DE69332978D1 - Methode zur inhibition der replikation von hyperproliferativen zellen - Google Patents
Methode zur inhibition der replikation von hyperproliferativen zellenInfo
- Publication number
- DE69332978D1 DE69332978D1 DE69332978T DE69332978T DE69332978D1 DE 69332978 D1 DE69332978 D1 DE 69332978D1 DE 69332978 T DE69332978 T DE 69332978T DE 69332978 T DE69332978 T DE 69332978T DE 69332978 D1 DE69332978 D1 DE 69332978D1
- Authority
- DE
- Germany
- Prior art keywords
- hyperproliferative cells
- hyperproliferative
- polypeptide
- relates
- adenovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 6
- 230000002401 inhibitory effect Effects 0.000 title 1
- 230000010076 replication Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 5
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 108010024878 Adenovirus E1A Proteins Proteins 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 230000001575 pathological effect Effects 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 210000005260 human cell Anatomy 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/10011—Adenoviridae
- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/13011—Gammaretrovirus, e.g. murine leukeamia virus
- C12N2740/13041—Use of virus, viral particle or viral elements as a vector
- C12N2740/13043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Virology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US960112 | 1992-10-13 | ||
| US07/960,112 US5516631A (en) | 1992-10-13 | 1992-10-13 | Method of inhibiting replication of hyperproliferative cells |
| PCT/US1993/009774 WO1994009160A1 (en) | 1992-10-13 | 1993-10-13 | Method of inhibiting replication of hyperproliferative cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69332978D1 true DE69332978D1 (de) | 2003-06-18 |
| DE69332978T2 DE69332978T2 (de) | 2004-02-26 |
Family
ID=25502805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69332978T Expired - Fee Related DE69332978T2 (de) | 1992-10-13 | 1993-10-13 | Methode zur inhibition der replikation von hyperproliferativen zellen |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5516631A (de) |
| EP (1) | EP0666929B1 (de) |
| JP (1) | JP3492364B2 (de) |
| AT (1) | ATE240404T1 (de) |
| CA (1) | CA2147127A1 (de) |
| DE (1) | DE69332978T2 (de) |
| DK (1) | DK0666929T3 (de) |
| ES (1) | ES2194849T3 (de) |
| PT (1) | PT666929E (de) |
| WO (1) | WO1994009160A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643567A (en) * | 1990-12-04 | 1997-07-01 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
| JPH06296489A (ja) * | 1992-11-20 | 1994-10-25 | Univ Texas Syst | 網膜芽腫−関連タンパク質をコードする細胞性遺伝子 |
| US5776743A (en) | 1994-09-06 | 1998-07-07 | La Jolla Cancer Research Foundation | Method of sensitizing tumor cells with adenovirus E1A |
| US6326356B1 (en) | 1996-10-18 | 2001-12-04 | Board Of Regents, The University Of Texas System | Suppression of neu overexpression using a mini-E1A gene |
| US5869040A (en) * | 1995-06-07 | 1999-02-09 | Biogen, Inc | Gene therapy methods and compositions |
| WO1997005898A1 (en) * | 1995-08-03 | 1997-02-20 | The Johns Hopkins University School Of Medicine | Delivery of an agent to the ductal epithelium in the prophylactic and therapeutic treatment of cancer |
| US5763415A (en) | 1995-08-03 | 1998-06-09 | John Hopkins University School Of Medicine | Destruction of the epithelium of an exocrine gland in the prophylactic and therapeutic treatment of cancer |
| US7462605B2 (en) * | 1998-01-23 | 2008-12-09 | Celmed Oncology (Usa), Inc. | Phosphoramidate compounds and methods of use |
| DE69900841T2 (de) | 1998-01-23 | 2002-10-02 | Newbiotics Inc | Durch enzymkatalyse erhaltene therapeutische substanzen. |
| US6413974B1 (en) * | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
| US6479487B1 (en) * | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| US6683061B1 (en) | 1999-07-22 | 2004-01-27 | Newbiotics, Inc. | Enzyme catalyzed therapeutic activation |
| CN1391486A (zh) | 1999-07-22 | 2003-01-15 | 新生物公司 | 治疗对治疗有抗性的肿瘤的方法 |
| US20040266834A1 (en) * | 1999-10-14 | 2004-12-30 | Copland John A. | Thiazolidinediones alone or in cabination with other therapeutic agents for cancer therapy |
| IL149404A0 (en) * | 2002-04-29 | 2002-11-10 | Yissum Res Dev Co | METHODS AND COMPOSITIONS FOR MODULATING β-CATENIN PHOSPHORYLATION |
| US20040191761A1 (en) * | 2003-03-27 | 2004-09-30 | Routes John M. | Modified adenoviral E1A constructs and methods of use thereof |
| ES2385251B1 (es) | 2009-05-06 | 2013-05-06 | Fundació Privada Institut D'investigació Biomèdica De Bellvitge | Adenovirus oncolíticos para el tratamiento del cáncer. |
| WO2012071492A1 (en) | 2010-11-23 | 2012-05-31 | Georgia Tech Research Corporation | Mir-200 family induces mesenchymal-to-epithelial transition (met) in ovarian cancer cells |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643567A (en) * | 1990-12-04 | 1997-07-01 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
| US5651964A (en) * | 1990-12-04 | 1997-07-29 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by the adenoviral EIA gene |
| US5641484A (en) * | 1990-12-04 | 1997-06-24 | Board Of Regents, The University Of Texas System | Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen |
| AU682854B2 (en) * | 1993-02-16 | 1997-10-23 | Onyx Pharmaceuticals | Cytopathic viruses for therapy and prophylaxis of neoplasia |
-
1992
- 1992-10-13 US US07/960,112 patent/US5516631A/en not_active Expired - Lifetime
-
1993
- 1993-10-13 CA CA002147127A patent/CA2147127A1/en not_active Abandoned
- 1993-10-13 PT PT93924312T patent/PT666929E/pt unknown
- 1993-10-13 EP EP93924312A patent/EP0666929B1/de not_active Expired - Lifetime
- 1993-10-13 JP JP51023394A patent/JP3492364B2/ja not_active Expired - Fee Related
- 1993-10-13 DE DE69332978T patent/DE69332978T2/de not_active Expired - Fee Related
- 1993-10-13 AT AT93924312T patent/ATE240404T1/de not_active IP Right Cessation
- 1993-10-13 WO PCT/US1993/009774 patent/WO1994009160A1/en active IP Right Grant
- 1993-10-13 ES ES93924312T patent/ES2194849T3/es not_active Expired - Lifetime
- 1993-10-13 DK DK93924312T patent/DK0666929T3/da active
-
1995
- 1995-06-06 US US08/473,399 patent/US5866550A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK0666929T3 (da) | 2003-09-15 |
| WO1994009160A1 (en) | 1994-04-28 |
| DE69332978T2 (de) | 2004-02-26 |
| EP0666929B1 (de) | 2003-05-14 |
| PT666929E (pt) | 2003-08-29 |
| JP3492364B2 (ja) | 2004-02-03 |
| CA2147127A1 (en) | 1994-04-28 |
| EP0666929A4 (de) | 1996-07-10 |
| US5516631A (en) | 1996-05-14 |
| US5866550A (en) | 1999-02-02 |
| ES2194849T3 (es) | 2003-12-01 |
| JPH08504573A (ja) | 1996-05-21 |
| EP0666929A1 (de) | 1995-08-16 |
| ATE240404T1 (de) | 2003-05-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |