FI955604A - 3-(indol-3-yyli)propenoiinihappojohdannaiset NMDA-antagonisteina - Google Patents

3-(indol-3-yyli)propenoiinihappojohdannaiset NMDA-antagonisteina Download PDF

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Publication number
FI955604A
FI955604A FI955604A FI955604A FI955604A FI 955604 A FI955604 A FI 955604A FI 955604 A FI955604 A FI 955604A FI 955604 A FI955604 A FI 955604A FI 955604 A FI955604 A FI 955604A
Authority
FI
Finland
Prior art keywords
acid derivatives
propenoic acid
indol
hydrogen
represented
Prior art date
Application number
FI955604A
Other languages
English (en)
Swedish (sv)
Other versions
FI955604A0 (fi
Inventor
Francesco Gerald Salituro
Bruce Michael Baron
Boyd Lynn Harrison
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of FI955604A0 publication Critical patent/FI955604A0/fi
Publication of FI955604A publication Critical patent/FI955604A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
FI955604A 1993-05-27 1995-11-21 3-(indol-3-yyli)propenoiinihappojohdannaiset NMDA-antagonisteina FI955604A (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US6836793A 1993-05-27 1993-05-27
US13932393A 1993-10-19 1993-10-19
US19081494A 1994-02-02 1994-02-02
PCT/US1994/005023 WO1994027964A1 (en) 1993-05-27 1994-05-02 3-(indol-3-yl) propenoic acid derivatives and as nmda antagonists

Publications (2)

Publication Number Publication Date
FI955604A0 FI955604A0 (fi) 1995-11-21
FI955604A true FI955604A (fi) 1995-11-21

Family

ID=27371322

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955604A FI955604A (fi) 1993-05-27 1995-11-21 3-(indol-3-yyli)propenoiinihappojohdannaiset NMDA-antagonisteina

Country Status (17)

Country Link
EP (1) EP0701551B1 (fi)
JP (1) JP3334805B2 (fi)
KR (1) KR100314482B1 (fi)
CN (1) CN1051302C (fi)
AT (1) ATE151750T1 (fi)
AU (1) AU681402B2 (fi)
CA (1) CA2161768C (fi)
DE (1) DE69402703T2 (fi)
DK (1) DK0701551T3 (fi)
ES (1) ES2103590T3 (fi)
FI (1) FI955604A (fi)
GR (1) GR3023973T3 (fi)
HU (1) HU216633B (fi)
IL (1) IL109744A (fi)
NO (1) NO306021B1 (fi)
TW (1) TW262467B (fi)
WO (1) WO1994027964A1 (fi)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9304500D0 (en) * 1993-03-05 1993-04-21 Glaxo Spa Heterocyclic compounds
US5563157B1 (en) 1994-10-31 1999-02-02 Hoecst Marion Roussel Inc Heterocycle substituted propenoic acid derivatives and pharmaceutical compositions thereof
AU732997B2 (en) * 1996-09-30 2001-05-03 Aventis Pharmaceuticals Inc. NMDA (N-methyl-D-aspartate) antagonists
CN101770315B (zh) 2009-01-05 2012-05-23 鸿富锦精密工业（深圳）有限公司 具有滑动控制的触摸电子装置及其滑动控制方法
CN113419009B (zh) * 2021-06-29 2023-02-07 国家烟草质量监督检验中心 一种氟噻虫砜代谢物的液相色谱串联质谱测定方法
CN113419008B (zh) * 2021-06-29 2023-02-07 国家烟草质量监督检验中心 一种氟噻虫砜代谢物的合相色谱串联质谱测定方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5284862A (en) * 1991-03-18 1994-02-08 Warner-Lambert Company Derivatives of 2-carboxyindoles having pharmaceutical activity
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
WO2019021625A1 (ja) * 2017-07-25 2019-01-31 株式会社日立ハイテクノロジーズ 自動分析装置

Also Published As

Publication number Publication date
JPH09508615A (ja) 1997-09-02
JP3334805B2 (ja) 2002-10-15
FI955604A0 (fi) 1995-11-21
HUT74620A (en) 1997-01-28
HU9503367D0 (en) 1996-01-29
NO954769D0 (no) 1995-11-24
CN1051302C (zh) 2000-04-12
DE69402703D1 (de) 1997-05-22
KR960702438A (ko) 1996-04-27
KR100314482B1 (ko) 2002-02-28
HU216633B (hu) 1999-07-28
NO306021B1 (no) 1999-09-06
ATE151750T1 (de) 1997-05-15
DE69402703T2 (de) 1997-11-27
EP0701551B1 (en) 1997-04-16
CN1124484A (zh) 1996-06-12
NO954769L (no) 1996-01-25
GR3023973T3 (en) 1997-10-31
TW262467B (fi) 1995-11-11
ES2103590T3 (es) 1997-09-16
CA2161768C (en) 1998-08-18
AU6784394A (en) 1994-12-20
IL109744A (en) 1999-06-20
WO1994027964A1 (en) 1994-12-08
AU681402B2 (en) 1997-08-28
EP0701551A1 (en) 1996-03-20
IL109744A0 (en) 1994-08-26
DK0701551T3 (da) 1997-10-20
CA2161768A1 (en) 1994-12-08

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