DE69402703T2 - 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND - Google Patents

3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND

Info

Publication number
DE69402703T2
DE69402703T2 DE69402703T DE69402703T DE69402703T2 DE 69402703 T2 DE69402703 T2 DE 69402703T2 DE 69402703 T DE69402703 T DE 69402703T DE 69402703 T DE69402703 T DE 69402703T DE 69402703 T2 DE69402703 T2 DE 69402703T2
Authority
DE
Germany
Prior art keywords
acid derivatives
indol
derivatives useful
nmda antagonists
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69402703T
Other languages
German (de)
English (en)
Other versions
DE69402703D1 (de
Inventor
Francesco Salituro
Bruce Baron
Boyd Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69402703D1 publication Critical patent/DE69402703D1/de
Publication of DE69402703T2 publication Critical patent/DE69402703T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
DE69402703T 1993-05-27 1994-05-02 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND Expired - Lifetime DE69402703T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6836793A 1993-05-27 1993-05-27
US13932393A 1993-10-19 1993-10-19
US19081494A 1994-02-02 1994-02-02
PCT/US1994/005023 WO1994027964A1 (en) 1993-05-27 1994-05-02 3-(indol-3-yl) propenoic acid derivatives and as nmda antagonists

Publications (2)

Publication Number Publication Date
DE69402703D1 DE69402703D1 (de) 1997-05-22
DE69402703T2 true DE69402703T2 (de) 1997-11-27

Family

ID=27371322

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69402703T Expired - Lifetime DE69402703T2 (de) 1993-05-27 1994-05-02 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND

Country Status (17)

Country Link
EP (1) EP0701551B1 (fi)
JP (1) JP3334805B2 (fi)
KR (1) KR100314482B1 (fi)
CN (1) CN1051302C (fi)
AT (1) ATE151750T1 (fi)
AU (1) AU681402B2 (fi)
CA (1) CA2161768C (fi)
DE (1) DE69402703T2 (fi)
DK (1) DK0701551T3 (fi)
ES (1) ES2103590T3 (fi)
FI (1) FI955604A0 (fi)
GR (1) GR3023973T3 (fi)
HU (1) HU216633B (fi)
IL (1) IL109744A (fi)
NO (1) NO306021B1 (fi)
TW (1) TW262467B (fi)
WO (1) WO1994027964A1 (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5563157B1 (en) * 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
BR9712144A (pt) * 1996-09-30 1999-08-31 Hoechst Marion Roussel Inc Novos antagonistas de nmda (d- aspartato de n-metila).
CN101770315B (zh) 2009-01-05 2012-05-23 鸿富锦精密工业（深圳）有限公司 具有滑动控制的触摸电子装置及其滑动控制方法
CN113419008B (zh) * 2021-06-29 2023-02-07 国家烟草质量监督检验中心 一种氟噻虫砜代谢物的合相色谱串联质谱测定方法
CN113419009B (zh) * 2021-06-29 2023-02-07 国家烟草质量监督检验中心 一种氟噻虫砜代谢物的液相色谱串联质谱测定方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
WO2019021625A1 (ja) * 2017-07-25 2019-01-31 株式会社日立ハイテクノロジーズ 自動分析装置

Also Published As

Publication number Publication date
JPH09508615A (ja) 1997-09-02
NO954769L (no) 1996-01-25
AU681402B2 (en) 1997-08-28
EP0701551A1 (en) 1996-03-20
DK0701551T3 (da) 1997-10-20
FI955604A (fi) 1995-11-21
CN1124484A (zh) 1996-06-12
JP3334805B2 (ja) 2002-10-15
ATE151750T1 (de) 1997-05-15
HUT74620A (en) 1997-01-28
EP0701551B1 (en) 1997-04-16
ES2103590T3 (es) 1997-09-16
AU6784394A (en) 1994-12-20
DE69402703D1 (de) 1997-05-22
FI955604A0 (fi) 1995-11-21
IL109744A0 (en) 1994-08-26
CN1051302C (zh) 2000-04-12
HU9503367D0 (en) 1996-01-29
HU216633B (hu) 1999-07-28
KR100314482B1 (ko) 2002-02-28
NO306021B1 (no) 1999-09-06
NO954769D0 (no) 1995-11-24
GR3023973T3 (en) 1997-10-31
IL109744A (en) 1999-06-20
KR960702438A (ko) 1996-04-27
CA2161768C (en) 1998-08-18
CA2161768A1 (en) 1994-12-08
WO1994027964A1 (en) 1994-12-08
TW262467B (fi) 1995-11-11

Similar Documents

Publication Publication Date Title
LV11617A (lv) Morfolins un tiomorfolins ar tahikinina receptoru antagonistu ipasibam
DE69027562D1 (de) Xanthinverbindungen
LU91162I2 (fr) Aloxi-Palonosétrone et ses dérivés pharmaceutiquement acceptables.
AU641952B2 (en) Substituted N-(imidazolyl)alkyl alanine derivatives
DK0902018T3 (da) 2-(arylpheny)amino-imidazolinderivater
DE69402703D1 (de) 3-(INDOL-3-YL) PROPENSäURDERIVATE, DIE ALS NMDA- ANTAGONISTEN NÜTZLICH SIND
ATE170851T1 (de) Guanidinothiazolederivate und ihre anwendung als h2-rezeptor-antagonisten
TW334428B (en) Novel benzodiazepine derivatives
EA200101050A1 (ru) Замещенные бензолактамные соединения
NZ291855A (en) Bridged azabicyclo-piperazin-1-yl-2-phenyl-butan-1-one derivatives as 5-ht1a antagonists
CA2009542A1 (en) Cyclic guanidines as calcium antagonists
ATE264320T1 (de) 5-aminoalkyl- und 5-aminocarbonylsubstituierte indole

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AVENTIS INC. (N.D.GES.D. STAATES PENNSYLVANIA), GR

8327 Change in the person/name/address of the patent owner

Owner name: AVENTISUB II INC., GREENVILLE, DEL., US