DE69407049T2 - Verfahren zur enzymatischen herstellung von beta-lactam derivaten und abtrennung von d-phenylglycine amid - Google Patents

Verfahren zur enzymatischen herstellung von beta-lactam derivaten und abtrennung von d-phenylglycine amid

Info

Publication number
DE69407049T2
DE69407049T2 DE69407049T DE69407049T DE69407049T2 DE 69407049 T2 DE69407049 T2 DE 69407049T2 DE 69407049 T DE69407049 T DE 69407049T DE 69407049 T DE69407049 T DE 69407049T DE 69407049 T2 DE69407049 T2 DE 69407049T2
Authority
DE
Germany
Prior art keywords
beta
phenylglycine
phenylglycine amide
separation
enzymatic production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69407049T
Other languages
English (en)
Other versions
DE69407049D1 (de
Inventor
Wilhelmus Boesten
Harold Moody
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of DE69407049D1 publication Critical patent/DE69407049D1/de
Publication of DE69407049T2 publication Critical patent/DE69407049T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/16—Preparation of optical isomers
    • C07C231/20—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69407049T 1993-07-19 1994-07-13 Verfahren zur enzymatischen herstellung von beta-lactam derivaten und abtrennung von d-phenylglycine amid Expired - Fee Related DE69407049T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BE9300750A BE1007296A3 (nl) 1993-07-19 1993-07-19 Werkwijze voor de bereiding van een beta-lactamderivaat.
PCT/NL1994/000161 WO1995003420A1 (en) 1993-07-19 1994-07-13 Process for the enzymatic preparation of a beta-lactam derivative

Publications (2)

Publication Number Publication Date
DE69407049D1 DE69407049D1 (de) 1998-01-08
DE69407049T2 true DE69407049T2 (de) 1998-07-09

Family

ID=3887201

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69407049T Expired - Fee Related DE69407049T2 (de) 1993-07-19 1994-07-13 Verfahren zur enzymatischen herstellung von beta-lactam derivaten und abtrennung von d-phenylglycine amid

Country Status (8)

Country Link
EP (1) EP0712443B1 (de)
KR (1) KR960704061A (de)
CN (1) CN1127531A (de)
AT (1) ATE160589T1 (de)
BE (1) BE1007296A3 (de)
DE (1) DE69407049T2 (de)
ES (1) ES2110255T3 (de)
WO (1) WO1995003420A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1009264A3 (nl) * 1995-03-31 1997-01-07 Dsm Nv Werkwijze voor de winning van ampicilline.
US5916762A (en) * 1995-03-31 1999-06-29 Chemferm V.O.F. Process for the recovery of ampicillin
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
NL1007077C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
NL1007076C2 (nl) * 1997-09-19 1999-03-22 Dsm Nv Werkwijze voor de winning van een ß-lactam antibioticum.
KR100423442B1 (ko) * 1999-12-28 2004-03-19 주식회사 포스코 편류를 방지할 수 있는 연속주조용 슬라이딩 게이트장치
CN102851332A (zh) * 2012-09-07 2013-01-02 石药集团中诺药业（石家庄）有限公司 一种酶法氨苄西林母液中d（-）苯甘氨酸的回收方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL187110C (nl) * 1976-11-10 1991-06-03 Stamicarbon Werkwijze voor het scheiden van een mengsel van een optisch aktief fenylglycine-amide en een optisch aktief fenylglycine.
NL9000387A (nl) * 1990-02-16 1991-09-16 Stamicarbon Werkwijze voor het racemiseren van een optisch aktief aminozuuramide.
NL9000386A (nl) * 1990-02-16 1991-09-16 Stamicarbon Werkwijze voor de bereiding van optisch aktief aminozuuramide.
AU8208691A (en) * 1990-07-04 1992-02-04 Novo Nordisk A/S Process for preparation of beta -lactams
JPH06504947A (ja) * 1991-01-25 1994-06-09 ノボ　ノルディスク　アクティーゼルスカブ ２種類の固体成分の分離方法

Also Published As

Publication number Publication date
ES2110255T3 (es) 1998-02-01
EP0712443B1 (de) 1997-11-26
ATE160589T1 (de) 1997-12-15
WO1995003420A1 (en) 1995-02-02
BE1007296A3 (nl) 1995-05-09
EP0712443A1 (de) 1996-05-22
DE69407049D1 (de) 1998-01-08
KR960704061A (ko) 1996-08-31
CN1127531A (zh) 1996-07-24

Similar Documents

Publication Publication Date Title
US4497957A (en) Process for preparing optically active tryptophans
MY103698A (en) Method for production of an upgraded coconut product.
CA1128443A (en) Process for the preparation of l-tryptophan by enzyme
ATE317912T1 (de) Verfahren zur herstellung von beta-lactamen
DE69407049D1 (de) Verfahren zur enzymatischen herstellung von beta-lactam derivaten und abtrennung von d-phenylglycine amid
DE3581218D1 (de) Verfahren zur herstellung von 6-hydroxynikotinsaeure.
CA2235590A1 (en) Improved microbial production of indigo
ATE283348T1 (de) Verfahren zur herstellung von aminoalkoholen und derivaten davon
ATE234934T1 (de) Verfahren zur herstellung von einem beta-laktam antibiotikum
DE69614711T2 (de) Verfahren zur gewinnung von cephalexin
DE68915568T2 (de) Verfahren zur Gewinnung der Protease von Endothia parasitica.
DE69622193D1 (de) Verfahren zur winnung von ampicillin
JP3483604B2 (ja) アミノ酸の製造方法
ATE222887T1 (de) Verfahren zur herstellung von inorganischen salzen von optisch aktiven phenylglycin-derivaten
DE69529765T2 (de) Verfahren zur fermentativen herstellung von clavamderivaten, wobei der ammoniak und harnstoffgehalt im fermentationsmedium niedrig gehalten wird
US5348882A (en) Method of producing enantiomerically pure, open-chain N-alkyl-L or D-amino acids using comamonas testosteroni
ATE191508T1 (de) Mikrobiologisches verfahren zur herstellung von 1-ungesättigten, 17-beta-carboxysubstituierten 3- oxo-4-azaandrostan-3-onen
TR200100167T2 (tr) Klavulanik asit üretimi için geliştirilmiş yöntem
DE69718450T2 (de) Einfaches verfahren zur herstellung von hochwertigem captropril
JPH08173188A (ja) Ｄ−リジンの製法
GEP19981476B (en) Method for Production of Protein from MilkWhey

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee