DE69414348D1 - Fluorenonderivate, verfahren zu ihrer herstellung sowie wiederherstellungs- und schutzmittel für zentrale und periphere nervendegenerationen - Google Patents

Fluorenonderivate, verfahren zu ihrer herstellung sowie wiederherstellungs- und schutzmittel für zentrale und periphere nervendegenerationen

Info

Publication number
DE69414348D1
DE69414348D1 DE69414348T DE69414348T DE69414348D1 DE 69414348 D1 DE69414348 D1 DE 69414348D1 DE 69414348 T DE69414348 T DE 69414348T DE 69414348 T DE69414348 T DE 69414348T DE 69414348 D1 DE69414348 D1 DE 69414348D1
Authority
DE
Germany
Prior art keywords
central
fluoreneon
degenerations
restoration
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414348T
Other languages
English (en)
Other versions
DE69414348T2 (de
Inventor
Tatsuyoshi - Tanaka
Yohji Sakurai
Nobutaka - Fujisawa
Osamu - - Hongoh
Takao - Nishi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of DE69414348D1 publication Critical patent/DE69414348D1/de
Application granted granted Critical
Publication of DE69414348T2 publication Critical patent/DE69414348T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C225/18—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings the carbon skeleton containing also rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/10—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings
    • C07C229/14—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of carbon skeletons containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/36—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/757—Unsaturated compounds containing a keto groups being part of a ring containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/112—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • C07D295/116—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings with the doubly bound oxygen or sulfur atoms directly attached to a carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyridine Compounds (AREA)
DE69414348T 1993-06-18 1994-06-15 Fluorenonderivate, verfahren zu ihrer herstellung sowie wiederherstellungs- und schutzmittel für zentrale und periphere nervendegenerationen Expired - Fee Related DE69414348T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14774093 1993-06-18
PCT/JP1994/000966 WO1995000468A1 (en) 1993-06-18 1994-06-15 Fluorenone derivatives, process for preparing the same and central or peripheral nerve degeneration repair and protective agent

Publications (2)

Publication Number Publication Date
DE69414348D1 true DE69414348D1 (de) 1998-12-10
DE69414348T2 DE69414348T2 (de) 1999-05-12

Family

ID=15437076

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414348T Expired - Fee Related DE69414348T2 (de) 1993-06-18 1994-06-15 Fluorenonderivate, verfahren zu ihrer herstellung sowie wiederherstellungs- und schutzmittel für zentrale und periphere nervendegenerationen

Country Status (12)

Country Link
US (1) US5942641A (de)
EP (2) EP0791570A1 (de)
KR (1) KR950702953A (de)
CN (1) CN1110875A (de)
AT (1) ATE172956T1 (de)
AU (1) AU670696B2 (de)
CA (1) CA2142735A1 (de)
DE (1) DE69414348T2 (de)
DK (1) DK0655992T3 (de)
ES (1) ES2123139T3 (de)
TW (1) TW363961B (de)
WO (1) WO1995000468A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004959A (en) * 1996-05-30 1999-12-21 Hoechst Marion Roussel, Inc. Alkyloxyamino substituted fluorenones and their use as protein kinase-C inhibitors
GB2351081A (en) * 1999-06-18 2000-12-20 Lilly Forschung Gmbh Pharmaceutically active imidazoline compounds and analogues thereof
WO2001009117A1 (en) * 1999-07-29 2001-02-08 Allellix Neuroscience Inc. Tricyclic compounds as glycine transport inhibitors
US20030044680A1 (en) * 2001-08-24 2003-03-06 Im&T Research, Inc. Polymer materials for use in an electrode
US6767446B2 (en) * 2001-08-24 2004-07-27 Im&T Research, Inc. Method for preparing polymers containing cyclopentanone structures
US6835296B2 (en) * 2001-08-24 2004-12-28 Im&T Research, Inc. Method for preparing polymers containing cyclopentanone structures
US7365193B2 (en) 2004-02-04 2008-04-29 Abbott Laboratories Amino-substituted tricyclic derivatives and methods of use
CN103012099B (zh) * 2013-01-15 2014-08-20 云南民族大学 一种芴酮类化合物及其制备方法和应用
EP3639817B1 (de) * 2017-06-16 2024-10-09 Korpharm Co., Ltd. Zusammensetzungen mit pterosin-verbindung und deren derivate als wirkstoffe zur prävention oder behandlung von degenerativen gehirnerkrankungen
CN115028522B (zh) * 2022-07-28 2023-10-24 杭州卢普生物科技有限公司 一种2,7-二羟基-9-芴酮的制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622580A (en) * 1969-03-25 1971-11-23 Smith Kline French Lab Piperazino-acetylamino-9-fluorenones and-anthraquinones
US3639624A (en) * 1970-04-20 1972-02-01 Merck & Co Inc Pharmaceutical compositions and methods of treatment
US3662062A (en) * 1970-09-02 1972-05-09 Richardson Merrell Inc Antiviral compositions and methods of use
US3903145A (en) * 1971-06-18 1975-09-02 Squibb & Sons Inc 9-Substituted fluorene-2-acetic acid derivatives
DE2208893A1 (de) * 1972-02-25 1973-08-30 Boehringer Mannheim Gmbh Tricyclische alpha-oxy-carbonsaeurederivate und verfahren zur herstellung derselben
DE2348534A1 (de) * 1972-09-28 1974-04-04 Searle & Co 2,7-bs eckige klammer auf 2-(4azatricyclo eckige klammer auf 4.3.1.1 hoch 3,8 eckige klammer zu undec-4-yl) aethoxy eckige klammer zu -fluoren-9-on und dessen derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
US3976686A (en) * 1972-10-13 1976-08-24 Merck & Co., Inc. [1-Oxo-2,3-hydrocarbylene-5-indanyloxy(or thio)]alkanoic acids
ZA737960B (en) * 1972-10-13 1974-10-30 Merck & Co Inc 1-oxo-2,2-disubstituted-5-indanyloxy-(or thio)alkanoic acids
JPS4984432A (de) * 1972-12-18 1974-08-14
US3959319A (en) * 1974-01-08 1976-05-25 The Upjohn Company Phenyl and naphthyl esters of PGF2 α type prostaglandins
US3987067A (en) * 1974-01-08 1976-10-19 The Upjohn Company Substituted aromatic esters of PGF2.sub.α
US3929862A (en) * 1974-01-08 1975-12-30 Upjohn Co Substituted tolylesters of PGF{HD 2{B {60
PL98342B1 (pl) * 1974-07-30 1978-04-29 Sposob wytwarzania kwasu 1-keto-2-arylo-/lub tienylo/-2-podstawionego-indanyloksy-/lub tio/-5-alkanokarboksylowego
DE2812542A1 (de) * 1978-03-22 1979-10-04 Thomae Gmbh Dr K Neue schwefelhaltige fluorenyl-und phenanthryl-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
JPS58178956A (ja) * 1982-04-14 1983-10-20 Toyota Central Res & Dev Lab Inc アルカリ蓄電池用亜鉛極
US4447420A (en) * 1982-09-30 1984-05-08 Velsicol Chemical Corporation Fluorenone esters of phosphoric and phosphonic acids as insecticides
JPS60104027A (ja) * 1983-11-09 1985-06-08 Nippon Shinyaku Co Ltd フルオレン誘導体
JPS60215080A (ja) * 1984-04-10 1985-10-28 Ricoh Co Ltd 水性インク組成物
US4683241A (en) * 1984-05-21 1987-07-28 G. D. Searle & Co. Phenolic ester derivatives as elastase inhibitors
US4801610A (en) * 1984-05-21 1989-01-31 G. D. Searle & Co. Phenolic ester derivatives as elastase inhibitors
DK575387A (da) * 1986-11-04 1988-05-05 Otsuka Pharma Co Ltd Hydrofluorenderivater, fremgangsmaade til fremstilling deraf og praeparater indeholdende saadanne forbindelser
US4788336A (en) * 1987-01-23 1988-11-29 Eastman Kodak Company Novel organic compounds for use in electrophotographic elements
US4976887A (en) * 1988-01-21 1990-12-11 Kabushiki Kaisha Toshiba Optically active liquid crystal compound and method of manufacturing the same, liquid crystal composition containing the same and liquid crystal display device
JPH01200362A (ja) * 1988-02-05 1989-08-11 Konica Corp 電子写真感光体
DK0382213T3 (da) * 1989-02-08 1995-07-10 Otsuka Pharma Co Ltd Biphenylderivat, middel til reparation af eller beskyttelse mod nervecelledegeneration og fremgangsmåde til fremstilling af et phenylderivat, som indgår i dette middel
US4996230A (en) * 1990-02-16 1991-02-26 Eli Lilly And Company Leukotriene antagonists
JP2857223B2 (ja) * 1990-05-02 1999-02-17 キヤノン株式会社 液晶性化合物、それを含有する液晶組成物およびそれを使用した液晶素子
EP0469844A1 (de) * 1990-08-01 1992-02-05 Merck & Co. Inc. 2-(9-Fluorenonyl)-Carbapenem

Also Published As

Publication number Publication date
AU670696B2 (en) 1996-07-25
ATE172956T1 (de) 1998-11-15
AU6981994A (en) 1995-01-17
TW363961B (en) 1999-07-11
EP0791570A1 (de) 1997-08-27
DK0655992T3 (da) 1999-07-19
DE69414348T2 (de) 1999-05-12
EP0655992B1 (de) 1998-11-04
EP0655992A1 (de) 1995-06-07
WO1995000468A1 (en) 1995-01-05
CA2142735A1 (en) 1995-01-05
KR950702953A (ko) 1995-08-23
US5942641A (en) 1999-08-24
ES2123139T3 (es) 1999-01-01
CN1110875A (zh) 1995-10-25

Similar Documents

Publication Publication Date Title
ATE233730T1 (de) Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende mittel und verfahren zu ihrer herstellung
EP1607387A3 (de) 3,4,4-Trisubstituierte Piperidinderivate und ihre Verwendung als Opioid Antagonisten
ATE128143T1 (de) 17-beta-substituierte-4-aza-5-alpha-androstan-3 one-derivate und verfahren zu ihrer herstellung.
HU9203110D0 (en) Method for producing amino-6-demethyl-desoxi-tetracycline derivatives substituted in locations 7 and 9 as well as pharmaceuitcal preparatives containing these compounds
DE68914488D1 (de) 2-(2-Hydroxy-3-phenoxypropylamino)ethylphenoxyacetamide, Verfahren und Zwischenprodukte zu deren Herstellung.
EP1138673A3 (de) Neue Carbamat- und Harnstoffderivate als Mittel gegen Multidrugresistenz
DE69434313D1 (de) Superoxiddismutase memetika
DE69827906D1 (de) Kautschukzusammensetzung und reifen
DE69414348D1 (de) Fluorenonderivate, verfahren zu ihrer herstellung sowie wiederherstellungs- und schutzmittel für zentrale und periphere nervendegenerationen
CA2017934A1 (en) Nitrogen-containing titanocenes, and the use thereof
ATE246180T1 (de) Benzofuranon-derivate und verfahren zu ihrer herstellung
ATE138062T1 (de) Propoxybenzolderivate und verfahren zu ihrer herstellung
GR3034615T3 (en) Aminophenylalanine derivatives, process for their production, their use and agents containing them as anti-coagulants.
DE69021172D1 (de) Verfahren zum Abschrecken eines gebrauchten Siliziumbettes, verwendet bei der Herstellung von Organohalosilanen.
DE3873524D1 (de) Iodierte polymere, verfahren zu ihrer herstellung und ihre verwendung als kontrastmittel.
ATE152709T1 (de) Tetrahydrocyclopent(b>indole-methanamine und verwandte verbindungen, und verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
NO950665L (no) Nye polyjoderte forbindelser, fremgangsmåte for deres fremstilling og kontrastmidler inneholdende disse
ATE206105T1 (de) Alkykendiamin di- oder tri-essigsäurederivate, verfahren zu ihrer herstellung und ihre verwendung in kosmetischen zusammensetzungen
DE69016085D1 (de) Serinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung in der Humantherapie.
ATE126797T1 (de) Aryliden-1-azacycloalkane und arylalkyl-1- azacycloalkane, deren salze, diese verbindungen enthaltende arzneimittel und deren verwendung sowie verfahren zu ihrer herstellung.
ATE140228T1 (de) Hydroxymethyl-indolizidine und -chinolizidine
ATE179191T1 (de) Auf uretoniminzusammensetzungen basierende polyurethanteile und verfahren zu ihrer herstellung
ATE157961T1 (de) Acetaldehyd-derivate, verfahren zu ihrer herstellung und ihre verwendung
DE69116383D1 (de) Hexapeptidderivate von teicoplanin und verfahren zu deren herstellung
CA2171972A1 (en) Heteroarylamino and heteroarylsulfonamido substituted 3-benzylaminomethyl piperidines and related compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee