070148096A1 (en) * 2005-12-15 2007-06-28 Lars-Goran Wistrand Contrast Agents
EP1986993B1 (en) * 2006-02-14 2012-12-05 Ge Healthcare As Contrast agents
US8067637B2 (en) 2006-02-14 2011-11-29 Ge Healthcare As Contrast agents
ES2357861T3 (en) 2006-02-15 2011-05-03 Ge Healthcare As CONTRAST AGENTS.
EP2021317A1 (en) * 2006-05-11 2009-02-11 GE Healthcare AS Contrast agents
ES2390494T3 (en) * 2006-05-11 2012-11-13 Ge Healthcare As Contrast agents
US7662859B2 (en) * 2007-02-16 2010-02-16 Ge Healthcare As Contrast agents
WO2008123779A1 (en) * 2007-04-04 2008-10-16 Ge Healthcare As Trisubstituted triazamacrocycli c compounds and their use as contrast agents
US20080260651A1 (en) * 2007-04-17 2008-10-23 Ge Healthcare As Contrast agents
NO20073382L (en) * 2007-06-29 2008-12-30 Ge Healthcare As Contrast Agents
JP6087504B2 (en) 2008-11-07 2017-03-01 マサチューセッツ インスティテュート オブ テクノロジー Amino alcohol lipidoids and uses thereof
PL2691443T3 (en) 2011-03-28 2021-08-30 Massachusetts Institute Of Technology Conjugated lipomers and uses thereof
WO2014028487A1 (en) 2012-08-13 2014-02-20 Massachusetts Institute Of Technology Amine-containing lipidoids and uses thereof
US9315472B2 (en) * 2013-05-01 2016-04-19 Massachusetts Institute Of Technology 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof
WO2016004202A1 (en) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Polyamine-fatty acid derived lipidoids and uses thereof
US10918742B2 (en) 2016-03-25 2021-02-16 Nanoprobes, Inc. Iodine-based particles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734953A (en) * 1969-08-11 1973-05-22 Squibb & Sons Inc Tris-triiodoisophthalamic acids and derivatives
NL7102816A (en) * 1970-03-12 1971-09-14
GB1346795A (en) * 1971-06-14 1974-02-13 Mallinckrodt Chemical Works Nitrilotriacyltriimino-tris-2,4,6-triidobenzoic acid compounds
AR207465A1 (en) * 1974-05-31 1976-10-08 Guerbet Lab Andre PROCEDURE FOR THE PREPARATION OF TRIIODO-2,4,6- (TRIIODO-2,4,6-BENZOYL) -AMINO-ALKANOYLAMINOBENZOIC ACID DERIVATIVES FROM TRIIODO-2,4,6- (TRIIODO-2,4,6- (TRIIODO- 2,4,6-BENZOYL) -AMINOALKANOYLAMINOBENZOYL) -AMINO-ALKANOYL-AMINOBENZOIC AND OF TRIIODE-2,4,6-BIS ((TRIIODO-2,4,6-PHENYL) -CARBAMOYL-METHYL) -AMINOALKANOYL-AMINOBENZOIC ACID
FR2511870A1 (en) * 1981-08-28 1983-03-04 Guerbet Sa PROCESS FOR INCREASING THE TOLERANCE OF OPACIFYING PRODUCTS, COMPOUNDS USEFUL THEREFOR AND OPACIFYING PRODUCTS CONTAINING THEM
US4507466A (en) * 1983-01-07 1985-03-26 The Dow Chemical Corporation Dense star polymers having core, core branches, terminal groups
EP0271180B2 (en) * 1986-08-18 1997-06-18 The Dow Chemical Company Starburst conjugates
FR2635327B1 (en) * 1988-08-10 1990-11-16 Guerbet Sa IODINE POLYMERS WITH DEXTRAN SKELETON, METHODS OF PREPARING THEM AND APPLICATIONS THEREOF AS CONTRAST PRODUCTS
NO905299L (en) * 1989-12-08 1991-06-10 Milos Sovak ROENTGEN CONTRAST MATERIAL FOR THE MAVE GAS.

Also Published As

Publication number Publication date
EP0648203B1 (en) 1998-11-18
NO307962B1 (en) 2000-06-26
FI945464A0 (en) 1994-11-21
CA2136243A1 (en) 1994-09-29
ATE173462T1 (en) 1998-12-15
HU218083B (en) 2000-05-28
AU6285594A (en) 1994-10-11
IL108967A0 (en) 1994-06-24
HUT71474A (en) 1995-11-28
IL108967A (en) 1999-01-26
WO1994021600A1 (en) 1994-09-29
NO944424D0 (en) 1994-11-18
YU13794A (en) 1997-08-22
NO944424L (en) 1995-01-23
FR2703055A1 (en) 1994-09-30
ES2126101T3 (en) 1999-03-16
EP0648203A1 (en) 1995-04-19
ZA941959B (en) 1995-09-21
JPH07507572A (en) 1995-08-24
US5817873A (en) 1998-10-06
DE69414678D1 (en) 1998-12-24
FI945464A (en) 1994-11-21
FR2703055B1 (en) 1995-07-07

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee