DE69334298D1 - Verwendung von dna sequenzen in der herstellung von rekombinanten menschlichen bssl/cel in transgenen nicht-menschlichen tieren, und hergestelltes bssl - Google Patents

Verwendung von dna sequenzen in der herstellung von rekombinanten menschlichen bssl/cel in transgenen nicht-menschlichen tieren, und hergestelltes bssl

Info

Publication number
DE69334298D1
DE69334298D1 DE69334298T DE69334298T DE69334298D1 DE 69334298 D1 DE69334298 D1 DE 69334298D1 DE 69334298 T DE69334298 T DE 69334298T DE 69334298 T DE69334298 T DE 69334298T DE 69334298 D1 DE69334298 D1 DE 69334298D1
Authority
DE
Germany
Prior art keywords
bssl
cel
manufactured
manufacture
dna sequences
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69334298T
Other languages
English (en)
Inventor
Karl Gunnar Bjursell
Peter Nils Carlsson
Curt Sven Enerbaeck
Stig Lennart Hansson
Ulf Fredrik Lidberg
Jeanette Annika Nilsson
Jan Birger Toernell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Arexis AB
Original Assignee
Arexis AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9201809A external-priority patent/SE9201809D0/xx
Priority claimed from SE9201826A external-priority patent/SE9201826D0/xx
Priority claimed from SE9202088A external-priority patent/SE9202088D0/xx
Priority claimed from SE9300902A external-priority patent/SE9300902D0/xx
Application filed by Arexis AB filed Critical Arexis AB
Application granted granted Critical
Publication of DE69334298D1 publication Critical patent/DE69334298D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/20—Dietetic milk products not covered by groups A23C9/12 - A23C9/18
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/01—Animal expressing industrially exogenous proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Nutrition Science (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
DE69334298T 1992-06-11 1993-06-09 Verwendung von dna sequenzen in der herstellung von rekombinanten menschlichen bssl/cel in transgenen nicht-menschlichen tieren, und hergestelltes bssl Expired - Lifetime DE69334298D1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
SE9201809A SE9201809D0 (sv) 1992-06-11 1992-06-11 New dna sequences
SE9201826A SE9201826D0 (sv) 1992-06-12 1992-06-12 New dna sequences ii
SE9202088A SE9202088D0 (sv) 1992-07-03 1992-07-03 New dna sequences iii
SE9300902A SE9300902D0 (sv) 1993-03-19 1993-03-19 New dna sequences iv
PCT/SE1993/000515 WO1993025669A1 (en) 1992-06-11 1993-06-09 Dna sequences used in the production of recombinant human bssl/cel in transgenic non-human mammals, and the produced bssl/cel used in infant formulas

Publications (1)

Publication Number Publication Date
DE69334298D1 true DE69334298D1 (de) 2009-12-10

Family

ID=27484751

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69334298T Expired - Lifetime DE69334298D1 (de) 1992-06-11 1993-06-09 Verwendung von dna sequenzen in der herstellung von rekombinanten menschlichen bssl/cel in transgenen nicht-menschlichen tieren, und hergestelltes bssl

Country Status (31)

Country Link
US (2) US5616483A (de)
EP (1) EP0651793B1 (de)
JP (1) JP4231105B2 (de)
KR (1) KR100357670B1 (de)
CN (1) CN1071791C (de)
AP (1) AP411A (de)
AT (1) ATE447012T1 (de)
AU (1) AU670598B2 (de)
CA (1) CA2137815C (de)
CZ (1) CZ288677B6 (de)
DE (1) DE69334298D1 (de)
DK (1) DK0651793T3 (de)
ES (1) ES2335626T3 (de)
FI (1) FI945793A (de)
HR (1) HRP930935A2 (de)
HU (1) HU220338B (de)
IL (1) IL105874A (de)
IS (1) IS4029A (de)
MA (1) MA22905A1 (de)
MX (1) MX9303439A (de)
NO (1) NO944715L (de)
NZ (1) NZ253391A (de)
PH (1) PH31680A (de)
PT (1) PT651793E (de)
RU (1) RU2128708C1 (de)
SG (1) SG52580A1 (de)
SI (1) SI9300319A (de)
SK (1) SK286993B6 (de)
TN (1) TNSN93067A1 (de)
UA (1) UA41322C2 (de)
WO (1) WO1993025669A1 (de)

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US7008776B1 (en) * 1996-12-06 2006-03-07 Aventis Pharmaceuticals Inc. Compositions and methods for effecting the levels of high density lipoprotein (HDL) cholesterol and apolipoprotein AI very low density lipoprotein (VLDL) cholesterol and low density lipoprotein (LDL) cholesterol
FR2763958A1 (fr) * 1997-05-29 1998-12-04 Transgene Sa Produit de combinaison associant un acide nucleique a une substance desorganisant la matrice extracellulaire pour la therapie genique
US6177545B1 (en) * 1997-09-02 2001-01-23 Insight Strategy & Marketing Ltd. Heparanase specific molecular probes and their use in research and medical applications
US20040213789A1 (en) * 1997-09-02 2004-10-28 Oron Yacoby-Zeevi Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies
US20010006630A1 (en) * 1997-09-02 2001-07-05 Oron Yacoby-Zeevi Introducing a biological material into a patient
US6699672B1 (en) * 1997-09-02 2004-03-02 Insight Biopharmaceuticals Ltd. Heparanase specific molecular probes and their use research and medical applications
US20020088019A1 (en) * 1997-09-02 2002-07-04 Oron Yacoby-Zeevi Methods of and pharmaceutical compositions for improving implantation of embryos
SE9801424D0 (sv) * 1998-04-22 1998-04-22 Astra Ab Expression methods
US20030217375A1 (en) * 1998-08-31 2003-11-20 Eyal Zcharia Transgenic animals expressing heparanase and uses thereof
EP1157118A4 (de) * 1999-03-01 2002-07-17 Insight Strategy & Marketing POLYNUKLEOTID, DAS FüR EIN POLYPEPTID MIT HEPARANASE-AKTIVäT KODIERT, UND DESSEN EXPRESSION IN GENETISCH VERäNDERTEN ZELLEN
EP1175503A1 (de) * 1999-04-09 2002-01-30 Human Genome Sciences, Inc. 49 humane sekretierte proteine
AU5032600A (en) * 1999-05-19 2001-12-03 Barnes-Jewish Hospital Enhanced triglyceride digestion in a deficiency of bile salts
EP1307557A2 (de) 2000-08-02 2003-05-07 The Johns Hopkins University Expressionsmuster von endothelzellen
IT1319655B1 (it) 2000-11-15 2003-10-23 Eurand Int Microsfere di enzimi pancreatici con elevata stabilita' e relativometodo di preparazione.
US20100268658A1 (en) * 2001-05-14 2010-10-21 Prolacta Bioscience Method for collecting, testing and distributing milk
US20020182243A1 (en) * 2001-05-14 2002-12-05 Medo Elena Maria Method of producing nutritional products from human milk tissue and compositions thereof
US6671189B2 (en) * 2001-11-09 2003-12-30 Minebea Co., Ltd. Power converter having primary and secondary side switches
US20030213007A1 (en) * 2002-03-27 2003-11-13 Slattery Charles Wilbur Human milk produced by human mammary tissue implanted in non-human host animals and uses thereof
WO2004108065A2 (en) * 2003-06-09 2004-12-16 Insight Biopharmaceuticals Ltd. Heparanase activity neutralizing anti- heparanase monoclonal antibody and other anti-heparanase antibodies
CA2623483A1 (en) 2005-09-20 2007-03-29 Prolacta Bioscience, Inc. A method for testing milk
US20090228996A1 (en) * 2006-02-03 2009-09-10 William Anderson Paxton Means and Methods for influencing Interactions Between Dc-Sign and Dc-Sign Ligands
CN105123950A (zh) * 2006-11-29 2015-12-09 普罗莱克塔生物科学公司 人乳组合物及其制备和使用方法
ES2396571T3 (es) * 2006-12-08 2013-02-22 Prolacta Bioscience, Inc. Composiciones de lípidos humanos y procedimientos de preparación y utilización de los mismos
WO2008102264A2 (en) 2007-02-20 2008-08-28 Eurand Pharmaceuticals Limited Stable digestive enzyme compositions
US10087493B2 (en) 2008-03-07 2018-10-02 Aptalis Pharma Canada Ulc Method for detecting infectious parvovirus in pharmaceutical preparations
US8927027B2 (en) 2008-12-02 2015-01-06 Prolacta Bioscience Human milk permeate compositions and methods of making and using same
CL2011002432A1 (es) 2010-10-01 2012-04-20 Aptalis Pharma Ltd Composicion que comprende al menos una enzima digestiva y al menos un portador, en donde el portador comprende celulosa microcristalina que tiene un tamaño de particulas mayor que 100 um; una forma de dosificacion; el envase que la contiene; un proceso para preparar la composicion; y sus usos.
DK2629790T3 (en) * 2010-10-21 2016-10-24 Swedish Orphan Biovitrum Ab (Publ) Approach to increase growth rate of human babies
CN103189070A (zh) * 2010-10-21 2013-07-03 瑞典孤儿比奥维特鲁姆有限公司 增加人婴儿对不饱和脂肪酸之吸收的方法
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CN103088000A (zh) * 2012-03-23 2013-05-08 北京济福霖生物技术有限公司 在哺乳动物乳腺中过表达胆盐激活脂酶的方法
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Also Published As

Publication number Publication date
HRP930935A2 (en) 1994-12-31
EP0651793A1 (de) 1995-05-10
US5616483A (en) 1997-04-01
NZ253391A (en) 1996-01-26
AP411A (en) 1995-09-28
ATE447012T1 (de) 2009-11-15
FI945793A (fi) 1995-02-09
CN1086262A (zh) 1994-05-04
SK286993B6 (sk) 2009-09-07
EP0651793B1 (de) 2009-10-28
MX9303439A (es) 1994-04-29
UA41322C2 (uk) 2001-09-17
RU94046360A (ru) 1997-06-10
AP9300538A0 (en) 1993-07-31
CA2137815A1 (en) 1993-12-23
TNSN93067A1 (fr) 1994-03-17
PT651793E (pt) 2010-01-20
IL105874A (en) 1998-12-27
HU220338B (hu) 2001-12-28
ES2335626T3 (es) 2010-03-30
HU9403536D0 (en) 1995-02-28
CN1071791C (zh) 2001-09-26
AU670598B2 (en) 1996-07-25
SK148694A3 (en) 1995-08-09
IS4029A (is) 1993-12-12
SI9300319A (en) 1994-03-31
CA2137815C (en) 2010-11-09
NO944715L (no) 1995-02-07
NO944715D0 (no) 1994-12-07
CZ288677B6 (cs) 2001-08-15
IL105874A0 (en) 1993-10-20
US5716817A (en) 1998-02-10
MA22905A1 (fr) 1993-12-31
KR100357670B1 (ko) 2003-04-11
JP4231105B2 (ja) 2009-02-25
AU4366793A (en) 1994-01-04
DK0651793T3 (da) 2010-03-15
RU2128708C1 (ru) 1999-04-10
HUT71789A (en) 1996-02-28
SG52580A1 (en) 1998-09-28
PH31680A (en) 1999-01-18
JPH07507687A (ja) 1995-08-31
WO1993025669A1 (en) 1993-12-23
CZ309194A3 (en) 1995-07-12
FI945793A0 (fi) 1994-12-09

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Owner name: AREXIS AB, STOCKHOLM, SE

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