DE69333689D1 - Inhibitorresistente serinproteasen - Google Patents

Inhibitorresistente serinproteasen

Info

Publication number
DE69333689D1
DE69333689D1 DE69333689T DE69333689T DE69333689D1 DE 69333689 D1 DE69333689 D1 DE 69333689D1 DE 69333689 T DE69333689 T DE 69333689T DE 69333689 T DE69333689 T DE 69333689T DE 69333689 D1 DE69333689 D1 DE 69333689D1
Authority
DE
Germany
Prior art keywords
pct
serine proteases
inhibitor
date feb
sec
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69333689T
Other languages
English (en)
Other versions
DE69333689T2 (de
Inventor
Keith Martyn Dawson
Richard James Gilbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vernalis R&D Ltd
Original Assignee
Vernalis Oxford Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vernalis Oxford Ltd filed Critical Vernalis Oxford Ltd
Publication of DE69333689D1 publication Critical patent/DE69333689D1/de
Application granted granted Critical
Publication of DE69333689T2 publication Critical patent/DE69333689T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69333689T 1992-08-04 1993-08-03 Inhibitorresistente serinproteasen Expired - Lifetime DE69333689T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929216558A GB9216558D0 (en) 1992-08-04 1992-08-04 Modified proteases
GB9216558 1992-08-04
PCT/GB1993/001632 WO1994003614A1 (en) 1992-08-04 1993-08-03 Inhibitor resistant serine proteases

Publications (2)

Publication Number Publication Date
DE69333689D1 true DE69333689D1 (de) 2004-12-16
DE69333689T2 DE69333689T2 (de) 2005-11-03

Family

ID=10719807

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69333689T Expired - Lifetime DE69333689T2 (de) 1992-08-04 1993-08-03 Inhibitorresistente serinproteasen

Country Status (10)

Country Link
US (2) US5645833A (de)
EP (1) EP0658206B1 (de)
JP (1) JP3449717B2 (de)
AT (1) ATE282089T1 (de)
AU (1) AU4720093A (de)
DE (1) DE69333689T2 (de)
ES (1) ES2232812T3 (de)
GB (1) GB9216558D0 (de)
WO (1) WO1994003614A1 (de)
ZA (1) ZA935660B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7278094A (en) * 1994-06-07 1996-01-04 M D Serv Europe S.A. Intravasal thrombolysis
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
US6942978B1 (en) * 1999-03-03 2005-09-13 The Board Of Trustees Of The University Of Arkansas Transmembrane serine protease overexpressed in ovarian carcinoma and uses thereof
US7700341B2 (en) * 2000-02-03 2010-04-20 Dendreon Corporation Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon
JP2001275677A (ja) * 2000-03-30 2001-10-09 Canon Inc 核酸断片プライマーまたはプローブ、およびこれを用いたポリヒドロキシアルカノエート合成微生物の検出方法
EP1390497A2 (de) 2001-05-25 2004-02-25 Genset Menschliche cdns und proteine und verwendungen davon
DE102006053404A1 (de) * 2006-11-10 2008-05-15 Hydro Aluminium Alucast Gmbh Gießform zum Gießen eines Gussteils und Verwendung einer solchen Gießform
JP2018537976A (ja) * 2015-11-25 2018-12-27 アカデミシュ・ジークンホイス・ライデン 組換えセリンプロテアーゼ
US11613744B2 (en) 2018-12-28 2023-03-28 Vertex Pharmaceuticals Incorporated Modified urokinase-type plasminogen activator polypeptides and methods of use
EP3902913A1 (de) 2018-12-28 2021-11-03 Catalyst Biosciences, Inc. Modifizierte urokinaseartige plasminogenaktivatorpolypeptide und verfahren zur verwendung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2007364A1 (en) * 1989-01-17 1990-07-17 David J. Livingston Gene sequences encoding modified residues situated in the protease domain of tpa
US5304482A (en) * 1989-03-06 1994-04-19 The Board Of Regents Of The University Of Texas System Serine protease mutants of the chymotrypsin superfamily resistant to inhibition by their cognate inhibitors
EP1029921B1 (de) * 1989-03-06 2002-10-23 The Board of Regents of The University of Texas System Serpin-resistenter T-PA; Mutanten; Gene
GB8927722D0 (en) * 1989-12-07 1990-02-07 British Bio Technology Proteins and nucleic acids

Also Published As

Publication number Publication date
GB9216558D0 (en) 1992-09-16
JPH07509610A (ja) 1995-10-26
AU4720093A (en) 1994-03-03
ATE282089T1 (de) 2004-11-15
US5932213A (en) 1999-08-03
WO1994003614A1 (en) 1994-02-17
EP0658206B1 (de) 2004-11-10
DE69333689T2 (de) 2005-11-03
JP3449717B2 (ja) 2003-09-22
ZA935660B (en) 1994-03-17
EP0658206A1 (de) 1995-06-21
US5645833A (en) 1997-07-08
ES2232812T3 (es) 2005-06-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition